Category: 76-84-6

Sheng, Yu-Jing; Su, Min; Xiao, Hang; Shi, Quan-Xi; Sun, Xiao-Li; Zhang, Ruliang; Bao, Hongli; Wan, Wen-Ming published the artcile< Barbier Hyperbranching Polymerization-Induced Emission from an AB-Type Monomer>, Application of C19H16O, the main research area is Barbier hyperbranching polymerization induced emission photophys property; barbier reaction; hyperbranching polymerization; luminescence; nonconjugated polymer; polymerization-induced emission.

Luminescent polymer materials have gained considerable research efforts in the past decades and are generally mol. designed by extending the π system of the polymer main chain or by incorporating chromophores into the polymer chain, which suffer from poor solubility, difficult synthesis, or multi-step procedures. Meanwhile, according to the step-growth polymerization theory, synthesis of hyperbranched polymers from an AB-type monomer is still challenging. Herein, we report a one-pot synthesis of nonconjugated luminescent hyperbranched polymer material via Barbier hyperbranching polymerization-induced emission (PIE) from an AB-type monomer. The key step in the realization of the hyperbranched polymer is bi-functionalization of a mono-functional group. Through a Barbier reaction between an organohalide and an ester group in one pot, bi-functionalization of mono-functional ester is realized through two-step nucleophilic additions, resulting in hyperbranched polytriphenylmethanols (HPTPM). Attributed to through-space conjugation and inter- and intramol. charge-transfer effects induced by polymer chain, nonconjugated HPTPMs are PIEgens, which are tunable by monomer structure and polymerization time. When all Ph groups are rotatable, HPTPM is aggregation-induced emission type PIEgen. Whereas, it is aggregation-caused quenching type PIEgen if some Ph groups are rotation forbidden. Further potential applications of PIEgen are in the fields of explosive detection and artificial light harvesting systems. This work, therefore, expands the monomer library and mol. design library of hyperbranched polymers through “”bi-functionalization of mono-functional group”” strategy, which eventually expands the preparation library of nonconjugated luminescent polymer materials through one-pot PIE from nonemissive monomer.

Chemistry – A European Journal published new progress about Aggregation-induced emission. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rodriguez Tzompantzi, Tomasa; Amaro Hernandez, Aldo Guillermo; Meza-Leon, Rosa Luisa; Bernes, Sylvain published the artcile< Deciphering the hydrogen-bonding scheme in the crystal structure of triphenylmethanol: a tribute to George Ferguson and co-workers>, Quality Control of 76-84-6, the main research area is triphenylmethanol crystal structure hydrogen bond; alcohol; crystal structure; disorder; hydrogen bond; topological chirality; triphenylmethanol.

The crystal structure of triphenylmethanol, C19H16O, has been redetermined using data collected at 295 and 153 K, and is compared to the model published by Ferguson et al. over 25 years ago [Ferguson et al. (1992). Acta Crystalline C48, 1272-1275] and that published by Serrano-Gonzalez et al., using neutron and X-ray diffraction data [Serrano-Gonzalez et al. (1999). J. Phys. Chem. B, 103, 6215-6223]. As predicted by these authors, the hydroxy groups are involved in weak intermol. hydrogen bonds in the crystal, forming tetrahedral tetramers based on the two independent mols. in the asym. unit, one of which is placed on the threefold symmetry axis of the R [inline formula omitted] space group. However, the reliable determination of the hydroxy H-atom positions is difficult to achieve, for two reasons. Firstly, a positional disorder affects the full asym. unit, which is split over two sets of positions, with occupancy factors of ca 0.74 and 0.26. Secondly, all hydroxy H atoms are further disordered, either by symmetry, or through a positional disorder in the case of parts placed in general positions. We show that the correct description of the hydrogen-bonding scheme is possible only if diffraction data are collected at low temperature The prochiral character of the hydrogen-bonded tetrameric supramol. clusters leads to enantiomorphic three-dimensional graphs in each tetramer. The crystal is thus a racemic mixture of supS and supR motifs, consistent with the centrosym. nature of the R [inline formula omitted] space group.

Acta Crystallographica, Section C: Structural Chemistry published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Quality Control of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comotti, A.; Castiglioni, F.; Bracco, S.; Perego, J.; Pedrini, A.; Negroni, M.; Sozzani, P. published the artcile< Fluorinated porous organic frameworks for improved CO2 and CH4 capture>, SDS of cas: 76-84-6, the main research area is fluoropolymer polyacetylene synthesis adsorbent carbon dioxide methane adsorption.

A porous 3D selectively fluorinated framework (F-PAF1), robust yet flexible and with a surface area of 2050 M2 g-1, was synthesized by condensation of an ad hoc prepared fluorinated tetraphenylmethane (TPM) monomer to ensure homogeneously distributed C-F dipoles in the swellable architecture. Tetradentate TPM was also the comonomer for the reaction with fluorinated difunctional monomers to obtain frameworks (FMFs) with a controlled amount of regularly spaced reorientable C-F dipoles. The isosteric heat of adsorption of CO2 was increased by 53% by even moderate C-F dipole insertion, with respect to the non-fluorinated frameworks. CO2/N2 selectivity was also increased up to a value of 50 for the difluoro-containing comonomer. Moreover, methane shows optimal interaction energies of 24 kJ mol-1.

Chemical Communications (Cambridge, United Kingdom) published new progress about Adsorbents. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, SDS of cas: 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Jianwu; Shi, Yinfei; Li, Xiao; Liang, Xiaomin; Wang, Yinquan; Yuan, Shun; Wu, Taizhi published the artcile< Understanding and Controlling the Formation of an N-Alkyl Impurity in Olmesartan Medoxomil: A Derivative via Michael-Type Addition between Tetrazole and Mesityl Oxide In Situ Generated from Acetone>, COA of Formula: C19H16O, the main research area is olmesartan medoxomil API impurity quality by design definitive screening.

An unknown impurity was detected in olmesartan medoxomil active pharmaceutical ingredient (API), which was determined as 2-methyl-4-oxopentan-2-yl-protected olmesartan medoxomil by NMR and mass spectrometry (MS). The formation mechanism of this impurity was investigated. In summary, the tetrazole of the final product was condensed with the potential genotoxic compound mesityl oxide generated from acetone self-condensation in acidic conditions to form the N-Alkyl impurity. Further quality control of the reaction was investigated using statistical methods (design of experiment, DoE) via a definitive screening design. The key factors of the reaction were determined to control the process parameters. Three batches of validation experiments showed that the generation of the N-Alkyl impurity was suppressed (<0.1%) and the residual mesityl oxide was not detected (<2.5 ppm). Organic Process Research & Development published new progress about Antihypertensives. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, COA of Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Seki, Tomohiro; Mashimo, Takaki; Ito, Hajime published the artcile< Anisotropic strain release in a thermosalient crystal: correlation between the microscopic orientation of molecular rearrangements and the macroscopic mechanical motion>, COA of Formula: C19H16O, the main research area is anisotropic strain thermosalient crystal structure microscopic orientation.

The salient effect, which refers to a jumping phenomenon of org and organometallic mol. crystals typically triggered by phase transitions in response to external stimuli, has been investigated intensively in the last five years. A challenging topic in this research area is the question of how to characterize the release of microscopic strain accumulated during phase transitions, which generates macroscopic mech. motion. Herein, we describe the thermosalient effect of the triphenylethenyl gold 4-chlorophenyl isocyanide complex 1, which jumps reversibly at approx -100°C upon cooling at 50°C min-1 and heating at 30°C min-1. Single-crystal X-ray diffraction measurements and differential scanning calorimetric analyses of 1 suggest the occurrence of a thermal phase transition at this temperature Detailed structural analyses indicate that anisotropic changes to the mol arrangement occur in 1, whereby the crystallog a axis contracts upon cooling while the b axis expands. Simultaneously, macroscopic changes of the crystal dimensions occur. This is observed as bending, i.e., as an inclination of the crystal edges, and in the form of splitting, which occurs in a perpendicular direction to the major crystal axis. This study thus bridges the gap between macroscopic mech responses that are observed in high-speed photog images and microscopic changes of the crystal structure, which are evaluated by X-ray diffraction measurements with face indexing.

Chemical Science published new progress about Bending. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, COA of Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kinsinger, Thorsten; Kazmaier, Uli published the artcile< Application of Vinyl Nucleophiles in Matteson Homologations>, Synthetic Route of 76-84-6, the main research area is allyl boronic ester preparation enantioselective; alkyl boronic ester vinyl nucleophile Grignard reagent Matteson homologation.

The Matteson homologation with vinyl nucleophiles was found to be a versatile tool for the synthesis of highly substituted and functionalized allyl boronic esters I (R = phenylethyl, Me, butan-2-yl, etc.), II (R1 = H, Me; R2 = H, Me; R3 = H, Me), III and IV (R4 = Me, Et, n-Pr; R5 = H, Me). High yields and stereoselectivities are obtained with sterically demanding alkyl boronic esters and/or Grignard reagents. With the application of such vinyl Matteson homologations, the polyketide fragment of lagunamide B is synthesized.

Organic Letters published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Amtawong, Jaruwan; Skjelstad, Bastian Bjerkem; Handford, Rex C.; Suslick, Benjamin A.; Balcells, David; Tilley, T. Don published the artcile< C-H Activation by RuCo3O4 Oxo Cubanes: Effects of Oxyl Radical Character and Metal-Metal Cooperativity>, Electric Literature of 76-84-6, the main research area is carbon hydrogen bond activation ruthenium cobalt oxo cubane; oxyl radical preparation character metal cooperativity.

High-valent multimetallic-oxo/oxyl species have been implicated as intermediates in oxidative catalysis involving proton-coupled electron transfer (PCET) reactions, but the reactive nature of these oxo species has hindered the development of an in-depth understanding of their mechanisms and multimetallic character. The mechanism of C-H oxidation by previously reported RuCo3O4 cubane complexes bearing a terminal RuV-oxo ligand, with significant oxyl radical character, was investigated. The rate-determining step involves H atom abstraction (HAA) from an organic substrate to generate a Ru-OH species and a carbon-centered radical. Radical intermediates are subsequently trapped by another equivalent of the terminal oxo to afford isolable radical-trapped cubane complexes. D. functional theory (DFT) reveals a barrierless radical combination step that is more favorable than an oxygen-rebound mechanism by 12.3 kcal mol-1. This HAA reactivity to generate organic products is influenced by steric congestion and the C-H bond dissociation energy of the substrate. Tuning the electronic properties of the cubane (i.e., spin d. localized on terminal oxo, basicity, and redox potential) by varying the donor ability of ligands at the Co sites modulates C-H activations by the RuV-oxo fragment and enables construction of structure-activity relationships. These results reveal a mechanistic pathway for C-H activation by high-valent metal-oxo species with oxyl radical character and provide insights into cooperative effects of multimetallic centers in tuning PCET reactivity.

Journal of the American Chemical Society published new progress about C-H bond activation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nandi, Poulomi; Goel, Komal; Sreenivasulu, Chinnabattigalla; Satyanarayana, Gedu published the artcile< Microwave-Assisted Condensation of Benzylic Alcohols and Alkynes Promoted by Zinc Halides: Concise Access to Alkenyl Halides>, Synthetic Route of 76-84-6, the main research area is benzylic alc terminal alkyne zinc halide condensation microwave green; alkenyl halide indene ketone preparation regioselective.

A simple Lewis acid-mediated route for the synthesis of alkenyl halides under microwave-assisted conditions is described. The reaction proceeds through condensation of secondary alcs. with terminal acetylenes and regioselective hydrohalogenation across the triple bond in the presence of simple and com. available zinc halides. Unlike earlier reports, the methodol. is successfully exemplified with three halide sources. As a result, a diverse range of alkenyl halide products have been obtained. Further, indenes were obtained as the end products when tertiary alcs. and arylacetylenes were used, wherein the Thorpe-Ingold and electronic effects, would be dominant. Furthermore, when an electron-rich arylacetylene was employed, the reaction yielded carbonyl products.

European Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ottenbacher, Roman V.; Bryliakova, Anna A.; Shashkov, Mikhail V.; Talsi, Evgenii P.; Bryliakov, Konstantin P. published the artcile< To Rebound or...Rebound? Evidence for the ""Alternative Rebound"" Mechanism in C-H Oxidations by the Systems Nonheme Mn Complex/H2O2/Carboxylic Acid>, Reference of 76-84-6, the main research area is oxidation mechanism nonheme manganese complex hydrogen peroxide carboxylic acid.

In this work, it has been shown that aliphatic C-H oxidations by bioinspired catalyst systems Mn aminopyridine complex/H2O2/carboxylic acid in acetonitrile afford predominantly a mixture of the corresponding alc. and the ester. The alc./ester ratio is higher for catalysts bearing electron-donating groups at the aminopyridine core. Isotopic labeling studies witness that the oxygen atom of the alc. originates from the H2O2 mol., while the ester oxygen comes exclusively from the acid. Oxidation of ethylbenzene in the presence of acetic acid affords enantiomerically enriched 1-phenylethanol and 1-Ph acetate, with close enantioselectivities and the same sign of absolute chirality. Exptl. data and d. functional theory calculations provide evidence in favor of the rate-limiting benzylic H atom abstraction by the high-spin (S = 1) [LMnV(O)OAc]2+ active species followed by competitive OH/OC(O)R rebound. This mechanism has been unprecedented for C-H oxidations catalyzed by bioinspired Mn complexes. The trends governing the alc./ester ratios have been rationalized in terms of steric properties of the catalyst, acid, and substrate.

ACS Catalysis published new progress about Alkylarenes Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Ivy; Chakraborty, Biswarup; Bera, Abhijit; Paul, Satadal; Paine, Tapan Kanti published the artcile< Selective oxygenation of C-H and C=C bonds with H2O2 by high-spin cobalt(II)-carboxylate complexes>, Application of C19H16O, the main research area is cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex catalyst preparation; Reaction kinetics cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex; crystal structure cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex; electrochem DFT cobalt aminemethyltrispyridine phenylacetato benzoato benzilato mandelato complex.

Four cobalt(II)-carboxylate complexes [(6-Me3-TPA)CoII(benzoate)](BPh4) (1), [(6-Me3-TPA)CoII(benzilate)](ClO4) (2), [(6-Me3-TPA)CoII(mandelate)](BPh4) (3), and [(6-Me3-TPA)CoII(MPA)](BPh4) (4) (HMPA = 2-methoxy-2-phenylacetic acid) of the 6-Me3-TPA (tris((6-methylpyridin-2-yl)methyl)amine) ligand were isolated to investigate their ability in H2O2-dependent selective oxygenation of C-H and CC bonds. All six-coordinate complexes contain a high-spin cobalt(II) center. While the cobalt(II) complexes are inert toward dioxygen, each of these complexes reacts readily with hydrogen peroxide to form a diamagnetic cobalt(III) species, which decays with time leading to the oxidation of the Me groups on the pyridine rings of the supporting ligand. Intramol. ligand oxidation by the cobalt-based oxidant is partially inhibited in the presence of external substrates, and the substrates are converted to their corresponding oxidized products. Kinetic studies and labeling experiments indicate the involvement of a metal-based oxidant in affecting the chemo- and stereo-selective catalytic oxygenation of aliphatic C-H bonds and epoxidation of alkenes. An electrophilic cobalt-oxygen species that exhibits a kinetic isotope effect (KIE) value of 5.3 in toluene oxidation by 1 is proposed as the active oxidant. Among the complexes, the cobalt(II)-benzoate (1) and cobalt(II)-MPA (4) complexes display better catalytic activity compared to their α-hydroxy analogs (2 and 3). Catalytic studies with the cobalt(II)-acetonitrile complex [(6-Me3-TPA)CoII(CH3CN)2](ClO4)2 (5) in the presence and absence of externally added benzoate support the role of the carboxylate co-ligand in oxidation reactions. The proposed catalytic reaction involves a carboxylate-bridged dicobalt complex in the activation of H2O2 followed by the oxidation of substrates by a metal-based oxidant.

Dalton Transactions published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts