Category: 78-70-6

Lafontaine, Scott; Varnum, Scott; Roland, Aurelie; Delpech, Stephane; Dagan, Laurent; Vollmer, Daniel; Kishimoto, Toru; Shellhammer, Thomas published the artcile< Impact of harvest maturity on the aroma characteristics and chemistry of Cascade hops used for dry-hopping>, Product Details of C10H18O, the main research area is hop oil ripening beer aroma thiol; 3-Mercaptohexanol (PubChem CID: 521348); 3-Mercaptohexylacetate (PubChem CID: 17774879); 4-Methyl-4-mercaptopentan-2-one (PubChem CID: 88290); Beer; Dry-hopping; Geraniol (PubChem CID: 637566); Harvest maturity; Hop quality; Humulone (PubChem CID: 442911); Humulus lupulus; Linalool (PubChem CID: 6549); Polyfunctional thiols; Sensory; β-Myrcene (PubChem CID: 31253).

The impact of ripening on the dry-hop aroma potential and chem. development of Cascade hops is not well understood. Therefore, 5-6 weekly hop samples were collected over the 2014, 2015 and 2016 harvests. Concentrations of humulones did not change as a function of harvest date, while total hop essential oil content displayed significant pos. trends. Concentrations of thiol precursors decreased over harvest while concentrations of free thiols increased. These weekly samples were used to dry-hop an unhopped base beer. Overall hop aroma intensity and citrus quality attributed to beer during dry-hopping increased as a function of harvest date. These results suggest that for brewers to maximize the efficiency of hop usage, early harvested Cascades might be better for bittering, while, later harvested Cascades might be better for dry-hopping or aroma additions because they attributed more intense citrus aromas to beer and had higher concentrations of free thiols and terpene alcs.

Food Chemistry published new progress about Beer. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yunusoglu, Oruc published the artcile< Linalool attenuates acquisition and reinstatement and accelerates the extinction of nicotine-induced conditioned place preference in male mice>, Computed Properties of 78-70-6, the main research area is Nicotine addiction; acquisition; extinction; linalool; reinstatement.

Background: Nicotine is the addictive agent in tobacco products. The monoterpene linalool is the main ingredient in the essential oils of various aromatic plants. It has previously been demonstrated that linalool has beneficial effects on some mechanisms that are important in drug addiction. Objectives: The goal of the current study was to investigate the effect of linalool on nicotine-induced conditioned place preference (CPP) in male mice. Methods: CPP was induced by administering i.p. (i.p.) injection of nicotine (0.5 mg/kg) during the conditioning phase. The effects of nicotinic acetylcholine receptor partial agonist varenicline and linalool on the rewarding characteristics of nicotine were tested in mice with administration of linalool (12.5, 25, and 50 mg/kg, i.p.), varenicline (2 mg/kg, i.p.) or saline 30 min before nicotine injection. CPP was extinguished by repeated testing, during which conditioned mice were administered varenicline and linalool every day. One day after the last extinction trial, mice that received linalool, varenicline or saline 30 min before a priming injection of nicotine (0.1 mg/kg, i.p.) were immediately tested for reinstatement of CPP. Results: Linalool attenuated nicotine acquisition (50 mg/kg, p < .01) and reinstatement (25 and 50 mg/kg, resp. p < .05, p < .01) and accelerated the extinction of nicotine-induced CPP (50 mg/kg, p < .05). Linalool exhibited similar effects on the reference drug varenicline in the CPP phases. Conclusion: These results suggest that linalool may be helpful as an adjuvant for the treatment of nicotine use disorder. American Journal of Drug and Alcohol Abuse published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zeng, Lanting; Xiao, Yangyang; Zhou, Xiaochen; Yu, Jizhong; Jian, Guotai; Li, Jianlong; Chen, Jiaming; Tang, Jinchi; Yang, Ziyin published the artcile< Uncovering reasons for differential accumulation of linalool in tea cultivars with different leaf area>, Application In Synthesis of 78-70-6, the main research area is Camellia Tea Aroma Linalool oxide Leaf; Aroma; Camellia sinensis; Geranyl pyrophosphate (PubChem CID: 44134732).; Leaf area; Linalool; Linalool (PubChem CID: 6549); Linalool oxide; Tea; cis-linalool oxide (furaniod) (PubChem CID: 6428573); trans-linalool oxide (furaniod) (PubChem CID: 6431475).

It is generally proposed that tea cultivars with larger leaves contain more linalool, an important tea aroma contributor, than ones with smaller leaves. The objective of this study was to confirm the trait and explore the involved reason. Investigation on ten tea cultivars with different leaf areas demonstrated a significant pos. correlation between linalool content and leaf area (R2 = 0.739, p = 0.010). Anal. of metabolite and gene expression level showed that the transform ability of linalool into linalool oxides was the key factor. Feeding experiments that supplied tea leaves of different leaf areas with [2H3]linalool under different light conditions revealed that the larger tea leaves receive more light and are less capable of transformation of linalool to linalool oxides, thus leading to linalool accumulation. This information will advance understanding of the variation of linalool content in tea varieties and will provide assistance in breeding and screening of high-linalool tea cultivars.

Food Chemistry published new progress about Camellia sinensis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaudhari, Anand Kumar; Singh, Vipin Kumar; Dwivedy, Abhishek Kumar; Das, Somenath; Upadhyay, Neha; Singh, Akanksha; Dkhar, Mumtaz S.; Kayang, Highland; Prakash, Bhanu; Dubey, Nawal Kishore published the artcile< Chemically characterized Pimenta dioica (L.) Merr. essential oil as a novel plant based antimicrobial against fungal and aflatoxin B1 contamination of stored maize and its possible mode of action>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is Pimenta essential oil antimicrobial agent maize aflatoxin B1 contamination; Pimenta dioica essential oil; aflatoxin B1; ergosterol; lipid peroxidation; methylglyoxal; α-Terpineol.

The chem. characterization of P. dioica essential oil (PDEO) revealed the presence of 50 components, among which α-terpineol (30.31%) was the major component followed by β-linalool (6.75%) and γ-terpinene (4.64%). The oil completely inhibited the growth of aflatoxin B1-secreting strain Aspergillus flavus LHP-VS-8, and aflatoxin B1 production at 2.5 and 1.5μL/mL, resp. The oil caused dose-dependent reduction of methylglyoxal (an AFB1 inducer), enhanced leakage of Ca2+, Mg2+ and K+ ions, and significantly reduced the ergosterol content of the fungal plasma membrane. During in situ experiments, PDEO exhibited complete protection of fumigated maize cob slices from fungal infestation without affecting seed germination. The chem. characterized PDEO is recommended as a plant based preservative and shelf life enhancer of food commodities by preventing fungal growth, AFB1 production and lipid peroxidation This is the 1st report on PDEO as inhibitor of AFB1 secretion, and methylglyoxal biosynthesis.

Natural Product Research published new progress about Aspergillus flavus. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Api, A. M.; Belsito, D.; Botelho, D.; Bruze, M.; Burton, G. A. Jr.; Buschmann, J.; Cancellieri, M. A.; Dagli, M. L.; Date, M.; Dekant, W.; Deodhar, C.; Fryer, A. D.; Jones, L.; Joshi, K.; Kumar, M.; Lapczynski, A.; Lavelle, M.; Lee, I.; Liebler, D. C.; Moustakas, H.; Na, M.; Penning, T. M.; Ritacco, G.; Romine, J.; Sadekar, N.; Schultz, T. W.; Selechnik, D.; Siddiqi, F.; Sipes, I. G.; Sullivan, G.; Thakkar, Y.; Tokura, Y. published the artcile< RIFM fragrance ingredient safety assessment, linalool, CAS Registry number 78-70-6>, HPLC of Formula: 78-70-6, the main research area is .

There is no abstract available for this document.

Food and Chemical Toxicology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, HPLC of Formula: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bialon, Marietta; Krzysko-lupicka, Teresa; Nowakowska-Bogdan, Ewa; Wieczorek, Piotr P. published the artcile< Chemical composition of two different lavender essential oils and their effect on facial skin microbiota>, Computed Properties of 78-70-6, the main research area is facial skin microbiota; gas chromatography with mass spectrometry; lavender essential oil.

Lavender oil is one of the most valuable aromatherapy oils, its anti-bacterial and anti-fungal activities can be explained by main components such as linalool, linalyl acetate, lavandulol, geraniol, or eucalyptol. The aim of the study was to assess the anti-microbial effects of two different lavender oils on a mixed microbiota from facial skin. The com. lavender oil and essential lavender oil from the Crimean Peninsula, whose chem. composition and activity are yet to be published, were used. Both oils were analyzed by gas chromatog. coupled to mass spectrometry. The composition and properties of studied oils were significantly different. The com. ETJA lavender oil contained 10% more linalool and linalyl acetate than the Crimean lavender oil. Both oils also had different effects on the mixed facial skin microbiota. The Gram-pos. bacilli were more sensitive to ETJA lavender oil, and Gram-neg. bacilli were more sensitive to Crimean lavender oil. However, neither of the tested oils inhibited the growth of Gram-pos. cocci. The tested lavender oils decreased the cell number of the mixed microbiota from facial skin, but ETJA oil showed higher efficiency, probably because it contains higher concentrations of monoterpenoids and monoterpenes than Crimean lavender oil does.

Molecules published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Yu; Jin, Guo-Jie; Wang, Xing-Jie; Kong, Cai-Lin; Liu, Ji Bin; Tao, Yong-Sheng published the artcile< Chemical profiles and aroma contribution of terpene compounds in Meili (Vitis vinifera L.) grape and wine>, Quality Control of 78-70-6, the main research area is aroma terpene glycoside grape wine; Cedrol (PubChem CID: 65575); Citronellol (PubChem CID: 8842); Farnesol (PubChem CID: 445070); GC–MS; Geraniol (PubChem CID: 637566); Geranyl acetone (PubChem CID: 1549778); Linalool (PubChem CID: 6549); Mathematical regression; Meili; Menthol (PubChem CID: 1254); Nerol (PubChem CID: 643820); Terpene compound; Terpinene (PubChem CID: 7462); Terpineol (PubChem CID: 17100); Wine aroma.

The chem. profiles and aroma contribution of terpene compounds in Meili grapes and wine were analyzed. Bound terpene compounds were extracted using methanol, purified using Amberlite XAD-2 resin, concentrated in methanol/ethyl acetate, and enzymically hydrolyzed to release aglycons. Free terpene compounds were identified using solid-phase microextraction (SPME) coupled with gas chromatog.-mass spectrometry (GC-MS). Wine aroma characteristics were quantified by a trained sensory panel. Seventeen terpene glycosides were quantified in grapes and wines as pentosyl-glucopyranoside, the content of which ranged from 804 to 836 μg/kg, and from 155 to 192 μg/L, resp. Eight free terpenes were present in wines with their content ranging from 40.1 to 59.7 μg/L. Linalool was abundant both in bound and free terpenes, and math. regression revealed that terpenes, especially linalool (contribution efficient > 0.4), contributed heavily to Meili wine aroma. Finally, a mol. rearrangement scheme based on linalool was proposed in Meili grape and wine.

Food Chemistry published new progress about Flavor. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Quality Control of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Zhongzhou; Li, Yueqing; Gao, Fengzhan; Jin, Wei; Li, Shuying; Kimani, Shadrack; Yang, Song; Bao, Tingting; Gao, Xiang; Wang, Li published the artcile< MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flwers of Freesia hybrida and Arabidopsis thaliana>, SDS of cas: 78-70-6, the main research area is terpene synthase gene Freesia hybrida Arabidopsis thaliana MYB21 MYC2; Freesia hybrida ; Arabidopsis; MYB–bHLH complex; flower scents; linalool; terpene synthase; transcription factor.

Previously, linalool was found to be the most abundant component among the cocktail of volatiles released from flwers of Freesia hybrida. Linalool formation is catalyzed by monoterpene synthase TPS1. However, the regulatory network developmentally modulating the expression of the TPS1 gene in Freesia hybrida remains unexplored. In this study, three regulatory genes, FhMYB21L1, FhMYB21L2, and FhMYC2, were screened from 52 candidates. Two MYB transcription factor genes were synchronously expressed with FhTPS1 and could activate its expression significantly when overexpressed, and the binding of FhMYB21L2 to the MYBCORE sites in the FhTPS1 promoter was further con firmed, indicating a direct role in activation. FhMYC2 showed an inverse expression pattern compared with FhTPS1; its expression led to a decreased binding of FhMYB21 to the FhTPS1 promoter to reduce its activation capacity when co-expressed, suggesting a role for an MYB-bHLH complex in the regulation of the FhTPS1 gene. In Arabidopsis, both MYB21 and MYC2 regulators were shown to activate the expression of sesquiterpene synthase genes, and the regu latory roles of AtMYB21 and AtMYC2 in the expression of the linalool synthase gene were also confirmed, implying conserved functions of the MYB-bHLH complex in these two evolutionarily divergent plants. Moreover, the expression ratio between MYB21 and MYC2 orthologues might be a determinant factor in floral linalool emission.

Journal of Experimental Botany published new progress about Arabidopsis thaliana. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weng, Shidan; Fu, Xueqing; Gao, Yu; Liu, Tianlei; Sun, Yi; Tang, Dongqin published the artcile< Identification and Evaluation of Aromatic Volatile Compounds in 26 Cultivars and 8 Hybrids of Freesia hybrida>, SDS of cas: 78-70-6, the main research area is Freesia hybrida; VOCs; floral scent; heterosis; monoterpenes.

Freesia hybrida is a group of cultivars in the genus Freesia with a strong floral scent composed of diverse volatile organic compounds (VOCs). In this study, the VOCs of 34 F. hybrida were extracted and analyzed by headspace solid phase microextraction and gas chromatog. mass spectrometry (HS-SPME-GC-MS). A total of 164 VOCs whose relative contents were higher than 0.05% were detected. The numbers of VOCs in all germplasms differed between 11 to 38, and the relative contents ranged from 32.39% to 94.28%, in which most germplasms were higher than 80%. Terpenoids, especially monoterpenes, were the crucial type of VOCs in most germplasms, of which linalool and D-limonene were the most frequently occurring. Principal component anal. (PCA) clearly separated samples based on whether linalool was the main component, and hierarchical clustering anal. (HCA) clustered samples into 4 groups according to the preponderant compounds linalool and (E)-β-ocimene. Comparison of parental species and hybrids showed heterosis in three hybrids, and the inherited and novel substances suggested that monoterpene played an important role in F. hybrida floral scent. This study established a foundation for the evaluation of Freesia genetic resources, breeding for the floral aroma and promoting com. application.

Molecules published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Lei; Li, Xiaofei; Zhang, Yumeng; Ding, Meng; Sun, Baoshan; Su, Guangyue; Zhao, Yuqing published the artcile< The effects of linalool acupoint application therapy on sleep regulation>, Category: alcohols-buliding-blocks, the main research area is sleep latency lavender linalool hypnotic sedative.

The Shenque acupoint is located in the umbilicus of the human body. In the human body meridians, the Shenque acupoint can regulate body functions. The Shenque acupoint was one of the important acupuncture acupoints for the treatment of insomnia. However, the effect of linalool applied at the Shenque acupoint to improve sleep was unknown. This study explored the hypnotic and sedative effects of the main component of lavender, linalool, on the Shenque acupoint of mice and rats. The effects on the sleep latency and sleep duration were studied with the supra-threshold dose of pentobarbital sodium, and the effects on the sleep rate were studied with the sub-threshold dose of pentobarbital sodium. In order to further study the feasibility and superiority of linalool administered at the Shenque acupoint, a pharmacokinetic study was carried out. The pharmacodynamic results showed that the mice and rats treated with linalool at Shenque had the highest sleep rate, the shortest sleep latency, and the longest sleep duration compared with other groups. The Tmax and t1/2 of the LS were longer than those of the LO, and had the characteristics of sustained release. The relative bioavailability of LS was 323.0 ± 31.66%. This showed that the combination of linalool and the Shenque acupoint had greater medicinal effects. This development will provide a new direction for improving sleep.

RSC Advances published new progress about Bioavailability. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts