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Yadav, Bhavna; Baire, Beeraiah published an article in 2022. The article was titled 《Ag(I)-Promoted, Diastereoselective Cyclo-isomerization of N-Alkynyl-7-azaindole-2-carbinols. Selective Synthesis of syn-1,2-Diarylpyrrolo[1,2-a]indol-3-ones and (Z)-8-Benzylideneoxazolo[3′,4”:1,5]pyrrolo[2,3-b]pyridinesã€? and you may find the article in Organic Letters.Safety of Oxetan-3-ol The information in the text is summarized as follows:

The design and development of an Ag(I)-promoted, highly diastereoselective cycloisomerization strategy for the synthesis of syn-1,2-diarylpyrrolo[1,2-a]indol-3-ones from N-alkynyl-indole-2-carbinols was reported. The H218O control experiment and identification of 18O-labeled product suggested the involvement of an external water. The 7-azaindole substrates showed a distinct reactivity to give the (Z)-8-benzylideneoxazolo[3′,4′:1,5]pyrrolo[2,3-b]pyridines. Key features of this strategy were its 100% atom economy, access to important heterocycles, diverse substrate scope, yields up to 95%, operationally simple procedure, and distinct reactivity of indole vs 7-azaindoles.Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol) was used in this study.

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《Exploring an anomaly: the synthesis of 7,7′-diazaindirubin through a 7-azaindoxyl intermediateã€?was published in RSC Advances in 2020. These research results belong to Shriver, James A.; Wang, Katelyn R.; Patterson, Andrew C.; DeYoung, James R.; Lipsius, Richard J.. Safety of Oxetan-3-ol The article mentions the following:

Two independent methods generating 7-azaindoxyl as an intermediate verified that 7,7′-diazaindirubin was formed exclusively over 7,7′-diazaindigo. This contrasted with long-standing knowledge related to the reactivity of indoxyl, which proceeded via a radical-initiated homodimerization process, leading to indigo. A series of experiments confirmed 7-azaindoxyl as an intermediate with resulted suggesting a condensation pathway followed by oxidation In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol

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In 2022,Shriver, James A.; Kaller, Kaylie S.; Kinsey, Ally L.; Wang, Katelyn R.; Sterrenberg, Summer R.; Van Vors, Madison K.; Cheek, Joshua T.; Horner, John S. published an article in RSC Advances. The title of the article was 《A tunable synthesis of indigoids: targeting indirubin through temperatureã€?Application of 7748-36-9 The author mentioned the following in the article:

The spontaneous conversion of 3-indoxyl to indigo was a well-established process used to produce indigo dyes. It was recently shown that some indoles, when reacted with molybdenum hexacarbonyl and cumyl peroxide, proceed through an indoxyl intermediate to produce significant amounts of indirubin through a competing mechanism. Modulation of this system to lower temperatures allows for careful tuning, leading to selective production of indirubins in a general process. A systematic assay of indoles show that electron deficient indoles work well when substituted at the 5 and 7 positions. In contrast, 6-substituted electron rich indoles give the best results whereas halogeno indoles work well in all cases. This process shows broad functional group tolerance for generally reactive carbonyl-containing compounds such as aldehydes and carboxylic acids. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

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In 2022,Zhong, Shuting; Fang, Xianfu; Wang, Yiting; Zhang, Gong; Li, Yangfeng; Li, Yizhou published an article in Organic Letters. The title of the article was 《DNA-compatible diversification of indole π-activated alcohols via a direct dehydrative coupling strategyã€?Application of 7748-36-9 The author mentioned the following in the article:

Indole-based diversification is highly desired in the DNA-encoded chem. library construction. Herein, we present a general strategy for on-DNA synthesis of diverse C3-functionalized indole derivatives via indole π-activated alc. formation followed by direct dehydrative coupling. Highly efficient bond linkages of C-C, C-N, and C-S were achieved to fuse building blocks that are widely com. available. DNA-encoding compatibility of the method has been further demonstrated to pave an avenue for application in constructing indole-focused three-dimensional libraries. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

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In 2022,Sun, Kangkang; Shan, Hongbin; Ma, Rui; Wang, Peng; Neumann, Helfried; Lu, Guo-Ping; Beller, Matthias published an article in Chemical Science. The title of the article was 《Catalytic oxidative dehydrogenation of N-heterocycles with nitrogen/phosphorus co-doped porous carbon materialsã€?Reference of Oxetan-3-ol The author mentioned the following in the article:

A metal-free oxidative dehydrogenation of N-heterocycles e.g., quinoline utilizing a nitrogen/phosphorus co-doped porous carbon (NPCH) catalyst was reported. The optimal material is robust against traditional poisoning agents and shows high antioxidant resistance. It exhibits good catalytic performance for the synthesis of various quinolines I (R1 = H, 5-Br, 6-OMe, 8-OH, etc.; R1 = H, 2-Me, 2-Ph, 3-Me, 4-Me), indoles II (R3 = H, 4-CN, 5-Me, 5-Cl, etc.; R4 = 2-Me, 3-Me, 3-COOMe), isoquinolines III (R5 = H, Me, Ph), and quinoxalins IV (R6 = H, Me, Ph; R7 = H, NO2) ‘on-water’ under air atm. The active sites in the NPCH catalyst are proposed to be phosphorus and nitrogen centers within the porous carbon network. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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Zhang, Jinquan; Zhang, Shuaizhong; Zou, Hongbin published an article in 2021. The article was titled 《Acid- and Base-Switched Palladium-Catalyzed γ-C(sp3)-H Alkylation and Alkenylation of Neopentylamineã€? and you may find the article in Organic Letters.Electric Literature of C3H6O2 The information in the text is summarized as follows:

Reported Pd-catalyzed γ-C(sp3)-H-selective alkylation and alkenylation with removable 7-azaindole as a directing group. Acid and base were found to be the decisive regulators for the selective alkylation and alkenylation, resp., on the same single substrate under otherwise the same reaction conditions. Various acrylates were compatible for the formation of C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds. The alkenylation protocol could be further extended to acrylates with natural product units and α,β-unsaturated ketones. The preliminary synthetic manipulation of the alkylation and alkenylation products demonstrates the potential of this strategy for structurally diverse aliphatic chain extension and functionalization. Mechanistic exptl. studies showed that the acidic and basic catalytic transformations shared the same six-membered dimer palladacycle.Oxetan-3-ol(cas: 7748-36-9Electric Literature of C3H6O2) was used in this study.

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Mudasani, Gopal; Paidikondala, Kalyani; Gundla, Rambabu; Joseph Maddirala, Shambabu; Das, Viswanath published their research in ChemistrySelect in 2021. The article was titled 《Synthesis and Biological Evaluation of 5′-Arylspiro[piperidine-4,3′-pyrrolo-[2,3-b]pyridin] Analogues》.Related Products of 7748-36-9 The article contains the following contents:

The synthesis of a novel series of spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one analogs I [R = H, CONH2; Ar = pyrimidin-5-yl, 4-fluorophenyl, 1,3-benzodioxol-5-yl, etc.] and in-vitro antiproliferative activity of these compounds against four human cancer cell lines were reported. Synthesis of analogs I were done using a rational designing approach in a seven-step sequence and the characterization of compounds was performed using 1H-NMR, LC-MS, and 13C-NMR. Thirteen novel compounds I were synthesized in moderate to good yields. The anti-proliferation activity of the compounds I against human breast MCF-7 and MDA-MB-231, leukemic K-562 and lung A549 cancer cells were determined by a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Two compounds among all the synthesized compounds I had moderate IC50 values in MCF-7 cells and thus were identified to have better antiproliferative activity against estrogen-receptor-pos. cancer cells. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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《Synthesis and photophysical studies of an indigo derivative: N-octyl-7,7′-diazaindigo》 was written by de Miguel, Gustavo; Garzon-Ruiz, Andres; Navarro, Amparo; Garcia-Frutos, Eva M.. Recommanded Product: Oxetan-3-ol And the article was included in RSC Advances in 2020. The article conveys some information:

In this paper, we explore the synthesis, characterization, and photophys. properties of a novel indigo derivative, N-octyl-7,7′-diazaindigo, being the first time that diazaindigos have been studied as photophys.-active chem. entities. Reduction of the neutral “”keto-form”” to the so-called “”leuco-form”” changes the global spectroscopic and photophys. behaviors. Both species have been investigated by different photophys. studies, such as anal. of absorption and emission spectra, fluorescence quantum yields (ϕF) and lifetimes. Finally, to appraise in depth the deactivation of the excited state of the keto form, femtosecond transient absorption (TA) experiments and D. Functional Theory (DFT) and Time Dependent (TD)-DFT calculations were performed. In an organic aprotic solvent (N,N-dimethylformamide), TA experiments showed a fast deactivation channel (τ1 = 2.9 ps), which was ascribed to solvent reorganization, and a longer decay component (τ2 = 86 ps) associated with an internal conversion (IC) process to the ground-state, in opposition to the excited state proton transfer (ESPT) mechanism that takes place in the indigo mols. but in protic solvents. A comparative study was also carried out on the parent mol., 7,7′-diazaindigo, corroborating the previous conclusions obtained for the alkyl derivative In agreement with exptl. observations, DFT and TD-DFT calculations revealed that the deactivation of the S1 state of the keto form takes place through an internal conversion process. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

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Product Details of 7748-36-9In 2022 ,《Palladium-Catalyzed Three-Component Dearomatization/Sulfonylation Cascade》 was published in Organic Letters. The article was written by Bajohr, Jonathan; Bohme, Matthias D.; Gao, Jiacheng; Hahn, F. Ekkehardt; Lautens, Mark. The article contains the following contents:

The diastereoselective synthesis of sulfonylated indolines is reported. A palladium-catalyzed dearomative sulfination of (aza)indole-tethered aryl iodides generates reactive benzylic sulfinates. These intermediates react with electrophiles in a one-pot, two-step process to generate sulfonylated products in good yields and excellent diastereoselectivity. This three-component sequence demonstrates good scalability and can be applied toward the synthesis of sulfonamides. Addnl., further derivatizations of aryl iodide containing products furnish spiro- and alkynylated indoline products. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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In 2022,Leclair, Alexandre; Wang, Qian; Zhu, Jieping published an article in ACS Catalysis. The title of the article was 《Two-Carbon Ring Expansion of Cyclobutanols to Cyclohexenones Enabled by Indole Radical Cation Intermediate: Development and Application to a Total Synthesis of Uleine》.Related Products of 7748-36-9 The author mentioned the following in the article:

A single-electron transfer (SET) oxidation of indole or benzo[b]thiophene to a radical cation reverses the intrinsic polarity of these π-excessive bicyclic heteroarenes. Here we report an oxidative two-carbon homologation of cyclobutanols to cyclohexenones under a visible-light photoredox catalysis. 1-(Indol-2-yl)cyclobutan-1-ols are converted to 2,3,4,9-tetrahydro-1H-carbazol-1-ones, important structural motifs found in alkaloids and pharmaceuticals, with a broad substrate scope. A mechanistic study suggests that the reaction is initiated by an SET from an indole to an excited acridinium salt to generate the radical cation, which is followed by two consecutive 1,2-alkyl migrations and a rearomatization. Benzo[b]thiophene-substituted cyclobutanols are similarly converted to 2,3-dihydrodibenzo[b,d]thiophen-4(1H)-ones. A total synthesis of (±)-uleine featuring this ring-expansion process is documented. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

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