Category: 78-70-6

Ghosh, Enakshi; Venkatesan, Radhika published the artcile< Plant Volatiles Modulate Immune Responses of Spodoptera litura>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is Herbivory; Insect immunity; Linalool; Ocimene; Plant volatiles; Tritrophic interaction.

Plants emit a specific blend of volatiles in response to herbivory and these volatiles, which often attract predators and parasitoids function as an indirect plant defense. The impact of plant volatiles in shaping herbivore defenses is unclear. Here, we report that specific plant volatiles induce immune responses in the polyphagous herbivore, Spodoptera litura. We characterized the hemocyte profile and established their functional significance with respect to ontogeny and exposure to specific plant volatiles. Fifth instar larvae showed the highest number and hemocytes diversity. We characterized seven different types of hemocytes, of which granulocytes performed phagocytosis, oenocytoids showed melanization activity, and plasmatocytes along with granulocytes and oenocytoids were found to be involved in encapsulation. Among the six volatiles tested, exposure to (E)-β-ocimene caused the highest increase in total hemocytes number (THC) followed by linalool and (Z)-3-hexenyl acetate exposure. Although THC did not differ between these three volatile treatments, circulating hemocytes diversity varied significantly. (E)-β-ocimene exposure showed higher number of plasmatocytes and phenol oxidase activity. The interaction of the parasitic wasp Bracon brevicornis with (E)-β-ocimene exposed larvae was poor in terms of delayed paralysis and lower egg deposition. In choice assays, the wasp showed clear preference towards control larvae indicating (E)-β-ocimene treatment renders the host unattractive. Hemocyte profiles post-parasitoid exposure and (E)-β-ocimene treatment were similar indicating cue-based priming. When challenged with Bacillus thuringiensis, linalool exposure resulted in the highest survival as compared to other volatiles. Our results show that specific HIPVs can modulate cellular immunity of S. litura, revealing a new role for HIPVs in tri-trophic interactions.

Journal of Chemical Ecology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Kegang; Lin, Yahui; Chai, Xianghua; Duan, Xuejuan; Zhao, Xinxin; Chun, Chen published the artcile< Mechanisms of vapor-phase antibacterial action of essential oil from Cinnamomum camphora var. linaloofera Fujita against Escherichia coli>, Reference of 78-70-6, the main research area is Cinnamomum camphora essential oil vapor phase antibacterial agent Escherichia; antibacterial mechanism; essential oil; linaloofera fujita; vapor‐phase antimicrobial activity.

The purpose of this study was to investigate antibacterial activity of essential oil from Cinnamomum camphora var. linaloofera Fujita (EOL) at vapor phase and its mechanism of bactericidal action against Escherichia coli. Results showed that the vapor-phase EOL had significant antibacterial activity with a min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) of 200μl/L. Further analyses showed that treatment of E. coli with vapor-phase EOL resulted in partial degradation of cell membrane, increased membrane permeability, leakage of cytoplasm materials, and prominent distortion and shrinkage of bacterial cells. FTIR showed that EOL altered bacterial protein secondary and tertiary structures. GC/MS anal. showed that the components of vapor-phase EOL included linalool (69.94%), camphor (10.90%), nerolidol (10.92%), and safrole (8.24%), of which linalool had bactericidal activity. Quantum chem. anal. suggested that the antibacterial reactive center of linalool was oxygen atom (O10) which transferred electrons during antibacterial action by the donation of electrons.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Antibacterial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jing, Tingting; Zhang, Na; Gao, Ting; Zhao, Mingyue; Jin, Jieyang; Chen, Yongxian; Xu, Miaojing; Wan, Xiaochun; Schwab, Wilfried; Song, Chuankui published the artcile< Glucosylation of (Z)-3-hexenol informs intraspecies interactions in plants: A case study in Camellia sinensis>, HPLC of Formula: 78-70-6, the main research area is Camellia UGT Z hexenol pest control; airborne (Z)-3-hexenol; glucosyltransferase; overexpression; site-directed mutagenesis; tea plant.

Plants emit a variety of volatiles in response to herbivore attack, and (Z)-3-hexenol and its glycosides have been shown to function as defense compounds Although the ability to incorporate and convert (Z)-3-hexenol to glycosides is widely conserved in plants, the enzymes responsible for the glycosylation of (Z)-3-hexenol remained unknown until today. In this study, uridine-diphosphate-dependent glycosyltransferase (UGT) candidate genes were selected by correlation anal. and their response to airborne (Z)-3-hexenol, which has been shown to be taken up by the tea plant. The allelic proteins UGT85A53-1 and UGT85A53-2 showed the highest activity towards (Z)-3-hexenol and are distinct from UGT85A53-3, which displayed a similar catalytic efficiency for (Z)-3-hexenol and nerol. A single amino acid exchange E59D enhanced the activity towards (Z)-3-hexenol, whereas a L445M mutation reduced the catalytic activity towards all substrates tested. Transient overexpression of CsUGT85A53-1 in tobacco significantly increased the level of (Z)-3-hexenyl glucoside. The functional characterization of CsUGT85A53 as a (Z)-3-hexenol UGT not only provides the foundation for the biotechnol. production of (Z)-3-hexenyl glucoside but also delivers insights for the development of novel insect pest control strategies in tea plant and might be generally applicable to other plants.

Plant, Cell & Environment published new progress about Camellia sinensis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, HPLC of Formula: 78-70-6.

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Alcohol – Wikipedia,
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Wu, Han; Li, Rui-Ting; Dong, Jun-Feng; Jiang, Nan-Ji; Huang, Ling-Qiao; Wang, Chen-Zhu published the artcile< An odorant receptor and glomerulus responding to farnesene in Helicoverpa assulta (Lepidoptera: Noctuidae)>, Category: alcohols-buliding-blocks, the main research area is Helicoverpa larva glomerulus odorant receptor farnesene oviposition index; Farnesene; Glomeruli; Labeled-line; Odorant receptor.

Terpenoids emitted from herbivore-damaged plants were found to play an important role in regulating tritrophic interactions. How herbivores and their natural enemies perceive terpenoids has not been thoroughly elucidated to date. Using in vivo calcium imaging, we found in this study that farnesene activates one glomerulus in the antennal lobe of female Helicoverpa assulta. The response induced by a mixture of farnesene isomers is stronger than that elicited by E-β-farnesene alone. In the Xenopus oocyte expression system, HassOR23/ORco is narrowly tuned to farnesene isomers and compounds with similar structures. Finally, the behavioral studies showed that the farnesene isomers have an inhibitory effect on oviposition of female H. assulta, but have an attractive effect on host searching of Campoletis chlorideae, the key endoparasitoid of H. assulta larvae. These results demonstrate that farnesene isomers are encoded by a labeled-line mode in the olfactory system of female H. assulta, suggesting that farnesene as a chem. signal from plants has important behavioral relevance and evolutionary implications in the tritrophic context.

Insect Biochemistry and Molecular Biology published new progress about Antennal lobe. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
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Couto, Hyrla Grazielle Silva de Araujo; Blank, Arie Fitzgerald; de Oliveira e Silva, Ana Mara; Nogueira, Paulo Cesar de Lima; Arrigoni-Blank, Maria de Fatima; Nizio, Daniela Aparecida de Castro; Pinto, Jessika Andreza de Oliveira published the artcile< Essential oils of basil chemotypes: Major compounds, binary mixtures, and antioxidant activity>, Reference of 78-70-6, the main research area is essential oil basil genotype antioxidant eugenol; 1,8 cineole (PubChem CID: 2758); Antagonism; Eugenol; Eugenol (PubChem CID: 3314); Geranial (PubChem CID: 638011); Linalool (PubChem CID: 6549); Methyl chavicol (PubChem CID: 8815); Methyl cinnamate (PubChem CID: 637520); Neral (PubChem CID: 643779); Ocimum; Synergism; Volatile oil.

The antioxidant potential of the essential oils (EO) of 24 basil genotypes was assessed by 4 distinct in vitro evaluation methods. Different combinations of the major compounds found in the EO were also tested to identify those combinations responsible for the antioxidant activity of the volatile oils and verify the occurrence of synergism or antagonism between them. Results indicate that 9 EO exhibited promising antioxidant potential, with at least 52.68% of inhibition of the linoleic acid peroxidation at 10 μL/mL and 76.34% of inhibition of the DPPH· radical at 1 μL/mL. The major compound eugenol had the highest antioxidant activity. The antioxidant activity of these EO cannot be explained solely by the presence of the major compounds Despite the influence of eugenol, the antioxidant activity is also related to the synergism between other minor compounds found in the EO. This fact confers a potent antioxidant activity to some basil EO.

Food Chemistry published new progress about Antioxidants. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Engleder, Matthias; Mueller, Monika; Kaluzna, Iwona; Mink, Daniel; Schuermann, Martin; Leitner, Erich; Pichler, Harald; Emmerstorfer-Augustin, Anita published the artcile< Exploring Castellaniella defragrans linalool (de)hydratase-isomerase for enzymatic hydration of alkenes>, Quality Control of 78-70-6, the main research area is Castellaniella defragrans; dehydratase; geraniol; hydratase; isomerase; linalool; monoterpene hydration; myrcene; tertiary alcohol.

Acyclic monoterpenes constitute a large and highly abundant class of secondary plant metabolites and are, therefore, attractive low-cost raw materials for the chem. industry. To date, numerous biocatalysts for their transformation are known, giving access to highly sought-after monoterpenoids. In view of the high selectivity associated with many of these reactions, the demand for enzymes generating com. important target mols. is unabated. Here, linalool (de)hydratase-isomerase (Ldi, EC 4.2.1.127) from Castellaniella defragrans was examined for the regio- and stereoselective hydration of the acyclic monoterpene β-myrcene to (S)-(+)-linalool. Expression of the native enzyme in Escherichia coli allowed for identification of bottlenecks limiting enzyme activity, which were investigated by mutating selected residues implied in enzyme assembly and function. Combining these analyses with the recently published 3D structures of Ldi highlighted the precisely coordinated reduction-oxidation state of two cysteine pairs in correct oligomeric assembly and the catalytic mechanism, resp. Subcellular targeting studies upon fusion of Ldi to different signal sequences revealed the significance of periplasmic localization of the mature enzyme in the heterologous expression host. This study provides biochem. and mechanistic insight into the hydration of β-myrcene, a nonfunctionalized terpene, and emphasizes its potential for access to scarcely available but com. interesting tertiary alcs.

Molecules published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Quality Control of 78-70-6.

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Natsch, Andreas; Nagelin, Marco; Leijs, Hans; van Strien, Michel; Gimenez-Arnau, Elena; Vey, Matthias; Gonzalez, Cecile published the artcile< Exposure source for skin sensitizing hydroperoxides of limonene and linalool remains elusive: An analytical market surveillance>, Computed Properties of 78-70-6, the main research area is Consumer products; Market surveillance; Quantification; Skin allergy; Terpene hydroperoxides.

Pos. patch test reactions of dermatol. patients to oxidized samples of linalool and limonene are frequently reported. The sensitizing ingredients in the oxidation mixtures are hydroperoxides (HP). It is not clear whether fragranced consumer products are a relevant exposure source for HP. Anal. methodologies had been validated, allowing quantification of HP in different consumer products. The anal. approach was used to analyze 104 consumer products. Samples included aged and new samples from the same brand, products suspected by patients to elicit their symptoms and products containing essential oils. Only four samples contained >50 μg/g of at least one of the HP by the screening method. Confirmatory anal. by LC-MS methods indicated that levels are even below those observed by the conservative screening method. The samples retrieved from patch-test pos. patients were below detection limit for all target analytes. This market surveillance indicates that concentrations of HP in consumer products and patient products are orders of magnitude below sensitizing doses in animal tests. No evidence for hydroperoxide accumulation in aged products or products used by patients was found. The nature and source of the inducing agent responsible for the frequent pos. patch test reactions to oxidized terpenes remains elusive.

Food and Chemical Toxicology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohamed, Maged E.; Abduldaium, Yamen S.; Younis, Nancy S. published the artcile< Ameliorative effect of linalool in cisplatin-induced nephrotoxicity: the role of HMGB1/TLR4/NF-κB and Nrf2/HO1 pathways>, Safety of 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is linalool cisplatin induced nephrotoxicity ameliorative effect; apoptosis; essential oil; human cell line cytotoxicity; monoterpenes; oxidative stress; toll-like receptors.

The monoterpene linalool is a well-known essential oil component produced by several aromatic plants. Cisplatin is a widely used anticancer drug that produces many side effects, particularly nephrotoxicity. Here, we aimed to inspect linalool′s protective activity against cisplatin-induced nephrotoxicity and explore part of the underlying mechanisms. Male Wistar rats were given linalool (50 and 100 mg/kg/day orally) for 15 days; then challenged with cisplatin (8 mg/kg) on the 12th day. Renal function parameters, oxidative stress, inflammatory and apoptotic markers, and toll-like receptor pathway gene, and protein expressions were investigated. Histopathol., immunohistochem., and cell-line mediated cytotoxicity assays were conducted. Linalool ameliorated kidney function after cisplatin challenge and managed all oxidation system parameters including GSH, SOD, CAT, MDA, NADPH, and particularly the Nrf2-mediated pathway markers. Linalool decreased TLR4, MYD88 and TRIF gene and protein expressions; diminished related inflammatory mediators such as TNF-α, IL-1β, IL-6, and NF-κB; and down-regulated HMBG1. Linalool mitigated cisplatin-induced apoptotic markers such as caspase 3, caspase 9, and Bax expression, and boosted the anti-apoptotic Bcl2 expression. Linalool potentiated the cytotoxic effect of cisplatin when investigated on HeLa and PC3 human cancer cell lines. Linalool could protect against cisplatin-induced kidney function and tissue damage.

Biomolecules published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Bax). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Safety of 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Becker, Vivien; Hui, Xin; Nalbach, Lisa; Ampofo, Emmanuel; Lipp, Peter; Menger, Michael D.; Laschke, Matthias W.; Gu, Yuan published the artcile< Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8>, Application of C10H18O, the main research area is linalool TRPM8 antiangiogenic agent angiogenesis; ATP; Angiogenesis; Endothelial cells; Linalool; TRPM8; Vascularization.

Angiogenesis crucially contributes to various diseases, such as cancer and diabetic retinopathy. Hence, anti-angiogenic therapy is considered as a powerful strategy against these diseases. Previous studies reported that the acyclic monoterpene linalool exhibits anticancer, anti-inflammatory and anti-oxidative activity. However, the effects of linalool on angiogenesis still remain elusive. Therefore, we investigated the action of (3R)-(-)-linalool, a main enantiomer of linalool, on the angiogenic activity of human dermal microvascular endothelial cells (HDMECs) by a panel of angiogenesis assays. Non-cytotoxic doses of linalool significantly inhibited HDMEC proliferation, migration, tube formation and spheroid sprouting. Linalool also suppressed the vascular sprouting from rat aortic rings. In addition, Matrigel plugs containing linalool exhibited a significantly reduced microvessel d. 7 days after implantation into BALB/c mice. Mechanistic analyses revealed that linalool promotes the phosphorylation of extracellular signal-regulated kinase (ERK), downregulates the intracellular level of ATP (ATP) and activates the transient receptor potential cation channel subfamily M (melastatin) member (TRPM)8 in HDMECs. Inhibition of ERK signaling, supplementation of ATP and blockade of TRPM8 significantly counteracted linalool-suppressed HDMEC spheroid sprouting. Moreover, ATP supplementation completely reversed linalool-induced ERK phosphorylation. In addition, linalool-induced ERK phosphorylation inhibited the expression of bone morphogenetic protein (BMP)-2 and linalool-induced TRPM8 activation caused the inhibition of β1 integrin/focal adhesion kinase (FAK) signaling. These findings indicate an anti-angiogenic effect of linalool, which is mediated by downregulating intracellular ATP levels and activating TRPM8.

Angiogenesis published new progress about Angiogenesis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, JianCai; Niu, Yunwei; Xiao, ZuoBing published the artcile< Characterization of the key aroma compounds in Laoshan green teas by application of odour activity value (OAV), gas chromatography-mass spectrometry-olfactometry (GC-MS-O) and comprehensive two-dimensional gas chromatography mass spectrometry (GC x GC-qMS)>, Electric Literature of 78-70-6, the main research area is nonanol decanal skatole furaneol Laoshan green tea aroma olfactometry; Characteristic aroma compound; Comprehensive two-dimensional gas chromatography mass spectrometry (GC × GC-qMS); Laoshan green tea; Odor activity value (OAV); S-curve.

To investigate the key aroma compounds in Laoshan green teas (Huangshan (S1), Changling (S2), and Fangling (S3)), gas chromatog.-mass spectrometry-olfactometry (GC-MS-O), a flame photometric detector (FPD), odor activity value (OAV), and comprehensive two-dimensional gas chromatog. mass spectrometry (GC x GC-qMS) were employed. A total of 50 aroma compounds were perceived and 24 compounds were identified as important compounds related to OAV, such as di-Me sulfide (OAV: 126-146), skatole (OAV: 27-50), furaneol (OAV: 8-27), (Z)-jasmone (OAV: 16-23), 2-methylbutanal (OAV: 15-22), and 3-methylbutanal (OAV: 68-87). Furthermore, the S-curve method was used to research the effect of aroma compounds on the threshold of aroma recombination (AR). The AR thresholds decreased from 3.8 mL to 0.45, 0.66, 0.93, 0.95, 0.75, 1.09, 3.01, and 2.57 mL after addition of eight compounds (skatole, furaneol, (Z)-jasmone, α-damascenone, sclareololide, dihydroactinidiolide, vanillin, and δ-valerolactone), indicating that those compounds (OAV >1) were contributors to the overall aroma of Laoshan teas.

Food Chemistry published new progress about Flame photometric detectors. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts