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In 2022,Banerjee, Arghya; Sarkar, Satavisha; Shah, Jagrut A.; Frederiks, Nicoline C.; Bazan-Bergamino, Emmanuel A.; Johnson, Christopher J.; Ngai, Ming-Yu published an article in Angewandte Chemie, International Edition. The title of the article was 《Excited-State Copper Catalysis for the Synthesis of Heterocycles》.Product Details of 7748-36-9 The author mentioned the following in the article:

Herein, the discovery and development of visible-light-induced, synergistic excited-state copper catalysis using a combination of Cu(IPr)I as a catalyst and rac-BINAP as a ligand, which produces more than 10 distinct classes of heterocycles was reported. The reaction tolerated a broad array of functional groups and complex mol. scaffolds, including derivatives of peptides, natural products and marketed drugs. Preliminary mechanistic investigation suggested in situ generations of [Cu(BINAP)2]+ and [Cu(IPr)2]+ catalysts that work cooperatively under visible-light irradiation to facilitate catalytic carbo-aroylation of unactivated alkenes, affording a wide range of useful heterocycles. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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Lemir, Ignacio D.; Oksdath-Mansilla, Gabriela; Castro-Godoy, Willber D.; Schmidt, Luciana C.; Arguello, Juan E. published an article in 2022. The article was titled 《Photochemical Csp2-H bond thiocyanation and selenocyanation of activated arenes, batch and continuous-flow approaches》, and you may find the article in Photochemical & Photobiological Sciences.Recommanded Product: Oxetan-3-ol The information in the text is summarized as follows:

An eco-friendly photochem. oxidative Csp2-H thiocyanation and selenocyanation of activated arenes were reported. The reaction proceeded under Violet LED irradiation in the presence of K2S2O8, which quickly oxidized KSCN and KSeCN, finally producing arylthio/selenocyanates. Using this benign, atom-economic protocol, the desired chalcogenide products were obtained regioselectively, with isolated yields that range from very good to excellent. Although, mechanistic study indicated that it is difficult to distinguish between a radical to a SEAr reaction mechanism between the photo-induced formed •SCN, for the former, or NCSSCN, for the latter, to the aromatic heterocycles. The inhibition experiment together with the observed reactivity and regioselectivity, would be in agreement with the latter. The synthetic methodol. designed could be successfully adapted to continuous-flow systems in a segmented-flow regime, employing the organic phase as the product reservoir. Using this setup, the advantage of the latter could be demonstrated by reducing the reaction time and improving the product yields. Similarly, the scaling up of the reaction to gram scale resulted in favorable outcomes by the flow setup, which installed the photo-flow chem. as a powerful tool to be included into routine reaction procedures, which had great relevance for the pharmaceutical industry.Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

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《Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors》 was written by Qhobosheane, Malikotsi A.; Legoabe, Lesetja J.; Josselin, Beatrice; Bach, Stephane; Ruchaud, Sandrine; Petzer, Jacobus P.; Beteck, Richard M.. Electric Literature of C3H6O2 And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:

The synthesis and biol. evaluation of new 7-azaindole derivatives I [X = O, CH2, (CH2)2, CH2O, CH2S; R = H, 6-OH, 6,7-(MeO)2, etc.] bearing benzocycloalkanone motifs as potential protein kinase inhibitors are reported. Four compounds I [X = (CH2)2, R = H, 6-OH; X = CH2, R = 5,6-(MeO)2; X = O, R = 6-OH] were discovered to inhibit cyclin-dependent kinase 9 (CDK9/CyclinT) and/or Haspin kinase in the micromolar to nanomolar range. The compound I [X = O, R = 6-OH] was identified as the most potent Haspin inhibitor (IC50 = 14 nM), while I [X = (CH2)2; R = H, 6-OH] acted as dual inhibitors of CDK9/CyclinT and Haspin. These novel compounds constitute a promising starting point for the discovery of dual protein kinase inhibitors that have potential to be developed as anticancer agents, since both CDK9/CyclinT and Haspin are considered to be drug targets in oncol. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Electric Literature of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Electric Literature of C3H6O2

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In 2022,Ansari, Sumaira; Mushtaq, Nousheen; Ahmed, Ahsaan; Asghar, Saira; Munawar, Rabya; Saify, Zafar Saied published an article in Pakistan Journal of Pharmaceutical Sciences. The title of the article was 《Synthesis, biological screening and docking studies of some indole derivatives as potential antioxidant》.Safety of Oxetan-3-ol The author mentioned the following in the article:

The present study envisioned some antioxidant candidates having 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles I [R = Ph, 4-FC6H4, 2,4,6-tri-MeC6H2, etc.; Y = C(O), C(O)CH2, SO2, C(O)CH2CH2], 3-(2-bromoethyl)indole (BEI) and 7-azindole (AI) nucleus. Derivatives of these indole mols. were synthesized and their scavenging activity for reactive oxygen species (ROS) investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Compounds I [R = biphenyl-4-yl, Y = CH2C(O); R = 2,4,6-tri-MeC6H2, Y = SO2] exhibited significant radical scavenging potential which was comparable to ascorbic acid (standard), while compound I [R = 2-naphthyl, Y = CH2C(O)] appeared as most potent antioxidant by displaying better scavenging activity than standard mol. Mol. docking study revealed good binding score and interactions of compound I [R = 2-naphthyl, Y = CH2C(O)] with target human antioxidant enzyme (PDB code: 3MNG) validating the results of biol. activity. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol

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《Discovery of a novel class of covalent dual inhibitors targeting the protein kinases BMX and BTK》 was written by Forster, Michael; Liang, Xiaojun Julia; Schroeder, Martin; Gerstenecker, Stefan; Chaikuad, Apirat; Knapp, Stefan; Laufer, Stefan; Gehringer, Matthias. Reference of Oxetan-3-ol And the article was included in International Journal of Molecular Sciences in 2020. The article conveys some information:

Here a novel class of dual BMX/BTK inhibitors, which were designed from irreversible inhibitors of Janus kinase (JAK) 3 targeting a cysteine located within the solvent-exposed front region of the ATP binding pocket was presented. Structure-guided design exploiting the differences in the gatekeeper residues enabled the achievement of high selectivity over JAK3 and certain other kinases harboring a sterically demanding residue at this position. The most active compounds inhibited BMX and BTK with apparent IC50 values in the single digit nanomolar range or below showing moderate selectivity within the TEC family and potent cellular target engagement. These compounds represent an important first step towards selective chem. probes for the protein kinase BMX. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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《Visible-Light-Induced Metal-Free Trifluoromethylselenolation of Electron-Rich Heteroarenes Using the Nucleophilic [Me4N][SeCF3] Reagent》 was written by De Zordo-Banliat, Arnaud; Barthelemy, Lucas; Bourdreux, Flavien; Tuccio, Beatrice; Dagousset, Guillaume; Pegot, Bruce; Magnier, Emmanuel. Name: Oxetan-3-ol And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A metal-free visible-light-promoted regioselective trifluoromethylselenolation of electron-rich heteroarenes was developed using C-H functionalization. This eco-friendly, atom-economical, and easy-to-operate protocol provides direct access to a wide range of functionalized SeCF3-containing heteroarenes in high yields, and is amenable to continuous flow techniques. A radical mechanism was supported by EPR experiments In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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《Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenyl-methanols using K2CO3/n-Bu4PBr in water》 was written by Pillaiyar, Thanigaimalai; Sedaghati, Masoud; Schnakenburg, Gregor. Product Details of 7748-36-9This research focused ontrifluoromethyl indolyl phenyl methanol preparation regioselective; indole fluoromethyl ketone Friedel Crafts alkylation; C3-funtionalization of indole; C–C-bond formation; Friedel–Crafts reaction; diindolylmethane; indole; indole-3-carbinol; large-scale synthesis; recyclability. The article conveys some information:

A new, mild and efficient protocol is provided for the synthesis of trifluoromethyl(indolyl)phenylmethanols e.g., I by the reaction of indoles e.g., 5-methoxyindole with a variety of aromatic fluoromethyl ketones RC(O)C(R1)F2 (R = Ph, Bn, thiophen-2-yl, etc.; R1 = H, F, Cl, CF3, etc.) in the presence of K2CO3 (15 mol) and n-Bu4PBr (15 mol) in water. The desired products were obtained in good to excellent yields without requiring a column chromatog. purification The reusability of the catalytic system and large-scale synthesis of indolyl(phenyl)methanols e.g., I, which would further transform into biol. active indole-derived compounds, are further advantages of this protocol. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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In 2022,Sagadevan, Arunachalam; Ghosh, Atanu; Maity, Partha; Mohammed, Omar F.; Bakr, Osman M.; Rueping, Magnus published an article in Journal of the American Chemical Society. The title of the article was 《Visible-Light Copper Nanocluster Catalysis for the C-N Coupling of Aryl Chlorides at Room Temperature》.Recommanded Product: 7748-36-9 The author mentioned the following in the article:

A copper nanocluster-based catalyst, [Cu61(StBu)26S6Cl6H14] (Cu61NC) that enabled C-N bond-forming reactions of aryl chlorides under visible-light irradiation at room temperature A range of N-heterocyclic nucleophiles and electronically and sterically diversed aryl/hetero chlorides react in this new Cu61NC-catalyzed process to afford the C-N coupling products in good yields. Mechanistic studies indicated that a single-electron-transfer (SET) process between the photoexcited Cu61NC complex and aryl halide enabled the C-N-arylation reaction. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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In 2022,Lin, Hui-Shan; Chen, Shu-Jun; Huang, Jing-Mei published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Electrosynthesis of (hetero)aryl nitriles from α-imino-oxy acids via oxidative decarboxylation/N-O cleavage》.Related Products of 7748-36-9 The author mentioned the following in the article:

A new method for the synthesis of (hetero)aryl nitriles via iminyl radicals was developed through the electrochem. oxidative decarboxylation of α-imino-oxy acids. This protocol provides an efficient approach to nitriles with a broad range of functional-group tolerance under ambient conditions and can be applied for one-pot gram-scale synthesis. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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《Enantioselective [3+2] annulation of isatin-derived MBH-carbonates and 3-nitroindoles enabled by a bifunctional DMAP-thiourea》 was written by Mei, Ming-Shun; Wang, Yu-Hui; Hu, Qing; Li, Qing-Hua; Shi, Da-Yu; Gao, Dingding; Ge, Guangbo; Lin, Guo-Qiang; Tian, Ping. Category: alcohols-buliding-blocks And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A highly enantioselective [3+2] annulation of isatin-derived Morita-Baylis-Hillman (MBH) carbonates I (R = Me, Bn, prop-2-en-1-yl, (tert-butoxy)carbonyl; R1 = methoxycarbonyl, ethoxycarbonyl, cyano; R2 = H, Me, Cl, F, etc; R3 = H, Br; R4 = H, Me, F, Br) and 3-nitroindoles II (R5 = (4-tert-butylphenyl)carbonyl, Bz, Ts, (naphthalen-1-yl)carbonyl, etc; X = CH, N) was enabled by a chiral DMAP-thiourea bifunctional catalyst III, affording the corresponding polycyclic spirooxindoles IV bearing three consecutive stereocenters with good to excellent yields and enantioselectivities. Transformations of the annulation product were subsequently elaborated and the preliminary biol. assays demonstrated that these artificial spirooxindoles potentially inhibited pancreatic lipase in a dose-dependent manner. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

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