Category: 7748-36-9

In 2022,Truong, Tan Sang; Retailleau, Pascal; Nguyen, Thanh Binh published an article in Asian Journal of Organic Chemistry. The title of the article was 《TFA/DMSO-Promoted Cross-Dehydrogenative Coupling of Hetaryl Thiols with Indoles: Access to 3-(Hetarylsulfenyl)indole under Mild Conditions》.Safety of Oxetan-3-ol The author mentioned the following in the article:

TFA/DMSO combination was found to efficiently promote the cross-dehydrogenative coupling of a wide range of hetaryl thiols with indole derivatives, leading to 3-(hetarylsulfenyl)indoles in good-to excellent yields under mild heating conditions. Two-fold hetarylsulfenylation of indoles in 2- and 3-positions could be conveniently achieved by simply adapting the molar ratio of the starting materials. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol

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In 2022,Hernandez-Llado, Pol; Garrec, Kilian; Schmitt, Daniel C.; Burton, Jonathan W. published an article in Advanced Synthesis & Catalysis. The title of the article was 《Transition Metal-Free, Visible Light-Mediated Radical Cyclization of Malonyl Radicals onto 5-Ring Heteroaromatics》.COA of Formula: C3H6O2 The author mentioned the following in the article:

Here a metal-free, visible light-mediated cyclization of malonates onto 5-ring heteroaromatics using iodomalonates as key intermediates was reported. The iodomalonates were prepared and photolysed in situ to give the desired annulated products, in yields of 46-94% without the need for external catalysts. The scope of this transformation includes N-alkyl, N-acyl and carbon-tethered malonates adding onto a wide range of 5-membered heteroaromatics The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

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Application of 7748-36-9In 2021 ,《Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Yang, Bowen; Wu, Qian; Huan, Xiajuan; Wang, Yingqing; Sun, Yin; Yang, Yueyue; Liu, Tongchao; Wang, Xin; Chen, Lin; Xiong, Bing; Zhao, Dongmei; Miao, Zehong; Chen, Danqi. The article conveys some information:

In an inhouse screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC50 values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

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Related Products of 7748-36-9In 2020 ,《Solubility and Dissolution Behavior Analysis of 7-Azaindole in Pure and Binary Mixture Solvents at Temperatures Ranging from 278.15 to 323.15 K》 was published in Journal of Chemical & Engineering Data. The article was written by Deng, Zhenmei; Li, Fangzhao; Zhao, Guomin; Yang, Wenge; Hu, Yonghong. The article contains the following contents:

In this paper, the solubility of 7-azaindole was measured in nine pure solvents (ethanol, isopropanol, n-propanol, methanol, EA, acetone, acetonitrile, n-hexane, THF) as well as in three binary mixed solvents (acetone + n-hexane, THF + n-hexane, and isopropanol + n-hexane) by a gravimetric method at temperatures from 278.15 to 323.15 K under atm. pressure. The solubility of 7-azaindole in selected solvents is closely related to the temperature and solvent composition: in nine pure solvents, the order of solubility of 7-zazindole is THF > acetone > methanol > isopropanol ≥ EA > ethanol > acetonitrile > n-hexane when the temperature is below 298.15 K. Nevertheless, as the temperature increases continually (298.15-328.15 K), the order of solubility changes to THF > acetone > methanol > isopropanol > n-propanol > ethanol > EA > acetonitrile > n-hexane; in three binary mixed solvents, both the temperature and solvent composition can influence the solubility of 7-azaindole, and the latter has a greater impact. The modified Apelblat model, λh model, Jouyban-Acree model, and CNIBS/R-K equation were used to correlate the exptl. value. In these models, the Apelblat equation is more suitable for correlating 7-azaindole solubility in nine pure solvents; however, for three binary mixed solvents, the solubility of 7-azaindole is closer to the simulated value of the Jouyban-Acree model. Moreover, the KAT LASER model was used to deeply understand the influence of solvents on the solubility of 7-azaindole by multiple linear regression anal. (MLRA) of the solvent parameters involved in this model. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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《Influence of the N atom and its position on electron photodetachment of deprotonated indole and azaindole》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Noble, Jennifer A.; Marceca, Ernesto; Dedonder, Claude; Jouvet, Christophe. SDS of cas: 7748-36-9 The article mentions the following:

Electron photodetachment of cold deprotonated indole and azaindole anions has been studied by use of a mass-selective photofragmentation spectrometer capable of neg. ion and neutral particle detection. The electron affinities of the indolyl radical and the 5-, 6- and 7-azaindolyl radicals have been measured with an uncertainty of less than 0.002 eV. The presence of the nitrogen atom in the six-membered ring of the azaindolide anions stabilizes the electron by 0.3 to 0.4 eV, i.e. about 10-15%, compared to the indolide anion. No fragmentation was observed in either the anionic or radical forms of the species studied. The appearance of dipole-bound states in the spectra of deprotonated 6- and 7-azaindole anions allowed us to analyze the vibrational structure of the neutral 6- and 7-azaindolyl radicals produced following photodetachment. Although no dipole-bound states were clearly identified for deprotonated indole or 5-azaindole, the shape of the photodetachment threshold suggests the presence of a very weakly dipole-bound state or dipole resonance, which cannot be resolved with our laser resolutionOxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

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《Influence of the N atom position on the excited state photodynamics of protonated azaindole》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Noble, Jennifer A.; Marceca, Ernesto; Dedonder, Claude; Phasayavan, Witchaya; Feraud, Geraldine; Inceesungvorn, Burapat; Jouvet, Christophe. COA of Formula: C3H6O2 The article mentions the following:

We present a study of the photofragmentation of three protonated azaindole mols. – 7-azaindole, 6-azaindole, and 5-azaindole – consisting of fused pyrrole-pyridine bicyclic aromatic systems, in which the pyridinic (protonated) nitrogen heteroatom is located at the 7, 6, and 5 positions, resp. Photofragmentation electronic spectra of the isolated aforementioned azaindolinium cations reveal that their photodynamics extends over timescales covering nine orders of magnitude and provide evidence about the resultant fragmentation pathways. Moreover, we show how the position of the heteroatom in the aromatic skeleton influences the excited state energetics, fragmentation pathways, and fragmentation timescales. Computed ab initio adiabatic transition energies are used to assist the assignation of the spectra, while geometry optimization in the excited electronic states as well as ab initio calculations along the potential surfaces demonstrate the role of ππ*/πσ* coupling and/or large geometry changes in the dynamics of these species. Evidence supporting the formation of Dewar valence isomers as intermediates involved in sub-picosecond relaxation processes is discussed. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

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In 2022,Corpas, Javier; Gomez-Mendoza, Miguel; Ramirez-Cardenas, Jonathan; de la Pena O’Shea, Victor A.; Mauleon, Pablo; Gomez Arrayas, Ramon; Carretero, Juan C. published an article in Journal of the American Chemical Society. The title of the article was 《One-Metal/Two-Ligand for Dual Activation Tandem Catalysis: Photoinduced Cu-Catalyzed Anti-hydroboration of Alkynes》.Related Products of 7748-36-9 The author mentioned the following in the article:

A dual catalyst system based on ligand exchange of two diphosphine ligands possessing different properties in a copper complex has been devised to merge metal- and photocatalytic activation modes. This strategy has been applied to the formal anti-hydroboration of activated internal alkynes via a tandem sequence in which Cu/Xantphos catalyzes the B2pin2-syn-hydroboration of the alkyne whereas Cu/BINAP serves as a photocatalyst for visible light-mediated isomerization of the resulting alkenyl boronic ester. Photochem. studies by means of UV-vis absorption, steady-state and time-resolved fluorescence, and transient absorption spectroscopy have allowed characterizing the photoactive Cu/BINAP species in the isomerization reaction and its interaction with the intermediate syn-alkenyl boronic ester through energy transfer from the triplet excited state of the copper catalyst. In addition, mechanistic studies shed light into catalyst speciation and the interplay between the two catalytic cycles as critical success factors. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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In 2022,Mouhsine, Bouchaib; Karim, Abdallah; Dumont, Clement; Saint Pol, Anthony; Suisse, Isabelle; Sauthier, Mathieu published an article in European Journal of Organic Chemistry. The title of the article was 《The Selective Nickel-Catalyzed N-Allylation of C3-Unprotected Indoles under Mild and Clean Conditions》.HPLC of Formula: 7748-36-9 The author mentioned the following in the article:

A simple salt free and selective N-allylation of indoles with allylic alcs. was developed. The protocol uses a catalytic amount of a nickel complex generated in situ from Ni(cod)2 and dppf as diphosphine. The use of DMSO as the reaction solvent was crucial to control the regioselectivity of the reaction with the exclusive formation of the N-allyl product among up to three possible products. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

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《Design and synthesis of 7-azaindole derivatives and their antitumor and analgesic activities》 was published in Journal of the Chemical Society of Pakistan in 2020. These research results belong to Liu, Xue-Kun; Wang, Yan-Qiu; Zhao, Tong-Jian; Lu, Yuan-Hua; Zhao, Jia-Nan; Geng, Xiao-Yu; Ma, Jie. Computed Properties of C3H6O2 The article mentions the following:

To develop effective anti-tumor and analgesic drugs, a series of novel 7-azaindole derivatives I (R = COMe, COEt, SO2Me, etc.), II were designed and synthesized through a four-step reaction. Eighteen target compounds were obtained and characterized through NMR and High Resolution Mass Spectrometry. Their anti-proliferative activities and analgesic effect were evaluated. When the 1-position was a methylsulfonyl group and the 5-position was a nitro group, compound II (R = SO2Me) demonstrated the best activity and furthermore, there was a dramatic difference between the IC50 values of this compound in tumor and in healthy cell line. The IC50 values of the above compound in MCF7 breast cancer cell line was 5.781μmol/L and 8.077μmol/L in HepG2 hepatoma carcinoma cell line, but more than 100μmol/L in HL7702 liver cell line. Preliminary results showed that compounds I (R = COMe, 3,5-(F)2SO2C6H3), II (R = SO2Ph) had significant analgesic effects in mice, which were stronger than aspirin. These compounds have good prospects for new drug development. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

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《The source of conductivity and proton dynamics study in TEMPO-oxidized cellulose doped with various heterocyclic molecules》 was published in Cellulose (Dordrecht, Netherlands) in 2020. These research results belong to Culica, Madalina Elena; Avadanei, Mihaela; Baron, Raluca Ioana; Chibac-Scutaru, Andreea Laura; Asandulesa, Mihai; Biliuta, Gabriela; Lisa, Gabriela; Coseri, Sergiu. Reference of Oxetan-3-ol The article mentions the following:

Our manuscript focuses on the study of proton conductivity phenomena caused by a high degree of mobility and dynamic movement of protons that occur in some hybrid composites obtained from TEMPO oxidized cellulose doped with three heterocyclic compounds The first stage consists in the preparation of the organic matrix, the reaction conditions being chosen so as to allow the incorporation of as many carboxyl groups as possible. The numerous COOH groups, introduced after oxidation in the cellulose backbone, allow the successful attachment of N-base mols., such as: 1-hydroxybenzotriazole (HBT), imidazole (IM), and 7-azaindole (AI). The as prepared cellulose-based powder composites (OxC-HBT, OxC-IM, OxC-AI) were firstly analyzed using extensive FTIR study. A good thermal stability of the prepared samples has been revealed by thermal analyses. Moreover, the composites showed good values of proton conductivity both at lower and higher temperatures, for example, under anhydrous conditions, the proton conductivity has been found equal to 1.2 x 10-1 S/m for the composite containing IM and 2.3 x 10-2 S/m for the hybrid material containing HBT. The activation energies were also calculated and discussed for each heterocyclic dopant. The use of derivatives of natural polymers, i.e.TEMPO oxidized cellulose, create the prerequisite conditions for cheap, non-hazardous and environmentally safety approaches to find new biopolymer composites materials with proton conductive properties with potential application in fuel cell technol. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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