Category: 7748-36-9

In 2022,Xie, Qi; Zhang, Xiuqi; Liu, Huijin; Zhang, Fukuan; Luo, Xuzhong; Luo, Haiqing published an article in Asian Journal of Organic Chemistry. The title of the article was 《Copper-Catalyzed N-Arylation of Indoles and Anilines with Aryltrialkoxysilanes》.Name: Oxetan-3-ol The author mentioned the following in the article:

An efficient copper-catalyzed aerobic Chan-Lam type N-arylation of various indoles and anilines with structurally diverse aryltrialkoxysilanes to afford phenyl-indoles I [R = H, 7-Me, 5-F, etc.; R1 = H, 4-Me, 4-tBu, etc.] and diphenylamines II [R2 = 4-Me, 4-Cl, 4-F, etc.] under mild conditions was reported. This silicon-based protocol enabled the efficient C-N cross-coupling of indoles and anilines with user-friendly organosilicon reagents by employing inexpensive and nontoxic Cu(OAc)2, which was efficient and practical without the addition of other ligands, bases and metal oxidants. This transformation was compatible with a wide range of substrates, and typically proceeded with high efficiency as well as with good functional group compatibility. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
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In 2022,Xiong, Biquan; Si, Lulu; Liu, Yu; Xu, Weifeng; Jiang, Tao; Cao, Fan; Tang, Ke-Wen; Wong, Wai-Yeung published an article in Chemistry – An Asian Journal. The title of the article was 《Metal-free, Phosphoric Acid-catalyzed Regioselective 1,6-Hydroarylation of para-Quinone Methides with Indoles in Water》.Formula: C3H6O2 The author mentioned the following in the article:

An efficient, cheap and green protocol for the highly regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with indoles at the C-3 position has been established by phosphoric acid catalysis in water under transition-metal-free reaction conditions. A wide range of indole derivatives and para-quinone methides (p-QMs) are compatible for the reaction, affording the corresponding 1,6-hydroarylation products with good to excellent yields. The possible mechanism of the reaction has been explored through step-by-step control experiments The protocol is convenient for practical applications, leading to a safe, green and feasible way for the formation of C-3 diarylmethyl functionalized indole derivatives The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,M. C. F. Lima, Cintia; Opatz, Till; Victor, Mauricio M. published an article in Results in Chemistry. The title of the article was 《Synthesis of new substituted 7-azaisoindigos》.Recommanded Product: 7748-36-9 The author mentioned the following in the article:

Here the syntheses of new substituted 7-azaisoindigos was reported. The strategy employed was an acid-catalyzed coupling reaction between 7-azaoxindole and substituted isatins. ZrCl4 in refluxing ethanol as a catalyst showed better results and permitted the syntheses of 6 new 7-azaisoindigos derivatives (R = Cl, Br, and NO2) in yields ranging from 27 to 60%. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Izgi, Samet; Sengul, Ibrahim F.; Sahin, Engin; Koca, Mehmet Serdar; Cebeci, Fatma; Kandemir, Hakan published an article in Journal of Molecular Structure. The title of the article was 《Synthesis of 7-azaindole based carbohydrazides and 1,3,4-oxadiazoles; Antioxidant activity, α-glucosidase inhibition properties and docking study》.Computed Properties of C3H6O2 The author mentioned the following in the article:

In this current work, 7-azaindole based 1,3,4-oxadiazoles was successfully prepared by treatment of 3-(hydrazonomethyl)-7-azaindole with the different acyl chlorides or acetic anhydrides to give the corresponding carbohydrazides, followed by iodine mediated synthetic protocol in order to afford the corresponding 2,5-disubstituted 1,3,4-oxadiazoles. The full characterization data of the novel compounds were obtained by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry and single crystal X-ray diffraction techniques. The antioxidant activity and α-glucosidase inhibition potential of the prepared compounds were examined by in-vitro assays. The targeted hydrazide linked 7-azaindoles and their corresponding cyclized form 1,3,4-oxadiazoles exhibited inhibitory potential with IC50 values ranges between 0.46 and 24.92 mM. Plausible binding mode and interaction of ligands with α-glucosidase enzyme was studied by mol. docking, supporting the exptl. results. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nie, Zhiwen; Lv, Huifang; Yang, Tonglin; Su, Miaodong; Luo, Weiping; Liu, Qiang; Guo, Cancheng published an article in 2022. The article was titled 《Synthesis of Non-Terminal Alkenyl Ethers, Alkenyl Sulfides, and N-Vinylazoles from Arylaldehydes or Diarylketones, DMSO and O, S, N-Nucleophiles》, and you may find the article in Advanced Synthesis & Catalysis.Product Details of 7748-36-9 The information in the text is summarized as follows:

A transition-metal-free protocol for the synthesis of non-terminal alkenyl ethers, alkenyl sulfides, and N-vinylazoles from arylaldehydes or diarylketones, DMSO and O, S, N-nucleophiles has been reported. In this protocol, 24 examples of non-terminal alkenyl ethers and 28 examples of non-terminal alkenyl sulfides in 72-95% yields have been synthesized within 5 min. Moreover, 27 examples of non-terminal N-vinylazoles with 57-88% yields have also been synthesized within 2 h. The preliminary mechanism investigations revealed that arylaldehydes or diarylketones offered a carbon atom, DMSO provided a methine and O, S, N-nucleophiles contributed one X atom for constructing C=C-X structure. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Selective synthesis of alkyl amines and N-vinylazoles from vinyl sulfonium salts with N-nucleophiles》 was written by Zou, Liang-Hua; Liu, Biao; Wang, Cheng; Shao, Zeyu; Zhou, Junqi; Shao, Andong; Wen, Jian. Recommanded Product: Oxetan-3-olThis research focused onvinyltetrahydrothiophenium salt amine coupling; sulfanylalkylamine preparation green chem; alkenyl amine preparation green chem. The article conveys some information:

An efficient and green method for the synthesis of various alkyl amines via the C(sp3)-S bond cleavage of vinylsulfonium salts was developed. The reaction proceeded under air atm. with a broad scope of N-nucleophiles ranging from primary and secondary alkyl and aryl amines to various N-containing heterocycles. Moreover, in the presence of a base, the reaction of vinylsulfonium salts with N-containing heterocycles at room temperature can also afford N-vinylazoles with moderate to good yields. Finally, the practicality of this protocol was demonstrated by one-pot reaction, scale-up reaction and product derivatization. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C3H6O2In 2021 ,《Synthesis of Terminal N-Vinylazoles from Aromatic Aldehydes, DMSO, and Azoles Based DMSO as Terminal Carbon Synthon》 was published in Advanced Synthesis & Catalysis. The article was written by Nie, Zhiwen; Lv, Huifang; Li, Hui; Su, Miaodong; Yang, Tonglin; Luo, Weiping; Liu, Qiang; Guo, Cancheng. The article contains the following contents:

A protocol for the synthesis of terminal N-vinylazoles such as H2C=CR1R [R = indol-1-yl, pyrrol-1-yl, pyrazol-1-yl, etc.; R1 = Ph, 2-MeC6H4, 4-FC6H4, etc.] from aromatic aldehydes, DMSO and azoles was reported. The scope of aldehydes and amides for preparation of enamides I [Ar = Ph, 4-ClC6H4, 4-tBuC6H4, etc.; n = 1, 2] was also reported. In this strategy, DMSO was involved in the construction of the C=C bond as a terminal carbon synthon. Both aromatic aldehydes and azoles could be well tolerated and gave the corresponding terminal N-vinylazoles in 52-91% yields. Based on preliminary experiments, a plausible mechanism was proposed. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

Referemce:
Alcohol – Wikipedia,
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Formula: C3H6O2In 2022 ,《Visible-Light-Induced [2+2+1] Dearomative Cascade Cyclization of Indole/Furan Alkynes to Synthesize Sulfonyl Polycycles》 was published in Advanced Synthesis & Catalysis. The article was written by Luo, Jiajun; Zeng, Guohui; Cao, Xiaohui; Yin, Biaolin. The article contains the following contents:

Herein, authors report a visible-light-induced [2+2+1] dearomative cascade cyclization of indole/furan alkynes with NaHSO3, providing an array of diverse highly strained sulfonyl polycycles. Compared to authors previous work, this method does not require the use of addnl. sacrificial oxidants and have wider reaction scope. Preliminary mechanistic studies suggest that the indole moiety initiated the reaction, which proceeded via single-electron oxidation pathway. An alkenyl radical formed by intramol. addition capture SO2, and the resulting species is cyclized to furnish the final product. Also, DFT calculations disclosed that the groups on the indole ring or at the side chain probably affect the single electron distribution at the reaction site of IM-RC-I, and the distribution may be a decisive factor of spirocyclization. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Trifluoromethylselenolation and N-acylation of indoles with [Me4N][SeCF3]》 was written by Tan, Kai-Li; Wang, Hao-Nan; Dong, Tao; Zhang, Cheng-Pan. Name: Oxetan-3-ol And the article was included in Organic & Biomolecular Chemistry in 2021. The article conveys some information:

An efficient method for oxidative trifluoromethylselenolation/N-acylation of indoles with excess [Me4N][SeCF3] in the presence of acyl peroxides and their derivatives is described. The reaction is easy to handle, proceeds smoothly at room temperature under metal-free conditions, and shows advantages such as good functional group tolerance, excellent regioselectivity, and compatibility of a number of substrates, producing 1-acyl and 3-trifluoromethylselanyl substituted indoles I (R1 = H, 5-CN, 4-Cl, etc.; R2 = H, Me; Ar = Ph, 3-ClC6H4, 4-FC6H4, etc.) in good yields. Acyl peroxides and peroxycarboxylic acid behave as both oxidants and acyl sources in the transformation. This one-pot procedure provides a convenient access to a new class of indole derivatives, representing the first trifluoromethylselanyl bifunctionalization of indoles with the nucleophilic [Me4N][SeCF3] reagent. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts