Category: 76-84-6

Doan, Son H.; Hussein, Mohanad A.; Nguyen, Thanh Vinh published the artcile< Tropylium-promoted Ritter reactions>, Application In Synthesis of 76-84-6, the main research area is amide preparation microwave continuous flow; alc nitrile Ritter reaction tropylium salt catalyst.

Herein, the development of a new method using salts of the tropylium ion to promote the Ritter reaction was reported. This method works well on a range of alcs., e.g., 1-phenylethanol and nitriles, e.g., acetonitrile, giving the corresponding products, e.g., N-(1-phenylethyl)acetamide in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oloo, Williamson N.; Szavuly, Miklos; Kaizer, Jozsef; Que, Lawrence Jr. published the artcile< Nonheme diiron oxygenase mimic that generates a diferric-peroxo intermediate capable of catalytic olefin epoxidation and alkane hydroxylation including cyclohexane>, Computed Properties of 76-84-6, the main research area is nonheme diiron oxygenase mimic intermediate olefin epoxidation alkane hydroxylation.

Herein are described substrate oxidations with H2O2 catalyzed by [FeII(IndH)(CH3CN)3](ClO4)2 [IndH = 1,3-bis(2′-pyridylimino)isoindoline], involving a spectroscopically characterized (μ-oxo)(μ-1,2-peroxo)diiron(III) intermediate (2) that is capable of olefin epoxidation and alkane hydroxylation including cyclohexane. Species 2 also converts ketones to lactones with a decay rate dependent on [ketone], suggesting direct nucleophilic attack of the substrate carbonyl group by the peroxo species. In contrast, peroxo decay is unaffected by the addition of olefins or alkanes, but the label from H218O is incorporated into the epoxide and alc. products, implicating a high-valent iron-oxo oxidant that derives from O-O bond cleavage of the peroxo intermediate. These results demonstrate an ambiphilic diferric-peroxo intermediate that mimics the range of oxidative reactivities associated with O2-activating nonheme diiron enzymes.

Inorganic Chemistry published new progress about Alkenes Role: BUU (Biological Use, Unclassified), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nakajima, Isami; Shimizu, Minori; Okuda, Yuta; Akiyama, Ryo; Tadano, Ryu; Nagaoka, Masahiro; Uemura, Naohiro; Yoshida, Yasushi; Mino, Takashi; Shinozaki, Hiraku; Yamamoto, Tetsuya published the artcile< Synthesis and Catalysis of NHC Coordinated Cyclometalated Palladium(II) Complexes with Bridging Hydroxide Ligands>, Category: alcohols-buliding-blocks, the main research area is hydroxide palladium NHC addition catalyst boronic ester aldehyde ketone; crystal structure mol dipalladium hydroxide bridged heterocyclic carbene complex; palladium hydroxide bridged NHC cyclometalated dimer complex preparation.

1,2-Addition reactions using organoboron compounds are one of the useful syntheses of various functionalized alcs., but they generally require a large quantity of bases. In this study, we attempted to solve this problem by synthesizing unsym. 1,3-diarylimidazoline-type N-heterocyclic carbene (NHC)-coordinated CĈ* cyclometalated palladium(II) complexes with bridging hydroxide ligands (CYPOHs) in two steps and one pot from the corresponding Cl bridged dimer and using them as catalysts. 2,6-Di(pentan-3-yl)aniline (IPent)-based NHC coordinated PhS-IPent-CYPOH acted as a highly efficient catalyst for the 1,2-addition of (hetero)arylboronates to a large number of aldehydes and ketones, including unactivated ketones, under base-free conditions.

Advanced Synthesis & Catalysis published new progress about 1,2-Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Doan, Son H.; Hussein, Mohanad A.; Nguyen, Thanh Vinh published the artcile< Tropylium-promoted Ritter reactions>, Application In Synthesis of 76-84-6, the main research area is amide preparation microwave continuous flow; alc nitrile Ritter reaction tropylium salt catalyst.

Herein, the development of a new method using salts of the tropylium ion to promote the Ritter reaction was reported. This method works well on a range of alcs., e.g., 1-phenylethanol and nitriles, e.g., acetonitrile, giving the corresponding products, e.g., N-(1-phenylethyl)acetamide in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oloo, Williamson N.; Szavuly, Miklos; Kaizer, Jozsef; Que, Lawrence Jr. published the artcile< Nonheme diiron oxygenase mimic that generates a diferric-peroxo intermediate capable of catalytic olefin epoxidation and alkane hydroxylation including cyclohexane>, Computed Properties of 76-84-6, the main research area is nonheme diiron oxygenase mimic intermediate olefin epoxidation alkane hydroxylation.

Herein are described substrate oxidations with H2O2 catalyzed by [FeII(IndH)(CH3CN)3](ClO4)2 [IndH = 1,3-bis(2′-pyridylimino)isoindoline], involving a spectroscopically characterized (μ-oxo)(μ-1,2-peroxo)diiron(III) intermediate (2) that is capable of olefin epoxidation and alkane hydroxylation including cyclohexane. Species 2 also converts ketones to lactones with a decay rate dependent on [ketone], suggesting direct nucleophilic attack of the substrate carbonyl group by the peroxo species. In contrast, peroxo decay is unaffected by the addition of olefins or alkanes, but the label from H218O is incorporated into the epoxide and alc. products, implicating a high-valent iron-oxo oxidant that derives from O-O bond cleavage of the peroxo intermediate. These results demonstrate an ambiphilic diferric-peroxo intermediate that mimics the range of oxidative reactivities associated with O2-activating nonheme diiron enzymes.

Inorganic Chemistry published new progress about Alkenes Role: BUU (Biological Use, Unclassified), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nakajima, Isami; Shimizu, Minori; Okuda, Yuta; Akiyama, Ryo; Tadano, Ryu; Nagaoka, Masahiro; Uemura, Naohiro; Yoshida, Yasushi; Mino, Takashi; Shinozaki, Hiraku; Yamamoto, Tetsuya published the artcile< Synthesis and Catalysis of NHC Coordinated Cyclometalated Palladium(II) Complexes with Bridging Hydroxide Ligands>, Category: alcohols-buliding-blocks, the main research area is hydroxide palladium NHC addition catalyst boronic ester aldehyde ketone; crystal structure mol dipalladium hydroxide bridged heterocyclic carbene complex; palladium hydroxide bridged NHC cyclometalated dimer complex preparation.

1,2-Addition reactions using organoboron compounds are one of the useful syntheses of various functionalized alcs., but they generally require a large quantity of bases. In this study, we attempted to solve this problem by synthesizing unsym. 1,3-diarylimidazoline-type N-heterocyclic carbene (NHC)-coordinated CĈ* cyclometalated palladium(II) complexes with bridging hydroxide ligands (CYPOHs) in two steps and one pot from the corresponding Cl bridged dimer and using them as catalysts. 2,6-Di(pentan-3-yl)aniline (IPent)-based NHC coordinated PhS-IPent-CYPOH acted as a highly efficient catalyst for the 1,2-addition of (hetero)arylboronates to a large number of aldehydes and ketones, including unactivated ketones, under base-free conditions.

Advanced Synthesis & Catalysis published new progress about 1,2-Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Min; Jing, Ya-Nan; Bao, Hongli; Wan, Wen-Ming published the artcile< Triarylmethanolation as a versatile strategy for the conversion of PAHs into amorphization-induced emission luminogens for extremely sensitive explosive detection and fabrication of artificial light-harvesting systems>, Application In Synthesis of 76-84-6, the main research area is triarylmethanolation.

Current synthetic strategies involving π-system coupling reactions for the mol. design of luminescent materials suffer from the challenging precise synthesis on the desired reactive site and also difficulty in solubility derived from the rigid structures of π-systems. Herein, a novel and versatile triarylmethanolation strategy for the mol. design of luminescent materials with facile synthesis and good solubility is reported. The prepared luminescent materials exhibit unique amorphization-induced emission (AmIE) behaviors, which represent an entropy-favored and ubiquitous type of aggregation-induced emission that is currently famous and is contrary to crystallization-induced emission. Due to the outstanding AmIE behaviors, the luminescent materials exhibit applications in the fields of rewritable display and storage, extremely sensitive explosive detection at the ppb level, and high-efficiency artificial light-harvesting system with an antenna effect up to 21.3. This work therefore expands the methodol., structure, and functionality libraries of luminescent materials with outstanding properties in the application fields of explosive detection, energy transfer, and artificial light-harvesting systems.

Materials Chemistry Frontiers published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matthew, Susan; Chen, Qi-Yin; Ratnayake, Ranjala; Fermaintt, Charles S.; Lucena-Agell, Daniel; Bonato, Francesca; Prota, Andrea E.; Lim, Seok Ting; Wang, Xiaomeng; Diaz, J. Fernando; Risinger, April L.; Paul, Valerie J.; Oliva, Maria Angela; Luesch, Hendrik published the artcile< Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site>, Product Details of C19H16O, the main research area is natural product marine cyanobacterium cyclodepsipeptide Gatorbulin1 total synthesis; antitumor agent tubulin targeted chemotherapy microtubule drug mechanism action; GB1 total synthesis esterification protection peptide coupling macrolactamization reduction; crystal structure tubulin CB1 complex NMR conformer chelation fluorescence; cyanobacteria; marine natural product; microtubules; total synthesis; tubulin.

Tubulin-targeted chemotherapy has proven to be a successful and wide spectrum strategy against solid and liquid malignancies. Therefore, new ways to modulate this essential protein could lead to new antitumoral pharmacol. approaches. Currently known tubulin agents bind to six distinct sites at α/β-tubulin either promoting microtubule stabilization or depolymerization We have discovered a seventh binding site at the tubulin intradimer interface where a novel microtubule-destabilizing cyclodepsipeptide, termed gatorbulin-1 (GB1), binds. GB1 has a unique chemotype produced by a marine cyanobacterium. We have elucidated this dual chem. and mechanistic novelty through multidimensional characterization, starting with bioactivity-guided natural product isolation and multinuclei NMR-based structure determination, revealing the modified pentapeptide with a functionally critical hydroxamate group. and validation by total synthesis. The modified pentapeptide was validated by total synthesis. We have investigated the pharmacol. using isogenic cancer cell screening, cellular profiling, and complementary phenotypic assays, and unveiled the underlying mol. mechanism by in vitro biochem. studies and high-resolution structural determination of the α/β-tubulin-GB1 complex.

Proceedings of the National Academy of Sciences of the United States of America published new progress about (Fluorenylmethoxy)carbonyl group. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Haifan; Saltzberg, Daniel J.; Kratochvil, Huong T.; Jo, Hyunil; Sali, Andrej; DeGrado, William F. published the artcile< Glutamine Side Chain 13C=18O as a Nonperturbative IR Probe of Amyloid Fibril Hydration and Assembly>, Synthetic Route of 76-84-6, the main research area is glutamine carbon oxygen isotope amyloid fibril IR spectroscopy.

IR spectroscopy has provided considerable insight into the structures, dynamics, and formation mechanisms of amyloid fibrils. IR probes, such as main chain 13C=18O, have been widely employed to obtain site-specific structural information, yet only secondary structures and strand-to-strand arrangements can be probed. Very few nonperturbative IR probes are available to report on the side-chain conformation and environments, which are critical to determining sheet-to-sheet arrangements in steric zippers within amyloids. Polar residues, such as glutamine, contribute significantly to the stability of amyloids and thus are frequently found in core regions of amyloid peptides/proteins. Furthermore, polyglutamine (polyQ) repeats form toxic aggregates in several neurodegenerative diseases. Here the authors report the synthesis and application of a new nonperturbative IR probe-glutamine side chain 13C=18O. The authors use side chain 13C=18O labeling and isotope dilution to detect the presence of intermolecularly hydrogen-bonded arrays of glutamine side chains (Gln ladders) in amyloid-forming peptides. Moreover, the line width of the 13C=18O peak is highly sensitive to its local hydration environment. The IR data from side chain labeling allows us to unambiguously determine the sheet-to-sheet arrangement in a short amyloid-forming peptide, GNNQQNY, providing insight that was otherwise inaccessible through main chain labeling. With several different fibril samples, the authors also show the versatility of this IR probe in studying the structures and aggregation kinetics of amyloids. Finally, the authors demonstrate the capability of modeling amyloid structures with IR data using the integrative modeling platform (IMP) and the potential of integrating IR with other biophys. methods for more accurate structural modeling. Together, the authors believe that side chain 13C=18O will complement main chain isotope labeling in future IR studies of amyloids and integrative modeling using IR data will significantly expand the power of IR spectroscopy to elucidate amyloid assemblies.

Journal of the American Chemical Society published new progress about Amyloid fibril. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Longwitz, Lars; Jopp, Stefan; Werner, Thomas published the artcile< Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling>, Name: Triphenylmethanol, the main research area is alkyl chloride preparation organocatalyst alc chlorination.

A catalytic system for the chlorination of alcs. under Appel conditions was developed. Benzotrichloride was used as a cheap and readily available chlorinating agent in combination with trioctylphosphine as the catalyst and phenylsilane as the terminal reductant. The reaction has several advantages over other variants of the Appel reaction, e.g., no addnl. solvent is required and the phosphine reagent was used only in catalytic amounts In total, 27 different primary, secondary, and tertiary alkyl chlorides were synthesized in yields up to 95%. Under optimized conditions, it was also possible to convert epoxides and an oxetane to the dichlorinated products.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts