Category: 78-26-2

On April 21, 2016, Yan, Hong-Lei; Zong, Zhi-Min; Li, Zhan-Ku; Kong, Jiao; Zheng, Quan-Xi; Zhao, Mei-Xia; Li, Yan; Wei, Xian-Yong published an article.Quality Control of 2-Methyl-2-propylpropane-1,3-diol The title of the article was Insight into the Chemical Complexity of Soluble Portions from Cornstalk Methanolysis. And the article contained the following:

Cornstalk was subjected to methanolysis in the presence of NaOH at 220-320 °C to afford soluble portions (SPs) 1-5 (SP1-SP5) and an inextractable portion (IEP). The maximum total yield (ca. 51%) of SPs was acquired at 300 °C with the same mass of NaOH and cornstalk. Under the same conditions, SP1 has the highest yield, followed by SP5 and SP2. The relatively volatile and less polar species in the resulting SPs and IEP were identified with a gas chromatograph/mass spectrometer (GC/MS). The polar species in SP1, SP2, and SP5 were further analyzed with a neg.-ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometer (FTICRMS). The anal. with GC/MS shows that phenolic compounds and alcs. are the dominant group components in SP1 and SP2, resp., while the predominant compounds in esterified SP3-SP5 and IEP are esters. According to anal. with FTICRMS, thousands of compounds were detected in SP1, SP2, and SP5. Most of the compounds are On (n = 1-10) class species with double bond equivalent (DBE) values of 1-14 and carbon atom numbers of 5-35. The most abundant class species in SP1, SP2, and SP5 are O3, O3, and O8, resp. SP1 and SP2are rich in O2-O4 class species with DBE values of 5-8, which may be attributed to lignin-derived compounds Different from SP1 and SP2, SP5 has relatively high contents of O5-O10 class species, corresponding to various acidic species. In addition, N1On (n = 0-8) class species with DBE values of 3-14 were also identified, which should contain a pyrrole ring as the parent structure. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Quality Control of 2-Methyl-2-propylpropane-1,3-diol

The Article related to complexity portion cornstalk methanolysis, Industrial Organic Chemicals, Leather, Fats, and Waxes: General and other aspects.Quality Control of 2-Methyl-2-propylpropane-1,3-diol

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On April 2, 2021, Tailor, Sanita B.; Manzotti, Mattia; Smith, Gavin J.; Davis, Sean A.; Bedford, Robin B. published an article.Related Products of 78-26-2 The title of the article was Cobalt-Catalyzed Coupling of Aryl Chlorides with Aryl Boron Esters Activated by Alkoxides. And the article contained the following:

The cobalt-catalyzed Suzuki biaryl cross-coupling of aryl chloride substrates with aryl boron reagents, activated with more commonly used bases, remained a significant unmet challenge in the race to replace platinum group metal catalysts with Earth-abundant metal alternatives. This highly desirable process can be realized using alkoxide bases, provided the right counterion is employed, strict stoichiometric control of the base is maintained with respect to the aryl boron reagent, and the correct boron ester is selected. Potassium tert-butoxide works well, but any excess of the base first inhibits and then poisons the catalyst. Lithium tert-butoxide performs very poorly, while even catalytic amounts of lithium additives also poison the catalyst. Meanwhile, a neopentane diol-based boron ester is required for best performance. As well as delivering this sought-after transformation, a detailed mechanistic and computational investigations to probe the possible mechanism of the reaction has been discussed and explains the unexpected exptl. observations. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Related Products of 78-26-2

The Article related to biaryl preparation transmetalation key step kinetics linear free energy, aryl chloride boron reagent alkoxide suzuki coupling cobalt catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Others and other aspects.Related Products of 78-26-2

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On November 22, 2018, Marat, Xavier; Ma, Chunyu published a patent.Product Details of 78-26-2 The title of the patent was Resorcinol derivatives for their cosmetic use. And the patent contained the following:

The invention relates to resorcinol derivatives, I (R1, R2 = H, hydrocarbyl, etc.; R3, R4 = H, hydrocarbyl, etc., R3R4 = together O, P heterocycle), and also the salts thereof, the solvates thereof and the optical and/or geometrical isomers thereof, including enantiomers and diastereoisomers, and the racemic mixtures thereof, alone or as a mixture The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, especially the skin, using these compounds I. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Product Details of 78-26-2

The Article related to resorcinol phosphonate derivative preparation cosmetic use, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Product Details of 78-26-2

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On December 31, 2015, Cai, Zhuofu; Wang, Lihua; Yang, Hai-Jian; Zhao, Lu published an article.Recommanded Product: 78-26-2 The title of the article was Solubility of 2-methyl-2-propyl-1,3-propanediol and its derivatives in supercritical carbon dioxide: measurement and mathematical modeling [Erratum to document cited in CA159:706265]. And the article contained the following:

On page 72, Scheme 1 contained incorrect structures for compounds 2 and 3; the corrected scheme is given. On page 73, Table 2 contained several incorrect values and was missing a column; the corrected table is given. Addnl. solubility experiment details have been added to Section 2.3. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 78-26-2

The Article related to erratum methylpropylpropanediol derivative solubility supercritical carbon dioxide, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Recommanded Product: 78-26-2

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On November 30, 2013, Cai, Zhuofu; Wang, Lihua; Yang, Hai-Jian; Zhao, Lu published an article.Product Details of 78-26-2 The title of the article was Solubility of 2-methyl-2-propyl-1,3-propanediol and its derivatives in supercritical carbon dioxide: measurement and mathematical modeling. And the article contained the following:

The modifications for the end group of 2-methyl-2-propyl-1,3-propanediol were achieved by reacting with Me oxalyl chloride and Me malonyl chloride to generate two new CO2-philic compounds: bis(methoxyoxalic)-2-methyl-2-Pr propylene glycol ester and bis(methoxymalonic)-2-methyl-2-Pr propylene glycol ester. After that, the solubilities of these 3 compounds were tested and compared in supercritical CO2 (scCO2) within the temperature range of (313-353) K and in the pressure range of (9.3-19.0) MPa. The influence of molar mass and end group on the solubility of compound was also studied. In addition, the exptl. solubility data were correlated according to Bartle, Chrastil and JCF model, and good consistencies were obtained. The average absolute relative deviation (AARD) of the measured values were (5.83, 8.98, 8.77)% when using Bartle’s method, (10.95, 7.53, 7.55)% for Chrastil’s method, and (6.89, 4.10, 4.19)% for the JCF method, resp. It is obvious that the JCF model was proven to be the best model because it had more adjustable parameters of temperature and pressure. Finally, the partial molar volumes V2 for each compound in the supercritical phase were estimated in accordance with Kumar and Johnston’s theory. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Product Details of 78-26-2

The Article related to methylpropylpropanediol derivative solubility supercritical carbon dioxide, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Product Details of 78-26-2

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On December 31, 2013, Zhang, Piyong; Yang, Hai-Jian; Xu, Lingxiao published an article.Product Details of 78-26-2 The title of the article was Solubilities and partial molar volumes of new CO2-philic propane derivatives in supercritical carbon dioxide. And the article contained the following:

Three new potent CO2-philic propane derivatives were designed and synthesized. Their structures were characterized by NMR, FTIR, and elemental anal. Phase behavior of the three compounds was investigated at T = (313, 323, 333, 343 or 353) K and pressures from (7.7 to 12.1) MPa in supercritical carbon dioxide. The measured solubility data were correlated using three models: Chrastil, Sung and Shim (SS), and Jouyban-Chan-Foster (JCF) semi-empirical models, and satisfied agreements were obtained. Solubility data were also utilized to estimate the partial molar volume V̅2 for each compound in the supercritical phase using the theory developed by Kumar and Johnston. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Product Details of 78-26-2

The Article related to supercritical carbon dioxide philic propane derivative molar volume solubility, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Product Details of 78-26-2

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On February 7, 2014, Raman, Jayaraman Venkat; Sahu, Rajesh; Parikh, Ankur; Patel, Naresh published a patent.Safety of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was A process for preparing highly pure meprobamate. And the patent contained the following:

The invention relates to a process for preparing highly pure meprobamate (I). Compound I was prepared by O-acylation of 2-methyl-2-propyl-1,3-propanedione with phosgene; the resulting 2-methyl-2-propyl-1,3-propanediyl bis(chlorocarbonate) underwent amidation with ammonia to give compound I. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Safety of 2-Methyl-2-propylpropane-1,3-diol

The Article related to meprobamate preparation, propanediyl bischlorocarbonate preparation ammonia amidation, propanedione phosgene acylation, Aliphatic Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Safety of 2-Methyl-2-propylpropane-1,3-diol

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On October 7, 2013, Wang, Guqi; Lu, Qilong published an article.Name: 2-Methyl-2-propylpropane-1,3-diol The title of the article was A Nitrate Ester of Sedative Alkyl Alcohol Improves Muscle Function and Structure in a Murine Model of Duchenne Muscular Dystrophy. And the article contained the following:

Nitric oxide (NO) has major physiol. and cellular effects on muscle growth, repair, and function. In most muscle biopsies from humans with myopathies, sarcolemma-localized neuronal nitric oxide synthase (nNOS) is either reduced or not detected, particularly in dystrophin-deficient Duchenne muscular dystrophy (DMD). Abnormal NO signaling at the sarcolemmal level is integrally involved in the pathogenesis and accounts, at least in part, for the muscle weakness of DMD. Dystrophic muscle fibers exhibit an increased susceptibility to contraction-induced membrane damage. Muscle relaxants function to prevent muscle wasting by decreasing nerve impulses and reducing calcium influx that regulates tensing or tightening of muscle fibers. We have recently developed a new class of nitric esters that combines the pharmacol. functions of NO and muscle relaxation. Here, we report the synthesis and properties of the nitric ester (MMPN) of 2-methyl-2-n-propyl-1,3-propanediol (MPP) and its effect in mdx dystrophic mice, a murine model of DMD. MMPN produced significant improvements in biochem., pathol., and functional phenotypes in the mouse model. The endurance of exercise was extended by 47% in time to exhaustion and 84% in running distance. Serum CK level was decreased by 30%. Addnl., MMPN decreased intracellular free calcium concentration without causing skeletal muscle weakness. No hepatic or renal toxicities were observed during the study. Our investigations unveil a potential new treatment for muscular diseases. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Name: 2-Methyl-2-propylpropane-1,3-diol

The Article related to nitrate ester sedative muscle duchenne dystrophy, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: 2-Methyl-2-propylpropane-1,3-diol

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On June 2, 2011, Wang, Guqi; Lu, Qi Long published a patent.Computed Properties of 78-26-2 The title of the patent was Nitrate esters and their use for the treatment of muscle and muscle related diseases. And the patent contained the following:

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: Et-C(R1)(R2)(R3), wherein,R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H;R2 is ONO2, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH2CH2CH3 or H; andR3 is ONO2, CH2ONO2, Cn'””H2n””+1OH, Cn””H2n””+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n’ is an integer from 0 to 9, and n”” is an integer from 0 to 9, and n+n’+n””≤9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Computed Properties of 78-26-2

The Article related to muscular dystrophy alkyl nitrate ester nitric oxide prodrug, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 78-26-2

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On December 5, 2012, Wang, Guqi; Lu, Qi Long published a patent.Quality Control of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Nitrate esters and their use for the treatment of muscle and muscle related diseases. And the patent contained the following:

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula I wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R2 is ON02, CH2ONO2, Cn H2n +1OH, Cn H2n +1OH, CH3, CH2CH3, CH2CH2CH3, or H; R3 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; and R4 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; wherein n is an integer from 0 to 9, n’ is an integer from 0 to 9, and n”” is an integer from 0 to 9, and n+n’+n”” ≤ 9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ON02, CH2ONO2, and combinations thereof. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Quality Control of 2-Methyl-2-propylpropane-1,3-diol

The Article related to alkyl nitrate ester nitric oxide prodrug muscular dystrophy treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 2-Methyl-2-propylpropane-1,3-diol

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