Category: 769-30-2

Related Products of 769-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.15, as common compound, the synthetic route is as follows.

A solution of (benzo[d][l,3]dioxol-7-yl)methanol (2.0 g, 13.1 mmol) and 6i(lH-imidazol-l-yl)methanone (4.26 g, 26.2 mmol) in 20 mL CH2CI2 was heated overnight at 50 C The reaction was quenched with water and extracted with CH2CI2, and the combined layers were dried over MgS04, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2C12 gave (benzo[d][l,3]dioxol-7-yl)methyl lNo.-imidazole-l-carboxylate (2.8 g, 86%). ltt NMR (400 MHz, CDC13) 8 8.15 (t, /= 0.9 Hz, 1H), 7.44 (t, J= 1.4 Hz, 1H), 7.07 (dd, J= 1.6, 0.8 Hz, 1H), 6.95 (m, 2H), 6.84 (m, 1H), 6.01 (s, 2H), 5.33 (s, 2H).

Statistics shows that 769-30-2 is playing an increasingly important role. we look forward to future research findings about Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
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Alcohols – Chemistry LibreTexts

Electric Literature of 769-30-2, Adding some certain compound to certain chemical reactions, such as: 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol,molecular formula is C8H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 769-30-2.

General procedure: A mixture of corresponding alcohol (1, 1 mmol) and 3,4-dihydro-2H-pyran (2, 100 mg, 1.2 mmol) was stirred in the presence of zwitterionic-salt A (10 mg, 10 mol%) at 60-80 C (oil bath) for 10-12 h in a seal tube. After completion of the reaction (TLC), the reaction mixture was cooled to room temperature and diluted with water (10 mL) and extracted with ethyl acetate (20 mL). Organic layer was dried over anhydrous Na2SO4. After evaporation of solvent the crude product was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (4-5%) as eluent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mahato, Sachinta; Chatterjee, Rana; Chakraborty Ghosal, Nirnita; Majee, Adinath; Synthetic Communications; vol. 47; 20; (2017); p. 1905 – 1915;,
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Alcohols – Chemistry LibreTexts

Synthetic Route of 769-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 6; Method AT5; Preparation of 1-Benzof1 3]dioxol-4-yl-2-bromo-ethanone; Step 1: Preparation of starting material 1-Benzor1, 3]dioxol-4-yl-ethanone; To a solution of MeMgBr in THF (1 M, 50 mL, 50 mmol, 1.5 eq) was diluted with 50 mL THF and cooled to-10 C. A solution of benzo [1,3] dioxole-4-carboxaldehyde (5.0 g, 33.3 mmol) in 50 mL THF was slowly added, and the reaction left to stir for 1 h. The reaction mixture was then quenched by pouring into 500 mL of ice cold sat. ammonium chloride and the mixture extracted with ether. The organic layers were dried over sodium sulfate and filtered through a plug of silica gel before concentrating in vacuo, providing 4.9 g of a white solid. A mixture of this solid (2.0 g, 12.0 mmol) and MnO2 (10.5 g, 120. 4 mmol, 10.0 eq) in 75 mL diethyl ether was stirred vigorously for 48 h. The reaction mixture was then filtered first through a plug of silica gel, then through a 0. 46 um frit before concentrating in vacuo to provide 2. 1g of an off-white solid. Purification by MPLC (Biotage) using a hexane-ethyl acetate gradient provided 1.47 g (74%) of 1- benzo [1,3] dioxol-4-yl-ethanone as an off-white solid. 1H-NMR (CDC13) 6 7.35 (d, J = 8 Hz, 1H), 6.97 (dm, J = 8 Hz, 1H), 6.87 (dd, J = 8 Hz, 1H), 6.08 (s, 2 H), 2.59 (s, 3H); TLC Rf = 0.18, 25% ethyl acetate-hexanes.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 769-30-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. A new synthetic method of this compound is introduced below.

To a solution of 4-hydroxymethyl-benzo[1 ,3]dioxole (1.00 g, 6.6 mmol) and carbon tetrabromide (3.50 g, 10.5 mmol) in anhydrous tetrahydrofuran (30 ml.) was added at 00C triphenylphosphine (2.80 g, 10.5 mmol) in solution in tetrahydrofuran (10 mL). The resulting reaction mixture was stirred at room temperature for 2 hours. Water (30 mL) was added followed by ethyl acetate (30 mL). The organic layer was washed first with a concentrated aqueous sodium hydrogenocarbonate solution (30 mL) and then brine (30 mL), dried over anhydrous potassium carbonate and concentrated in vacuum. The resulting crude product was purified by flash chromatography on silica gel, eluting with cyclohexane – dichloromethane (7:3) to afford the title compound (1.23 g, 87%) as colorless oil.[00694] 1H NMR (CDCI3): delta 6.86 – 6.75 (m, 3H), 6.02 (s, 2H), 4.47 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; NPS PHARMACEUTICALS, INC.; WO2007/44796; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 769-30-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. A new synthetic method of this compound is introduced below.

A solution of (benzo[d][l,3]dioxol-7-yl)methanol (2 g, 13.14 mmol) and di(lNo.-imidazol-l-yl)methanone (4.26 g, 26.28 mmol) in 20 mL CH2CI2 was heated overnight at 50 C. The reaction was quenched with water, extracted with CH2CI2, dried over Na2S04, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2CI2 gave (benzo[d][l,3]dioxol-7-yl)methyl 177-imidazole-l-carboxylate (2.8 g, 86%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol, molecular formula is C8H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C8H8O3

Benzo[d][1,3]dioxo-4-ylmethanol (223 mg, 1.47 mmol)Dissolved in dichloromethane (10 mL), then phosphorus tribromide (0.17 mL, 1.8 mmol) was added dropwise at 0 C.After the completion of the dropwise addition, the mixture was stirred at room temperature for 3 hours.The reaction was quenched with saturated aqueous sodium bicarbonate and extracted with dichloromethane (50 Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wang Xiaojun; Zuo Yinglin; Yu Chuan; Yang Chuanwen; Wang Jiancheng; Li Jing; Cao Shengtian; Wu Fangyuan; Zhang Yingjun; S ¡¤geerdeman; (79 pag.)CN108690016; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts