Category: 78573-45-2

78573-45-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 21; [00089] A lO liter glass stirred reactor was flushed with nitrogen. The nitrogen blanketing continued during the reaction, and was stopped when the work-up was started. 600 g of compound V, 3.6 liter of Toluene and 492 ml of triethyl amine were charged into the reactor at room temperature. The stirrer was turned on, and then the reactor content was cooled to 4.50C. 255.6 ml of Mesyl chloride (MsCl) was charged drop-wise during 50 minutes, while cooling the reactor. The reactor was heated to 250C, and the triethyl amine salt (TEAHCl) was filtered under reduced pressure, and then the filter cake was washed with 1.8 liter of Toluene (3×600 ml). The organic phase was washed with 500 ml of 0.2N HCl, then the phases were separated, and the organic phase was washed with water (3×1.2L) to achieve pH=7. Toluene was evaporated under reduced pressure. After completion of the evaporation, 1.2 liter of fresh Toluene was charged into the reactor, and the solvent was evaporated at similar conditions. 858g of compound VI were obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2006/125026; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

78573-45-2, Adding a certain compound to certain chemical reactions, such as: 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 78573-45-2, blongs to alcohols-buliding-blocks compound.

Example 4 Preparation of methanesulfonic acid 3-(3-trifluoromethyl-phenyl)-propyl ester To a stirred solution of 3-(3-trifluoromethyl-phenyl)-propan-1-ol (250 g, 1.224 mol) and triethylamine (148.52 g, 1.47 mol) in dichloromethane (1.25 L), methanesulfonyl chloride (161.32 g, 1.41 mol) was added at 25 C. to 40 C. and reaction mixture was stirred for 2-3 hours at 40 C. Thereafter, reaction mixture was washed with demineralized water (500 ml*3) and dried over anhydrous sodium sulfate. The dichloromethane was distilled off to give 335 g of title compound having purity 91.58% by HPLC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,78573-45-2, its application will become more common.

Reference:
Patent; IND-SWIFT LABORATORIES LIMITED; US2011/172455; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

78573-45-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Example 2: Synthesis of 3-[3-(trifluoromethyl)phenyl]-propionaldehyde (II) A solution of compound (V) (1.0 g, 4.90 mmol) in dichloromethane (20 ml) is cooled in water / ice bath, treated in succession with DMSO (770 mg, 9.80 mmol) and P2O5 (1.39 g, 9.80 mmol) and left under stirring for 30 minutes, while temperature raises to 20C. The reaction mixture is then cooled in water / ice bath and triethylamine (2.4 ml, 17.15 mmol). The resulting solution is kept under stirring while temperature raises to 20C. After one hour the mixture is treated with 5% HCl, the phases are separated and the organic one is further washed with 5% HCl. The organic phase is then washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure, to afford 0.99 g of the aldehyde of formula (II) in quantitative yield. 1H NMR (300 MHz, CDCl3), ppm: 9.83 (t, 1H, J 0.9 Hz), 7.48-7.38 (m, 4H), 3.02 (t, 2H, J 7.2 Hz), 2.82 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol.

Reference:
Patent; Dipharma Francis S.r.l.; EP2327684; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts