7748-36-9 Archives - Page 10 of 20 - Alcohols-buliding-blocks

Ogawa, Hiroshi team published research in Bulletin of the Chemical Society of Japan in 1998 | 7748-36-9

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Quality Control of 7748-36-9

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Quality Control of 7748-36-9

Ogawa, Hiroshi;Kodera, Yasutake;Kanoh, Shigeyoshi;Ueyama, Akihiko;Motoi, Masatoshi research published 《 Preparation and Characterization of Side-Chain Liquid-Crystalline Polyoxetanes Anchoring a Pendant Spacer-Separated Mesogen at the Tertiary-Like C-3 Carbon of the Oxetane Unit》, the research content is summarized as follows. Polyoxetanes anchoring a pendant spacer-separated mesogen at the tertiary-like C-3 carbon of the oxetane unit were prepared by cationic ring-opening polymerization of the corresponding oxetane derivatives The resulting polymers were liquid-crystalline substances showing textures assignable to the nematic or smectic mesophase over a wide temperature range from about 260 °C to room temperature These mesogens also behaved in the manner similar to that of the mesogens in the analogous polyoxetanes attached by a Me side chain at the quaternary C-3 carbon, although the less bulky polymer backbone in the present work indicated a somewhat higher isotropic phase-transition temperature than that of the methyl-substituted analogs. In both types of the polyoxetanes, their mesophase patterns were influenced by the core structure and alkoxy tail length in the pendant mesogen, but not by the bulkiness of the second side chains, H and CH₃, attached at the C-3 carbon of the polyoxetane unit.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Merrill, G. N. team published research in Journal of Physical Organic Chemistry in 2004 | 7748-36-9

Product Details of C3H6O2, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Merrill, G. N. research published 《 The gas-phase reactivity of epichlorohydrin with hydroxide》, the research content is summarized as follows. The reaction of hydroxide with epichlorohydrin in the gas phase was studied with ab initio calculations Three mechanisms were examined, each corresponding to nucleophilic attack at a different carbon atom of the substrate. Through attack at the ring methylene position was favored, whereas attacks at the alkyl methylene or ring methine positions have larger activation energies. These results are consistent with exptl. results found in the literature.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Merrill, G. N. team published research in Journal of Physical Organic Chemistry in 2007 | 7748-36-9

Name: Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Name: Oxetan-3-ol

Merrill, G. N. research published 《 A computational study into the reactivity of epichlorohydrin and epibromohydrin under basic conditions in the gas phase and solution》, the research content is summarized as follows. Ab initio MO calculations were carried out on epibromohydrin (EBH) and epichlorohydrin (ECH) in an attempt to elucidate their reactivity with respect to a hard nucleophile, hydroxide. These systems were modeled in both the gas phase and a polar solvent under basic conditions. In the gas phase, a direct displacement mechanism (nucleophilic attack at the C1 position) was operative for EBH, while an indirect pathway (nucleophilic attack at the C3 position and subsequent intramol. displacement) was followed for ECH. In an acetone solution, only the indirect displacement mechanism occurs. An electrostatic argument is advanced to account for this behavior in polar solution

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

MacQueen, Preston M. team published research in Journal of the American Chemical Society in 2018 | 7748-36-9

In general, the hydroxyl group makes alcohols polar. 7748-36-9, formula is C3H6O2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Formula: C3H6O2

MacQueen, Preston M.;Tassone, Joseph P.;Diaz, Carlos;Stradiotto, Mark research published 《 Exploiting Ancillary Ligation To Enable Nickel-Catalyzed C-O Cross-Couplings of Aryl Electrophiles with Aliphatic Alcohols》, the research content is summarized as follows. The use of (L)Ni(o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos, I or II, resp.) enables the C(sp²)-O cross-coupling of primary, secondary, or tertiary aliphatic alcs. with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. In addition to offering a competitive alternative to palladium catalysis, this work establishes the feasibility of utilizing ancillary ligation as a complementary means of promoting challenging nickel-catalyzed C(sp²)-O cross-couplings, without recourse to precious-metal photoredox catalytic methods.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Hongfu team published research in Journal of Medicinal Chemistry in 2018 | 7748-36-9

Lu, Hongfu;Yang, Ting;Xu, Zhongmiao;Lin, Xichen;Ding, Qian;Zhang, Yueting;Cai, Xin;Dong, Kelly;Gong, Sophie;Zhang, Wei;Patel, Metul;Copley, Royston C. B.;Xiang, Jianing;Guan, Xiaoming;Wren, Paul;Ren, Feng research published 《 Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists》, the research content is summarized as follows. CXCR2 has emerged as a therapeutic target for not only peripheral inflammatory diseases but also neurol. abnormalities in the central nervous system (CNS). Herein, we describe the discovery of a novel 1-cyclopentenyl-3-phenylurea series as potent and CNS penetrant CXCR2 antagonists. Extensive SAR studies, wherein mols.’ property forecast index (PFI) was carefully optimized for overall balanced developability profiles, led to the discovery of the advanced lead compound I with a desirable PFI. Compound I demonstrated good in vitro pharmacol. with excellent selectivity over CXCR1 and other chemokine receptors. Rat and dog pharmacokinetics (PK) revealed good oral bioavailability, high oral exposure, and desirable elimination half-life of the compound in both species. In addition, the compound demonstrated dose-dependent efficacy in the in vivo pharmacol. neutrophil infiltration “air pouch” model in rodents after oral administration. Further, compound I is a CNS penetrant mol. with high unbound fraction in brain tissue.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Peijun team published research in ACS Catalysis in 2021 | 7748-36-9

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 7748-36-9, formula is C3H6O2, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Category: alcohols-buliding-blocks

Li, Peijun;Zbieg, Jason R.;Terrett, Jack A. research published 《 A Platform for Decarboxylative Couplings via Photoredox Catalysis: Direct Access to Carbocations from Carboxylic Acids for Carbon-Oxygen Bond Formation》, the research content is summarized as follows. Within the past decade, photoredox catalysis has enabled numerous decarboxylative transformations to couple carboxylic acids with a variety of partners primarily through carbon-centered radical intermediates. Herein, we describe a method for the construction of carbon-oxygen bonds using a dual photoredox/iodine(III) platform directly from simple carboxylic acids and alcs. This activation platform enables the direct utilization of readily available acids and alcs. without the need for prefunctionalization and works broadly across primary, secondary, and tertiary carboxylic acid substrates. We propose that this transformation proceeds via a radical-polar crossover event to generate a discrete carbocation intermediate which is intercepted by a nucleophilic coupling partner, thereby overcoming the electronically mismatched nature inherent in previous radical-based decarboxylative couplings. The application of this mechanistic approach toward addnl. nucleophiles is also demonstrated using water, enabling a direct decarboxylative-hydroxylation reaction. Finally, we demonstrated that the decarboxylative etherification can be applied to a peptide substrate, selectively functionalizing serine over other nucleophilic residues, providing support for future potential bioconjugation applications.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Larsen, Jens team published research in Journal of Medicinal Chemistry in 2020 | 7748-36-9

Computed Properties of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Larsen, Jens;Lambert, Maja;Pettersson, Henrik;Vifian, Thomas;Larsen, Mogens;Ollerstam, Anna;Hegardt, Pontus;Eskilsson, Cecilia;Laursen, Steen;Soehoel, Anders;Skak-Nielsen, Tine;Hansen, Lene M.;Knudsen, Nina Oe.;Eirefelt, Stefan;Soerensen, Morten D.;Stilou, Tatiana G.;Nielsen, Simon F. research published 《 Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “Dual-Soft” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis》, the research content is summarized as follows. We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft) while being stable in human skin. Compound 40 was selected as a clin. candidate as it was potent and rapidly degraded by blood and liver to inactive metabolites and because in preclin. studies it showed high exposure at the target organ: the skin. Preclin. and clin. data are presented confirming the value of the dual-soft concept in reducing systemic exposure.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lauber, Markus B. team published research in ACS Catalysis in 2013 | 7748-36-9

Lauber, Markus B.;Stahl, Shannon S. research published 《 Efficient Aerobic Oxidation of Secondary Alcohols at Ambient Temperature with an ABNO/NO_x Catalyst System》, the research content is summarized as follows. New highly practical methods are presented for aerobic oxidation of secondary alcs. with a nitroxyl radical in combination with HNO₃, NaNO₂, or both as cocatalysts. Diverse nitroxyls are compared, including several novel bicyclic derivatives Catalyst systems with the readily available nitroxyls, 9-azabicyclo[3.3.1]-nonane-N-oxyl (ABNO) and 9-azabicyclo[3.3.1]-nonan-3-one-N-oxyl (keto-ABNO), are optimized in acetic acid or acetonitrile as the solvent. The reactions are compatible with substrates bearing diverse functional groups and proceed efficiently under mild conditions at ambient pressure and temperature

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Legnani, Luca team published research in Science (Washington, DC, United States) in 2018 | 7748-36-9

Synthetic Route of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Legnani, Luca;Prina-Cerai, Gabriele;Delcaillau, Tristan;Willems, Suzanne;Morandi, Bill research published 《 Efficient access to unprotected primary amines by iron-catalyzed aminochlorination of alkenes》, the research content is summarized as follows. Primary amines are essential constituents of biol. active mols. and versatile intermediates in the synthesis of drugs and agrochems. However, their preparation from easily accessible alkenes remains challenging. Here, the authors report a general strategy to access primary amines from alkenes through an operationally simple iron-catalyzed aminochlorination reaction. A stable hydroxylamine derivative and benign sodium chloride act as the resp. nitrogen and chlorine sources. The reaction proceeds at room temperature under air; tolerates a large scope of aliphatic and conjugated alkenes, including densely functionalized substrates; and provides excellent anti-Markovnikov regioselectivity with respect to the amino group. The reactivity of the 2-chloroalkylamine products, an understudied class of amphoteric mols., enables facile access to linear or branched aliphatic amines, aziridines, aminonitriles, azido amines, and homoallylic amines.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiryukhin, M. V. team published research in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya in 2007 | 7748-36-9

Kiryukhin, M. V.;Nurieva, E. V.;Shishov, D. V.;Nuriev, V. N.;Zyk, N. V.;Zefirov, N. S.;Zefirova, O. N. research published 《 Synthesis of derivatives of adamantane and bicyclo[3.3.1]nonane with an oxetane moiety》, the research content is summarized as follows. The synthesis of 3-hydroxyoxetane esters with adamantane- and bicyclo[3.3.1]nonane-containing carboxylic acids, e.g., I and II, resp., is presented in the paper.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts