Category: 7748-36-9

《An nπ* gated decay mediates excited-state lifetimes of isolated azaindoles》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Lamas, Iker; Montero, Raul; Martinez-Martinez, Virginia; Longarte, Asier; Blancafort, Lluis. Recommanded Product: 7748-36-9 The article mentions the following:

Aiming to serve as a guide to understand the relaxation mechanisms of more complex aza-aromatic compounds, such as purine bases, we have studied the non-radiative channels of a set of azaindole structural isomers: 4-, 5-, 6- and 7-azaindole (AI). The relaxation of the isolated mols., after excitation at the low energy portion of their spectra, has been tracked by femtosecond time-resolved ionization, and the decay paths have been obtained with MS-CASPT2//TD-DFT calculations Although the ultrashort measured lifetimes for 5- and 6-Al are in contrast to the long-living excited state found in 7-Al, the calculations describe a common relaxation pathway. Along it, the initially excited ππ* states decay to the ground state through a conical intersection accessed through an nπ* state that functions as a gate state. The work reveals that the position of the nitrogen atoms in the purine ring determines the barrier to access the gate state and therefore, the rate of the non-radiative relaxation. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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In 2022,Rajput, Shruti; Kaur, Ramandeep; Jain, Nidhi published an article in Organic & Biomolecular Chemistry. The title of the article was 《Pd and photoredox dual catalysis assisted decarboxylative ortho-benzoylation of N-phenyl-7-azaindoles》.Application of 7748-36-9 The author mentioned the following in the article:

The directing group assisted decarboxylative ortho-benzoylation of N-aryl-7-azaindoles with α-keto acids was achieved by synergistic visible light promoted photoredox and palladium catalysis. The approach tenders rapid entry to aryl ketone architectures from simple α-keto acid precursors via the in situ generation of a benzoyl radical intermediate. The transformation provided a range of ortho-benzoylated N-aryl-7-azaindoles, with excellent site-selectivity and good functional group compatibility under mild reaction conditions. Biol. target predictions indicate that these mols. may serve as potential anti-cancer and anti-viral agents. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

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Computed Properties of C3H6O2In 2021 ,《Synthesis and properties of syndiotactic 1,2-polybutadiene catalyzed by iron catalyst with phosphate as additive》 was published in Journal of Applied Polymer Science. The article was written by Hu, Zhonghan; Xu, Yuechao; Hu, Wenhong; Luo, Wanwei; Zhao, Yu; Huang, Weizhong; Gong, Dirong. The article contains the following contents:

1,2 Syndiotactic polymerization of butadiene is accessible by iron catalysts prepared from com. available iron sources, trialkylaluminum with addnl. phosphate as additive. The catalyst formation is quite robust in terms of handling and stability under polymerization conditions. Activity equal to 115 kg (polymer)/mol(Fe)·h is achieved at 10,000 equivalent of monomer relative to the catalyst loading in 2 h at 50°C. The resultant polymer possesses 1,2 incorporation up to 80.2-93.1% with syndiotactic configuration (rrrr) of 40.2-85.2%. Crystallinity of polymers can be also tuned over a wide range degree from weak (2.1%) to high crystallinity (68.2%) by varying catalyst component feeding, enabling potential application as both rubber and resin. The higher activity of iron catalyst is preferred at hydrocarbon solvent n-hexane, n-heptane or toluene, higher temperature as well as trialkylalumium, such as tri-iso-butylaluminum, tri-ethylaluminum, and tri-methylaluminum as cocatalyst. Significant stereospecificity stability to variation for monomer concentration, type of alkylaluminum and temperature is also found. The high activity and 1,2-stereoselectivity featured with these thermal robust iron catalysts sheds light on the significance of additive on regulating stereo-polymerization promoted by conventional Ziegler-Natta catalysts. These features collectively could offer advantages for application in industry production of 1,2-syndiotactic polybutadiene. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

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Zhu, Yan-Ying; Xu, Hui-Bei; Zhang, Jing; Luo, Yi; Dong, Lin published an article in 2021. The article was titled 《Ru(II)-Catalyzed Difluoromethylations of 7-Azaindoles: Access to Novel Fluoro-7-Azaindole Derivatives》, and you may find the article in Asian Journal of Organic Chemistry.Formula: C3H6O2 The information in the text is summarized as follows:

Herein, an efficient Ru(II)-catalyzed site-selective C-H functionalization/difluoromethylated reaction to sep. construct 3-difluoromethylated and remote meta-difluoromethylated 7-azaindole derivatives was developed. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

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Wang, Yuechun; Wang, Yuqin; Shen, Jiabing; Chen, Xiang published their research in Latin American Journal of Pharmacy in 2021. The article was titled 《Protective effect of azaindole on cerebral hemorrhage in rat model through down-regulation of TGF-β mediated ERK pathway》.Product Details of 7748-36-9 The article contains the following contents:

The present study investigated azaindole as therapeutic agent for treatment of cerebral hemorrhage in the rat model. Azaindole treatment in dose dependent manner enhanced viability of neurons and decreased escape latency in cerebral hemorrhage rats compared to the untreated group. Moreover, infarct volume showed a significant (p < 0.05) decrease in cerebral hemorrhage rats on treatment with azaindole in 1.0 to 1.75 mg/kg dosage range. Azaindole treatment of cerebral hemorrhage rats significantly (p < 0.05) decreased CWC, improved BBB and increased proportion of Iba1 and MPO +ive cells in neuronal cultures. Treatment with azaindole prevented induction of neuronal apoptosis, promoted Bcl2 and Bclxl proteins and suppressed Bad and Bax protein protein expression. Addnl., Azaindole elevated TGF-β and ERK protein expression in cerebral hemorrhage rats. Thus, azaindole promoted viability of neurons and decreased infarct volume in cerebral hemorrhage rats through TGF-β and ERK/p-ERK pathway up-regulation. Therefore, azaindole inhibits neuronal damage and may be developed for ischemic reperfusion mediated cerebral hemorrhage treatment. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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《Palladium-Catalyzed Barluenga-Valdes Type Cross-Coupling Reaction: Alkenylation of 7-Azaindoles》 was written by Raina, Gaurav; Kannaboina, Prakash; Ahmed, Qazi Naveed; Mondal, Krishanu; Das, Parthasarathi. Name: Oxetan-3-olThis research focused onvinyl azaindole preparation chemoselective; sulfonylhydrazone azaindole Barluenga Valdes cross coupling alkenylation palladium catalyst. The article conveys some information:

An efficient coupling method between sulfonylhydrazones ArC(CH3)=NNHTs (Ar = 3-nitrophenyl, pyridin-4-yl, naphthalen-2-yl, etc.) and 7-azaindoles I (R1 = H, 5-Br; R2 = H, I; R3 = Me, Bn, 4-methoxyphenyl) using Pd(OAc)2 as catalyst and dppf as ligand providing flexible and convergent access to different vinyl 7-azaindoles II and III is achieved. A wide variety of olefins II were obtained up to 86% yields via the coupling of numerous electronically distinct hydrazones with different 7-azaindoles I under the present catalytic conditions. The protocol was further extended to other heteroarenes such as indoles, quinolines, isoquinolines, and pyridine. The imperative feature of these protocols is its ease at the gram scale and their potential to get transformed into different valuable constructs. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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《Design and synthesis of azaindole heterocycle decorated new scaffold in fluorometric sensing of F- and H2PO4-》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Ghosh, Kumaresh; Ali, Sk. Sarfaraj; Joardar, Soumen. Recommanded Product: 7748-36-9 The article mentions the following:

7-Azaindole has been used in designing new mol. structure 1 on enediyne spacer for its application in anion sensing. New structure 1 has been established as efficient fluorescent sensor of H2PO4- and F- ions in CH3CN containing 1% DMSO. While in presence of H2PO4- the emission at 418 nm is decreased to the significant extent in nonratiometric fashion, a ratiometric response in presence of F- is noted with a sharp isoemissive point and two anions are effectively distinguished over a series of other anions tested. A similar study on model compound 2 with indole motifs is done to prove the pivotal role of extra ring nitrogen in azaindole of 1 in the binding process. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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Rostkowska, Hanna; Luchowska, Anna; Lapinski, Leszek; Nowak, Maciej J. published an article in 2021. The article was titled 《Effect of a Solid-Hydrogen Environment on UV-Induced Hydrogen-Atom Transfer in Matrix-Isolated Heterocyclic Thione Compounds》, and you may find the article in Journal of Physical Chemistry A.Product Details of 7748-36-9 The information in the text is summarized as follows:

To shed more light on the mechanisms of UV-induced hydrogen-atom-transfer processes in heterocyclic mols., phototautomeric thione → thiol reactions were investigated for thione compounds isolated in low-temperature Ar as well as in n-H2 (normal hydrogen) matrixes. These studies concerned thione compounds with a five-membered heterocyclic ring and thione compounds with a six-membered heterocyclic ring. The exptl. investigation of 2-thioimidazole and 3-thio-1,2,4-triazole (thione compounds with a five-membered heterocyclic ring) revealed that for the compounds isolated in solid n-H2 only trace amounts of thiol photoproducts were photogenerated; even though for the same compounds isolated in the solid Ar matrix, the thione → thiol photoconversion was nearly total. In contrast to that, for 3-thiopyridazine and 2-thioquinoline (thione compounds with a six-membered heterocyclic ring) isolated in solid n-H2, the UV-induced thione → thiol conversion occurred with the yield reaching 25-50% of the yield of the analogous process observed for the same species isolated in solid Ar. The obtained exptl. results allow us to conclude that the dissociation-association mechanism nearly exclusively governs the phototransformation in thione heterocycles with high barriers for tautomerization (such as thione compounds with a five-membered ring), whereas the strictly intramol. hydrogen-atom shift contributes to the mechanism of hydrogen-atom transfer in thione heterocycles with lower barriers (such as thione compounds with a six-membered ring). In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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In 2022,Mansour, Ritam; Mukherjee, Saikat; Pinheiro, Max Jr.; Noble, Jennifer A.; Jouvet, Christophe; Barbatti, Mario published an article in Physical Chemistry Chemical Physics. The title of the article was 《Pre-Dewar structure modulates protonated azaindole photodynamics》.Application In Synthesis of Oxetan-3-ol The author mentioned the following in the article:

Recent exptl. work revealed that the lifetime of the S3 state of protonated 7-azaindole is about ten times longer than that of protonated 6-azaindole. We simulated the nonradiative decay pathways of these mols. using trajectory surface hopping dynamics after photoexcitation into S3 to elucidate the reason for this difference. Both isomers mainly follow a common ππ* relaxation pathway involving multiple state crossings while coming down from S3 to S1 in the subpicosecond time scale. However, the simulations reveal that the excited-state topogs. are such that while the 6-isomer can easily access the region of nonadiabatic transitions, the internal conversion of the 7-isomer is delayed by a pre-Dewar bond formation with a boat conformation.Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol

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Formula: C3H6O2In 2021 ,《Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Ullah, Saif; El-Gamal, Mohammed I.; El-Gamal, Randa; Pelletier, Julie; Sevigny, Jean; Shehata, Mahmoud K.; Anbar, Hanan S.; Iqbal, Jamshed. The article conveys some information:

A series of sulfonylurea derivatives possessing pyrrolo[2,3-b]pyridine core I (R = H, 5-Br, 4-Cl, 4-NMe2; Ar = Ph, 3-O2NC6H4, 2-naphthyl, etc.) were synthesized and investigated as inhibitors of NPP1 and NPP3 isoenzymes that are over-expressed in cancer and diabetes. The enzymic evaluation highlighted compound I (R = H; Ar = Ph) as selective NPP1 inhibitor, however, compound I (R = H; Ar = 3-O2NC6H4) was observed as the most potent inhibitor of NPP1 with an IC50 value of 0.80 +/- 0.04μM. Compound I (R = 4-NMe2; Ar = Ph) was found to be the most potent and moderately selective inhibitor of NPP3 (IC50 = 0.55 +/- 0.01μM). Furthermore, in vitro cytotoxicity assays of compounds against MCF-7 and HT-29 cancer cell lines exhibited compound I (R = H; Ar = 3-O2NC6H4) (IC50 = 4.70 +/- 0.67μM), and I (R = 5-Br; Ar = 4-MeC6H4) (IC50 = 1.58 +/- 0.20μM) as the most cytotoxic compounds against MCF-7 and HT-29 cancer cell lines, resp. Both the investigated compounds showed high degree of selectivity towards cancer cells than normal cells (WI-38). Mol. docking studies of selective and potent enzyme inhibitors revealed promising mode of interactions with important binding sites residues of both isoenzymes i.e., Thr256, His380, Lys255, Asn277 residues of NPP1 and His329, Thr205, and Leu239 residues of NPP3. In addition, the most potent antiproliferative agent, compound I (R = 5-Br; Ar = 4-MeC6H4), doesn’t produce hypoglycemia as a side effect when injected to mice which is an addnl. merit of this promising compound After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

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