Category: 7661-33-8

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the ring contraction and deformylative functionalization of piperidine derivatives, published in 2019, which mentions a compound: 7661-33-8, mainly applied to piperidine ring contraction deformylative functionalization pyrrolidinone iodopyrrole synthesis, Product Details of 7661-33-8.

In this paper, a selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the cascade reactions of N-substituted piperidines is presented [e.g., N-phenylpiperidine → N-phenyl-2-pyrrolidinone (58%) in presence of Cu(OAc)2/KI/Oxone/O2 in MeCN and N-phenylpiperidine → 3-iodo-N-phenylpyrrole (65%) in presence of Cu(OAc)2/I2/DMAP/O2 in MeCN]. Mechanistically, the formation of pyrrolidin-2-ones involves a domino process including the in situ formation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation and ipso-oxidation On the other hand, 3-iodopyrroles are believed to be formed via the initial generation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation, dehydrogenation, iodination and aromatization. Interestingly, either pyrrolidin-2-ones or 3-iodopyrroles could be obtained selectively from the same substrates, and the selectivity was easily tuned by using a specific oxidant and additive.

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Product Details of 7661-33-8. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Dipole moments of substituted 1-phenyl-2-pyrrolidones. Author is Virtanen, P. Olavi I.; Ruostesuo, Pirkko; Ruostesuo, Pirkko.

The dipole moments of 1-phenyl-2-pyrrolidone and its 2′-methyl, 3′-methyl, 4′-methyl, 2′-chloro, 3′-chloro, 4′-chloro, 2′-methoxy, 3′-methoxy, and 4′-methoxy derivatives were measured in dioxane at 30° and the dipole moments of the 1st 4 compounds also in cyclohexane at 30°. The dipole moments were larger in dioxane than in cyclohexane. The dipole moments of all the compounds except 1-(3-methoxyphenyl)-2-pyrrolidone and 1-(4-methoxyphenyl)-2-pyrrolidone agree with the values calculated by applying Eyring’s treatment and assuming free rotation of the pyrrolidonyl group about the bond joining it to the aromatic ring.

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Synthetic Route of C10H10ClNO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Amidation of Aryl Chlorides Using a Microwave-Assisted, Copper-Catalyzed Concurrent Tandem Catalytic Methodology. Author is Chang, Raymond K.; Clairmont, Brice P.; Lin, Shirley; MacArthur, Amy H. Roy.

A copper iodide-catalyzed concurrent tandem catalytic (CTC) methodol. has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the N-aryl secondary or tertiary amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol% CuI, 60 mol% N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200° after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts Mechanistic studies are consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.

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Formula: C10H10ClNO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Decrease in intestinal permeability to polyethylene glycol 1000 during development in the pig. Author is Westroem, B. R.; Tagesson, C.; Leandersson, P.; Folkesson, H. G.; Svendsen, J..

Changes in intestinal permeability during postnatal development in the pig were investigated by using different-sized polyethylene glycols (PEGs) in the Mr 766-1338 range (PEG 1000) as permeability probes. Pigs of varying age, newborn (0 h), 36-45 h old, and 22-28 days old, were gavage-fed PEG 1000 together with the macromol. markers bovine serum albumin, ovalbumin, or FITC-labeled dextran 70,000. The 4-h blood serum concentrations of the different markers were determined and taken as an estimate of their intestinal transmission. In the newborn pigs, high serum levels of PEGs were obtained, concomitant with high serum levels of bovine serum albumin and FITC-dextran. After intestinal macromol. closure in the 36-45 h-old pigs, lower serum PEG levels were found, especially of those with a Mr > 1100 Da. In the 22-28 day-old pigs, PEG levels were reduced to ≤10% of those in the 36-45-h-old pigs, with the levels decreasing markedly with increasing mol. size. These results show that there is a correlation between the intestinal permeability of PEGs, especially those >1100 Da, and macromols. in the newborn pig around intestinal closure, suggesting that such PEGs traverse the gut by the macromol. route. During later development, further intestinal maturation results in a markedly reduced permeability to PEG 1000.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions》. Authors are Kalyani, Dipannita; Dick, Allison R.; Anani, Waseem Q.; Sanford, Melanie S..The article about the compound:1-(4-Chlorophenyl)pyrrolidin-2-onecas:7661-33-8,SMILESS:O=C1N(C2=CC=C(Cl)C=C2)CCC1).Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. Through the article, more information about this compound (cas:7661-33-8) is conveyed.

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Condensation of aniline, o-phenylenediamine, and their derivatives with lactones, the main research direction is aniline butyrolactone pyrrolidinone; benzimidazolepropanol phenylenediamine lactone.Product Details of 7661-33-8.

Heating equimol. amounts of RNH2 and γ-butyrolactone at 130-305° gave 2-pyrrolidinones (I) (R and % yield given): Ph, 80; m-MeC6H4, 75; p-MeC6H4, 78; m-BrC6H4, 60; α-naphthyl, 14; m-CF3C6H4, 19; p-ClC6H4, 77; β-naphthyl, 62. Boiling a mixture of equimol. amounts of substituted aromatic o-diamines and γ- or β-lactones in xylene gave the following 3-(2-benzimidazolyl)-1-alkanoles (II) (R1, R2, X, and % yield given): H, CCl3, CH2, 61; Cl, CCl3, CH2, 85; Me, CCl3, CH2, 87; H, H, (CH2)2, 80; Cl, H, (CH2)2, 24; Me, H, (CH2)2, 31; H, Me, (CH2)2, 78; H, Pr, (CH2)2, 78; Cl, Pr, (CH2)2, 7; Me, Pr, (CH2)2, 13; H, Bu, (CH2)2, 75; Cl, Bu, (CH2)2, 17; H, C7H15, (CH2)2, 66; H, H, CHOHCMe2, 50; H, H, CHAcCH2, 40; Cl, H, CHAcCH2, 16. Uv data for II are given.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one(SMILESS: O=C1N(C2=CC=C(Cl)C=C2)CCC1,cas:7661-33-8) is researched.Synthetic Route of C5H4O2. The article 《Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:7661-33-8).

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.

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Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Hydrogen bonding of pyrrole, indole and carbazole with substituted 1-phenyl-2-pyrrolidinones. Author is Karjalainen, J.; Virtanen, P. O. I..

The equilibrium constants (K) for the 1:1 H-bonded complexes between I (R = Me, Ph, substituted Ph) with pyrrole, indole, and carbazole were determined in CCl4 by IR. Hammett LFER were observed for each K and Δ υNH (the difference between pores and associated NH stretch). I (R = Me) is a stronger H acceptor than I (R = Ph, substituted Ph). The proton donor ability increases in the order; pyrrole < indole < carbazole. The ΔG°, ΔH°, ΔS° for the complexation are determined This literature about this compound(7661-33-8)Safety of 1-(4-Chlorophenyl)pyrrolidin-2-onehas given us a lot of inspiration, and I hope that the research on this compound(1-(4-Chlorophenyl)pyrrolidin-2-one) can be further advanced. Maybe we can get more compounds in a similar way.

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Product Details of 7661-33-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Carbon-13, nitrogen-15m, and oxygen-17 NMR chemical shifts of substituted 1-phenyl-2-pyrrolidinones. Author is Ruostesuo, P.; Hakkinen, A. M.; Karjalainen, J..

The C-13 and N-15 NMR chem. shifts and the direct C-proton coupling constants of 1-phenyl-2-pyrrolidinone and its 2′-Me,3′-Me,4′-Me,2′-chloro,3′-chloro,4′-chloro,3′-methoxy,4′-methoxy and 4′-nitro derivatives were measured in di-Me sulfoxidde. The O-17 NMR chem. shifts of some of the compounds were determined in acetone. The effect of substituents on the chem. shifts of carbonyl carbons correlates well with the Hammett substituent parameters and the N chem. shifts seem to follow a similar trend. The variation of the O chem. shift due to the substituents is small. The chem. shifts of aromatic carbons can mainly be derived using the substituent parameters of benzene, some deviation probably due to steric effects is observable, however.

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Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Synthetic Exploration of α-Diazo γ-Butyrolactams. Author is Zhukovsky, Daniil; Dar’in, Dmitry; Kantin, Grigory; Krasavin, Mikhail.

Diazo transfer reaction onto γ-butyrolactams (activated by α-ethyloxalylation) gave rare α-diazo-γ-butyrolactams. Decomposition of the latter by Rh2(OAc)4 in the presence of alcs. and water gave products of O-H insertion of the resp. metal-cabene species. Silver triflate (1 mol%) was found to convert the investigated γ-butyrolactams into 1,5-dihydro-2H-pyrrol-2-ones which represent versatile building blocks. Particular instability was noted for α-diazo γ-butyrolactams bearing alkyl or o-substituted aryl substituents on the nitrogen atom. These were found to dimerize in solution or upon storage at room temperature to give fully conjugated bis-hydrazones along with the loss of a nitrogen mol.

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