Category: 78-26-2

On September 1, 2021, Maudhoo, Ashwini; Maharaj, Avinaash; Buonocore, Federica; Martos-Moreno, Gabriel Angel; Argente, Jes煤s; Achermann, John C; Chan, Li F; Metherell, Lou A published an article.COA of Formula: C7H16O2 The title of the article was Missplicing due to a synonymous, T96= exonic substitution in the T-box transcription factor TBX19 resulting in isolated ACTH deficiency.. And the article contained the following:

SUMMARY: Congenital isolated ACTH deficiency (IAD) is a rare condition characterised by low plasma ACTH and serum cortisol with normal production of other pituitary hormones. TBX19 (also known as TPIT) is a T-box pituitary restricted transcription factor important for POMC gene transcription and terminal differentiation of POMC-expressing cells. TBX19 gene mutations have been shown to cause neonatal-onset congenital IAD. We report a neonate of Romanian origin, who presented at 15 h of life with respiratory arrest and hypoglycaemia which recurred over the following 2 weeks. Biochemical investigations revealed IAD, with undetectable serum cortisol (cortisol < 1 渭g/dL; normal range (NR): 7.8-26.2) and plasma ACTH levels within the normal range (22.1 pg/mL; NR: 4.7-48.8). He responded to hydrocortisone treatment. Patient DNA was analysed by a HaloPlex next-generation sequencing array targeting genes for adrenal insufficiency. A novel homozygous synonymous mutation p.Thr96= (Chr1:168260482; c.288G>A; rs376493164; allele frequency 1 脳 10-5, no homozygous) was found in exon 2 of the TBX19 gene. The effect of this was assessed by an in vitro splicing assay, which revealed aberrant splicing of exon 2 giving rise to a mutant mRNA transcript whereas the WT vector spliced exon 2 normally. This was identified as the likely cause of IAD in the patient. The predicted protein product would be non-functional in keeping with the complete loss of cortisol production and early presentation in the patient. LEARNING POINTS: Synonymous variants (a nucleotide change that does not alter protein sequence) usually thought to be benign may still have detrimental effects on RNA and protein function causing disease. Hence, they should not be ignored, especially if very rare in public databases. In vitro splicing assays can be employed to characterise the consequence of intronic and exonic nucleotide gene changes that may alter splicing. Establishing a diagnosis due to a TBX19 mutation is important as it defines a condition of isolated ACTH deficiency not associated with additional pituitary deficiencies. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).COA of Formula: C7H16O2

2-Methyl-2-propylpropane-1,3-diol(cas:78-26-2) belongs to alcohols. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. COA of Formula: C7H16O2

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On July 16, 2021, Mizenko, Christopher; Bennett, Jeffrey L; Owens, Gregory; Vollmer, Timothy L; Piquet, Amanda L published an article.Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol The title of the article was A Longitudinal, Observational Analysis of Neuronal Injury Biomarkers in a Case Report of a Patient With Paraneoplastic Anti-CRMP5 Antibody-Associated Transverse Myelitis.. And the article contained the following:

Biomarkers are needed to guide therapeutic decision making in autoimmune and paraneoplastic neurologic disorders. Here, we describe a case of paraneoplastic collapsing response-mediator protein-5 (CRMP5)-associated transverse myelitis (TM) where plasma neurofilament light (NfL) chain and glial fibrillary protein (GFAP) levels were observed over a 14-month clinical course, correlating with radiographical and clinical outcome measures in response to treatment. Blood and CSF samples obtained at diagnosis as well as 7 and 14 months into treatment. At the time of initial diagnosis, both plasma NfL (782.62 pg/ml) and GFAP (283.26 pg/ml) were significantly elevated. Initial treatment was with IV steroids and plasma exchange (PLEX) followed by neuroendocrine tumor removal, chemotherapy, and radiation. After initial improvement with chemotherapy, the patient experienced clinical worsening and transient elevation of plasma NfL (103.27 pg/ml and GFAP (211.58 pg/ml) levels. Whole body positron emission tomography PET scan did not demonstrate recurrence of malignancy. Repeat PLEX and rituximab induction resulted in improvements in patient function, neurologic exam, and plasma biomarker levels. To our knowledge, this is the first described longitudinal, prospective analysis of neuronal injury biomarkers and association of clinical treatment outcomes in CRMP5 myelitis. Our findings suggest that clinical improvement correlates with NfL and GFAP concentrations. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

2-Methyl-2-propylpropane-1,3-diol(cas:78-26-2) belongs to alcohols. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

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On February 3, 2015, Katsargyris, A; Ritter, W; Pedraza, M; Moehner, B; Bruck, M; Verhoeven, E L published an article.Name: 2-Methyl-2-propylpropane-1,3-diol The title of the article was Percutaneous endovascular thrombosuction for acute lower limb ischemia: a 5-year single center experience.. And the article contained the following:

AIM: The aim of this paper was to report a 5-year single center experience with the use of percutaneous endovascular thrombosuction (PET) for acute lower limb ischemia (ALLI). METHODS: All patients that underwent PET for ALLI within the period January 2009-December 2013 in our institution were included. Data were collected retrospectively. RESULTS: A total of 262 patients (132 female, mean age 74.5卤11 years) were treated. Level of severity of ALLI preoperatively was stratified as class I (viable) in 76% (199/262) of patients, class IIa (threatened marginally) in 19.4% (51/262), and class IIb (threatened immediately) in 4.6% (12/262). Initial technical success was 91% (237/262). Additional PTA was performed in 29.8% (78/262) of patients, and PTA with stenting in 27.5% (72/262). Open surgery due to technical failure of PET was required in 4.2% (11/262) of patients. Thirty-day mortality was 4.6% (12/262). Perioperative complications occurred in 9.2% (24/262). Thirty-day amputation rate was 3.8% (10/262). The mean duration of follow-up was 26.2卤16 months. Estimated cumulative survival was 84.2卤2.5% at 1 year, and 73.7卤3.6% at 3 years. Estimated freedom from amputation during follow-up was 92.4卤1.8% at 1 year, and 91.2卤2% at 3 years. Estimated freedom from reintervention was 90.4卤2% at 1 year, and 80卤3.7% at 3 years. CONCLUSION: PET in selected patients with ALLI provides high initial technical success, low mortality and morbidity rates, and favorable early and mid-term limb salvage rates. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Name: 2-Methyl-2-propylpropane-1,3-diol

The Article related to aged, aged, 80 and over, amputation, disease-free survival, endovascular procedures: adverse effects, endovascular procedures: methods, endovascular procedures: mortality, female, germany: geographic, humans, ischemia: diagnosis, ischemia: mortality, ischemia: therapy, kaplan-meier estimate, limb salvage and other aspects.Name: 2-Methyl-2-propylpropane-1,3-diol

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Pierce, Cason; Keniston, Angela; Albert, Richard K published an article in 2019, the title of the article was Imaging in Acute Pyelonephritis: Utilization, Findings, and Effect on Management..Electric Literature of 78-26-2 And the article contains the following content:

OBJECTIVES: To determine the frequency, timing, and types of imaging obtained in patients with a discharge diagnosis of acute pyelonephritis, and how often imaging findings affect therapy. METHODS: This was a retrospective chart review of 1062 adults with a diagnosis of acute pyelonephritis discharged from an urban, safety-net hospital between January 1, 2008 and December 31, 2012. From the 739 patients selected after exclusions, we determined the number and proportion of patients imaged within the first 24 hours of admission, stratified by risk factors for pyelonephritis complications, and the frequency of positive findings leading to invasive interventions. RESULTS: Of 739 patients, 468 (63%) were imaged within 24 hours of admission, 262/414 (63%) of whom had risk factors for complications and 206/325 of whom (63%) did not. Among these, studies were positive in 117/468 (25%), 78/262 (30%) in those with risk factors, and 39/206 (19%) of those without risk factors. Of the 117 patients with positive imaging findings within 24 hours of admission, 58 (50%) underwent invasive procedures, 47 (60%) with risk factors and 11 (28%) without. Among all of the patients, interventions were directed at relieving obstructions much more commonly than treating abscess (51 patients vs 8). CONCLUSIONS: Among this population, imaging is frequently done earlier than recommended. Because the majority of interventions targeted stone disease, ultrasound may be the preferred initial modality rather than contrasted tomography when obtaining imaging early. Current guidelines may need to be revisited. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Electric Literature of 78-26-2

The Article related to acute disease, adolescent, adult, aged, aged, 80 and over, disease management, emergency service, hospital, female, hospitalization: statistics & numerical data, humans, male, middle aged, pyelonephritis: diagnosis, pyelonephritis: therapy, retrospective studies, risk factors, tomography, x-ray computed: statistics & numerical data and other aspects.Electric Literature of 78-26-2

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On February 7, 2022, Cao, Yuefeng; Fan, Xiangming published an article.Electric Literature of 78-26-2 The title of the article was Surgical Repair of Secondary Subaortic Stenosis in Congenital Heart Disease Without Initial Subaortic Obstruction.. And the article contained the following:

BACKGROUND: Secondary subaortic stenosis (SSS) is a rare heart disease of the left ventricular outflow tract (LVOT). It usually occurs after cardiovascular correction with or without initial left ventricular outflow tract obstruction (LVOTO). Because most patients with SSS are asymptomatic, many do not realize the need for reoperation until the obstruction worsens. Few studies suggest the characteristics and reasons of SSS without initial SAS. We conducted a retrospective study to describe the characteristics and surgical outcomes of these patients. METHODS: In this study, we examined a single-center retrospective cohort of SSS patients without initial SAS undergoing resection from 2010 to 2019. Patients are defined as secondary subaortic obstruction requiring surgery after cardiovascular correction. Demographics, perioperative findings, and clinical data were analyzed. RESULTS: Twenty-three patients had undergone secondary cardiac surgery for SSS without initial SAS during 10 years in our center. The median age at operation was 7.3 (4.0-13.5) years. In this study, the most commonly associated cardiac lesions were ventricular septal defect (VSD), atrioventricular septal defect (AVSD), patent ductus arteriosus (PDA), and coarctation arch hypoplasia (COA). The surgical techniques included membranous resection of five patients, fibromuscular resection of 17 patients, and reconstruction of the intraventricular baffle of one patient. The results of surgery in these patients are satisfied. The average LVOT gradient at the last follow up was 14.9 (7.8-26.2) mmHg. There was no operative mortality. Two patients had postoperative complications. The median follow-up period was 2.9 (1.1-4.3) years with one late death. Two patients (8.7%) had recurrence of stenosis. CONCLUSIONS: Secondary subaortic stenosis is an uncommon heart disease. The reason is related to several causes, including missed diagnosis, unnoticed abnormalities of LVOT, and further changes of geometric morphology by intracardiac surgery. The results of surgery in these patients are satisfied. However, the recurrence of stenosis is still frequent. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Electric Literature of 78-26-2

The Article related to aortic stenosis, subvalvular: complications, aortic stenosis, subvalvular: diagnosis, aortic stenosis, subvalvular: surgery, constriction, pathologic: surgery, heart defects, congenital: complications, heart defects, congenital: diagnosis, heart defects, congenital: surgery, heart septal defects: surgery, humans, infant, reoperation and other aspects.Electric Literature of 78-26-2

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On May 28, 2015, Duan, Wenwen; Li, Jin; Inks, Elizabeth S.; Chou, C. James; Jia, Yuping; Chu, Xiaojing; Li, Xiaoyang; Xu, Wenfang; Zhang, Yingjie published an article.Computed Properties of 78-26-2 The title of the article was Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor. And the article contained the following:

On the basis of the strategy of creating multifunctional drugs, a novel series of phenylsulfonylfuroxan-based hydroxamates with histone deacetylase (HDAC) inhibitory and nitric oxide (NO) donating activities were designed, synthesized, and evaluated. The most potent NO donor-HDAC inhibitor (HDACI) hybrid, 5c, exhibited a much greater in vitro antiproliferative activity against the human erythroleukemia (HEL) cell line than that of the approved drug SAHA (Vorinostat), and its antiproliferative activity was diminished by the NO scavenger Hb in a dose-dependent manner. Further mechanism studies revealed that 5c strongly induced cellular apoptosis and G1 phase arrest in HEL cells. Animal experiment identified 5c as an orally active agent with potent antitumor activity in a HEL cell xenograft model. Interestingly, although compound 5c was remarkably HDAC6-selective at the mol. level, it exhibited pan-HDAC inhibition in a western blot assay, which is likely due to class I HDACs inhibition caused by NO release at the cellular level. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Computed Properties of 78-26-2

The Article related to phenylsulfonyl furoxan hydroxamate preparation histone deacetylase no cancer, Pharmacology: Structure-Activity and other aspects.Computed Properties of 78-26-2

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On November 30, 2006, Yatake, Masahiro published a patent.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Ink containing propanediol derivatives for ink-jet recording. And the patent contained the following:

The jet recording ink has excellent stability, high color saturation on regular paper, high glossiness on gloss paper, and excellent discharge stability from an ink jet head. This ink uses 2-methyl-2-propyl-1,3-propanediol (0.1-2%) penetrant. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to anticlogging jet printing ink alkyl propanediol derivative penetrant, Coatings, Inks, and Related Products: Inks and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

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On December 31, 2010, Kumar, K. Ashok; Setty, S. Ramachandra; Narsu, Laxmi published an article.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the article was Pharmacognostic and phytochemical investigations of roots of Hibiscus micranthus Linn. And the article contained the following:

The objective of the present investigation was determine the Pharmacognostical, physicochem. and phytochem. parameters as standardization markers for Hibiscus micranthus Linn. The macroscopic and microscopic characters, phys. constant values, extractive values, ash values, micro chem. anal. and fluorescence anal. were performed. The presence of lignified, thick wall, libiform type of fibers with pointed tips & vessel elements with oblique perforations plates having short, pointed tails, calcium oxalate druses are abundant in the phloem and periderm as seen in the powder/transverse sections of root were the distinguishing microscopic features and can be used as anatomical markers. Chemomicroscopic characters present included lignin, starch, suberin, mucilage, cellulose, protein bodies and calcium oxalate crystals. Phys. constants performed were loss on drying, ash content, acid insoluble ash and water soluble ash. Extractive values in pet. ether (60-80°C), chloroform, alc. and hydroalcoholic were determined Fluorescence studies of the powder were carried in ordinary light and UV light with various solvents. Phytochem. screening of successive extracts showed pos. reactions for steroids, flavonoids, carbohydrates, phenols and tannins. The fingerprints of the hydroalcoholic extract were obtained by HPTLC technique in three best mobile phase solvent systems. The flavonoid content of hydroalcoholic extract was determined by colorimetric method. Chem. profiling of hydroalcoholic extract was also performed by GC-MS anal. Further a HPLC method with photodiode array detector was followed to quantify rutin in hydroalcoholic extract of Hibiscus micranthus (HEHM). The present study provides details to characterize the Pharmacognostical, physicochem. and phytochem. parameters. An accurate and rapid HPLC quantification method has also been developed for quality control determination of rutin from Hibiscus micranthus roots. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to hibiscus root pharmacognosy physicochem phytochem, Plant Biochemistry: Composition and Products and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

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On June 25, 2020, Gao, Zhisheng; Dance, Smruti A.; Taggi, Andrew E.; Bair, Joseph S. published a patent.Application of 78-26-2 The title of the patent was Low viscosity heat transfer fluids with increasing flash point and thermal conductivity. And the patent contained the following:

This disclosure relates to a heat transfer fluid having at least one first ester that is partially esterified, and at least one second ester that is fully esterified. The heat transfer fluid has a flash point from about 125°C to about 225°C as determined by ASTM D-93, and a kinematic viscosity (KV100) from about 1 to about 5 at 100°C as determined by ASTM D-445. The at least one first ester and the at least one second ester are present in an amount such that, as the flash point and thermal conductivity of the heat transfer fluid are increased, the kinematic viscosity (KV100) of the heat transfer fluid is decreased or essentially maintained. This disclosure also relates to a method for increasing flash point and thermal conductivity, while decreasing or essentially maintaining viscosity, of a heat transfer fluid by using the heat transfer fluid. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application of 78-26-2

The Article related to low viscosity heat transfer fluid flash point thermal conductivity, Unit Operations and Processes: Heat Transfer and other aspects.Application of 78-26-2

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Guo, Wusheng; Laserna, Victor; Rintjema, Jeroen; Kleij, Arjan W. published an article in 2016, the title of the article was Catalytic One-Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules.SDS of cas: 78-26-2 And the article contains the following content:

Oxetanes are versatile building blocks in drug-related synthesis to induce property-modulating effects. Whereas related oxiranes are widely used in coupling chem. with CO2 to afford value-added commodity chems., oxetane/CO2 couplings remain extremely limited despite the recent advances in the synthesis of these four-membered heterocycles. Here we report an effective one-pot three-component reaction (3CR) strategy for the coupling of (substituted) oxetanes, amines, and CO2 to afford a variety of functionalized carbamates with excellent chemoselectivity and good yields. The process is mediated by an aluminum-based catalyst under relatively mild conditions and the developed catalytic methodol. can be applied to the formal synthesis of two pharmaceutically relevant carbamates with the 3CR being a key step. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).SDS of cas: 78-26-2

The Article related to carbamate preparation, three component reaction carbon dioxide oxetane amine aluminum catalyst, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 78-26-2

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