Category: 7748-36-9

Category: alcohols-buliding-blocks, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Yang, Wen;Wang, Zhaobin;Sun, Jianwei research published 《 Enantioselective Oxetane Ring Opening with Chloride: Unusual Use of Wet Molecular Sieves for the Controlled Release of HCl》, the research content is summarized as follows. In the presence of a nonracemic spirobiindanephosphoric acid, 3-substituted oxetanes underwent enantioselective ring opening and desymmetrization with chloride generated in situ from trimethoxychlorosilane and water in the presence of 5Å mol. sieves in benzene to yield nonracemic chloropropanols such as (R)-HOCH₂CHRCH₂Cl [R = Ph, 4-MeC₆H₄, 2-MeOC₆H₄, 3-BrC₆H₄, 3-F₃CC₆H₄, 4-F₃CC₆H₄, 2-naphthyl, 2-benzofuranyl, (E)-PhCH:CH, PhCH₂, PhCH₂O] as highly functionalized three-carbon building blocks. The excellent enantiocontrol is enabled not only by the use of the new spirobiindanephosphoric acid catalyst, but also by the unusual use of wet mol. sieves for the controlled release of HCl.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 7748-36-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Yates, Peter;Szabo, Arthur G. research published 《 Photochemical synthesis of 3-oxetanols》, the research content is summarized as follows. Irradiation of 1% solution of RCOCH₂OCH₂R’ (I, R = Ph, R’ = H) (II) in C₆H₆ (N atm.) 12 hrs. with a 450-w., H₂O-cooled, high pressure Hg lamp yielded 29% 3-phenyl-3-oxetanol (III, R = Ph, R’ = H) (IV), m. 55-6° The N.M.R. signal at 6.28 ppm. was absent after treatment with D₂O. Treatment of 3-oxetanone with PhMgBr followed by decomposition with aqueous NH₄Cl also yielded IV. Identification of BzMe and H₂CO among the products of the photochem. reaction showed that the synthesis of IV was accompanied by a Norrish type II cleavage of the alkoxy ketone (Srinivasan, CA 57, 7091i). Similar irradiation of I (R = Ph, R’ = Me) yielded 34% III (R = Ph, R’ = Me) (V), b_0.5 75-80°, n²⁵_D 1.5392; V consisted largely or entirely of a single diastereoisomeric form. Irradiation of I (R = tert-Bu, R’ = H) yielded only 5% III (R = tert-Bu, R’ = H), m. 118-19.5° (after sublimation), indicating that the reaction is not restricted to aromatic ketones.

Application In Synthesis of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Recommanded Product: Oxetan-3-ol

Ye, Danfeng;Liu, Zhiyuan;Chen, Hao;Sessler, Jonathan L.;Lei, Chuanhu research published 《 Cesium Carbonate Catalyzed Esterification of N-Benzyl-N-Boc-amides under Ambient Conditions》, the research content is summarized as follows. A general activated amide to ester transformation catalyzed by Cs₂CO₃, is reported. Using this approach, esterification proceeds under relatively mild conditions and without the need for a transition metal catalyst. This method exhibits broad substrate scope and represents a practical alternative to existing esterification strategies. The synthetic utility of this protocol is demonstrated via the facile synthesis of crown ether derivatives and the late-stage modification of a representative natural product and several sugars in reasonable yields.

Recommanded Product: Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. HPLC of Formula: 7748-36-9

Yue, Fuyang;Dong, Jianyang;Liu, Yuxiu;Wang, Qingmin research published 《 Visible-Light-Mediated C-I Difluoroallylation with an α-Aminoalkyl Radical as a Mediator》, the research content is summarized as follows. Herein, a protocol for direct visible-light-mediated C-I difluoroallylation reactions of α-trifluoromethyl arylalkenes RC(=CH₂)CF₃ [R = 4-(benzyloxy)phenyl, 3,4,5-trimethoxyphenyl, naphthalen-2-yl, etc.] with alkyl iodides R¹I (R¹ = Et, cyclohexyl, oxetan-3-yl, etc.) at room temperature with an α-aminoalkyl radical as a mediator was reported. The protocol permits efficient functionalization of various α-trifluoromethyl arylalkenes with cyclic and acyclic primary, secondary, and tertiary alkyl iodides and is scalable to the gram level. This mild protocol uses an inexpensive mediator and is suitable for late-stage functionalization of complex natural products and drugs.

HPLC of Formula: 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Product Details of C3H6O2

Xue, Ting;Zhang, Zongnan;Zeng, Rong research published 《 Photoinduced Ligand-to-Metal Charge Transfer (LMCT) of Fe Alkoxide Enabled C-C Bond Cleavage and Amination of Unstrained Cyclic Alcohols》, the research content is summarized as follows. An alkoxy radical process for the C-C bond cleavage and functionalization of unstrained tertiary and secondary cyclic alcs. was reported. In the absence of a chlorine atom, the readily available iron catalysts [Fe(OBu-t)₃ or Fe(acac)₃/t-BuONa] facilitate alkoxy radical formation via the direct ligand-to-metal charge transfer of Fe alkoxide and further enable the ring opening and amination of cyclic alcs. The remote amino carbonyl compounds could be obtained with a broad scope in up to excellent yields under the mildly redox-neutral system. Light-driven electron transfer, alkoxy radical formation, and subsequent C-C bond cleavage via β-scission were the keys to the transformation.

Product Details of C3H6O2, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Reference of 7748-36-9

Yan, Xingxiu;Wang, Shengchun;Liu, Zhao;Luo, Yujie;Wang, Pengjie;Shi, Wenyan;Qi, Xiaotian;Huang, Zhiliang;Lei, Aiwen research published 《 Precise electro-reduction of alkyl halides for radical defluorinative alkylation》, the research content is summarized as follows. A precise electro-reduction strategy for radical defluorinative alkylation towards the synthesis of gem-difluoroalkenes from α-trifluoromethylstyrenes was reported. According to the redox-p.d. of the radical precursors, direct or indirect electrolysis was resp. adopted to realize the precise reduction An easy-to-handle, catalyst- and metal-free condition was developed for the reduction of alkyl radical precursors that are generally easier to be reduced than α-trifluoromethylstyrenes, while a novel electro-Ni-catalytic system was established for the electro-reduction of alkyl bromides or chlorides towards the electrochem. synthesis of gem-difluoroalkenes. The merit of this protocol was exhibited by its mild conditions, wide substrate scope, and scalable preparation Mechanistic studies and DFT calculations proved that the coordination of α-trifluoromethylstyrenes to Ni-catalyst prevents the direct reduction of the alkene and, in turn, promotes the activation of alkyl bromide through halogen atom transfer mechanism.

Reference of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Formula: C3H6O2

Wu, Zhongxin;Liao, Daohua;Pi, Hongjun;Li, Chao;Wang, Meijuan;Yang, Fang;Shi, Wenjuan research published 《 Synthesis of Oxasulfuron》, the research content is summarized as follows. Oxasulfuron was synthesized by the reaction of 2-(oxetan-3-oxycarbonyl)-phenylsulfonamide (3) with Ph N-(4,6-dimethylpyrimidin-2-yl) carbamate (6). Using 2-chlorosulfonylbenzoyl chloride, 3-hydroxyoxetane and ammonia as starting materials, compound (3) was conveniently obtained. Meantime, amidation of Ph chlorocarbonate afforded the intermediate (6), while triethylamine was selected as a more efficient deacid reagent. The total yield was 41%, and the purity of the target product was up to 97.4%.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Formula: C3H6O2

Wuitschik, Georg;Carreira, Erick M.;Wagner, Bjorn;Fischer, Holger;Parrilla, Isabelle;Schuler, Franz;Rogers-Evans, Mark;Muller, Klaus research published 《 Oxetanes in Drug Discovery: Structural and Synthetic Insights》, the research content is summarized as follows. The use of oxetanes as replacements for gem-di-Me or carbonyl groups and their effects on the aqueous solubility, lipophilicity, metabolic stability, and conformation for various compounds are studied; methods for the preparation of a variety of substituted oxetanes are given. The magnitude of changes in properties and in metabolic stability with oxetane substitution depends on the structural context; for example, substitution of a gem-di-Me group with an oxetane, aqueous solubility may increase by a factor of 4 to more than 4000 while reducing the rate of metabolic degradation in most cases. Incorporation of an oxetane into an aliphatic chain increases in some cases the preference for synclinal conformations rather than antiplanar conformations of the chain. Spirocyclic oxetanes such as an oxazaspiroheptane resemble commonly used fragments in drug discovery, such as morpholines, and in some cases increase aqueous solubility more effectively than morpholines. An improved chemoselective oxidation of 3-oxetanol to 3-oxetanone is disclosed; olefination of 3-oxetanone by a variety of methods yields alkylideneoxetanes I [R = (EtO)₂P(:O), OHC, O₂N, EtO₂C, NC, PhO₂S, MeCO, 1-(4-chlorophenyl)-1-cyclobutanecarbonyl]. I (R = EtO₂C, OHC, O₂N) undergo addition reactions with nucleophiles such as amines, carbonyl compounds, and arylboronic acids to give oxetanes such as II. The crystal structures of a variety of oxetanes are determined

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 7748-36-9, formula is C3H6O2, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Synthetic Route of 7748-36-9

Xia, X. Y.;Sun, W.;He, W.;Feng, Y.;Zhan, L.;Luo, Y. research published 《 A Modified Synthesis of Oxetan-3-ol》, the research content is summarized as follows. A highly regioselective ring opening reaction of terminal epoxides with 2-bromobenzoic acid catalyzed by tetrabutylammonium bromide was accomplished. The procedure is operationally simple and practical for the synthesis of a series of β-hydroxy esters. Using this protocol, oxetan-3-ol could be prepared efficiently in a good yield.

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Related Products of 7748-36-9

Wang, Zhaobin;Chen, Zhilong;Sun, Jianwei research published 《 Catalytic Enantioselective Intermolecular Desymmetrization of 3-Substituted Oxetanes》, the research content is summarized as follows. Under optimized reaction conditions, the synthesis of the target compounds was achieved using (11aR)-10,11,12,13-tetrahydro-5-hydroxy-3,7-di(9-phenanthrenyl)diindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin 5-oxide (chiral cyclic phosphate) as a catalyst. A stereoselective ring opening reaction of 3-(phenyl)oxetane (I) with 2(3H)-benzothiazolethione [thiol, 2-(mercapto)benzothiazole] gave a chiral mercapto alc. (II).

Related Products of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts