Category: 7748-36-9

In 2022,Sarkar, Souradip; Samanta, Rajarshi published an article in Organic Letters. The title of the article was 《Weakly Coordinating tert-Amide-Assisted Ru(II)-Catalyzed Synthesis of Azacoumestans via Migratory Insertion of Quinoid Carbene: Application in the Total Synthesis of Isolamellarins》.Related Products of 7748-36-9 The author mentioned the following in the article:

A weakly coordinating tert-amide-directed straightforward method was developed for the synthesis of azacoumestans, e.g., I, using the corresponding azaheterocycle derivatives II (R1 = H, Me, Bn, etc., R2 = H, Me, R3 = Cl, F, R4 = MeO, Br, Ph, etc.) and diazonaphthoquinones III (R5 = OH, R6 = Br, COMe, Ph, etc.) under cheap Ru(II)-catalyzed conditions. The reaction proceeds via migratory insertion of quinoid carbene and subsequent Bronsted acid-mediated cyclization. The optimized C2-selective method offered a wide scope of important azaheterocycles. Bioactive natural products like isolamellarins A and B were synthesized via the developed protocol. Preliminary mechanistic studies highlighted the probable mechanistic pathway. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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Kamaraj, Santhosh; Shanmugam, Ganesan; Gunasekeran, Ahalya; Selvaraj, Balamurugan; Thirugnanasambandam, Eswaramoorthi; Kandhasamy, Mohanraj; Sambandam, Anandan published their research in Energy & Fuels in 2021. The article was titled 《Performance of 4-Subsituted Pyridine Based Additive and Cobalt Redox in Poly(ethylene glycol)-Hydroxyethylcellulose Polymer Electrolytes with DTTCY Acid Sensitizer on Dye Sensitized Solar Cells》.Recommanded Product: Oxetan-3-ol The article contains the following contents:

The photovoltaic performance of dye-sensitized solar cells fabricated with newly designed and synthesized heterocyclic aromatic pyridine based additive is described. The incorporation of the 4-substituted pyridine based additive into the quasi-solid state polymer blend of poly(ethylene glycol)-hydroxyethylcellulose (PEG-HEC) with Co2+/3+[bnbip] redox mediator as electrolyte and (E)-3-(5-((E)-2-(1-(5-(2,2-bis(4-(dimethylamino)phenyl)vinyl)thiophen-2-yl)-1H-indol-3-yl)-1-cyanovinyl)thiophen-2-yl)-2-cyanoacrylic acid (DTTCY) as organic photosensitizer has been investigated. The influences of synthesized additives in current-voltage characteristics and photoelectro behavior of devices assembled with [TiO2/DTTCY/Co2+/3+[bnbip]/additive/PEG-HEC/Pt] device were investigated. The presence of different additives in the gel polymer matrix enhanced the photovoltage and was related to the neg. shift that occurred in the Quasi Fermi level of TiO2 and also higher charge relaxation time. These additives probably reduce the recombination reaction between the TiO2 surface and the Co3+ ion that boosts the photocurrent (JSC) and PCE of the DSSCs. Furthermore, additives affect the catalytic behavior of the Pt electrode, trap diffusion of the Co3+ species, and charge transfer resistance that limits Jsc produced by the device. The PAZ additive possesses an azaindole moiety with bicyclic ring attached on the fourth position of the pyridine, which greatly supports the device for exhibiting good ionic conductivity (1.46 x 10-3 S cm-1), high chem. capacitance (Cμ = 11.96 μF), high recombination resistance (9.78 Ω), and lower charge transfer resistance (54.98 Ω) compared with other pyridine based additives. The overall results were also sustained with dielec. constant, dielec. loss, and elec. modulus studies. The cell integrated with PAZ additive generates a maximum JSC of 13.59 mA cm-2 and Voc of 912 mV, yielding an overall power conversion efficiency η of 5.82% under simulated sunlight with 1.5AM condition (i.e., 100 mW cm-2). These QS-DSSCs possess long-term stability for 196 h at ambient conditions. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

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《Modeling the protein-nucleic acid base interactions through hydrogen-bonded complexes of N-heterocyclic analogs of Indene with amino acid side-chain mimics》 was written by Chopra, Neha; Chopra, Geetanjali; Kaur, Damanjit. Name: Oxetan-3-ol And the article was included in Structural Chemistry in 2020. The article conveys some information:

A series of hydrogen-bonded complexes between N-heterocyclic analogs of indene and amino acid side-chain mimics were analyzed employing second-order Moller-Plesset perturbation (MP2) theory and d. functional theory with dispersion function (DFT-D) calculations with the aim of gaining greater insight in to the nature of intermol. interactions in these systems. In this study, the hydrogen bonding ability of N-heterocyclic analogs of indene towards amino acid side-chain mimics followed the sequence azaindazole (AIND) > indazole (IND) > azaindole (AIN) > indole (IN) whereas the hydrogen bonding ability of amino acid side-chain mimics towards N-heterocyclic analogs of indene followed the sequence AcOH > MeNH2 > MeOH > MeSH. Bader’s theory of atoms in mols. (AIM) and natural bond orbitals (NBO) analyses were employed to elucidate the interaction characteristics in the complexes under study. The purpose of conducting these studies was to measure the relative strength of hydrogen bonding interactions such as N-H···O=C, N-H···O, N-H···S, N-H···N, and O-H···N in these complexes and their role in providing stability to the complexes. The AIM theory showed good correlation of the electron d. and its Laplacian at the bond critical points (BCP) with the computed stabilization energy for all the complexes under study. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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《Catalyst-Free N-Deoxygenation by Photoexcitation of Hantzsch Ester》 was written by Konev, Mikhail O.; Cardinale, Luana; Jacobi von Wangelin, Axel. Name: Oxetan-3-ol And the article was included in Organic Letters in 2020. The article conveys some information:

A mild and operationally simple protocol for the deoxygenation of a variety of heteroaryl N-oxides and nitroarenes has been developed. A mixture of substrate and Hantzsch ester is proposed to result in an electron donor-acceptor complex, which upon blue-light irradiation undergoes photoinduced electron transfer between the two reactants to afford the products. N-oxide deoxygenation is demonstrated with 22 examples of functionally diverse substrates, and the chemoselective reduction of nitroarenes to the corresponding hydroxylamines is also shown.Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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Category: alcohols-buliding-blocksIn 2022 ,《C(sp3)-H oxygenation via alkoxypalladium(II) species: an update for the mechanism》 was published in Chemical Science. The article was written by Zhang, Shuaizhong; Zhang, Jinquan; Zou, Hongbin. The article contains the following contents:

In the present study of γ-C(sp3)-H acyloxylation of amine derivatives, a different mechanism was shown when tert-Bu hydroperoxide (TBHP) was used as an oxidant-namely, a bimetallic oxidative addition-oxo-insertion process. This catalytic model results in an alkoxypalladium(II) intermediate from which acyloxylation and alkoxylation products was formed. Exptl. and computational studies, including isolation of the putative post-oxo-insertion alkoxypalladium(II) intermediates, support this mechanistic model. D. functional theory revealed that the classical alkylpalladium(IV) oxidative addition pathway was higher in energy than the bimetallic oxo-insertion pathway. Further kinetic studies revealed second-order dependence on [Pd] and first-order on [TBHP], which was consistent with DFT anal. This procedure was compatible with a wide range of acids and alcs. for γ-C(sp3)-H oxygenation. Preliminary functional group transformations of the products underscore the great potential of this protocol for structural manipulation. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

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《Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides》 was published in Chemical Science in 2020. These research results belong to Pagire, Santosh K.; Kumagai, Naoya; Shibasaki, Masakatsu. Recommanded Product: 7748-36-9 The article mentions the following:

A cooperative catalytic system comprising a chiral Cu(I) complex and an Ir(III) photocatalyst fueled by visible-light irradiation that allows for seamless integration of the catalytic formation of a-amino alkyl radicals and subsequent enantioselective addition to α,β-unsaturated amides I [R = H, OMe; R1 = Me, Ph, pyridin-2-yl, etc.; R2 = H, Me; R3 = H, OMe, Cl; X = CH2, C(CH3)2] was reported. A 7-aza-6-MeO-indoline attachment on the amide substrates plays a pivotal role in suppressing the undesired pathways, resulting in excellent enantioselectivity and enabling expedited access to valuable γ-aminobutyramides II (R4 = Ph, 2-fluorophenyl; R5 = H, Me, i-Pr, Bn). The indoline amide was readily diversified with full recovery of the azaindoline attachment, highlighting the synthetic utility of this cooperative catalytic system. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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In 2022,Kim, Yong-Guy; Lee, Jin-Hyung; Park, Sunyoung; Lee, Jintae published an article in Microbiology Spectrum. The title of the article was 《The anticancer agent 3,3′-diindolylmethane inhibits multispecies biofilm formation by acne-causing bacteria and Candida albicans》.HPLC of Formula: 7748-36-9 The author mentioned the following in the article:

The Gram-pos. anaerobic bacterium Cutibacterium acnes is a major inhabitant of human skin and has been implicated in acne vulgaris formation and in the formation of multispecies biofilms with other skin-inhabiting organisms like Staphylococcus aureus and Candida albicans. Indoles are widespread in nature (even in human skin) and function as important signaling mols. in diverse prokaryotes and eukaryotes. In the present study, we investigated the antibacterial and antibiofilm activities of 20 indoles against C. acnes. Of the indoles tested, indole-3-carbinol at 0.1 mM significantly inhibited biofilm formation by C. acnes without affecting planktonic cell growth, and the anticancer drug 3,3′-diindolylmethane (DIM) at 0.1 mM (32μg/mL) also significantly inhibited planktonic cell growth and biofilm formation by C. acnes, whereas the other indoles and indole itself were less effective. Also, DIM at 0.1 mM successfully inhibited multispecies biofilm formation by C. acnes, S. aureus, and C. albicans. Transcriptional analyses showed that DIM inhibited the expressions of several biofilm-related genes in C. acnes, and at 0.05 mM, DIM inhibited hyphal formation and cell aggregation by C. albicans. These results suggest that DIM and other indoles inhibit biofilm formation by C. acnes and have potential use for treating C. acnes associated diseases. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

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In 2022,Hu, Chunyang; Chen, Fangming; Lu, Guo-Ping; Yi, Wen-Bin published an article in Chinese Chemical Letters. The title of the article was 《Deuterated N-difluoromethylthiophthalimide: A stable, scalable reagent for radical and electrophilic deuteriodifluoromethylthiolations》.Related Products of 7748-36-9 The author mentioned the following in the article:

A new, stable and scalable reagent for deuteriodifluoromethylthiolation (deuterated N-difluoromethylthiophthalimide, PhthSCF2D) has been developed. This reagent can be applied for the photocatalytic radical deuteriodifluoromethylthiolation of various olefins and aldehydes (30 examples). Meanwhile, it can achieve the electrophilic deuteriodifluoromethylthiolation of a series of electrophilic substrates including electron-rich arenes, aryl/vinylboronicacids, alkynes, amines, thiols and β-ketoesters (22 examples). Some complex mols. can also be applied in both radical and electrophilic deuteriodifluoromethylthiolation using PhthSCF2D as the reagent. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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Recommanded Product: Oxetan-3-olIn 2021 ,《Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues》 appeared in Nature Communications. The author of the article were Kastan, Nathaniel; Gnedeva, Ksenia; Alisch, Theresa; Petelski, Aleksandra A.; Huggins, David J.; Chiaravalli, Jeanne; Aharanov, Alla; Shakked, Avraham; Tzahor, Eldad; Nagiel, Aaron; Segil, Neil; Hudspeth, A. J.. The article conveys some information:

Hippo signaling is an evolutionarily conserved pathway that restricts growth and regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap. Using a high-throughput phenotypic screen, we identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling. The substance prevents Yap phosphorylation and induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Muller glia in retinal organoids. The RNA sequencing indicates that the inhibitor reversibly activates the expression of transcriptional Yap targets: upon withdrawal, a subset of supporting-cell progeny exits the cell cycle and upregulates genes characteristic of sensory hair cells. Our results suggest that the pharmacol. inhibition of Lats kinases may promote initial stages of the proliferative regeneration of hair cells, a process thought to be permanently suppressed in the adult mammalian inner ear. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

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Milic, Mira; Targos, Karina; Tellez Chavez, Magda; Thompson, Madison A. M.; Jennings, Julia J.; Franz, Annaliese K. published an article in 2021. The article was titled 《NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules》, and you may find the article in Journal of Organic Chemistry.Name: Oxetan-3-ol The information in the text is summarized as follows:

The hydrogen-bond-accepting abilities for more than 100 organic mols. are quantified using 19F and 31P NMR spectroscopy with pentafluorobenzoic acid (PFBA) and phenylphosphinic acid (PPA) as com. available, inexpensive probes. Anal. of pyridines and anilines with a variety of electronic modifications demonstrates that changes in NMR shifts can predict the secondary effects that contribute to H-bond-accepting ability, establishing the ability of PFBA and PPA binding to predict electronic trends. The H-bond-accepting abilities of various metal-chelating ligands and organocatalysts are also quantified. The measured Δδ(31P) and Δδp(19F) values correlate strongly with Hammett parameters, pKa of the protonated HBA, and proton-transfer basicity (pKBH+). The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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