Category: 7735-42-4

Adding a certain compound to certain chemical reactions, such as: 7735-42-4, 1,16-Hexadecanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 7735-42-4, blongs to alcohols-buliding-blocks compound. Recommanded Product: 7735-42-4

Synthesis Example C-(18) 1,16-Hexadecanediol (13.75 g) was dissolved in 37 ml of cyclohexane, and 57% hydrobromic acid solution (37 ml) was added to this solution. The reaction mixture was refluxed for six hours while stirring. After the reaction, the mixture was extracted three times with diethyl ether. The organic layer was neutralized with saturated sodium hydrogen carbonate solution, washed with saline solution, dried over magnesium sulfate, and filtered, and the solvent was distilled off under reduced pressure. Purification of the residue by silica gel flash chromatography (hexane: ethyl acetate = 7:3) gave 16-bromohexadecan-1-ol as white crystals at a 67% yield. Molecular weight: 320.9 (C16H33BrO) TLC: (hexane-ethyl acetate 7-3) Rf value=0.53 1H-NMR: (300MHz, CDCl3)delta: 1.26 (s large, 24H, -(CH2)12-); 1.56 (qt, 2H, J=7.2Hz, -CH2-); 1.85 (qt, 2H, J=7.1 Hz, -CH2-); 3.40 (t, 2H, J=7.1Hz, -CH2-Br); 3.63 (t, 2H, J=6.6Hz, -CH2-O-) 13C-NMR: (75MHz, CDCl3) delta: 25.84; 27.28; 28.22; 29.48-29.50; 32.90; 33.20; 34.01; 63.01

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7735-42-4, 1,16-Hexadecanediol, and friends who are interested can also refer to it.

Reference:
Patent; Meiji Dairies Corporation; EP1854777; (2007); A1;,
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Related Products of 7735-42-4 ,Some common heterocyclic compound, 7735-42-4, molecular formula is C16H34O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The diol (1 eq.) and 100 mL acetonitrile were placed in a 200 mL beaker with a stirring element. The mixture was re-heated to a temperature of 50C, after which copper complex [Cu(MeCN)4]PF6 (10 mol%), TEMPO (10 mol%) 2,2′-bipyridyl (10 mol%) and 1 -methylimidazole (20 mol%) were added one by one. The reaction was conducted for 4 hours until the substrate disappeared. Afterwards, the whole was evaporated and dissolved in methylene chloride, and SnachCat solution was then added. After stirring, the solution was filtered (through Si02), washing it with methylene chloride, and then the solution was evaporated. (0814) Hexyl triphenylphosphine bromide (2.1 eq.) was dissolved in 120 mL tetrahydrofuran under the atymosphere of argon in a 250 mL single-necked round flask. 2.5M solution of n-butyllithium in hexane (2.1 eq) was added dropwise to the resulting mixture, and allowed to rest while stirring for 30 minutes. The resulting solution was cooled to 0C, and the previously obtained aldehyde in a solution of tetrahydrofuran (1 eq.) was slowly added dropwise. The reaction mixture was heated to room temperature and then stirring was continued for another 2 hours at room temperature. 50 mL of saturated ammonium chloride solution was then added. The mixture was washed four times with methylene chloride. The combined ether layers were dried over MgS04. The product was purified by chromatography using n- hexane. A colourless oil was obtained. 75% yield. (0815) 1 H NMR (400 MHz, CDCI3) 5.46 – 5.27 (m, 4H), 2.10 – 1 .90 (m, 8H), 1 .44 – 1 .16 (m, 36H), 0.97 – 0.80 (m, 6H); 13C NMR (101 MHz, CDCI3) delta 130.05, 130.04, 31 .69, 29.93, 29.85, 29.82, 29.73, 29.62, 29.48, 27.36, 27.33, 22.75, 14.25

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7735-42-4, 1,16-Hexadecanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIWERSYTET WARSZAWSKI; GRELA, Karol; CZARNOCKA-?NIAD?A, Sylwia; SYTNICZUK, Adrian; MILEWSKI, Mariusz; URBAN, Mateusz; BANACH, ?ukasz; D?BROWSKI, Micha?; (109 pag.)WO2018/197963; (2018); A1;,
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Related Products of 7735-42-4, Adding some certain compound to certain chemical reactions, such as: 7735-42-4, name is 1,16-Hexadecanediol,molecular formula is C16H34O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7735-42-4.

4.2 1 6-Bromohexadecan- 1 -ol10215] The diol 14 (1.047 g, 4.05 mmol) was dissolved in cyclohexane (30 mE) and vigorously stirred with 48% HBr (0.5 mE, 4.46 mmol, 1.1 eq.). The mixture was refluxed for 6 h, diluted with water (50 mE) and the phases were separated. The aqueous phase was extracted with a mixture of dichloromethane and methanol (v/v, 4:1 3×20 mE). The combined organic layer was dried over Mg504. The product was purified by column chromatography with silica gel (6×6 cm, cyclohexane/ethyl acetate, 8:1) and isolated as a white solid. Yield: 4.598 g (96%). Traces of i,i6-dibromohexadecane were also found.1515 13 11 9 7 5 3 1j0216] M.p.: 65 C. (lit. 53-54 C.)j0217] ?H-NMR (300 MHz, CDC13) oe [ppm]: 1.26-1.47 (m, 23H, 4-CH2 to i4-CH2, i-OH), 1.51-1.62 (m, 4H, 2-CH2, 3-CH2), 1.85 (m, 2H, i5-CH2), 3.41 (t, 3JH,H=6.9 Hz, 2H, i6-CH2), 3.64 (t, 3J,y=6.6 Hz, 2H, i-CH2).10218] ?3C-NMR (75 MHz, CDC13) oe [ppm]: 25.9 (t, C-3),28.3, 28.9, 29.6, 29.7, 29.8 (t, C-4 to C-i4), 33.0 (t, C-2, C-iS), 34.3 (t, C-i6), 63.3 (t, C-i).10219] Refs.: M.p. P. Chuit, J. Hausser, Helv. Chim. Acta1929, 12, 850-859.10220] ?H-NMR spectroscopic data agree with those given by: S. Takanashi, M. Takagi, H. Takikawa; K. Mori, I Chem. Soc., Perkin Trans. 11998, 1603-1606.

According to the analysis of related databases, 7735-42-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; Haufe, Guenter; Levkau, Bodo; Schaefers, Michael; Schilson, Stefani Silke; Keul, Petra; US2014/170067; (2014); A1;,
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Related Products of 7735-42-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7735-42-4, name is 1,16-Hexadecanediol, molecular formula is C16H34O2, molecular weight is 258.44, as common compound, the synthetic route is as follows.

The acetone is then evaporated off with the rotary evaporator, the residue is taken up in ethyl ether and water and the product is extracted three times with ether. The ethereal phases are combined and are dried over magnesium sulphate. The white solid obtained is then recrystallized from methanol (M.p. 42-43 C.). Yield=95%. 1,16-diiodohexadecane is obtained from hexadecane-1,16-diol, by adding 5 g of this diol and 19 g of potassium iodide to a solution of 2.5 g of phosphoric anhydride and 5.2 mL of 85% phosphoric acid. The mixture is heated at 100 C. for 5 hours. A dense oil forms, and the mixture is poured into 50 mL of water. The organic phase is separated, and the aqueous phase extracted with ether. The organic phases are discoloured by stirring with 50 mL of a 10% solution of sodium thiosulphate. The ether is evaporated off. The oil obtained is crystallized from methanol (M.p.=52 C.). Yield: 82%.

The chemical industry reduces the impact on the environment during synthesis 7735-42-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CNRS; US6972343; (2005); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7735-42-4, name is 1,16-Hexadecanediol, molecular formula is C16H34O2, molecular weight is 258.44, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

The diol 14 (1 .047 g, 4.05 mmol) was dissolved in cyclohexane (30 mL) and vigorously stirred with 48% HBr (0.5 mL, 4.46 mmol, 1.1 eq.). The mixture was refluxed for 6 h, diluted with water (50 mL) and the phases were separated. The aqueous phase was extracted with a mixture of dichloromethane and methanol (v/v, 4:1 3 x 20 mL). The combined organic layer was dried over MgS04. The product was purified by column chromatography with silica gel (6 x 6 cm, cyclohexane/ethyl acetate, 8:1 ) and isolated as a white solid. Yield: 4.598 g (96%). Traces of 1 ,16-dibromohexadecane were also found. 15 M.p.: 65 C (lit. 53-54 C) 1H-NMR (300 MHz, CDCI3) delta [ppm]: 1.26-1.47 (m, 23 H, 4-CH2 to 14-CH2, 1 -OH), 1.51 -1.62 (m, 4 H, 2-CH2, 3-CH2), 1 .85 (m, 2 H, 15-CH2), 3.41 (t, 3JH,H = 6.9 Hz, 2 H, 16-CH2), 3.64 (t, 3JH,H = 6.6 HZ, 2 H, 1 -CH2). 13C-NMR (75 MHz, CDCI3) delta [ppm]: 25.9 (t, C-3), 28.3, 28.9, 29.6, 29.7, 29.8 (t, C-4 to C-14), 33.0 (t, C-2, C-15), 34.3 (t, C-16), 63.3 (t, C-1 ). Refs.: M.p. P. Chuit, J. Hausser, Helv. Chim. Acta 1929, 72,850-859. 1H-NMR spectroscopic data agree with those given by: S. Takanashi, M. Takagi, H. Takikawa; K. Mori, J. Chem. Soc, Perkin Trans. 1 1998, 1603-1606.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7735-42-4, 1,16-Hexadecanediol, and friends who are interested can also refer to it.

Reference:
Patent; WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; HAUFE, Guenter; LEVKAU, Bodo; SCHAEFERS, Michael; SCHILSON, Stefani Silke; KEUL, Petra; WO2013/26765; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts