Category: 7748-36-9

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Safety of Oxetan-3-ol

Wojtowicz, J. A.;Polak, R. J. research published 《 3-Substituted oxetanes》, the research content is summarized as follows. 3-Allyloxyoxetane was isomerized with tert-BuOK to give 85-90% 3-propenoxyoxetane (I) (96% cis). I was cleaved by acid to produce 84% 3-oxetanol. Oxetanone is formed either by oxidation of oxetanol with chromic oxide-pyridine complex or by heating oxetyl tosylate in Me2SO. Heating oxetyl tosylate above 150° with alkali halides in triethylene glycol gave 75-85% 3-halooxetanes. A lower yield (10-20%) of 3-chlorooxetane was obtained when SOCl2 was reacted with 3-oxetanol. Reaction of iodooxetane with Et2NH at 200° gave 3-dimethylaminooxetane. Oxetyl acetate was prepared in 84% yield by transesterification of oxetanol with allyl acetate. Transesterification of oxetanol with Et acrylate gave a low yield of oxetyl acrylate; the main product was Et 3-(3-oxetoxy)propionate. The acetate and acrylate esters were also prepared by acylation of oxetanol.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Safety of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 7748-36-9, formula is C3H6O2, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Computed Properties of 7748-36-9

Wu, Cheng-Jun;Wu, Jia-Qiang;Hu, Yunfei;Pu, Suyun;Lin, Yuying;Zeng, Zimai;Hu, Jinhui;Chen, Wen-Hua research published 《 Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors》, the research content is summarized as follows. A series of indole-based [1,2,4]triazolo [4,3-a]pyridine derivatives was designed and synthesized as novel microtubulin polymerization inhibitors by using a conformational restriction strategy. These compounds exhibited moderate to potent anti-proliferative activities against a panel of cancer cell lines (HeLa, A549, MCF-7 and HCT116). Among them, compound I featuring a N-methyl-5-indolyl substituent at the C-6 position of the [1,2,4]triazolo [4,3-a]pyridine core exhibited the highest antiproliferative activity with the IC₅₀ values ranging from 15 to 69 nM, and remarkable inhibitory effect on tubulin polymerization with an IC₅₀ value of 1.64μM. Mechanistic studies revealed that compound I induced cellular apoptosis and cell cycle arrest at the G₂/M phase in a dose-dependent fashion. Moreover, compound I significantly suppressed wound closure and disturbed microtubule networks.

Computed Properties of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Safety of Oxetan-3-ol

Wu, Hongxiang;Guo, Weijie;Daniel, Stelck;Li, Yue;Liu, Chao;Zeng, Zhuo research published 《 Fluoride-Catalyzed Esterification of Amides》, the research content is summarized as follows. A new method was designed for fluoride-catalyzed activation of secondary and primary amides. This method was enabled the synthesis of esters I [R¹ = Ph, 2-thienyl, cyclohexyl, etc.; R² = n-hexyl, CH₂-2-furyl, 3-oxetanyl, etc.] from a wide range of amides using fluoride as a catalyst and alc. as a nucleophiles. This method was showing high functional group tolerance and notably it requires only a slight excess of the alc. nucleophile, which was a rare case in transition-metal-free amide transformations. This approach might provide a new understanding for further studies on esterification of amides and was expected to stimulate the development of alternative methods for direct functionalization of amides.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Safety of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 7748-36-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Wang, Le;Pratt, John K.;Soltwedel, Todd;Sheppard, George S.;Fidanze, Steven D.;Liu, Dachun;Hasvold, Lisa A.;Mantei, Robert A.;Holms, James H.;McClellan, William J.;Wendt, Michael D.;Wada, Carol;Frey, Robin;Hansen, T. Matthew;Hubbard, Robert;Park, Chang H.;Li, Leiming;Magoc, Terrance J.;Albert, Daniel H.;Lin, Xiaoyu;Warder, Scott E.;Kovar, Peter;Huang, Xiaoli;Wilcox, Denise;Wang, Rongqi;Rajaraman, Ganesh;Petros, Andrew M.;Hutchins, Charles W.;Panchal, Sanjay C.;Sun, Chaohong;Elmore, Steven W.;Shen, Yu;Kati, Warren M.;McDaniel, Keith F. research published 《 Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors》, the research content is summarized as follows. Members of the BET family of bromodomain containing proteins have been identified as potential targets for blocking proliferation in a variety of cancer cell lines. A 2-dimensional NMR fragment screen for binders to the bromodomains of BRD4 identified a Ph pyridazinone fragment with a weak binding affinity (I, K_i = 160 μM). SAR investigation of fragment I, aided by X-ray structure-based design, enabled the synthesis of potent pyridone and macrocyclic pyridone inhibitors exhibiting single digit nanomolar potency in both biochem. and cell based assays, e.g. II. Advanced analogs in these series exhibited high oral exposures in rodent PK studies and demonstrated significant tumor growth inhibition efficacy in mouse flank xenograft models.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., SDS of cas: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Synthetic Route of 7748-36-9

Wang, Xueqin;Xu, Ruiqiu;Zhang, Pang research published 《 Synthesis of 3-hydroxyoxetane and the Finkelstein reaction of its p-toluenesulfonate with sodium iodide》, the research content is summarized as follows. Successive tosylation and benzoylation of HOCH₂CH(OCH₂Ph)CH₂OH gave PhCO₂CH₂CH(OCH₂Ph)CH₂OTs (Ts = p-tosyl), which was cyclized with MeONa in boiling MeOH to give I (R = PhCH₂) (II) in 30% overall yield. Catalytic hydrogenolysis of II gave 90% title compound (I; R = H), which was tosylated to give 86% I (R = Ts) (III). III underwent a slower Finkelstein reaction with NaI than 1,3-di-O-methylglycerol p-tosylate due to the electron-withdrawing inductive effect of the ring O atom.

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. 7748-36-9, formula is C3H6O2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. SDS of cas: 7748-36-9

Wang, Yang;Hong, Lei;Tapriyal, Deepak;Kim, In Chul;Paik, Ik-Hyeon;Crosthwaite, Jacob M.;Hamilton, Andrew D.;Thies, Mark C.;Beckman, Eric J.;Enick, Robert M.;Johnson, J. Karl research published 《 Design and Evaluation of Nonfluorous CO₂-Soluble Oligomers and Polymers》, the research content is summarized as follows. Ab initio mol. modeling is used to design nonfluorous polymers that are potentially soluble in liquid CO₂. We have used calculations to design three nonfluorous compounds meant to model the monomeric repeat units of polymers that exhibit multiple favorable binding sites for CO₂. These compounds are methoxy iso-Pr acetate, 2-methoxy ethoxy-propane, and 2-methoxy methoxy-propane. We have synthesized oligomers or polymers based on these small compounds and have tested their solubility in CO₂. All three of these exhibit appreciable solubility in CO₂. At 25°C, oligo(3-acetoxy oxetane)₆ is 5 weight % soluble at 25 MPa, the random copolymer (vinyl methoxymethyl ether₃₀-co-vinyl acetate₉) is 5 weight % soluble at 70 MPa and random copolymer (vinyl 1-methoxyethyl ether₃₀-co-vinyl acetate₉) is 3 weight % soluble at 120 MPa. These oligomers and polymers represent new additions to the very short list of nonfluorous CO₂-soluble polymers. However, none of these are more soluble than poly(vinyl acetate), which exhibits the highest CO₂ solubility of any known polymer containing only the elements C, H, and O.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., SDS of cas: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Name: Oxetan-3-ol

Vandenberg, E. J.;Mullis, J. C.;Juvet, R. S. Jr.;Miller, T.;Nieman, R. A. research published 《 Poly(3-hydroxyoxetane) – an analog of poly(vinyl alcohol): synthesis, characterization, and properties》, the research content is summarized as follows. The spontaneous polymer formed from 3-hydroxyoxetane (I) is linear, low-mol.-weight, water-soluble, atactic poly(3-hydroxyoxetane) (II) of high crystallinity with -OCH₂CH(OH)CH₂OH end units. The highly crystalline nature of II may be related to the crystalline nature of atactic poly(vinyl alc.) since I can be considered a copolymer of vinyl alc. and HCHO. Spontaneous II apparently is formed in a cationic polymerization by the carboxylic acids produced by the air oxidation of I on standing at room temperature for several months. The polymerization can be duplicated by the addition of 2% hydroxyacetic acid to I. The rate of this unusual cationic polymerization increases greatly with acid strength, e.g., trifluoromethanesulfonic acid reacts explosively with pure I. A mechanism is proposed for this cationic polymerization High-mol.-weight, water-soluble, linear, atactic, and highly crystalline II (m.p. = 155°) was made by polymerizing the trimethylsilyl ether of I with the iso-Bu₃Al-0.7H₂O cationic catalyst followed by hydrolysis. Two ¹H NMR methods for measuring the tacticity of II were developed based on finding two different types of methylene units at 400 MHz with the methine protons decoupled. Also, an ¹H-NMR method was developed for measuring branching in II. High-mol.-weight, linear II with enhanced isotacticity (80%) was obtained in low yield as a water-insoluble fraction with T_m = 223°. The low-mol.-weight II prepared previously by the base-catalyzed, rearrangement polymerization of glycidol is highly branched.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 7748-36-9, formula is C3H6O2, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Synthetic Route of 7748-36-9

Vidal, Juliana L.;Wyper, Olivia M.;MacQuarrie, Stephanie L.;Kerton, Francesca M. research published 《 Ring-Closing Metathesis of Aliphatic Ethers and Esterification of Terpene Alcohols Catalyzed by Functionalized Biochar》, the research content is summarized as follows. Functionalized biochars, renewable carbon materials prepared from waste biomass, can catalyze transformations of a range of oxygen-containing substrates via hydrogen-bonding interactions. Good conversions (up to 75.2%) to different O-heterocycles are obtained from ring-closing C-O/C-O metathesis reactions of different aliphatic ethers under optimized conditions using this heterogeneous, metal-free, and easy separable catalyst. The diversity in the sorts of O-containing feedstocks is further demonstrated by the utilization of functionalized biochar to promote the esterification of terpene alcs., an important reaction in food and flavor industries. Under the optimized conditions, full conversions to various terpene esters are obtained. Moreover, both of the reactions studied herein are performed under neat conditions, thus increasing the overall sustainability of the process described.

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Category: alcohols-buliding-blocks

Toledo-Sherman, Leticia;Breccia, Perla;Cachope, Roger;Bate, Jennifer R.;Angulo-Herrera, Ivan;Wishart, Grant;Matthews, Kim L.;Martin, Sarah L.;Cox, Helen C.;McAllister, George;Penrose, Stephen D.;Vater, Huw;Esmieu, William;Van de Poel, Amanda;Van de Bospoort, Rhea;Strijbosch, Annelieke;Lamers, Marieke;Leonard, Philip;Jarvis, Rebecca E.;Blackaby, Wesley;Barnes, Karen;Eznarriaga, Maria;Dowler, Simon;Smith, Graham D.;Fischer, David F.;Lazari, Ovadia;Yates, Dawn;Rose, Mark;Jang, Sung-Wook;Munoz-Sanjuan, Ignacio;Dominguez, Celia research published 《 Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington’s Disease Models》, the research content is summarized as follows. Genetic and pharmacol. evidence indicates that the reduction of ataxia telangiectasia-mutated (ATM) kinase activity can ameliorate mutant huntingtin (mHTT) toxicity in cellular and animal models of Huntington’s disease (HD), suggesting that selective inhibition of ATM could provide a novel clin. intervention to treat HD. Here, we describe the development and characterization of ATM inhibitor mols. to enable in vivo proof-of-concept studies in HD animal models. Starting from previously reported ATM inhibitors, we aimed with few modifications to increase brain exposure by decreasing P-glycoprotein liability while maintaining potency and selectivity. Here, we report brain-penetrant ATM inhibitors that have robust pharmacodynamic (PD) effects consistent with ATM kinase inhibition in the mouse brain and an understandable pharmacokinetic/PD (PK/PD) relationship. Compound 17 engages ATM kinase and shows robust dose-dependent inhibition of X-ray irradiation-induced KAP1 phosphorylation in the mouse brain. Furthermore, compound 17 protects against mHTT (Q73)-induced cytotoxicity in a cortical-striatal cell model of HD.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of Oxetan-3-ol, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Stafford, Nicholas P.;Cheng, Melinda J.;Dinh, Duong Nguyen;Verboom, Katherine L.;Krische, Michael J. research published 《 Chiral α-Stereogenic Oxetanols and Azetidinols via Alcohol-Mediated Reductive Coupling of Allylic Acetates: Enantiotopic π-Facial Selection in Symmetric Ketone Addition》, the research content is summarized as follows. Iridium-tol-BINAP-catalyzed reductive coupling of allylic acetates with oxetanones and azetidinones mediated by 2-propanol provides chiral α-stereogenic oxetanols and azetidinols. As illustrated in 50 examples, complex, nitrogen-rich substituents that incorporate the top 10 N-heterocycles found in Food and Drug Administration (FDA)-approved drugs are tolerated. In addition to 2-propanol-mediated reductive couplings, oxetanols and azetidinols may serve dually as reductant and ketone proelectrophiles in redox-neutral C-C couplings via hydrogen autotransfer, as demonstrated by the conversion of dihydro- and dihydro to adducts. The present method delivers hitherto inaccessible chiral oxetanols and azetidinols, which are important bioisosteres.

Safety of Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts