Category: 76-84-6

Kato, Yuichi; Inoue, Tomoka; Furuyama, Yuuki; Ohgane, Kenji; Sadaie, Mahito; Kuramochi, Kouji published the artcile< Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile>, Recommanded Product: Triphenylmethanol, the main research area is alkane preparation; tertiary secondary alc deoxygenation.

In this study, a deoxygenation method was developed for tertiary and secondary alcs., ROH [R = triphenylmethyl, 9-phenyl-9H-xanthen-9-yl, bis(4-methoxyphenyl)(thiophen-2-yl)methyl, etc.] using trimethylsilane and trimethylsilyl iodide generated in situ from sodium borohydride and trimethylsilyl chloride, and trimethylsilyl chloride and potassium iodide, resp. In this method, tertiary and secondary alcs., which provided stable carbocations, were converted into the corresponding alkanes RH. This paper also presents the optimization of the reaction conditions, the reaction mechanism, as well as the scope and limitations of the method.

Tetrahedron Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jennings, Julia J.; Milic, Mira; Targos, Karina; Franz, Annaliese K. published the artcile< NMR quantification of H-bond donating ability for bioactive functional groups and isosteres>, Reference of 76-84-6, the main research area is pharmaceutical hydrogen bond donor functional group NMR spectroscopy; (31)P NMR spectroscopy; Binding interaction; Drug fragment; Drug molecule; Hydrogen-bond donors; Isostere; Molecular interactions; Parameterization; Small molecules; TEPO.

The H-bond donating ability for 127 compounds including drug fragments and isosteres have been quantified using a simple and rapid method with 31P NMR spectroscopy. Functional groups important to medicinal chem. were evaluated including carboxylic acids, alcs., phenols, thioic acids and nitrogen group H-bond donors. 31P NMR shifts for binding to a phosphine oxide probe have a higher correlation with equilibrium constants for H-bonding (log KHA) than acidity (pKa), indicating that these binding experiments are representative of H-bonding ability and not proton transfer. Addnl., 31P NMR binding data for carboxylic acid isosteres correlates with physicochem. properties such as lipophilicity, membrane permeability and plasma protein binding. This method has been used to evaluate the H-bond donating ability of small mol. drug compounds such as NSAIDs and antimicrobials.

European Journal of Medicinal Chemistry published new progress about Antimicrobial agents. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Munshi, Sandip; Sinha, Arup; Yiga, Solomon; Banerjee, Sridhar; Singh, Reena; Hossain, Kamal Md.; Haukka, Matti; Valiati, Andrei Felipe; Huelsmann, Ricardo Dagnoni; Martendal, Edmar; Peralta, Rosely; Xavier, Fernando; Wendt, Ola F.; Paine, Tapan K.; Nordlander, Ebbe published the artcile< Hydrogen-atom and oxygen-atom transfer reactivities of iron(IV)-oxo complexes of quinoline-substituted pentadentate ligands>, Product Details of C19H16O, the main research area is iron quinolinylpyridylmethylamine complex preparation; crystal structure iron quinolinylpyridylmethylamine complex.

A series of iron(II) complexes with the general formula [FeII(L2-Qn)(L)]n+ (n = 1, L = F-, Cl-; n = 2, L = NCMe, H2O) were isolated and characterized. The X-ray crystallog. data reveals that metal-ligand bond distances vary with varying ligand field strengths of the sixth ligand. While the complexes with fluoride, chloride and water as axial ligand are high spin, the acetonitrile-coordinated complex is in a mixed spin state. The steric bulk of the quinoline moieties forces the axial ligands to deviate from the Fe-N-axial axis. A higher deviation/tilt is noted for the high spin complexes, while the acetonitrile coordinated complex displays least deviation. This deviation from linearity is slightly less in the analogous low-spin iron(II) complex [FeII(L1-Qn)(NCMe)]2+ of the related asym. ligand L1-Qn due to the presence of only one sterically demanding quinoline moiety. The two iron(II)-acetonitrile complexes [FeII(L2-Qn)(NCMe)]2+ and [FeII(L1-Qn)(NCMe)]2+ generate the corresponding iron(IV)-oxo species with higher thermal stability of the species supported by the L1-Qn ligand. The crystallog. and spectroscopic data for [FeIV(O)(L1-Qn)](ClO4)2 bear resemblance to other crystallog. characterized S = 1 iron(IV)-oxo complexes. The hydrogen atom transfer (HAT) and oxygen atom transfer (OAT) reactivities of both the iron(IV)-oxo complexes were investigated, and a Box-Behnken multivariate optimization of the parameters for catalytic oxidation of cyclohexane by [FeII(L2-Qn)(NCMe)]2+ using hydrogen peroxide as the terminal oxidant is presented. An increase in the average Fe-N bond length in [FeII(L1-Qn)(NCMe)]2+ is also manifested in higher HAT and OAT rates relative to the other reported complexes of ligands based on the N4Py framework. The results reported here confirm that the steric influence of the ligand environment is of critical importance for the reactivity of iron(IV)-oxo complexes, but addnl. electronic factors must influence the reactivity of iron-oxo complexes of N4Py derivatives

Dalton Transactions published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ou, Wei; Xiang, Xudong; Zou, Ru; Xu, Qing; Loh, Kian Ping; Su, Chenliang published the artcile< Room-Temperature Palladium-Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals>, Recommanded Product: Triphenylmethanol, the main research area is palladium catalyzed deuterogenolysis carbon oxygen bond preparation deuterated pharmaceutical; alc ketone deoxygenative deuteration; chemoselectivity; deoxygenative deuteration; drug molecules; electrocatalysis; reduction.

Site-specific incorporation of deuterium into drug mols. to study and improve their biol. properties is crucial for drug discovery and development. Herein, we describe a palladium-catalyzed room-temperature deuterogenolysis of carbon-oxygen bonds in alcs. and ketones with D2 balloon for practical synthesis of deuterated pharmaceuticals and chems. with benzyl-site (sp3 C-H) D-incorporation. The highlights of this deoxygenative deuteration strategy are mild conditions, broad scope, practicability and high chemoselectivity. To enable the direct use of D2O, electrocatalytic D2O-splitting is adapted to in situ supply D2 on demand. With this system, the precise incorporation of deuterium in the metabolic position (benzyl-site) of ibuprofen is demonstrated in a sustainable and practical way with D2O.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lubov, Dmitry P.; Bryliakova, Anna A.; Samsonenko, Denis G.; Sheven, Dmitriy G.; Talsi, Evgenii P.; Bryliakov, Konstantin P. published the artcile< Palladium-Aminopyridine Catalyzed C-H Oxygenation: Probing the Nature of Metal Based Oxidant>, Product Details of C19H16O, the main research area is palladium aminopyridine catalyzed carbon hydrogen bond oxygenation mechanism.

A mechanistic study of direct selective oxidation of benzylic C(sp3)-H groups with peracetic acid, catalyzed by palladium complexes with tripodal amino-tris(pyriylmethyl) ligands, is presented. The oxidation of arylalkanes having secondary and tertiary benzylic C-H groups, predominantly yields, depending on the substrate and conditions, either the corresponding ketones or alcs. One of the three 2-pyridylmethyl moieties, which is pending in the starting catalyst, apparently, facilitates the active species formation and takes part in stabilization of the high-valent Pd center in the active species, occupying the axial coordination site of palladium. The catalytic, as well as isotopic labeling experiments, in combination with ESI-MS data and DFT calculations, point out palladium oxyl species as possible catalytically active sites, operating essentially via C-H abstraction/oxygen rebound pathway. For the ketones formation, O-H abstraction/β-scission mechanism has been proposed.

ChemCatChem published new progress about Alkylarenes Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Chen; Hong, Gang; Nahide, Pradip D.; He, Yuchen; Zhou, Chen; Kozlowski, Marisa C.; Wang, Limin published the artcile< C(sp3)-H Hydroxylation of fluorenes, oxindoles and benzofuranones with a Mg(NO3)2-HP(O)Ph2 oxidation system>, Safety of Triphenylmethanol, the main research area is hydroxyfluorene preparation; fluorene hydroxylation; hydroxyoxindole preparation; oxindole hydroxylation; hydroxybenzofuranone preparation; benzofuranone hydroxylation.

A novel oxidation system consisting of magnesium nitrate [Mg(NO3)2] as an oxidant in the presence of diphenylphosphine oxide [HP(O)Ph2] was developed for the synthesis of hydroxyfluorenes I [R = n-Pr, Ph, 1-naphthyl, etc.; R1 = H, 2-NO2], hydroxyoxindoles II [R2 = Me, Ph, Bn, etc.; R3 = H, 5-Me, 5-t-Bu, etc.; X = NMe, NBn] and hydroxybenzofuranones II [X = O] via C(sp3)-H hydroxylation of fluorenes, oxindoles and benzofuranones. This method featured high efficiency, good functional group tolerance and operational simplicity.

Organic Chemistry Frontiers published new progress about Benzofurans Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xinya; Wang, Xiaohua; Zhen, Nuo; Gu, Jin; Zhang, Hao; Dong, Bo; Wang, Feng; Liu, Heng published the artcile< Sodium complexes bearing cavity-like conformations: a highly active and well-controlled catalytic system for macrolactone homo- and copolymerization>, COA of Formula: C19H16O, the main research area is sodium complex catalyst ROP macrolactone homo copolymerization.

This report describes the synthesis of a series of sodium complexes bearing cavity-like conformations formed with the aid of sterically hindered phenoxide and 15-crown-5 ether ligands. All the complexes are well-characterized via NMR spectroscopy anal., and through single crystal X-ray studies and DFT calculations it is found that the size of the cavity is very similar to that of macrolactone monomers. During subsequent studies of the ring-opening polymerization (ROP) of macrolactones, the present sodium complexes demonstrate high catalytic efficiencies in the ROP of pentadecalactone and ethylene brassylate, affording the corresponding polyester products in high yields. Moreover, due to chain propagation being confined within the cavity, transesterification can be suppressed because of mutual steric repulsion between the ligands and polymer chains, which further allows polymerization to proceed in a well-controlled manner. Owing to such uniqueness, block copolymerization between macrolactones and other cyclic esters can be also successfully achieved.

Polymer Chemistry published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, COA of Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alhamed, Samiyah; Alnakhli, Jawzah; Boadi, William; Beni, Ryan published the artcile< Triphenylmethanol conjugates of triptorelin as anti-lipid peroxidation prodrugs>, Electric Literature of 76-84-6, the main research area is triphenylmethanol triptorelin antilipid peroxidation.

Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable mols. that the body produces as a reaction to environmental and other pressures. Free radicals may play a role in heart disease, cancer and other diseases. If the body cannot process and remove free radicals efficiently, oxidative stress can result. This can harm cells and body function. Free radicals are also known as reactive oxygen species (ROS). In this research, Triptorelin (TRP) conjugates of triphenylmethanol derivatives (TPMs) were synthesized to evaluate their in vitro lipid peroxidation potency. Comparative lipid peroxidation assays between TRP-TPMs conjugates and the corresponding TPMs derivatives were measured using thiobarbituric reactive substance (TBARS) in a dose- and time-dependent manner following the Fenton’s pathway. Overall, TBARS decreased between 20% – 30% for the treated samples of synthesized conjugates compared to their resp. control phys. mixtures These data suggest that TRP-TPMs derivatives can be used to improve the biol. activity of TRP.

Open Journal of Medicinal Chemistry published new progress about Lipid peroxidation. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Electric Literature of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diemoz, Kayla M.; Franz, Annaliese K. published the artcile< NMR Quantification of Hydrogen-Bond-Activating Effects for Organocatalysts including Boronic Acids>, Synthetic Route of 76-84-6, the main research area is NMR quantification hydrogen bond activation organocatalyst boronic acid.

The hydrogen-bonding activation for 66 organocatalysts has been quantified using a 31P NMR binding experiment with triethylphosphine oxide (TEPO). Diverse structural classes, including phenols, diols, silanols, carboxylic acids, boronic acids, and phosphoric acids, were examined with a variety of steric and electronic modifications to understand how the structure and secondary effects contribute to hydrogen-bonding ability and catalysis. Hammett plots demonstrate high correlation for the Δδ 31P NMR shift to Hammett parameters, establishing the ability of TEPO binding to predict electronic trends. Upon correlation to catalytic activity in a Friedel-Crafts addition reaction, data demonstrate that 31P NMR shifts correlate to catalytic activity better than pKa values. Boronic acids were investigated, and 31P NMR binding experiments predicted strong hydrogen-bonding ability, for which catalytic activity was confirmed, resulting in the greatest rate enhancement observed in the Friedel-Crafts addition of all organocatalysts studied. A detailed investigation supports that boronic acid activation proceeds through hydrogen-bonding interactions and not coordination with the Lewis acidic boron center. Using 31P NMR spectroscopy offers a simple and rapid tool to quantify and predict hydrogen-bonding abilities for the design and applications of new organocatalysts and supramol. synthons.

Journal of Organic Chemistry published new progress about Alcohols Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), USES (Uses), PROC (Process). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Synthetic Route of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Graton, J.; Besseau, F.; Goupille, A.; Le Questel, J.-Y. published the artcile< Hydrogen-bond acidity of silanols: A combined experimental and theoretical study>, Name: Triphenylmethanol, the main research area is quantum chem hydrogen bond acidity silanol.

The hydrogen-bond (H-bond) donating ability of a series of silanol derivatives has been determined by FTIR spectrometry and complemented by quantum chem. calculations at the DFT (MPWB1K/6-31+G(d,p)) level. The equilibrium constants of complexation with N-methylpyrrolidinone have been measured in CCl4 solutions These data expand the pKAHY scale previously covering the field of aliphatic alcs., phenols and fluorohydrins. Compared to the corresponding alc. derivatives, the silanol chem. function is a stronger H-bond donor, although the observed frequency shifts, ΔνOH, suggest much greater differences in donor strength than is actually observed The electrostatic potential descriptor, Vα(r), is successfully used to complete the pKAHY vs. Vα(r) relationship, a helpful methodol. to validate the exptl. data and to estimate the H-bond acidity of unavailable, unstable, or immiscible compounds

Journal of Molecular Structure published new progress about Acidity. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts