Category: 7661-33-8

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Facile CuI-catalyzed arylation of azoles and amides using simple enaminones as efficient ligands.COA of Formula: C10H10ClNO.

(E)-3-(Dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one was found to be an excellent ligand for copper-catalyzed N-arylation of azoles and amides with aryl halides under mild conditions. The reaction took place at 82 °C in MeCN with broad functional-group compatibility. A combination of the ligand and CuI proved to be an efficient catalytic system to promote the coupling reactions of aryl halides with azoles and amides.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Dipole moments of substituted 1-phenyl-2-pyrrolidones, published in 1970, which mentions a compound: 7661-33-8, Name is 1-(4-Chlorophenyl)pyrrolidin-2-one, Molecular C10H10ClNO, Computed Properties of C10H10ClNO.

The dipole moments of 1-phenyl-2-pyrrolidone and its 2′-methyl, 3′-methyl, 4′-methyl, 2′-chloro, 3′-chloro, 4′-chloro, 2′-methoxy, 3′-methoxy, and 4′-methoxy derivatives were measured in dioxane at 30° and the dipole moments of the 1st 4 compounds also in cyclohexane at 30°. The dipole moments were larger in dioxane than in cyclohexane. The dipole moments of all the compounds except 1-(3-methoxyphenyl)-2-pyrrolidone and 1-(4-methoxyphenyl)-2-pyrrolidone agree with the values calculated by applying Eyring’s treatment and assuming free rotation of the pyrrolidonyl group about the bond joining it to the aromatic ring.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A β-Keto Ester as a Novel, Efficient, and Versatile Ligand for Copper(I)-Catalyzed C-N, C-O, and C-S Coupling Reactions, published in 2007-05-11, which mentions a compound: 7661-33-8, Name is 1-(4-Chlorophenyl)pyrrolidin-2-one, Molecular C10H10ClNO, Formula: C10H10ClNO.

Employing Et 2-oxocyclohexanecarboxylate as a novel, efficient, and versatile ligand, the copper-catalyzed coupling reactions of various N/O/S nucleophilic reagents with aryl halides could be successfully carried out under mild conditions. A variety of products including N-arylamides, N-arylimidazoles, aryl ethers, and aryl thioethers were synthesized in good to excellent yields.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one(SMILESS: O=C1N(C2=CC=C(Cl)C=C2)CCC1,cas:7661-33-8) is researched.Product Details of 2208-59-5. The article 《Lactams. VIII. Conformation of N-aryl lactams》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:7661-33-8).

N-Aryl β-lactams were characterized by strong uv maximum at about 250 mμ. Some N-aryl γ-lactams also show similar absorption maximum but heavily substituted γ-lactams or N-phenyl δ-lactam display only low absorption in this region. A study of uv and N.M.R. spectra indicates that in N-aryl β-lactams, the heterocyclic ring and the three valences of N are planar and the N-aryl ring lies in the plane of the β-lactam. This planarity as well as the strong uv absorption are the result of an extended conjugation between the aryl ring and the amide function. Ortho substitution on the aryl ring causes a slight departure from this planarity and reduces the intensity of the uv absorption. In case of N-aryl γ-lactams, ortho substitution on the aryl ring causes enough departure from planarity to eliminate altogether the absorption maximum near 250 mμ. 22 references.

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Formula: C10H10ClNO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Amidation of Aryl Chlorides Using a Microwave-Assisted, Copper-Catalyzed Concurrent Tandem Catalytic Methodology. Author is Chang, Raymond K.; Clairmont, Brice P.; Lin, Shirley; MacArthur, Amy H. Roy.

A copper iodide-catalyzed concurrent tandem catalytic (CTC) methodol. has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the N-aryl secondary or tertiary amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol% CuI, 60 mol% N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200° after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts Mechanistic studies are consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Rhodium(III)-Catalyzed C-H Vinylation of Arenes: Access to Functionalized Styrenes, the main research direction is vinyltriethoxysilane arene rhodium catalyst regioselective oxidative vinylation green chem; vinylarene preparation; acetanilide vinyltriethoxysilane rhodium catalyst regioselective oxidative vinylation palladium heterocyclization; acylindole preparation green chem.Formula: C10H10ClNO.

An effective method were developed for Rh(III)-catalyzed direct vinylation of arenes to give functionalized styrenes, using vinyltriethoxysilane as a convenient and inexpensive vinyl source. A wide variety of substrates, including 1-aryl-2-pyrrolidinones, anilines, benzamides and ketones were compatible with this reaction. Moreover, this method can be applied to the two-step synthesis of functionalized indoles. Mechanistic investigation reveals that the reaction probably proceeds through an oxidative Heck/desilylation pathway.

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Related Products of 7661-33-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions. Author is Kalyani, Dipannita; Dick, Allison R.; Anani, Waseem Q.; Sanford, Melanie S..

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7661-33-8, is researched, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNOJournal, Article, Chemical Communications (Cambridge, United Kingdom) called Interception of amide ylides with sulfonamides: synthesis of (E)-N-sulfonyl amidines catalyzed by Zn(OTf)2, Author is Chen, Jijun; Long, Wenhao; Fang, Shangwen; Yang, Yonggang; Wan, Xiaobing, the main research direction is sulfonyl amidine preparation diastereoselective crystal structure mol; sulfonamide amide intermol condensation zinc catalyst.Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one.

An efficient method was reported for the synthesis of (E)-N-sulfonyl amidines such as I [R1 = H, Me, Ph, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = Me, i-Pr, Ph, etc.; R1R3 = (CH2)2, (CH2)3; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2, etc.; R4 = Ph, 4-MeC6H4, 2-naphthyl, etc.] in good yields with excellent stereoselectivity via Zn-catalyzed intermol. condensation reaction between sulfonamides and various amides. The wide substrate scope, exceptional functional group tolerance, operational simplicity and neutral reaction conditions made this mechanistically novel method well suited for preparing amidine compounds I.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7661-33-8, is researched, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNOJournal, Organic Chemistry Frontiers called Selective cleavage and reconstruction of C-N/C-C bonds in saturated cyclic amines: tunable synthesis of lactams and functionalized acyclic amines, Author is He, Yan; Yang, Jintao; Zhang, Xinying; Fan, Xuesen, the main research direction is saturated cyclic amine cleavage functionalization tandem reaction; arylpyrrolidinone preparation; tetramethylpiperidinyl arylformamido alkanoate preparation.Formula: C10H10ClNO.

Selective cleavage and functionalization of C-N/C-C bonds in saturated cyclic amines under the promotion of oxoammonium salt and tert-Bu hydroperoxide in the presence of different additives was developed. To be specific, cascade cleavage and reconstruction of C-N and C-C bonds took place under acidic conditions to provide pyrrolidin-2-ones. Under basic conditions, on the other hand, selective cleavage and functionalization of C-C bonds occurred to afford multi-functionalized acyclic N-formal amines. In addition, studies for revealing the intriguing reaction mechanisms was also been performed.

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Recommanded Product: 7661-33-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Condensation of aniline, o-phenylenediamine, and their derivatives with lactones. Author is Shazhenov, A. A.; Kadyrov, Ch. Sh.; Kurbanov, P..

Heating equimol. amounts of RNH2 and γ-butyrolactone at 130-305° gave 2-pyrrolidinones (I) (R and % yield given): Ph, 80; m-MeC6H4, 75; p-MeC6H4, 78; m-BrC6H4, 60; α-naphthyl, 14; m-CF3C6H4, 19; p-ClC6H4, 77; β-naphthyl, 62. Boiling a mixture of equimol. amounts of substituted aromatic o-diamines and γ- or β-lactones in xylene gave the following 3-(2-benzimidazolyl)-1-alkanoles (II) (R1, R2, X, and % yield given): H, CCl3, CH2, 61; Cl, CCl3, CH2, 85; Me, CCl3, CH2, 87; H, H, (CH2)2, 80; Cl, H, (CH2)2, 24; Me, H, (CH2)2, 31; H, Me, (CH2)2, 78; H, Pr, (CH2)2, 78; Cl, Pr, (CH2)2, 7; Me, Pr, (CH2)2, 13; H, Bu, (CH2)2, 75; Cl, Bu, (CH2)2, 17; H, C7H15, (CH2)2, 66; H, H, CHOHCMe2, 50; H, H, CHAcCH2, 40; Cl, H, CHAcCH2, 16. Uv data for II are given.

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