Category: 7661-33-8

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water.Formula: C10H10ClNO.

A convenient and efficient protocol has been developed for the cross-coupling of amides and aryl iodides using a ligand-free copper(I) oxide catalyst in water. A variety of amide derivatives afforded the corresponding N-arylated products in moderate to good yields (up to 88%).

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Computed Properties of C10H10ClNO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Ozonation of tertiary aromatic amines. II. Reactions of N,N-dialkylanilines with diethyl azodicarboxylate and with ozone.

Thermolysis of the adduct I from N-phenylpyrrolidine and EtO2CN:NCO2Et gave the isomeric dimers II, which were also formed by ozonation of N-phenylpyrrolidine. The ozonation of 11 other N,N-dialkylanilines and 22-pyrrolylpyridines was also studied.

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Tan, Bryan Yong-Hao; Teo, Yong-Chua published the article 《Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water》. Keywords: aryl iodide aliphatic amide cross coupling cobalt catalyst water; arylamide flutamide preparation.They researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Related Products of 7661-33-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7661-33-8) here.

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N’-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products I [R1 = Pr, i-Pr, Bu, etc; R2 = Ph, 2-F-C6H4, 4-Me-C6H4, etc.] were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called An Annulative Synthetic Strategy for Building Triphenylene Frameworks by Multiple C-H Bond Activations, published in 2017, which mentions a compound: 7661-33-8, mainly applied to unactivated benzene cyclic diaryliodonium bond activation arylation; triphenylene preparation; C−H activation; arylation; diaryliodonium salt; palladium; triphenylene, SDS of cas: 7661-33-8.

C-H activation is a versatile tool for appending aryl groups to aromatic systems. However, heavy demands on multiple catalytic cycle operations and site-selectivity have limited its use for graphene segment synthesis. A Pd-catalyzed one-step synthesis of functionalized triphenylene frameworks is disclosed, which proceeds by 2- or 4-fold C-H arylation of unactivated benzene derivatives A Pd2(dibenzylideneacetone)3 catalytic system, using cyclic diaryliodonium salts as π-extending agents, leads to site-selective inter- and intramol. tandem arylation sequences. Moreover, N-substituted triphenylenes are applied to a field-effect transistor sensor for rapid, sensitive, and reversible alc. vapor detection.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7661-33-8, is researched, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNOJournal, Journal of Heterocyclic Chemistry called Efficient Synthesis of N-Substituted 2,4-Azepandione Ring System as an Active Intermediate for Heterocyclic Syntheses, Author is Waly, Mohamed A.; Yossif, Shiam A.; Ibrahim, Ismail T.; Sofan, Mamdouh A., the main research direction is azepandione preparation; butanoate acetylarylamino ethyl cyclization.Formula: C10H10ClNO.

An improved efficient synthesis for 2,4-azepandiones I [R = H, CH3, Cl; R1 = H, CO2CH3] could be achieved by a careful control of the reaction conditions to cyclize Et 4-(N-acetylarylamino)butanoates 4-R-2-R1C6H3N[(CH2)3CO2CH2CH3]C(O)CH3, resp. Et 4-arylamino butanoates 4-R-2-R1C6H3NH(CH2)3C(O)2CH2CH3 was prepared by stirring the Et 4-bromobutanoate and substituted anilines 4-R-2-R1C6H3NH2 at room temperature Then, they were acetylated with acetyl chloride and triethylamine under the conditions that avoid the formation of 2-pyrrolidinone derivatives II. Due to the rapid decomposition of Et 4-(N-acetylarylamino)butanoates to Et 4-arylaminobutanoates, the reaction mixture was directly transferred without workup to the next cyclization step. The azepandione synthesis was favored by using a weak base at low temperature, where it was in a competition with the other modes of ring closure. The structures of the new compounds were supported by correct anal. and spectral data.

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Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Utilization of Cyclic Amides as Masked Aldehyde Equivalents in Reductive Amination Reactions.

An operationally simple protocol has been discovered that couples primary or secondary amines with N-aryl-substituted lactams to deliver differentiated diamines in moderate to high yields. The process allows for the partial reduction of a lactam in the presence of Cp2ZrHCl (Schwartz’s reagent), followed by a reductive amination between the resulting hemiaminal and primary or secondary amine. These reactions can be telescoped in a one-pot fashion to significantly simplify the operation. The scope of amines and substituted lactams of various ring sizes was demonstrated through the formation of a range of differentiated diamine products. Furthermore, this methodol. was expanded to include N-aryl pyrrolidinone substrates with an enantiopure ester group at the 5-position, and α-amino piperidinones were prepared with complete retention of stereochem. information. The development of this chem. has enabled the consideration of lactams as useful synthons.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Communications (Cambridge, United Kingdom) called Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines, Author is Zheng, Yanling; Nie, Xufeng; Long, Yang; Ji, Li; Fu, Haiyan; Zheng, Xueli; Chen, Hua; Li, Ruixiang, which mentions a compound: 7661-33-8, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNO, HPLC of Formula: 7661-33-8.

The first example of synthesis of N-substituted lactams I (R = Ph, 4-(propan-2-yl)phenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.; n = 1,2,3) and N-(p-tolyl)isoindolin-2-one via an acceptorless dehydrogenative coupling of diols HO(CH2)2(CH2)nCH2OH and [2-(hydroxymethyl)phenyl]methanol with primary amines RNH2 in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst have been reported.

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HPLC of Formula: 7661-33-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Synthesis and pharmacological evaluation of benzamide derivatives as potent and selective sigma-1 protein ligands. Author is Donnier-Marechal, Marion; Carato, Pascal; Larchanche, Paul-Emmanuel; Ravez, Severine; Boulahjar, Rajaa; Barczyk, Amelie; Oxombre, Benedicte; Vermersch, Patrick; Melnyk, Patricia.

A series of novel N-(aminoalkyl)benzamide derivatives such as I [m = 2, 3; R1 = Me; R2 = Bn, (CH2)2C6H4; R1R2 = (CH2)4, (CH2)2O(CH2)2, (CH2)2NMe(CH2)2, etc.; R3 = H, 4-n-Bu, 4-Cl, etc.] and N-benzyl-N-methyl-propan-1-amine derivatives II [X = CH2NH, SO2NH, NHC(O)] was designed, synthesized and pharmacol. evaluated. In vitro competition binding assays against sigma proteins (sigma-1 S1R and sigma-2 S2R) revealed that most of them conferred S2R/S1R selectivity toward without cytotoxic effects on SY5Y cells, especially with compounds I [m = 2, 3; R1 = Me; R2 = Bn]. Some selected compounds were also evaluated for their agonist and antagonist activities on a panel of 40 receptors and results showed the importance of the nature and the position with halogeno atom on the benzamide scaffold, the length chain and also the contribution of the hydrophobic part on the amine group. Among them, compounds I [m = 2, 3; R1 = Me; R2 = Bn; R3 = 4-Cl, 4-CN, 4-NO2] showed excellent affinity for S1R (Ki = 1.2-3.6 nM), selectivity for S2R (Ki up to 1400 nM) and high selectivity index (IC50(SY5Y)/Ki(S1R) ratio from 28/000 to 83/000). Furthermore, these compounds I and II presented an excellent safety profile over 40 other receptors.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Rhodium(III)-Catalyzed C-H Vinylation of Arenes: Access to Functionalized Styrenes.Name: 1-(4-Chlorophenyl)pyrrolidin-2-one.

An effective method were developed for Rh(III)-catalyzed direct vinylation of arenes to give functionalized styrenes, using vinyltriethoxysilane as a convenient and inexpensive vinyl source. A wide variety of substrates, including 1-aryl-2-pyrrolidinones, anilines, benzamides and ketones were compatible with this reaction. Moreover, this method can be applied to the two-step synthesis of functionalized indoles. Mechanistic investigation reveals that the reaction probably proceeds through an oxidative Heck/desilylation pathway.

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COA of Formula: C10H10ClNO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Decrease in intestinal permeability to polyethylene glycol 1000 during development in the pig. Author is Westroem, B. R.; Tagesson, C.; Leandersson, P.; Folkesson, H. G.; Svendsen, J..

Changes in intestinal permeability during postnatal development in the pig were investigated by using different-sized polyethylene glycols (PEGs) in the Mr 766-1338 range (PEG 1000) as permeability probes. Pigs of varying age, newborn (0 h), 36-45 h old, and 22-28 days old, were gavage-fed PEG 1000 together with the macromol. markers bovine serum albumin, ovalbumin, or FITC-labeled dextran 70,000. The 4-h blood serum concentrations of the different markers were determined and taken as an estimate of their intestinal transmission. In the newborn pigs, high serum levels of PEGs were obtained, concomitant with high serum levels of bovine serum albumin and FITC-dextran. After intestinal macromol. closure in the 36-45 h-old pigs, lower serum PEG levels were found, especially of those with a Mr > 1100 Da. In the 22-28 day-old pigs, PEG levels were reduced to ≤10% of those in the 36-45-h-old pigs, with the levels decreasing markedly with increasing mol. size. These results show that there is a correlation between the intestinal permeability of PEGs, especially those >1100 Da, and macromols. in the newborn pig around intestinal closure, suggesting that such PEGs traverse the gut by the macromol. route. During later development, further intestinal maturation results in a markedly reduced permeability to PEG 1000.

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