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《Photosensitized Intramolecular [2+2] Cycloaddition of 1H-Pyrrolo[2,3-b]pyridines Enabled by the Assistance of Lewis Acids》 was published in Journal of Organic Chemistry in 2020. These research results belong to Arai, Noriyoshi; Ohkuma, Takeshi. Recommanded Product: 7748-36-9 The article mentions the following:

The [2+2] photocycloaddition of alkenyl-tethered 1H-pyrrolo[2,3-b]pyridine derivatives sensitized with 3′,4′-dimethoxyacetophenone under irradiation by a high-pressure mercury lamp through Pyrex glass was dramatically accelerated by the addition of Lewis acids, preferably Mg(OTf)2, to give the products stereoselectively in high yields. The reaction without a Lewis acid gave only small amounts of the [2+2] cycloaddition products. Conformational fixation of the substrates by coordination with a Lewis acid was presumed to facilitate the cycloaddition In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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《Detection and phase I metabolism of the 7-azaindole-derived synthetic cannabinoid 5F-AB-P7AICA including a preliminary pharmacokinetic evaluation》 was published in Drug Testing and Analysis in 2020. These research results belong to Giorgetti, Arianna; Mogler, Lukas; Haschimi, Belal; Halter, Sebastian; Franz, Florian; Westphal, Folker; Fischmann, Svenja; Riedel, Jan; Putz, Michael; Auwarter, Volker. Recommanded Product: 7748-36-9 The article mentions the following:

In June 2018, a ′research chemica′l labeled ′AB-FUB7AICA′ was purchased online and anal. identified as 5F-AB-P7AICA, the 7-azaindole analog of 5F-AB-PINACA. Here we present data on structural characterization, suitable urinary consumption markers, and preliminary pharmacokinetic data. Structure characterization was performed by NMR spectroscopy, gas chromatog.-mass spectrometry, IR and Raman spectroscopy. Phase I metabolites were generated by applying a pooled human liver microsome assay (pHLM) to confirm the anal. results of authentic urine samples collected after oral self-administration of 2.5 mg 5F-AB-P7AICA. Analyses of pHLM and urine samples were performed by liquid chromatog.-time-of-flight mass spectrometry and liquid chromatog.-tandem mass spectrometry (LC-MS/MS). An LC-MS/MS method for the quantification of 5F-AB-P7AICA in serum was validated. Ten phase I metabolites were detected in human urine samples and confirmed in vitro. The main metabolites were formed by hydroxylation, amide hydrolysis, and hydrolytic defluorination, though – in contrast with most other synthetic cannabinoids – the parent compound showed the highest signals in most urine samples. The compound detection window was more than 45 h in serum. The concentration-time profile was best explained by a two-phase pharmacokinetic model. 5F-AB-P7AICA was detected in urine samples until 65 h post ingestion. Monitoring of metabolite M07, hydroxylated at the alkyl chain, next to parent 5F-AB-P7AICA, is recommended to confirm the uptake of 5F-AB-P7AICA in urinalysis. It seems plausible that the shift of the nitrogen atom from position 2 to 7 (e.g. 5F-AB-PINACA to 5F-AB-P7AICA) leads to a lower metabolic reactivity, which might be of general interest in medicinal chem. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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Quality Control of Oxetan-3-olIn 2020 ,《Pd-Catalyzed ortho-C-H Olefination of Benzenesulfonamides Directed by 7-Azaindole》 appeared in Asian Journal of Organic Chemistry. The author of the article were Huo, Xing; Han, Jun; Yan, Xiaoxiao; Zhang, Heng; Xiong, Juan; Liu, Jian; Wang, Xiaolei; Li, Huilin; Huo, Leiming. The article conveys some information:

Demonstrated herein is a Pd-catalyzed ortho-C-H olefination of benzenesulfonamides I [R = H, Me, Cl; R1 = H; R2 = H, Cl, t-Bu, Ph, etc; R3 = H, Me, Cl; R3 = H, Me, Cl; R4 = H, Me, Cl; R1R2 = -(CH2)2O-; R2R3 = -(CH=CHCH=CH)-] using 7-azaindole as the directing group. This reaction proceeds with exclusive ortho selectivity, high efficiency and broad substrate scope. This method also provides access to sulfonic acids and ortho-alkylated sulfonamides I [R = Me; R1 = R2 = R3 = H; R4 = CH=CHC(O)OH, (CH2)2C(O)OCH2CH3]. Control experiments provides some insightful evidences to the mechanism and the plausible catalytic cycle is proposed to go through a unique seven-membered palladacycle species. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Quality Control of Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Quality Control of Oxetan-3-ol

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In 2022,Laha, Joydev K.; Gupta, Pankaj published an article in Journal of Organic Chemistry. The title of the article was 《Sulfoxylate Anion Radical-Induced Aryl Radical Generation and Intramolecular Arylation for the Synthesis of Biarylsultams》.Formula: C3H6O2 The author mentioned the following in the article:

A green and practically useful synthetic protocol to access diverse six- and seven-membered biarylsultams I (R = H, Me, Ph; R1 = H, OMe, OPh, Me; R2 = H; R1R2 = -CH=CH-CH=CH-; R3 = H, Me, Cl, OCF3, etc.; R4 = H, Me), and e.g., II, especially with a free NH group including demonstration of a gram-scale synthesis was reported. The sulfoxylate anion radical (SO2-•), generated in situ from the reagents rongalite or sodium dithionite (Na2S2O4), was found to be the key single electron transfer agent forming aryl radicals from aryl halides, e.g., 2-bromo-N-phenylbenzene-1-sulfonamide which upon intramol. arylation gives biarylsultams I, and e.g., II, with good to excellent yields. The approach features generation of aryl radicals that remained under-explored, use of a cheap and readily available industrial reagents, and transition metal-free, mild, and green reaction conditions. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

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Thiruchelvi, R.; Shivanika, C. published an article in 2021. The article was titled 《In-Silico analysis to identify the potent inhibitor of Rho GTPase activating protein for the usage of the Glaucoma》, and you may find the article in Materials Today: Proceedings.Name: Oxetan-3-ol The information in the text is summarized as follows:

Considered as the one of the leading irreversible loss of vision causing optic neuropathy, Glaucoma is estimated to hit more than 80 million by the end of 2020 via population survey. Increased intraocular pressure is taken as one of the risk factors among others behind the root of causing the disease. The imbalance in the secretion and the excretion of the aqueous humor inside and out of the ocular results in the IOP to deviate from the normal value of 22 mm of Hg. The Rho GAP pathway playing a crucial role in the modulation of the contractile and relaxation property of the actin smooth muscle, has shown in neg. regulating the protein kinase and subsequently increased IOP. In-vitro and Ex-vitro inhibition of the Rho GTPase protein through inhibitors have resulted in the relaxation of the actin and hence the IOP. The aim of the study is to use the in-silico technique such as, Autodock4, to explore the ligand interaction and its ability to inhibit the activity of RhoGTPase. The mols. AZA1 and Azaindole, with the least binding energies, have proven to be a potent inhibitor of the protein, hence as a lead towards the treatment of the glaucoma by decreasing the IOP to an extent.Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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Nandy, Anuradha; Kazi, Imran; Guha, Somraj; Sekar, Govindasamy published their research in Journal of Organic Chemistry in 2021. The article was titled 《Visible-Light-Driven Halogen-Bond-Assisted Direct Synthesis of Heteroaryl Thioethers Using Transition-Metal-Free One-Pot C-I Bond Formation/C-S Cross-Coupling Reaction》.Category: alcohols-buliding-blocks The article contains the following contents:

An efficient protocol for the synthesis of thioether directly from heteroarenes was developed in the presence of visible light in a one-pot manner at room temperature This method involved two sequential reactions in a single pot where the formation of the iodinated heteroarene was followed by a transition-metal-free C-S coupling reaction. A wide range of heteroarene and thiol partners (including aliphatic thiols) was used for the synthesis of thioethers. NMR studies and DFT calculations revealed the presence of a halogen bond between the thiolate anion (halogen bond acceptor) and iodoheteroarene (halogen bond donor). This halogen bonded complex on photoexcitation facilitated the electron transfer from the thiolate anion to the iodoheteroarene at room temperature After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

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HPLC of Formula: 7748-36-9In 2021 ,《Copper-catalyzed ortho-selective direct sulfenylation of N-aryl-7-azaindoles with disulfides》 was published in Organic & Biomolecular Chemistry. The article was written by Yu, Ru-Jian; Zhang, Chun-Yan; Xiang, Zhou; Xiong, Yan-Shi; Duan, Xue-Min. The article contains the following contents:

A copper-catalyzed direct C-H chalcogenation of N-aryl-azaindoles I (R = H, Me, Cl, etc.; R1 = H, Me, OMe, CF3; R2 = CH or N) with disulfides R3SSR3 (R3 = Ph, thiophen-2-yl, Pr, cyclohexyl, etc.), 1-thiophen-2-yl-1H-pyrrolo[2,3-b]pyridine is described. This transformation was performed using Earth abundant Cu(OAc)2 as a catalyst, benzoic acid as an additive, air as a terminal oxidant, and readily available diaryl and dialkyldisulfides (or (phenyldiselanyl)benzene) as chalcogenation reagents. High functional group tolerance and excellent regioselectivity are demonstrated by the efficient preparation of a wide range of ortho-sulfenylation-7-azaindoles II (X = S or Se), 1-(3-(phenylthio)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

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In 2022,Hwang, Jimin; Qiu, Xiaqiu; Borgelt, Lydia; Haacke, Neele; Kanis, Laurin; Petroulia, Stavroula; Gasper, Raphael; Schiller, Damian; Lampe, Philipp; Sievers, Sonja; Imig, Jochen; Wu, Peng published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents》.Application In Synthesis of Oxetan-3-ol The author mentioned the following in the article:

Aminothiophene is a scaffold that is widely present in drugs and biol. active small mols. as chem. probes. In this study, 43 compounds sharing a 2-aminothiophenone-3-carboxylate (ATPC) scaffold, known to activate the RNase L (RNase L), were synthesized and selected ATPCs showed enhancement of thermal stability of RNase L upon binding. Screening of antiproliferation activities against human cancer cell lines revealed that ATPCs represented by compounds 4l and 50 showed potent single-digit micromolar antiproliferation activity against human cancer cell lines. Compounds 4l and 50 exhibited time- and dose-dependent proliferation inhibition, induced cellular apoptosis measured by cleaved PARP and via flow cytometry, inhibited cell migration, and inhibited cell colony formation. Combining the results reported in this work, ATPCs were evaluated as potential anticancer agents mediated by RNase L-binding and apoptosis induction. The work contributes to the study on the polypharmacol. properties of aminothiophene-containing small mols. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol

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Canning, Peter; Bataille, Carole; Bery, Nicolas; Milhas, Sabine; Hayes, Angela; Raynaud, Florence; Miller, Ami; Rabbitts, Terry published an article in 2021. The article was titled 《Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds》, and you may find the article in Journal of Immunological Methods.SDS of cas: 7748-36-9 The information in the text is summarized as follows:

The use of intracellular antibodies as templates to derive surrogate compounds is an important objective because intracellular antibodies can be employed initially for target validation in pre-clin. assays and subsequently employed in compound library screens. LMO2 is a T cell oncogenic protein activated in the majority of T cell acute leukemias. We have used an inhibitory intracellular antibody fragment as a competitor in a small mol. library screen using competitive surface plasmon resonance (cSPR) to identify compounds that bind to LMO2. We selected four compounds that bind to LMO2 but not when the anti-LMO2 intracellular antibody fragment is bound to it. These findings further illustrate the value of intracellular antibodies in the initial stages of drug discovery campaigns and more generally antibodies, or antibody fragments, can be the starting point for chem. compound development as surrogates of the antibody combining site. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

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《Nature-inspired remodeling of (aza)indoles to meta-aminoaryl nicotinates for late-stage conjugation of vitamin B3 to (hetero)arylamines》 was written by Varun, Begur Vasanthkumar; Vaithegi, Kannan; Yi, Sihyeong; Park, Seung Bum. Related Products of 7748-36-9 And the article was included in Nature Communications in 2020. The article conveys some information:

The development of a strategy for the synthesis of meta-aminoaryl nicotinates from 3-formyl(aza)indoles was reported. The strategy was mechanistically different from the reported routes and involved the transformation of (aza)indole scaffolds into substituted meta-aminobiaryl scaffolds via Aldol-type addition and intramol. cyclization followed by C-N bond cleavage and re-aromatization. Unlike previous synthetic routes, this biomimetic method utilizes propiolates as enamine precursors and thus allows access to ortho-unsubstituted nicotinates. In addition, the synthetic feasibility toward the halo-/boronic ester-substituted aminobiaryls clearly differentiates the present strategy from other cross-coupling strategies. Most importantly, our method enables the late-stage conjugation of bioactive (hetero)arylamines with nicotinates and nicotinamides and allowed access to the previously unexplored chem. space for biomedical research. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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