Category: 76931-93-6

《Nanoparticle based simple electrochemical biosensor platform for profiling of protein-nucleic acid interactions》 was written by Dai, Yifan; Chiu, Liang-Yuan; Sui, Yongkun; Dai, Quanbin; Penumutchu, Srinivasa; Jain, Niyati; Dai, Liming; Zorman, Christian A.; Tolbert, Blanton S.; Sankaran, R. Mohan; Liu, Chung Chiun. Synthetic Route of C8H9NO5S And the article was included in Talanta on April 1 ,2019. The article conveys some information:

The anal. of protein-nucleic acid interactions is essential for biophysics related research. However, simple, rapid, and accurate methods for quant. anal. of biomol. interactions are lacking. The authors herein establish an electrochem. biosensor approach for protein-nucleic acid binding anal. Nanoparticle based sensors are fabricated by highly-controlled inkjet printing followed by plasma conversion. A novel bioconjugation method is demonstrated as a simple and rapid approach for protein-based biosensor fabrication. As a proof of concept, the authors analyzed the binding interaction between unwinding protein 1 (UP1) and SL3ESS3 RNA, confirming the accuracy of this nanoparticle based electrochem. biosensor approach with traditional biophys. methods. The authors further accurately profiled and differentiated a unique binding interaction pattern of multiple G-tract nucleic acid sequences with heterogeneous nuclear ribonucleoprotein H1. The authors’ study provides insights into a potentially universal platform for in vitro biomol. interaction anal. using a nanoparticle based electrochem. biosensor approach. In addition to this study using 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate, there are many other studies that have used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Synthetic Route of C8H9NO5S) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine on reaction with ketenedithioacetals gave mono- and dipyrrolidino derivatives. Reaction of parent pyrrolidine with alkyl/aryl isocyanates or isothiocyanates provided 1,3-disubstituted ureas/thioureas.Synthetic Route of C8H9NO5S

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《Development and pre-clinical evaluation of a synthetic oligosaccharide-protein conjugate vaccine against Neisseria meningitidis serogroup C》 was written by Dalal, Juned; Rana, Rakesh; Harale, Kishore; Hanif, Sarmad; Kumar, Nitin; Singh, Deepti; Chhikara, Manoj Kumar. Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate And the article was included in Vaccine on August 23 ,2019. The article conveys some information:

Significant improvement has been made in the development of vaccines against Neisseria meningitidis infections since the introduction of polysaccharide-protein conjugate vaccines. Conventional bacterial capsular polysaccharide (PS) based conjugate vaccines require unique and expensive manufacturing facilities, complex production processes and extensive quality testing. Synthetic oligosaccharide (OS) based approach is one of the novel technologies that is being developed to simplify production of conjugate vaccines. OSs can be chem. synthesized to a desired length long enough to represent the antigenic epitopes which often present as a homogenous mixture We prepared OSs corresponding to tetramer and octamer of N. meningitidis serogroup C (MenC) PS by organic synthesis. The MenC tetramer and octamer were further conjugated with tetanus toxoid to produce resp. monovalent conjugates having the desired physico-chem. characteristics. The conjugates were evaluated in a mouse model for immunogenicity and compared with a licensed PS conjugate vaccine. Synthetic conjugates could induce anti-MenC PS IgG as well as serum bactericidal titers at levels comparable to those elicited by the licensed vaccine. The increase in length of synthetic oligomers from tetramer to octamer did not appear to increase immunogenicity. The results establish the pre-clin. proof of concept for a synthetic MenC oligosaccharide conjugate vaccine candidate. In the experimental materials used by the author, we found 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine on reaction with ketenedithioacetals gave mono- and dipyrrolidino derivatives. Reaction of parent pyrrolidine with alkyl/aryl isocyanates or isothiocyanates provided 1,3-disubstituted ureas/thioureas.Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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Tapia, Daniel; Sanchez-Villamil, Javier I.; Torres, Alfredo G. published their research in npj Vaccines on December 31 ,2020. The article was titled 《Multicomponent gold nano-glycoconjugate as a highly immunogenic and protective platform against Burkholderia malleiã€?Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate The article contains the following contents:

Burkholderia mallei (Bm) is a facultative intracellular pathogen and the etiol. agent of glanders, a highly infectious zoonotic disease occurring in equines and humans. The intrinsic resistance to antibiotics, lack of specific therapy, high mortality, and history as a biothreat agent, prompt the need of a safe and effective vaccine. However, the limited knowledge of protective Bm-specific antigens has hampered the development of a vaccine. Further, the use of antigen-delivery systems that enhance antigen immunogenicity and elicit robust antigen-specific immune responses has been limited and could improve vaccines against Bm. Nanovaccines, in particular gold nanoparticles (AuNPs), have been investigated as a strategy to broaden the repertoire of vaccine-mediated immunity and as a tool to produce multivalent vaccines. To synthesize a nano-glycoconjugate vaccine, six predicted highly immunogenic antigens identified by a genome-wide bio- and immuno-informatic anal. were purified and coupled to AuNPs along with lipopolysaccharide (LPS) from B. thailandensis. Mice immunized intranasally with individual AuNP-protein-LPS conjugates, showed variable degrees of protection against intranasal Bm infection, while an optimized combination formulation (containing protein antigens OmpW, OpcP, and Hemagglutinin, along with LPS) showed complete protection against lethality in a mouse model of inhalational glanders. Animals immunized with different nano-glycoconjugates showed robust antigen-specific antibody responses. Moreover, serum from animals immunized with the optimized nano-glycoconjugate formulation showed sustained antibody responses with increased serum-mediated inhibition of adherence and opsonophagocytic activity in vitro. This study provides the basis for the rational design and construction of a multicomponent vaccine platform against Bm. After reading the article, we found that the author used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Quality Control of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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Rakauskaite, Rasa; Urbanaviciute, Giedre; Simanavicius, Martynas; Lasickiene, Rita; Vaitiekaite, Ausra; Petraityte, Grazina; Masevicius, Viktoras; Zvirbliene, Aurelija; Klimasauskas, Saulius published their research in iScience on December 18 ,2020. The article was titled 《Photocage-Selective Capture and Light-Controlled Release of Target Proteinsã€?Synthetic Route of C8H9NO5S The article contains the following contents:

Photochem. transformations enable exquisite spatiotemporal control over biochem. processes; however, methods for reliable manipulations of biomols. tagged with biocompatible photo-sensitive reporters are lacking. Here we created a high-affinity binder specific to a photolytically removable caging group. We utilized chem. modification or genetically encoded incorporation of noncanonical amino acids to produce proteins with photocaged cysteine or selenocysteine residues, which were used for raising a high-affinity monoclonal antibody against a small photoremovable tag, 4,5-dimethoxy-2-nitrobenzyl (DMNB) group. Employing the produced photocage-selective binder, we demonstrate selective detection and immunoprecipitation of a variety of DMNB-caged target proteins in complex biol. mixtures This combined orthogonal strategy permits photocage-selective capture and light-controlled traceless release of target proteins for a myriad of applications in nanoscale assays. After reading the article, we found that the author used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Synthetic Route of C8H9NO5S)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Synthetic Route of C8H9NO5S

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Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetateOn March 1, 2020, Townsend, Jakob M.; Sali, Goksel; Homburg, Hannah B.; Cassidy, Nina T.; Sanders, Megan E.; Fung, Kar-Ming; Andrews, Brian T.; Nudo, Randolph J.; Bohnstedt, Bradley N.; Detamore, Michael S. published an article in Acta Biomaterialia. The article was 《Thiolated bone and tendon tissue particles covalently bound in hydrogels for in vivo calvarial bone regeneration》. The article mentions the following:

Bone regeneration of large cranial defects, potentially including traumatic brain injury (TBI) treatment, presents a major problem with non-crosslinking, clin. available products due to material migration outside the defect. Com. products such as bone cements are permanent and thus not conducive to bone regeneration, and typical com. bioactive materials for bone regeneration do not crosslink. Our previous work demonstrated that non-crosslinking materials may be prone to material migration following surgical placement, and the current study attempted to address these problems by introducing a new hydrogel system where tissue particles are themselves the crosslinker. Specifically, a pentenoate-modified hyaluronic acid (PHA) polymer was covalently linked to thiolated tissue particles of demineralized bone matrix (TDBM) or devitalized tendon (TDVT), thereby forming an interconnected hydrogel matrix for calvarial bone regeneration. All hydrogel precursor solutions exhibited sufficient yield stress for surgical placement and an adequate compressive modulus post-crosslinking. Critical-size calvarial defects were filled with a 4% PHA hydrogel containing 10 or 20% TDBM or TDVT, with the clin. product DBX being employed as the standard of care control for the in vivo study. At 12 wk, micro-computed tomog. anal. demonstrated similar bone regeneration among the exptl. groups, TDBM and TDVT, and the standard of care control DBX. The group with 10% TDBM was therefore identified as an attractive material for potential calvarial defect repair, as it addnl. exhibited a sufficient initial recovery after shearing (i.e., > 80% recovery). Future studies will focus on applying a hydrogel in a rat model for treatment of TBI. Non-crosslinking materials may be prone to material migration from a calvarial bone defect following surgical placement, which is problematic for materials intended for bone regeneration. Unfortunately, typical crosslinking materials such as bone cements are permanent and thus not conducive to bone regeneration, and typical bioactive materials for bone regeneration such as tissue matrix are not crosslinked in com. products. The current study addressed these problems by introducing a new biomaterial where tissue particles are themselves the crosslinker in a hydrogel system. The current study successfully demonstrated a new material based on pentenoate-modified hyaluronic acid with thiolated demineralized bone matrix that is capable of rapid crosslinking, with desirable paste-like rheol. of the precursor material for surgical placement, and with bone regeneration comparable to a com. available standard-of-care product. Such a material may hold promise for a single-surgery treatment of severe traumatic brain injury (TBI) following hemicraniectomy. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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Vance, Nicholas; Zacharias, Neelie; Ultsch, Mark; Li, Guangmin; Fourie, Aimee; Liu, Peter; LaFrance-Vanasse, Julien; Ernst, James A.; Sandoval, Wendy; Kozak, Katherine R.; Phillips, Gail; Wang, Weiru; Sadowsky, Jack published an article on January 16 ,2019. The article was titled 《Development, optimization, and structural characterization of an efficient peptide-based photoaffinity cross-linking reaction for generation of homogeneous conjugates from wild-type antibodies》, and you may find the article in Bioconjugate Chemistry.HPLC of Formula: 76931-93-6 The information in the text is summarized as follows:

Site-specific conjugation of small mols. to antibodies represents an attractive goal for the development of more homogeneous targeted therapies and diagnostics. Most site-specific conjugation strategies require modification or removal of antibody glycans or interchain disulfide bonds or engineering of an antibody mutant that bears a reactive handle. While such methods are effective, they complicate the process of preparing antibody conjugates and can neg. impact biol. activity. Herein we report the development and detailed characterization of a robust photoaffinity crosslinking method for site-specific conjugation to fully glycosylated wild-type antibodies. The method employs a benzoylphenylalanine (Bpa) mutant of a previously described 13-residue peptide derived from phage display to bind tightly to the Fc domain; upon UV irradiation, the Bpa residue forms a diradical that reacts with the bound antibody. After the initial discovery of an effective Bpa mutant peptide and optimization of the reaction conditions to enable efficient conjugation without concomitant UV-induced photodamage of the antibody, we assessed the scope of the photoconjugation reaction across different human and nonhuman antibodies and antibody mutants. Next, the specific site of conjugation on a human antibody was characterized in detail by mass spectrometry experiments and at at. resolution by X-ray crystallog. Finally, we adapted the photoconjugation method to attach a cytotoxic payload site-specifically to a wild-type antibody and showed that the resulting conjugate is both stable in plasma and as potent as a conventional antibody-drug conjugate in cells, portending well for future biol. applications.2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6HPLC of Formula: 76931-93-6) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.HPLC of Formula: 76931-93-6

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Myerson, Jacob W.; Patel, Priyal N.; Rubey, Kathryn M.; Zamora, Marco E.; Zaleski, Michael H.; Habibi, Nahal; Walsh, Landis R.; Lee, Yi-Wei; Luther, David C.; Ferguson, Laura T.; Marcos-Contreras, Oscar A.; Glassman, Patrick M.; Mazaleuskaya, Liudmila L.; Johnston, Ian; Hood, Elizabeth D.; Shuvaeva, Tea; Wu, Jichuan; Zhang, Hong-Ying; Gregory, Jason V.; Kiseleva, Raisa Y.; Nong, Jia; Grosser, Tilo; Greineder, Colin F.; Mitragotri, Samir; Worthen, George S.; Rotello, Vincent M.; Lahann, Joerg; Muzykantov, Vladimir R.; Brenner, Jacob S. published an article on January 31 ,2022. The article was titled 《Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation》, and you may find the article in Nature Nanotechnology.Application In Synthesis of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate The information in the text is summarized as follows:

This study shows that the supramol. arrangement of proteins in nanoparticle structures predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We observed homing to inflamed lungs for a variety of nanoparticles with agglutinated protein (NAPs), defined by arrangement of protein in or on the nanoparticles via hydrophobic interactions, crosslinking and electrostatic interactions. Nanoparticles with sym. protein arrangement (for example, viral capsids) had no selectivity for inflamed lungs. Flow cytometry and immunohistochem. showed NAPs have tropism for pulmonary neutrophils. Protein-conjugated liposomes were engineered to recapitulate NAP tropism for pulmonary neutrophils. NAP uptake in neutrophils was shown to depend on complement opsonization. We demonstrate diagnostic imaging of ALI with NAPs; show NAP tropism for inflamed human donor lungs; and show that NAPs can remediate pulmonary edema in ALI. This work demonstrates that structure-dependent tropism for neutrophils drives NAPs to inflamed lungs and shows NAPs can detect and treat ALI. In the experiment, the researchers used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Application In Synthesis of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Application In Synthesis of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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Lenssen, T; Dankelman, J; Horeman, T published an article on January 22 ,2022. The article was titled 《SATA-LRS: A modular and novel steerable hand-held laparoscopic instrument platform for low-resource settings☆.》, and you may find the article in Medical engineering & physics.Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate The information in the text is summarized as follows:

BACKGROUND: Hospitals in low resource settings (LRS) can benefit from modern laparoscopic methodologies. However, cleaning, maintenance and costs requirements play a stronger role while training and technology are less available. Steerable laparoscopic instruments have additional requirements in these settings and need extra identified adaptations in their design. METHOD: Several modular detachability and tip steerability features were applied to the SATA-LRS instrument platform designed specifically for LRS. Ten subjects participated a dis- and reassembly experiment to validate the modularity, and in a steering experiment using a custom made set-up to validate steering. RESULTS: A new steerable SATA-LRS instrument was developed with the ability to exchange end-effectors through a disassembly of the shafts. Experiments showed an average 34 and 90 s for complete dis- and reassembly, respectively. Participants were able to handle the instrument independently after a single demonstration and 4 rounds of repetitions. Precise tip-target alignment in the box set-up showed a very short learning-curve of 6 repetitions. CONCLUSION: A novel instrument platform with articulating and rotating end-effector was designed for LRS. Within a minute the SATA-LRS can be disassembled to component level for inspection, cleaning, maintenance and repair, and can be autonomously reassembled by novices after a minimal training. The modular buildup is expected to reduce purchasing and repair costs. The instrument has been shown intuitive by use without extensive training. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Recommanded Product: 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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Formula: C8H9NO5SOn September 3, 2019 ,《Conjugation of Antibodies to Horseradish Peroxidase.》 was published in Cold Spring Harbor protocols. The article was written by Berg, Eric A; Fishman, Jordan B. The article contains the following contents:

Antibodies conjugated with horseradish peroxidase (HRP) are one of the most widely used bioreagents in the biological sciences. This protocol is a basic method for adding HRP to a thiolated antibody and can be adapted for use with different cross-linkers. Conjugation methods usually focus on linking through the lysines on HRP because there are only six of them and their modification does not adversely affect enzyme activity. The experimental process involved the reaction of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Formula: C8H9NO5S)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Formula: C8H9NO5S

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Recommanded Product: 76931-93-6On November 1, 2021 ,《Generation and characterisation of a semi-synthetic siderophore-immunogen conjugate and a derivative recombinant triacetylfusarinine C-specific monoclonal antibody with fungal diagnostic application》 appeared in Analytical Biochemistry. The author of the article were Moloney, Nicola M.; Larkin, Annemarie; Xu, Linan; Fitzpatrick, David A.; Crean, Holly L.; Walshe, Kieran; Haas, Hubertus; Decristoforo, Clemens; Doyle, Sean. The article conveys some information:

Invasive pulmonary aspergillosis (IPA) is a severe life-threatening condition. Diagnosis of fungal disease in general, and especially that caused by Aspergillus fumigatus is problematic. A. fumigatus secretes siderophores to acquire iron during infection, which are also essential for virulence. We describe the chemoacetylation of ferrated fusarinine C to diacetylated fusarinine C (DAFC), followed by protein conjugation, which facilitated triacetylfusarinine C (TAFC)-specific monoclonal antibody production with specific recognition of the ferrated form of TAFC. A single monoclonal antibody sequence was ultimately elucidated by a combinatorial strategy involving protein LC-MS/MS, cDNA sequencing, and RNAseq. The resultant murine IgG2a monoclonal antibody was secreted in, and purified from, mammalian cell culture (5 mg) and demonstrated to be highly specific for TAFC detection by competitive ELISA (detection limit: 15 nM) and in a lateral flow test system (detection limit: 3 ng), using gold nanoparticle conjugated-DAFC-bovine serum albumin for competition. Overall, this work reveals for the 1st time a recombinant TAFC-specific monoclonal antibody with diagnostic potential for IPA diagnosis in traditional and emerging patient groups (e.g., COVID-19) and presents a useful strategy for murine Ig sequence determination, and expression in HEK293 cells, to overcome unexpected limitations associated with aberrant or deficient murine monoclonal antibody production In addition to this study using 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate, there are many other studies that have used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Recommanded Product: 76931-93-6) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Recommanded Product: 76931-93-6

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