Category: 7748-36-9

In 2022,Pecoraro, Camilla; Parrino, Barbara; Cascioferro, Stella; Puerta, Adrian; Avan, Amir; Peters, Godefridus J.; Diana, Patrizia; Giovannetti, Elisa; Carbone, Daniela published an article in Molecules. The title of the article was 《A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cellsã€?Reference of Oxetan-3-ol The author mentioned the following in the article:

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years, protein kinases have emerged as promising pharmacol. targets for the treatment of several solid and hematol. tumors. Interestingly, cyclin-dependent kinase 1 (CDK1) is overexpressed in PDAC tissues and has been correlated to the aggressive nature of these tumors because of its key role in cell cycle progression and resistance to the induction of apoptosis. For these reasons, CDK1 is one of the main causes of chemoresistance, representing a promising pharmacol. target. In this study, we report the synthesis of new 1,2,4-oxadiazole compounds and evaluate their ability to inhibit the cell growth of PATU-T, Hs766T, and HPAF-II cell lines and a primary PDAC cell culture (PDAC3). Compound 6b was the most active compound, with IC50 values ranging from 5.7 to 10.7 μM. Mol. docking of 6b into the active site of CDK1 showed the ability of the compound to interact effectively with the ATP binding pocket. Therefore, we assessed its ability to induce apoptosis (which increased 1.5- and 2-fold in PATU-T and PDAC3 cells, resp.) and to inhibit CDK1 expression, which was reduced to 45% in Hs766T. Lastly, compound 6b passed the ADME prediction, showing good pharmacokinetic parameters. These data demonstrate that 6b displays cytotoxic activity, induces apoptosis, and targets CDK1, supporting further studies for the development of similar compounds against PDAC. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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Gu, Shunyan; Chen, Junqi; Musgrave, Charles B.; Gehman, Zoe M.; Habgood, Laurel G.; Jia, Xiaofan; Dickie, Diane A.; Goddard, William A.; Gunnoe, T. Brent published their research in Organometallics in 2021. The article was titled 《Functionalization of RhIII-Me Bonds: Use of “”Capping Arene”” Ligands to Facilitate Me-X Reductive Eliminationã€?Recommanded Product: 7748-36-9 The article contains the following contents:

Authors show how to improve the yield of MeX from CH4 activation catalysts from 12% to 90% through the use of “”capping arene”” ligands. Four (FP)RhIII(Me)(TFA)2 {FP = “”capping arene”” ligands, including 8,8′-(1,2-phenylene)diquinoline (6-FP), 8,8′-(1,2-naphthalene)diquinoline (6-NPFP), 1,2-bis(N-7-azaindolyl)benzene (5-FP), and 1,2-bis(N-7-azaindolyl)naphthalene (5-NPFP)} complexes. These complexes and (dpe)RhIII(Me)(TFA)2 (dpe = 1,2-di-2-pyridylethane) were synthesized and tested for their performance in reductive elimination of MeX (X = TFA or halide). The FP ligands were used with the goal of blocking a coordination site to destabilize the RhIII complexes and facilitate MeX reductive elimination. On the basis of single-crystal x-ray diffraction studies, the 6-FP and 6-NPFP ligated Rh complexes have Rh-arene distances shorter than those of the 5-FP and 5-NPFP Rh complexes; thus, it is expected that the Rh-arene interactions are weaker for the 5-FP complexes than for the 6-FP complexes. Consistent with authors hypothesis, the 5-FP and 5-NPFP RhIII complexes demonstrate improved performance (from 12% to ~60% yield) in the reductive elimination of MeX. The reductive elimination of MeX from (FP)RhIII(Me)(TFA)2 can be further improved by the use of chem. oxidants. For example, the addition of 2 equivalent of AgOTf leads to 87(2)% yield of MeTFA and can be achieved in CD3CN at 90° using (5-FP)Rh(Me)(TFA)2. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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COA of Formula: C3H6O2In 2020 ,《Site-Selective Functionalization of 7-Azaindoles via Carbene Transfer and Isolation of N-Aromatic Zwitterionsã€?appeared in Organic Letters. The author of the article were Liu, Junheng; Xu, Guangyang; Tang, Shengbiao; Chen, Qun; Sun, Jiangtao. The article conveys some information:

The first systematic study on metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization-aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

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《Visible-light-promoted oxidative halogenation of (hetero)arenesã€?was written by Lu, Lingling; Li, Yiming; Jiang, Xuefeng. Application In Synthesis of Oxetan-3-ol And the article was included in Green Chemistry in 2020. The article conveys some information:

Herein, a compatible oxidative halogenation of (hetero)arenes such as 4-phenylmorpholine, 1,3,5-trimethoxybenzene, imidazo[1,2-a]pyrazine, etc. with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure) was described. Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol

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《Cu(II)-Catalyzed Ortho C(sp2)-H Diarylamination of Arylamines To Synthesize Triarylaminesã€?was published in Organic Letters in 2020. These research results belong to Kumar, Mohit; Sharma, Rishabh; Raziullah; Khan, Afsar Ali; Ahmad, Ashfaq; Dutta, Himangsu Sekhar; Koley, Dipankar. Synthetic Route of C3H6O2 The article mentions the following:

A copper-catalyzed, directed ortho C-H diarylamination of indoles, indolines, anilines, and N-aryl-7-azaindoles has been established. Only copper salt as the catalyst and oxygen as the terminal oxidant are used to synthesize triarylamines using various diarylamines including carbazole and phenothiazine. Mechanistic interrogation reveals that copper plays a dual role. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Synthetic Route of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Synthetic Route of C3H6O2

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Liu, Xiaofeng; Shao, Ying; Sun, Jiangtao published their research in Organic Letters in 2021. The article was titled 《Ruthenium-Catalyzed Chemoselective N-H Bond Insertion Reactions of 2-Pyridones/7-Azaindoles with Sulfoxonium Ylidesã€?Recommanded Product: 7748-36-9 The article contains the following contents:

A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones I [R1 = H, 3-Cl, 5-Me, 4-(benzyloxy), etc.] has been developed, affording N-alkylated 2-pyridone derivatives II (R2 = Ph, n-Bu, thiophen-2-yl, etc.) in good yields and excellent N-selectivity. The key to achieve this unprecedented N-H rather than O-H insertion reaction is the use of CpRu(PPh3)2Cl as the catalyst and sulfoxonium ylides R2C(O)CH=S(O)(CH3)2 as the alkylation reagents. Moreover, this protocol is also amenable to 7-azaindoles III (R3 = H, 2-Et-3-Me, 4-Cl, etc.) by slightly varying the reaction conditions. Furthermore, sulfonium ylides are also suitable alkylation reagents, providing the N-alkylated 2-pyridones II in good selectivity. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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《Rhodium-catalyzed regioselective C(sp2)-H bond activation reactions of N-(hetero)aryl-7-azaindoles and cross-coupling with α-carbonyl sulfoxonium ylidesã€?was written by Tian, Yan; Kong, Xian-Qiang; Niu, Jie; Huang, Yi-Bo; Wu, Zhao-Hua; Xu, Bo. SDS of cas: 7748-36-9 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

A protocol for rhodium-catalyzed C(sp2)-H bond activation reactions of N-(hetero)aryl-7-azaindoles and cross-coupling with α-carbonyl sulfoxonium ylides were described. In the C-H activation reaction, the 7-azaindole moiety acted as a directing group which results in high regioselectivity. The protocol features excellent chem. yields and good functional group tolerance. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

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《Ambipolar organic field-effect transistors based on N-Unsubstituted thienoisoindigo derivativesã€?was published in Dyes and Pigments in 2020. These research results belong to Yoo, Dongho; Hasegawa, Tsukasa; Kohara, Akihiro; Sugiyama, Haruki; Ashizawa, Minoru; Kawamoto, Tadashi; Masunaga, Hiroyasu; Hikima, Takaaki; Ohta, Noboru; Uekusa, Hidehiro; Matsumoto, Hidetoshi; Mori, Takehiko. Name: Oxetan-3-ol The article mentions the following:

To investigate a hybrid of isoindigo and thienoisoindigo (TIIG), a new series of unsym. TIIG analogs, in which one of the outer thiophene rings of TIIG is replaced by benzene (CS) or pyridine (NS) are prepared In addition, the π-skeleton extension effects are studied by examining α-substituted TIIG derivatives with thienyl (Dth-TIIG), furyl (Dfu-TIIG), and 1-phenyl-5-pyrazolyl groups (Bis(1-ph-5-py)-TIIG). These materials exhibit ambipolar transistor properties as expected from the energy levels. Dth-TIIG and Dfu-TIIG show hole mobilities exceeding 0.05 cm2 V-1 s-1, and electron mobilities about 0.04 cm2 V-1 s-1, which are close to those of the di-Ph derivative These mols. are arranged nearly perpendicularly to the substrates in the thin films, and Dth-TIIG has a brickwork-like structure, whereas Dfu-TIIG has uniform columns. CS and Bis(1-ph-5-py)-TIIG have uniform stacking structures, but NS has a dimerized stacking structure due to the slightly bent mol. plane that results from largely unbalanced electron d. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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In 2022,Barth, Maximilian; Rudolph, Stefan; Kampschulze, Jan; Meyer zu Vilsendorf, Imke; Hanekamp, Walburga; Mulac, Dennis; Langer, Klaus; Lehr, Matthias published an article in ChemMedChem. The title of the article was 《Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Propertiesã€?Reference of Oxetan-3-ol The author mentioned the following in the article:

A series of hexafluoroisopropyl carbamates with indolylalkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). The synthesized derivatives with Bu to heptyl spacers between the heteroaryl and the carbamate moiety were inhibitors of both enzymes. For investigated compounds in which the alkyl chain was partially incorporated into a piperidine ring, different results were obtained. Compounds with a methylene spacer between the piperidine ring and the heteroaromatic system were found to be selective MAGL inhibitors, while an extension of the alkyl spacer to two to four atoms resulted in dual inhibition of FAAH/MAGL. The only small change in enzyme inhibitory activity with variation of the heteroaromatic system indicates that the reactive hexafluoroisopropyl carbamate group is mainly responsible for the strength of the inhibitory effect of the compounds Selected derivatives were also tested for hydrolytic stability in aqueous solution, liver homogenate and blood plasma as well as for aqueous solubility and for permeability in a Caco-2 cell model. Some compounds showed a slightly higher MAGL inhibitory effect than the known selective MAGL inhibitor ABX-1431 and also partly surpassed this substance with regard to certain physicochem. and biochem. properties such as water solubility and cell permeability. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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In 2022,Sun, Lincong; Zhao, Yuyao; Liu, Bingxian; Chang, Junbiao; Li, Xingwei published an article in Chemical Science. The title of the article was 《RhodiumIII-catalyzed remote difunctionalization of arenes assisted by a relay directing groupã€?Product Details of 7748-36-9 The author mentioned the following in the article:

Rhodium-catalyzed diverse tandem twofold C-H bond activation reactions of para-olefin-tethered arenes were realized, with unsaturated reagents such as internal alkynes, dioxazolones, and isocyanates being the coupling partner as well as a relay directing group which triggers cyclization of the para-olefin group under oxidative or redox-neutral conditions. The reaction proceeded via initial ortho-C-H activation assisted by a built-in directing group in the arene, and the ortho-incorporation of the unsaturated coupling partner simultaneously generated a relay directing group that allows sequential C-H activation at the meta-position and subsequent cyclization of the para-olefins. The overall reaction represents C-C or N-C difunctionalization of the arene with the generation of diverse 2,3-dihydrobenzofuran platforms, e.g., I. The catalytic system proceeded with good efficiency, simple reaction conditions, and broad substrate scope. The diverse transformations of the products demonstrated the synthetic utility of this tandem reaction. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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