Category: 78-26-2

On December 11, 2008, Pinchuk, Anatoly; Weichert, Jamey P.; Longino, Marc published a patent.Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Methods for the synthesis and use of phospholipid ether boronic acids and esters. And the patent contained the following:

The present invention discloses boronic acids and esters I [A = (CH2)n; X = boronic acid or ester; Y = NH2, NHR, NR2, NR+3; R = alkyl, arylalkly; n = 8 – 30], II [M = Li, Na, K, Cs, Rb] and III [Z = H, OH, OMe, OEt, OPr], of phospholipid ether (PLE) analogs and methods for their synthesis and use. A method of synthesizing a high specific activity PLE analog comprises: (a) coupling of a diboron with a PLE or alkyl phosphocholine (APC) analog in the presence of a catalyst to result in a boronic acid or ester PLE or APC analog; (b) optionally esterification the boronic acid of the PLE analog with 1,2- or 1,3-diols to result in the boronic esters of PLE or APC analogs; and, (c) optionally, reacting the boronic acid of ester of PLE or APC analog of (a) or (b) with sodium radiohalide, in the presence of an oxidant to result in a high specific activity radiohalogenated PLE or APC analog. Thus, NM404 (IV) was prepared from 4-IC6H4CH2Br via coupling with BrZn(CH2)11OAc, deacetylation with NaOH, Iodination with I2/PPH3/imidazole, coupling with BrZn(CH2)5CO2Et, saponification with NaOH, reduction with BH3·THF, phosphorylation with ethylene chlorophosphate, and reaction with NMe3. Coupling reaction of IV with bis(neopentylglycolato)diboron in MeOH containing KOAc and catalytic PdCl2(DPPF) gave II [X = B(OH)2], while coupling with bis(pinacolato)diboron gave II [X = pinacolborane]. Reaction of II [X = B(OH)2] with Na125I in aqueous NaOH containing chloramine-T gave 125I-NM404. The boronic acids and esters of phospholipid ether analogs described herein can be used in treating cancer and in particular can be used in conjunction with radiation therapy, such as external beam radiation therapy and neutron capture therapy to specifically target and kill cancer cells [see graphs]. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

The Article related to phospholipid ether boronic acid ester analog preparation cancer treatment, radiation therapy phospholipid ether boronic acid ester radiohalogenated analog, alkyl phosphocholine boronic acid ester analog preparation cancer treatment and other aspects.Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 31, 2005, Ghadwal, Rajendra Singh; Mehrotra, Ram C.; Singh, Anirudh published an article.Recommanded Product: 78-26-2 The title of the article was Synthesis and Spectroscopic Characterization of Two Different Types of Heterobimetallic Glycolate Complexes of Niobium(V). And the article contained the following:

An entirely new class of heterobimetallic homoleptic glycolate complexes Nb(OGO)3{Ta(OGO)2} [where G = CMe2CH2CH2CMe2 (G1) (3); CMe2CH2 CHMe (G2) (4); CHMeCHMe (G3) (5); CH2CMe2CH2 (G4) (6); CMe2CMe2(G5) (7); CH2CHMeCH2 (G6) (8); CH2CEt2CH2 (G7) (9); CH2CMe(Pr)CH2 (G8) (10)] were prepared by the reactions of Nb(OGO)2(OGOH) [G = G1 (1a); G2 (1b); G3 (1c); G4 (1d); G5 (1e); G6 (1f); G7 (1g); G8 (1h)] with Ta(OGO)2(OPri) (G = G1 (2a); G2 (2b); G3 (2c); G4 (2d); G5 (2e) G6 (2f); G7 (2g); G8 (2h)). In addition to the novel derivatives (2)-(10), the authors’ earlier studies on heterobimetallic glycolate-alkoxide derivatives were extended to derivatives Nb(OGO) [where M = Al n = 3, G = G3 (11); G4 (12); G6 (13) G7 (14); Gs (15); G9 = CH2CH2CH2 (16) and M = Ti (n = 4, G = G4) (17), Zr (n = 4, G = G4) (18)], which are conveniently prepared by the reactions of metalloligands Nb(OGO)2(OGOH) [G = G3 (1c); G4 (1d); G6 (1f); G7 (1g); G8 (1h); G9 (1i)] with different metal alkoxides. All of these new complexes were characterized by elemental analyses, mol. weight determinations, and spectroscopic (IR and 1H, 27Al-NMR) studies. Structural features of the new derivatives were elucidated from mol. weight and spectroscopic data. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 78-26-2

The Article related to niobium glycolate heterobimetallic complex with without alkoxide preparation, ir spectra niobium glycolate heterobimetallic complex with without alkoxide, nmr spectra niobium glycolate heterobimetallic complex with without alkoxide and other aspects.Recommanded Product: 78-26-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts