Category: 78-70-6

Wang, Meng-Qi; Ma, Wan-Jun; Shi, Jiang; Zhu, Yin; Lin, Zhi; Lv, Hai-Peng published the artcile< Characterization of the key aroma compounds in Longjing tea using stir bar sorptive extraction (SBSE) combined with gas chromatography-mass spectrometry (GC-MS), gas chromatography-olfactometry (GC-O), odor activity value (OAV), and aroma recombination>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is aroma compound tea SBSE GCMS GCO OAV; 1-Octen-3-ol (PubChem, CID: 18827); 2-Methyl butanal (PubChem, CID: 7284); Aromatic compounds; Benzaldehyde (PubChem, CID: 240); Benzeneacetaldehyde (PubChem, CID: 998); Concentration; Geraniol (PubChem, CID: 637566), β-Ionone(PubChem, CID: 638014).; Green tea; Heptanal (PubChem, CID: 8130); Identification; Key odorants; Linalool (PubChem, CID: 6549); Methyl salicylate (PubChem, CID: 4133); Nonanal (PubChem, CID: 31289); Volatile composition.

Longjing tea is the most famous premium green tea, and is regarded as the national tea in China, with its attractive aroma contributing as a prime factor for its general acceptability; however, its key aroma compounds are essentially unknown. In the present study, volatile compounds from Longjing tea were extracted and examined using stir bar sorptive extraction (SBSE) combined with gas chromatog.-mass spectrometry (GC-MS). Data obtained from the present study revealed that 151 volatile compounds from 16 different chem. classes were identified by GC-MS anal. Enols (8096 μg/kg), alkanes (6744 μg/kg), aldehydes (6442 μg/kg), and esters (6161 μg/kg) were the four major chem. classes and accounted for 54% of the total content of volatile compounds Geraniol (6736 μg/kg) was the most abundant volatile compound in Longjing tea, followed by hexanal (1876 μg/kg) and β-ionone (1837 μg/kg). Moreover, 14 volatile compounds were distinguished as the key aroma compounds of Longjing tea based on gas chromatog.-olfactometry (GC-O) anal., odor activity value (OAV) calculations, and a preliminary aroma recombination experiment, including 2-Me butyraldehyde, DMSO, heptanal, benzaldehyde, 1-octen-3-ol, (E, E)-2,4-heptadienal, benzeneacetaldehyde, linalool oxide I, (E, E)-3,5-octadien-2-one, linalool, nonanal, Me salicylate, geraniol, and β-ionone. This is the first comprehensive report describing the aroma characterizations and the key aroma compounds in Longjing tea using SBSE/GC-MS. The findings from this study contribute to the scientific elucidation of the chem. basis for the aromatic qualities of Longjing tea.

Food Research International published new progress about Gas chromatography-mass spectrometry. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Froiio, Francesca; Ginot, Lorianne; Paolino, Donatella; Lebaz, Noureddine; Bentaher, Abderrazzak; Fessi, Hatem; Elaissari, Abdelhamid published the artcile< Essential oils-loaded polymer particles: preparation, characterization and antimicrobial property>, Application In Synthesis of 78-70-6, the main research area is essential oil polymer particle antimicrobial; Escherichia coli; Eudragit RS100; antimicrobials; bergamot essential oil; nanoparticles; nanoprecipitation; sweet orange essential oil.

In the last few years, essential oils (EOs) derived from plants have aroused great interest due to their well-known antimicrobial activity. Unfortunately, they present several limitations in their use, such as photosensitivity, temperature sensitivity, high volatility, and poor water solubility The encapsulation technique represents a good solution to these problems and ensures protection of the functional properties of essential oils. In this work, bergamot essential oil (BEO) and sweet orange essential oil (OEO) loaded-Eudragit RS 100 (EuRS100) nanoparticles (NPs) were prepared by using the nanopptn. technique. We obtained nanoparticles characterized by a mean diameter of 57 to 208 nm and a pos. surface charge (39 to 74 mV). The antibacterial activity of the obtained systems against Escherichia coli was in vitro investigated. We demonstrated that both orange and bergamot essential oils were successfully encapsulated and our nanoparticles have good antibacterial activity. Finally, in order to evaluate the potential applicability of OEONps to prolong fresh orange juice shelf-life, survival of E. coli during a storage period of one week at 25°C was investigated: Orange essential oil-loaded nanoparticles (OEONPs) have been able to prolong the orange juice shelf life.

Polymers (Basel, Switzerland) published new progress about Antimicrobial agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Santiago, Marina; Sachdev, Shivani; Arnold, Jonathon C.; McGregor, Iain S.; Connor, Mark published the artcile< Absence of entourage: terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human CB1 and CB2 receptors>, SDS of cas: 78-70-6, the main research area is Cannabis terpenoids tetrahydrocannabinol CB1 CB2 receptor; THC; cannabinoid receptor; entourage effect; phytocannabinoid; signaling; terpenoid.

We examined six common terpenoids alone, and in combination with cannabinoid receptor agonists, on CB1 and CB2 signaling in vitro. Potassium channel activity in AtT20 FlpIn cells transfected with human CB1 or CB2 receptors was measured in real time using FLIPR membrane potential dye in a FlexStation 3 plate reader. Terpenoids were tested individually and in combination for periods up to 30 min. Endogenous somatostatin receptors served as a control for direct effects of drugs on potassium channels. Alpha-Pinene, β-pinene, β-caryophyllene, linalool, limonene and β-myrcene did not change membrane potential in AtT20 cells expressing CB1 or CB2, or affect the response to a maximally effective concentration of the synthetic cannabinoid CP55,940. The presence of individual or combination of terpenoids did not affect the hyperpolarization produced by Δ9-THC. To investigate possible effect on desensitization of CB1 responses, all six terpenoids were added together with Δ9-THC and signaling measured continuously over 30 min. Terpenoids did not affect desensitization, after 30 min control hyperpolarization recovered by 63% -6% in the presence of terpenoids recovery was 61% -5%. None of the six of the most common terpenoids in Cannabis directly activated CB1 or CB2, or modulated the signaling of phytocannabinoid agonist Δ9-THC.

Cannabis and Cannabinoid Research published new progress about Behavior. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tekeli, Ibrahim Ozan; Atessahin, Ahmet; Sakin, Fatih; Aslan, Abdullah; Ceribasi, Songul; Yipel, Mustafa published the artcile< Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats>, Reference of 78-70-6, the main research area is lycopene linalool sulfasalazine antiinflammatory agent ulcerative colitis; Colon targeting; Linalool; Lycopene; Rat; Ulcerative colitis.

Objective: To compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. Methods: Conventional and colon-targeted LC (10 mg/kg) and LN (200 mg/kg) were administered in vivo orally for 7 days and sulfasalazine (100 mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochem. and histopathol. anal. Results: Malondialdehyde (MDA), interleukin 1β (IL-1β), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) levels were decreased (p < 0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p < 0.05). Tumor necrosis factor α (TNF-α) level was also decreased (p < 0.05) and catalase activity (CAT) was increased (p < 0.05) in the TLC group compared to the AA group. IL-1β and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p < 0.05). COX-2 and NF-κB levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p < 0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p < 0.05). Conclusion: As expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further. Inflammopharmacology published new progress about Anti-inflammatory agents. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Reference of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Zhenming; Zhang, Guihua; Teixeira da Silva, Jaime A.; Zhao, Conghui; Duan, Jun published the artcile< The methyl jasmonate-responsive transcription factor DobHLH4 promotes DoTPS10, which is involved in linalool biosynthesis in Dendrobium officinale during floral development>, Application of C10H18O, the main research area is helix loop transcription factor floral volatile terpene synthase; orchid methyl jasmonate linalool; Floral volatiles; MeJA; Orchids; Terpene synthase; bHLH transcription factor.

Linalool is an aromatic monoterpene produced in the Chinese medicinal plant Dendrobium officinale, but little information is available on the regulation of linalool biosynthesis. Here, a novel basic helix-loop-helix (bHLH) transcription factor, DobHLH4 from D. officinale, was identified and functionally characterized. The expression profile of DobHLH4 was pos. correlated with that of DoTPS10 (R2 = 0.985, p < 0.01), which encodes linalool synthase that is responsible for linalool production, during floral development. DobHLH4 was highly expressed in petals, and was significantly induced by Me jasmonate. Anal. of subcellular localization showed that DobHLH4 was located in the nucleus. Yeast one-hybrid and dual-luciferase assays indicated that DobHLH4 bound directly to the DoTPS10 promoter harboring the G-box element, and up-regulated DoTPS10 expression. A yeast two-hybrid screen confirmed that DobHLH4 phys. interacted with DoJAZ1, suggesting that DobHLH4 might function in the jasmonic acid-mediated accumulation of linalool. Furthermore, transient overexpression of DobHLH4 in D. officinale petals significantly increased linalool production by triggering linalool biosynthetic pathway genes, especially DoTPS10. We suggest a hypothetical model that depicts how jasmonic acid signaling may regulate DoTPS10 by interacting with DobHLH4 and DoJAZ1. In doing so, the formation of linalool is controlled. Our results indicate that DobHLH4 is a pos. regulator of linalool biosynthesis and may be a promising target for in vitro-based metabolic engineering to produce linalool. Plant Science (Shannon, Ireland) published new progress about Dendrobium catenatum. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Weijuan; Zhang, Guohua published the artcile< Linalool monoterpene exerts potent antitumor effects in OECM 1 human oral cancer cells by inducing sub-G1 cell cycle arrest, loss of mitochondrial membrane potential and inhibition of PI3K/AKT biochemical pathway.>, SDS of cas: 78-70-6, the main research area is .

PURPOSE: Oral cancer is one of the prevalent types of cancer and has been reported to responsible for significant mortality and morbidity. Since treatment options for oral cancer are limited, there is need to explore novel molecules for treatment of oral cancer. In the current study we evaluated the anticancer activity of a plant derived monoterpene, Linalool against oral cancer cell line, OECM-1. METHODS: Cell viability was determined by MTT assay. Apoptosis was detected by DAPI and annexin V/PI staining. Cell cycle analysis was carried out by flow cytometry. Cell migration was assessed by wound healing assay and the expression of the proteins was determined by western blotting. RESULTS: The results showed that Linalool inhibited the viability of oral cancer OECM-1 cells in a concentration-dependent manner. The IC50 of Linalool against OECM-1 oral cancer cells was 10 µM as compared to its IC50 of 65 µM against non-cancer FR-2 cells. The anticancer effects were due to the induction of the apoptosis and sub-G1 cell cycle arrest. The results of annexin V/PI further revealed that the apoptotic cell populations increased from 2.6% in the control to 61.3% at 20 µM concentrations. It was observed that Linalool decreased the expression of p-PI3K and p-AKT in a concentration-dependent manner. However, the expression of PI3K and AKT remained almost unaltered. CONCLUSIONS: Taken together it was shown that Linalool monoterpene exerted significant anticancer effects in OECM-1 human oral cancer cells via inducing cell cycle arrest, loss of mitochondrial membrane potential (MMP) and suppressing PI3K/AKT signalling pathway.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prakash, Anand; Vadivel, Vellingiri published the artcile< Citral and linalool nanoemulsions: impact of synergism and ripening inhibitors on the stability and antibacterial activity against Listeria monocytogenes>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is Listeria citral linalool nanoemulsion antibacterial activity ripening inhibitor synergism; Citral; Linalool; Listeria monocytogenes; Nanoemulsions; Ripening inhibitors; Sesame oil.

The present work explored the influence of individual and combinations of citral and linalool along with different Ostwald ripening inhibitors on the nanoemulsion stability and their antibacterial activity against Listeria monocytogenes. Nine different nanoemulsions (N1-N9) containing individual or combinations of citral, linalool with or without ripening inhibitors (medium chain triglycerides, coconut oil, sesame oil and castor oil) were formulated with 5% Tween-80 using ultrasonic emulsification. N1 formulation containing 5% citral without ripening inhibitors showed the least mean droplet diameter of 20.44 nm. Addition of linalool with the citral nanoemulsions was found to have deleterious effect on the thermodn. and kinetic stabilities. Incorporation of ripening inhibitors controlled the increase of droplet size and polydispersity index in N6-N9 during the 90 days storage period, but decreased their antibacterial activity. N8 formulation containing sesame oil as ripening inhibitor was found to be the best in controlling Ostwald ripening. N1 formulation which showed the best antibacterial activity (MIC 0.312%) was found to disrupt the bacterial membrane integrity. N1 formulation also showed a promising biofilm inhibition of 83.51%. Therefore, N1 formulation containing 5% citral could be recommended as an efficient disinfectant against food-borne pathogen Listeria monoctyogenes in food industry. Moreover, addition of sesame oil in the nanoemulsion formulation of citral or linalool could increase their stability.

Journal of Food Science and Technology (New Delhi, India) published new progress about Acoustic emulsification. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yaoyao; Wang, Jin; Cao, Xianshuang; Liu, Wei; Yu, Hongwei; Ye, Lidan published the artcile< High-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is ERG20 mutant; Linalool; MVA pathway; Pathway compartmentation; Saccharomyces cerevisiae.

Linalool, a valuable monoterpene alc., is widely used in cosmetics and flavoring ingredients. However, its scalable production by microbial fermentation is not yet achieved. In this work, considerable increase in linalool production was obtained in Saccharomyces cerevisiae by dual metabolic engineering of the mevalonic acid (MVA) pathway in both mitochondria and cytoplasm. A farnesyl pyrophosphate synthase mutant ERG20F96W/N127W and a linalool synthase from Cinnamomum osmophloeum (CoLIS) were introduced and meanwhile the endogenous ERG20 was down-regulated to prevent the competitive loss of precursor. In addition, overexpression of the proteins of CoLIS and ERG20F96W/N127W and another copy of the same enzymes CoLIS/ERG20F96W/N127W with mitochondrial localization signal (MLS) were carried out to further pull the flux to linalool. Finally, a maximum linalool titer of 23.45 mg/L was obtained in a batch fermentation with sucrose as carbon source. This combinatorial engineering strategy may provide hints for biosynthesis of other monoterpenes.

Enzyme and Microbial Technology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Fengyu; Liang, Qiong; Zhang, Ming; Chen, Wenxue; Chen, Haiming; Yun, Yonghuan; Zhong, Qiuping; Chen, Weijun published the artcile< Antibacterial activity and mechanism of linalool against Shewanella putrefaciens>, Computed Properties of 78-70-6, the main research area is Shewanella putrefaciens; antibacterial mechanism; linalool; metabolomics.

The demand for reduced chem. preservative usage is currently growing, and natural preservatives are being developed to protect seafood. With its excellent antibacterial properties, linalool has been utilized widely in industries. However, its antibacterial mechanisms remain poorly studied. Here, untargeted metabolomics was applied to explore the mechanism of Shewanella putrefaciens cells treated with linalool. Results showed that linalool exhibited remarkable antibacterial activity against S. putrefaciens, with 1.5 μL/mL min. inhibitory concentration (MIC). The growth of S. putrefaciens was suppressed completely at 1/2 MIC and 1 MIC levels. Linalool treatment reduced the membrane potential (MP); caused the leakage of alk. phosphatase (AKP); and released the DNA, RNA, and proteins of S. putrefaciens, thus destroying the cell structure and expelling the cytoplasmic content. A total of 170 differential metabolites (DMs) were screened using metabolomics anal., among which 81 species were upregulated and 89 species were downregulated after linalool treatment. These DMs are closely related to the tricarboxylic acid (TCA) cycle, glycolysis, amino acid metabolism, pantothenate and CoA biosynthesis, aminoacyl-tRNA biosynthesis, and glycerophospholipid metabolism In addition, linalool substantially affected the activity of key enzymes, such as succinate dehydrogenase (SDH), pyruvate kinase (PK), ATPase, and respiratory chain dehydrogenase. The results provided some insights into the antibacterial mechanism of linalool against S. putrefaciens and are important for the development and application of linalool in seafood preservation.

Molecules published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Huajie; Hua, Jinjie; Jiang, Yongwen; Yang, Yanqin; Wang, Jinjin; Yuan, Haibo published the artcile< Influence of fixation methods on the chestnut-like aroma of green tea and dynamics of key aroma substances>, Computed Properties of 78-70-6, the main research area is green teachestnut aroma fixation method; Electromagnetic roller-hot air–steam triple fixation; Gas chromatography-tandem mass spectrometry (GC–MS); Infrared-assisted headspace coupled to solid-phase microextraction; Multiple experiment viewer (MEV); Odor activity value (OAV); Partial least-squares discriminant analysis (PLS-DA).

Fixation is the key process to ensure green tea quality; however, the effect of various fixation methods on the formation of green tea with a chestnut-like aroma and the evolution of key volatile compounds has not been assessed to date. In this study, we compared four types of fixation methods for green tea: roller-hot air-steam, roller-hot air, roller-steam, and single roller. IR-assisted headspace solid-phase microextraction and gas chromatog.-tandem dual mass spectrometry technol. were used to detect the volatile compounds of green tea samples during processing. Partial least-squares discriminant anal. (PLS-DA), multiple experiment viewer (MEV), odor activity value (OAV), and least-significant difference analyzes were then applied to clarify the best fixation method for forming a chestnut-like aroma and associated compounds, and to explore the change law of key volatile compounds using different green tea fixation processes. One hundred and eighty-four volatile compounds were detected in the processed samples, with roller-hot air fixation found as the optimal method for generating an intense and long-lasting chestnut-like aroma and floral taste, based on sensory evaluation. The PLS-DA model clearly distinguished the four kinds of fixation samples and obtained 32 differential volatile compounds Combining OAVs with screening by MEV anal., 2,6,10,10-tetramethyl-1-oxaspiro [4.5] dec-6-ene, linalool, cedrol, 3-methyl-butanal, trans-β-ionone, and τ-cadinol emerged as key differential volatile compounds between green teas with and without a chestnut-like aroma. The evolution of these six differential volatile compounds throughout the tea-making process confirmed that rolling-hot air coupling treatment is most conducive to produce a chestnut-like aroma, which is beneficial to form and transform 2,6,10,10-tetramethyl-1-oxaspiro[4.5] dec-6-ene, 3-methyl-butanal, and τ-cadinol with baking aromas and fruity substances. These results provide a theor. basis and tech. guidance for the precise and directional processing of high-quality green tea with a chestnut-like aroma.

Food Research International published new progress about Alcohols Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts