Category: 78-70-6

Soboleva, Oxana A.; Protsenko, Pavel V.; Korolev, Vadim V.; Viktorova, Jekaterina; Yakushenko, Alexey; Kudla, Ruth; Gutmann, Jochen S.; Tsarkova, Larisa A. published the artcile< Aroma Molecules as Dynamic Volatile Surfactants: Functionality beyond the Scent>, Related Products of 78-70-6, the main research area is aroma mol dynamics surfactant volatile interfacial; dynamic surface tension; essential oils; ink-jet printing; terpens; volatile surfactants; wetting.

Understanding of nonequilibrium processes at dynamic interfaces is indispensable for advancing design and fabrication of solid-state and soft materials. The research presented here unveils specific interfacial behavior of aroma mols. and justifies their usage as multifunctional volatile surfactants. As nonconventional volatile amphiphiles, we study com. available poorly water-soluble compounds from the classes of synthetic and essential flavor oils. Their disclosed distinctive feature is a high dynamic interfacial activity, so that they decrease the surface tension of aqueous solutions on a time scale of milliseconds. Another potentially useful property of such amphiphiles is their volatility, so that they notably evaporate from interfaces on a time scale of seconds. This behavior allows for control of wetting and spreading processes. A revealed synergetic interfacial behavior of mixtures of conventional and volatile surfactants is attributed to a decrease of the activation barrier as a result of high statistical availability of new sites at the surface upon evaporation of the volatile component. Our results offer promising advantages in manufacturing technologies which involve newly creating interfaces, such as spraying, coating technologies, ink-jet printing, microfluidics, laundry, and stabilization of emulsions in cosmetic and food industry, as well as in geosciences for controlling aerosol formation.

ACS Applied Materials & Interfaces published new progress about Aerosols. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jabir, Majid S.; Taha, Ali A.; Sahib, Usama I.; Taqi, Zainab J.; Al-Shammari, Ahmed M.; Salman, Alya S. published the artcile< Novel of nano delivery system for Linalool loaded on gold nanoparticles conjugated with CALNN peptide for application in drug uptake and induction of cell death on breast cancer cell line>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is breast cancer linalool gold nanoparticle CALNN peptide anticancer; Antioxidant activity; CALNN; Cellular uptake; Cytotoxicity; FTIC; Gold nanoparticles; Linalool; MCF-7.

Linalool is a monoterpene alc. which occurs naturally in several aromatic plants. The aims of this study are to load Linalool on gold nanoparticles, conjugate the complex with CALNN peptide, and investigate them for in-vitro anticancer activities against breast cancer (MCF-7) cell line. Linalool was obtained with 98% purity while gold nanoparticles and CALNN peptide were chem. synthesized. The formation of LIN-GNPs and LIN-GNPs-CALNN was observed through a color change. These compounds were confirmed and characterized using SEM, DLS, AFM, UV-VIS spectrophotometer, XRD, and FTIR. The free radical scavenging potential of each compound was confirmed based on its stable antioxidant effects using different parameters. Blood compatibility on red blood cells was confirmed by hemolytic and in vitro cytotoxicity assays. The in-vitro anticancer activity of each compound towardMCF-7 cell line was investigated using various parameters. From the results, Linalool, GNPs, LIN-GNPs, and LIN-GNPs-CALNN were found to exert cell growth arrest against MCF-7 cell line. The anti-proliferative effect of these compounds was due to cell death and induction of apoptosis confirmed using acridine orange-Ethidium bromide dual staining, DAPI staining, and electrophoresis anal. of DNA fragmentation. High fluorescent signals specific for the cellular uptake of LIN-GNPs and LIN-GNPs-CALNN into the cytoplasm of the cell line were confirmed. To study the toxicity of LIN-GNPs-CALNN in animal models, the hematol., histopathol., and body weight changes were estimated after 4 wk of i.p. injection of the compounds into the animal models. Our results demonstrate that Linalool, GNPs, Linalool-GNPs, and Linalool-GNPs-CALNN peptide had no side effects and could be clin. used for future therapeutic purposes.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about Antioxidants. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodriguez-Flores, M. Shantal; Falcao, Soraia I.; Escuredo, Olga; Seijo, M. Carmen; Vilas-Boas, Miguel published the artcile< Description of the volatile fraction of Erica honey from the northwest of the Iberian Peninsula>, Related Products of 78-70-6, the main research area is hotrienol phenylacetaldehyde volatile Erica honey; Erica; GC–MS; Honey; Palynological analysis; SPME; VOCs.

Heather honey is highly appreciated by consumers for its sensorial profile, which varies depending on the flora used by the honeybees. Volatile compounds contribute to these qualities. Characterization of the volatile profile related to the botanical origin is of great interest for the standardization of unifloral honey. For this reason, 33 heather honey samples from northwest of the Iberian Peninsula were analyzed by headspace solid-phase microextraction (HS-SPME) to identify the key volatile compounds in this type of honey. The aim of this research was to provide a descriptive anal. of these compounds, and to find whether there is any relationship with the main Erica species. A total of 58 volatile organic compounds were found, with hotrienol, phenylacetaldehyde, and cis-linalool being the most abundant. A principal component anal. and Spearmans rank correlation showed the homogeneity of the volatile profile in the samples, and their close relationship with the main pollen types.

Food Chemistry published new progress about Erica. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jabir, Majid S.; Taha, Ali A.; Sahib, Usama I.; Taqi, Zainab J.; Al-Shammari, Ahmed M.; Salman, Alya S. published the artcile< Novel of nano delivery system for Linalool loaded on gold nanoparticles conjugated with CALNN peptide for application in drug uptake and induction of cell death on breast cancer cell line>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is breast cancer linalool gold nanoparticle CALNN peptide anticancer; Antioxidant activity; CALNN; Cellular uptake; Cytotoxicity; FTIC; Gold nanoparticles; Linalool; MCF-7.

Linalool is a monoterpene alc. which occurs naturally in several aromatic plants. The aims of this study are to load Linalool on gold nanoparticles, conjugate the complex with CALNN peptide, and investigate them for in-vitro anticancer activities against breast cancer (MCF-7) cell line. Linalool was obtained with 98% purity while gold nanoparticles and CALNN peptide were chem. synthesized. The formation of LIN-GNPs and LIN-GNPs-CALNN was observed through a color change. These compounds were confirmed and characterized using SEM, DLS, AFM, UV-VIS spectrophotometer, XRD, and FTIR. The free radical scavenging potential of each compound was confirmed based on its stable antioxidant effects using different parameters. Blood compatibility on red blood cells was confirmed by hemolytic and in vitro cytotoxicity assays. The in-vitro anticancer activity of each compound towardMCF-7 cell line was investigated using various parameters. From the results, Linalool, GNPs, LIN-GNPs, and LIN-GNPs-CALNN were found to exert cell growth arrest against MCF-7 cell line. The anti-proliferative effect of these compounds was due to cell death and induction of apoptosis confirmed using acridine orange-Ethidium bromide dual staining, DAPI staining, and electrophoresis anal. of DNA fragmentation. High fluorescent signals specific for the cellular uptake of LIN-GNPs and LIN-GNPs-CALNN into the cytoplasm of the cell line were confirmed. To study the toxicity of LIN-GNPs-CALNN in animal models, the hematol., histopathol., and body weight changes were estimated after 4 wk of i.p. injection of the compounds into the animal models. Our results demonstrate that Linalool, GNPs, Linalool-GNPs, and Linalool-GNPs-CALNN peptide had no side effects and could be clin. used for future therapeutic purposes.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about Antioxidants. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodriguez-Flores, M. Shantal; Falcao, Soraia I.; Escuredo, Olga; Seijo, M. Carmen; Vilas-Boas, Miguel published the artcile< Description of the volatile fraction of Erica honey from the northwest of the Iberian Peninsula>, Related Products of 78-70-6, the main research area is hotrienol phenylacetaldehyde volatile Erica honey; Erica; GC–MS; Honey; Palynological analysis; SPME; VOCs.

Heather honey is highly appreciated by consumers for its sensorial profile, which varies depending on the flora used by the honeybees. Volatile compounds contribute to these qualities. Characterization of the volatile profile related to the botanical origin is of great interest for the standardization of unifloral honey. For this reason, 33 heather honey samples from northwest of the Iberian Peninsula were analyzed by headspace solid-phase microextraction (HS-SPME) to identify the key volatile compounds in this type of honey. The aim of this research was to provide a descriptive anal. of these compounds, and to find whether there is any relationship with the main Erica species. A total of 58 volatile organic compounds were found, with hotrienol, phenylacetaldehyde, and cis-linalool being the most abundant. A principal component anal. and Spearmans rank correlation showed the homogeneity of the volatile profile in the samples, and their close relationship with the main pollen types.

Food Chemistry published new progress about Erica. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kashiwadani, Hideki; Higa, Yurina; Sugimura, Mitsutaka; Kuwaki, Tomoyuki published the artcile< Linalool odor-induced analgesia is triggered by transient receptor potential ankyrin 1-independent pathway in mice>, Electric Literature of 78-70-6, the main research area is linalool odor analgesia transient receptor potential ankyrin 1; Analgesia; Linalool; TRPA1; TRPA1-deficient mice; TRPA1-selective antagonist.

Abstract: We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemial senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute toward triggering the linalool odor-induced analgesia, still remain unexplored. In vitro studies have shown that the transient receptor potential ankyrin 1 (TRPA1) responded to linalool, thus raising the possibility that TRPA1 expressed on the trigeminal nerve terminal detects linalool odor inhaled into the nostril and triggers the analgesic effects. To address this hypothesis, we measured the behavioral pain threshold for noxious mech. stimulation in TRPA1-deficient mice. In contrast to our expectation, we found a significant increase in the threshold after linalool odor exposure in TRPA1-deficient mice, indicating the analgesic effects of linalool odor even in TRPA1-deficient mice. Furthermore, intranasal application of TRPA1 selective antagonist did not alter the analgesic effect of linalool odor. These results showed that the linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.

Behavioral and Brain Functions published new progress about Analgesia. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liang, Ying; Li, Yi; Sun, Aidong; Liu, Xianjin published the artcile< Chemical compound identification and antibacterial activity evaluation of cinnamon extracts obtained by subcritical n-butane and ethanol extraction>, Safety of 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is chem compound identification antibacterial activity evaluation cinnamon extract obtained; subcritical butane ethanol extraction; GC‐MS; HPLC‐MS; antibacterial activity; cinnamon; subcritical extraction.

Four important Cinnamomum species in China including C. cassia, C. loureiroi, C. wilsonii, and C. burmannii were chosen to be extracted by subcritical n-butane and ethanol. The chem. compounds of extracts were identified by GC-MS and HPLC-MS, and the antibacterial activities were evaluated by agar-well diffusion assay and twofold microdilution broth method. There were 47 compounds identified in n-butane extracts and 11 compounds in ethanol extracts totally. The major compounds in n-butane extracts varied significantly among different Cinnamomum species, and (E)-cinnamaldehyde and coumarin were major compounds for C. cassia with area percentage of 74.32%; (E)-cinnamaldehyde and a-copaene for C. loureiroi with area percentage of 67.83%; linalool, (E)-cinnamaldehyde, and citral for C. wilsonii with area percentage of 58.74%; and eugenol, (E)-cinnamaldehyde, and coumarin for C. burmannii with area percentage of 76.43%. The maximum compounds in ethanol extracts were (E)-cinnamaldehyde and (Z)-cinnamaldehyde, and others varied among the Cinnamomum species. All cinnamon extracts showed antibacterial activities that n-butane extracts were much more sensitive than ethanol extracts The inhibition zone for N-butane extracts against Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Salmonella anatum was from 18.98 to 37.45 mm while for ethanol extracts from 7.11 to 10.11 mm. The min. bactericidal concentrations for n-butane extracts were ranged from 0.31 to 2.50 mg/mL and for ethanol extracts ranged from 20.00 to 160.00 mg/mL. N-butane extracts of C. cassia and C. loureiroi processed much higher antibacterial activities than C. wilsonii and C. burmannii. N-butane extracts of C. cassia and C. loureiroi have the potential to be used as food biopreservative.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Antibacterial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Safety of 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Durgadevi, Ravindran; Veera Ravi, Arumugam; Alexpandi, Rajaiah; Krishnan Swetha, Thirukannamangai; Abirami, Gurusamy; Vishnu, Selvam; Karutha Pandian, Shunmugaiah published the artcile< Virulence targeted inhibitory effect of linalool against the exclusive uropathogen Proteus mirabilis>, Related Products of 78-70-6, the main research area is urinary tract infection linalool proteus biofilm virulence; Antibiofilm activity; antivirulence activity; crystalline biofilm; linalool; motility; proteus.

Proteus mirabilis is one of the leading causes of catheter-associated UTIs (CAUTI) in individuals with prolonged urinary catheterization. Since, biofilm assisted antibiotic resistance is reported to complicate the treatment strategies of P. mirabilis infections, the present study was aimed to attenuate biofilm and virulence factor production in P. mirabilis. Linalool is a naturally occurring monoterpene alc. found in a wide range of flowers and spice plants and has many biol. applications. In this study, linalool exhibited concentration dependent anti-biofilm activity against crystalline biofilm of P. mirabilis through reduced production of the virulence enzyme urease that raises the urinary pH and drives the formation of crystals (struvite) in the biofilm. The results of q-PCR anal. unveiled the down regulation of biofilm/virulence associated genes upon linalool treatment, which was in correspondence with the in vitro bioassays. Thus, this study reports the feasibility of linalool acting as a promising anti-biofilm agent against P. mirabilis mediated CAUTI.

Biofouling published new progress about Biofilms (microbial). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodriguez-Lopez, Maria Isabel; Mercader-Ros, Maria Teresa; Pellicer, Jose Antonio; Gomez-Lopez, Vicente M.; Martinez-Romero, Domingo; Nunez-Delicado, Estrella; Gabaldon, Jose A. published the artcile< Evaluation of monoterpene-cyclodextrin complexes as bacterial growth effective hurdles>, COA of Formula: C10H18O, the main research area is monoterpene cyclodextrin complex antimicrobial agent.

Monoterpenes have antimicrobial properties but are associated with strong smells and flavors that limit their use in foods; therefore, strategies to keep their effectivity using lower concentrations are required. This work tested the antimicrobial capacity of thymol, carvacrol and linalool free or complexed in hydroxypropyl-β-cyclodextrins (HP- β-CDs) using two complexation methods. To this, these monoterpenes were complexed in HP- β-CDs by the solubility method or a microwave-assisted method, spray dried and their antimicrobial capacity was tested on Escherichia coli and Staphylococcus aureus by determining minimal inhibitory concentration and minimal bactericidal concentration The results show significant differences (p < 0.05) between the complexed and uncomplexed forms. In addition, thanks to the complexation of monoterpenes, the use of lower concentrations of these has been reached to achieve the same level of inhibition than uncomplexed forms. Likewise, it has been found that a lower minimal inhibitory concentration (MIC) is achieved for the solubility method for both microorganisms (3.82 mM for thymol and 2.44 mM for carvacrol in E. coli; and 3.91 and 2.61 mM, resp. for S. aureus) than for the microwave method. This implies that a lower concentration of these compounds can be used to inhibit microbial growth in foods, which should minimize their effects on their smell and taste. Food Control published new progress about Escherichia coli. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Neiens, Silva D.; Steinhaus, Martin published the artcile< Investigations on the impact of the special flavor hop variety Huell Melon on the odor-active compounds in late hopped and dry hopped beers>, COA of Formula: C10H18O, the main research area is flavor hop Huell Melon odor beer; AEDA; Huell Melon; Humulus lupulus; SIDA; aroma extract dilution analysis; dry hopping; hops; late hopping; spiking experiment; stable isotope dilution assay; transfer rate.

Bottom-fermented and top-fermented beers, both either late or dry hopped with Huell Melon hops, and resp. reference beers without late or dry hopping were subjected to a comparative odorant screening by aroma extract dilution analyses. On the basis of differences in the FD factors, 14 odorants were identified as hop-derived. Among them were Et 2-methylpropanoate, Me 2-methylbutanoate, Et 2-methylbutanoate, Pr 2-methylbutanoate, myrcene, linalool, and geraniol. Differences between late hopped, dry hopped, and reference beers were substantiated by quantitation. Results showed minimal transfer of myrcene from hops into beer. Moderate transfer was observed for Pr 2-methylbutanoate, geraniol, and linalool. Process-induced changes of Et 2-methylpropanoate, Et 2-methylbutanoate, and Me 2-methylbutanoate were beyond a direct transfer from hops into beer, suggesting a formation from the corresponding hop-derived carboxylic acids by yeast. Spiking experiments revealed that linalool and Pr 2-methylbutanoate contributed particularly to the characteristic aroma of beers flavored with Huell Melon hops.

Journal of Agricultural and Food Chemistry published new progress about Beer. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts