Category: 7748-36-9

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , COA of Formula: C3H6O2

Strassfeld, Daniel A.;Wickens, Zachary K.;Picazo, Elias;Jacobsen, Eric N. research published 《 Highly Enantioselective, Hydrogen-Bond-Donor Catalyzed Additions to Oxetanes》, the research content is summarized as follows. A precisely designed chiral squaramide derivative is shown to promote the highly enantioselective addition of trimethylsilyl bromide (TMSBr) to a broad variety of 3-substituted and 3,3-disubstituted oxetanes. The reaction provides direct and general access to synthetically valuable 1,3-bromohydrin building blocks from easily accessed achiral precursors. The products are readily elaborated both by nucleophilic substitution and through transition-metal-catalyzed cross-coupling reactions. The enantioselective catalytic oxetane ring opening was employed as part of a three-step, gram-scale synthesis of pretomanid, a recently approved medication for the treatment of multidrug-resistant tuberculosis. Heavy-atom kinetic isotope effect (KIE) studies are consistent with enantiodetermining delivery of bromide from the H-bond-donor (HBD) catalyst to the activated oxetane. While the nucleophilicity of the bromide ion is expected to be attenuated by association to the HBD, overall rate acceleration is achieved by enhancement of Lewis acidity of the TMSBr reagent through anion abstraction.

COA of Formula: C3H6O2, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Reference of 7748-36-9

Strassfeld, Daniel A.;Algera, Russell F.;Wickens, Zachary K.;Jacobsen, Eric N. research published 《 A Case Study in Catalyst Generality: Simultaneous, Highly-Enantioselective Bronsted- and Lewis-Acid Mechanisms in Hydrogen-Bond-Donor Catalyzed Oxetane Openings》, the research content is summarized as follows. Generality in asym. catalysis can be manifested in dramatic and valuable ways, such as high enantioselectivity across a wide assortment of substrates in a given reaction (broad substrate scope) or as applicability of a given chiral framework across a variety of mechanistically distinct reactions (privileged catalysts). Reactions and catalysts that display such generality hold special utility, because they can be applied broadly and sometimes even predictably in new applications. Despite the great value of such systems, the factors that underlie generality are not well understood. Here, we report a detailed investigation of an asym. hydrogen-bond-donor catalyzed oxetane opening with TMSBr that is shown to possess unexpected mechanistic generality. Careful anal. of the role of adventitious protic impurities revealed the participation of competing pathways involving addition of either TMSBr or HBr in the enantiodetermining, ring-opening event. The optimal catalyst induces high enantioselectivity in both pathways, thereby achieving precise stereocontrol in fundamentally different mechanisms under the same conditions and with the same chiral framework. The basis for that generality is analyzed using a combination of exptl. and computational methods, which indicate that proximally localized catalyst components cooperatively stabilize and precisely orient dipolar enantiodetermining transition states in both pathways. Generality across different mechanisms is rarely considered in catalyst discovery efforts, but we suggest that it may play a role in the identification of so-called privileged catalysts.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Reference of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Related Products of 7748-36-9

Sun, Jian;Gong, Shanshan;Sun, Qi research published 《 A novel synthesis of 3-bromo-1,2-propanediol from 3-oxetanol》, the research content is summarized as follows. Treatment of 3-oxetanol with carbon tetrabromide (CBr₄) and triphenylphosphine (PPh₃) under mild condition provides an efficient route for the synthesis of 3-bromo-1,2-propanediol. The exptl. results showed that an unexpected ring-opening reaction was selectively achieved under the routine bromination reaction condition.

Related Products of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of Oxetan-3-ol

Shibutani, Shotaro;Kodo, Taiga;Takeda, Mitsutaka;Nagao, Kazunori;Tokunaga, Norihito;Sasaki, Yusuke;Ohmiya, Hirohisa research published 《 Organophotoredox-Catalyzed Decarboxylative C(sp³)-O Bond Formation》, the research content is summarized as follows. This manuscript reports a visible-light-mediated organosulfide catalysis that enables the decarboxylative coupling between simple aliphatic alc. and tertiary or secondary alkyl carboxylic acid-derived redox active esters to produce a C(sp³)-O-C(sp³) fragment. Results of the coupling using other heteroatom nucleophiles such as water, amides, and thiols are also described.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Safety of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 7748-36-9, formula is C3H6O2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Reference of 7748-36-9

Shields, E. S.;Merrill, G. N. research published 《 A computational study into the reactivity of epichlorohydrin and epibromohydrin under acidic conditions in the gas phase and aqueous solution》, the research content is summarized as follows. Ab initio MO calculations have been carried out upon epichlorohydrin and epibromohydrin at the Hartree-Fock (HF) and Moller-Plesset (MP2) levels of theory to explore the reactivity of these species with respect to nucleophilic attack by water under acidic conditions in the gas phase and aqueous solution These results suggest that nucleophilic attack occurs preferentially at the epoxy carbon atoms in both the gas phase and aqueous solution These results are in contrast to those found for nucleophilic attack under basic conditions, where attack at the halocarbon atom is competitive with that at the epoxy carbon atoms.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Reference of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 7748-36-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Schuetz, Andri P.;Locher, Sebastian;Bernet, Bruno;Illarionov, Boris;Fischer, Markus;Bacher, Adelbert;Diederich, Francois research published 《 5-Substituted (1-Thiolan-2-yl)cytosines as Inhibitors of A. aeolicus and E. coli IspE Kinases: Very Different Affinities to Similar Substrate-Binding Sites》, the research content is summarized as follows. The enzymes of the non-mevalonate pathway for isoprenoid biosynthesis are potential new targets for the development of selective drugs for the treatment of important infectious diseases. This pathway is used by major human pathogens, such as Plasmodium falciparum and Mycobacterium tuberculosis, but not by humans. The fourth enzyme in the pathway is the kinase IspE, and we report here the development and biol. evaluation of new ligands for this enzyme from Escherichia coli and Aquifex aeolicus species as model systems for the pathogenic enzymes. The study focuses on anal. of the methylerythritol pocket of the 4-diphosphocytidyl-2-C-methyl-D-erythritol binding site. A series of 5-substituted 1-(thiolan-2-yl)cytosines with increasingly polar substituents were synthesized, opting for possible water-replacements in that sub-pocket as well as a high water-solubility of the ligands. In vitro studies showed IC₅₀ values in the micromolar range against E. coli IspE, but, unexpectedly, no inhibition against A. aeolicus IspE within the measurement range of the biol. tests.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., HPLC of Formula: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Related Products of 7748-36-9

Royappa, A. Timothy;Vashi, Mitra R.;Russo, Cholena L.;Blackwell, Aaron C. research published 《 A comparison of the cationic ring-opening polymerizations of 3-oxetanol and glycidol》, the research content is summarized as follows. The technol. important polymers poly(3-oxetanol) and polyglycidol (sometimes referred to as polyglycerol) were both synthesized in high yield by a one-pot BF₃-catalyzed cationic ring-opening polymerization of the resp. monomers in dichloromethane at ambient temperature The polymerization reactions and the resulting polymers were compared. The polymerization of 3-oxetanol was less exothermic than the polymerization of glycidol under identical reaction conditions, because of the lower ring strain in 3-oxetanol than in glycidol, confirmed by semi-empirical calculations The resulting polymers were similar, i.e., they had similar Fourier transform IR spectroscopy (FTIR) and NMR spectra, mol. weights, thermal properties and phys. characteristics. However, the poly(3-oxetanol) had a higher ratio of secondary to primary alcs. than did polyglycidol.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Related Products of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Computed Properties of 7748-36-9

Rueeger, Heinrich;Lueoend, Rainer;Rogel, Olivier;Rondeau, Jean-Michel;Mobitz, Henrik;Machauer, Rainer;Jacobson, Laura;Staufenbiel, Matthias;Desrayaud, Sandrine;Neumann, Ulf research published 《 Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides》, the research content is summarized as follows. Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by mol. modeling studies and by x-ray anal. of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochem. property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, highly potent compounds were obtained, such as I, with enzymic and cellular IC₅₀ values of 2 and 50 nM, resp., and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 μmol/kg demonstrated significant reduction of brain Aβ levels.

Computed Properties of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocks, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Russo, Cholena L.;Vashi, Mitra R.;Royappa, A. Timothy research published 《 Synthesis and characterization of hyperbranched poly(3-oxetanol)》, the research content is summarized as follows. Poly(3-oxetanol), a hyperbranched polyether-polyol, was synthesized by boron trifluoride-catalyzed cationic ring-opening polymerization in dichloromethane. This polymer is an analog of the more well-studied polymer, polyglycidol. Both polyglycidol and poly(3-oxetanol) are hyperbranched polymers. Because of this, and also since both these polymers are formed from monomers that may be considered anhydrides of the biocompatible mol. glycerol, they are under consideration for biomedical applications such as drug delivery. The spectral and thermal properties of poly(3-oxetanol) were analyzed and compared to those of polyglycidol. Both polymerizations were exothermic; however, the exothermicity was less dramatic with 3-oxetanol than with glycidol due to the lesser ring strain in 3-oxetanol.

Category: alcohols-buliding-blocks, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Computed Properties of 7748-36-9

Sakai, Holt A.;MacMillan, David W. C. research published 《 Nontraditional Fragment Couplings of Alcohols and Carboxylic Acids: C(sp³)-C(sp³) Cross-Coupling via Radical Sorting》, the research content is summarized as follows. In this report, the C(sp³)-C(sp³) cross-coupling of alcs. and carboxylic acids through the dual combination of N-heterocyclic carbene (NHC)-mediated deoxygenation and hypervalent iodine-mediated decarboxylation were described. This mild and practical Ni-catalyzed radical-coupling protocol was employed to prepare a wide array of alkyl-alkyl cross-coupled products, including highly congested quaternary carbon centers from the corresponding tertiary alcs. or tertiary carboxylic acids. Synthetic applications of this methodol. to alc. C1-alkylation and formal homologation, as well as to the late-stage functionalization of drugs, natural products, and biomols. were demonstrated.

Computed Properties of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts