Category: 76-84-6

Zhang, Zhenguo; Liu, Xiaoxiao; Ji, Liang; Zhang, Ting; Jia, Zhenhua; Loh, Teck-Peng published the artcile< Metal-Free Access to (Spirocyclic)Tetrahydro-β-carbolines in Water Using an Ion-Pair as a Superacidic Precatalyst>, Reference of 76-84-6, the main research area is tetrahydro carboline preparation; aryl aldehyde tryptamine Pictet Spengler triarylcarbonium ion pair catalyst; spirocyclic tetrahydro carboline preparation; cyclic ketone tryptamine Pictet Spengler triarylcarbonium ion pair catalyst.

The unprecedented triarylcarbonium ion-pair-catalyzed Pictet-Spengler reaction of tryptamines with aromatic aldehydes and cyclic ketones in water was disclosed. Under metal-free conditions, diverse tetrahydro-β-carbolines/spirocyclic tetrahydro-β-carbolines I [R1 = H, Me, Cl, etc.; R2 = H; R3 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2R3 = (CH2)5, CH2CH2CH(Me)CH2CH2, CH2CH2N(Boc)CH2CH2, etc.] were obtained in good yields with excellent functional group tolerance, including late-stage modification of natural products and small mol. drugs. The practicability of this protocol was also characterized in the gram-scale synthesis of komavine and several other functional compounds Preliminary mechanistic studies indicated that in aqueous media the in situ-generated superacidic species from the carbonium ion pair with water was crucial to promote the Pictet-Spengler reaction.

ACS Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Reference of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sai, Masahiro published the artcile< Direct Synthesis of Indanes via Iron-Catalyzed Dehydrative Coupling/Friedel-Crafts Cyclization of Two Different Alcohols>, Safety of Triphenylmethanol, the main research area is iron catalyzed cascade dehydrative coupling Friedel Crafts alc; indane synthesis atom economic green.

We report herein a novel iron-catalyzed cascade dehydrative coupling/Friedel-Crafts cyclization of two different alcs., providing a variety of indanes, which are ubiquitous substructures found in natural products, pharmaceuticals, and functional materials. Importantly, the developed approach is highly atom-economic and environmentally benign, as it employs readily available alcs. as substrates and generates water as the only byproduct. Thus, e.g., benzhydrol + t-BuOH → 1,1-dimethyl-3-phenylindan (82%) employing Fe(OTf)3 and PhCF3 as solvent at 105°.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moon, Hye Won; Maity, Ayan; Radosevich, Alexander T. published the artcile< Ancillary Tethering Influences σ3-P vs σ5-P Speciation and Enables Intermolecular S-H Oxidative Addition to Nontrigonal Phosphorus Compounds>, Formula: C19H16O, the main research area is dibenzoazepine phosphoramide preparation oxidative addition alc thiol phosphorane; crystal structure dibenzoazepine alkoxy alkylthio phosphorane; mol structure dibenzoazepine alkoxy alkylthio phosphorane.

The design and synthesis of dibenzoazepine-based nontrigonal phosphorus(III) triamide (2), bearing a peripheral ethylene bridge is described. By comparison to a compound lacking the ethylene bridge, PN(o-NMeC6H4)2 (1), the dibenzoazepine 2 is shown to exclusively form σ5-P oxidative addition products upon E-H addition (E = OR, SR) in preference to a σ3-P adduct from cooperative addition across one P-N bond. The resulting pentacoordinate phosphoranes have been characterized by multinuclear NMR spectroscopy and X-ray crystallog. DFT calculations on relative energies of σ3-P and σ5-P species indicate that the ethylene linker in 2 energetically destabilizes the σ3-P tautomer of the phosphorane product (2·[H][E]) by constraining rotation along the C-N bond, favoring formation of σ5-P phosphoranes by ring-chain tautomerism.

Organometallics published new progress about Azepines Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation) (dibenzo[b,f]azepines). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lakk-Bogath, Dora; Kripli, Balazs; Meena, Bashdar I.; Speier, Gabor; Kaizer, Jozsef published the artcile< Catalytic and stoichiometric C-H oxidation of benzylalcohols and hydrocarbons mediated by nonheme oxoiron(IV) complex with chiral tetrapyridyl ligand>, Formula: C19H16O, the main research area is oxidation hydroxylation benzylalc hydrocarbon kinetic nonheme oxoiron complex.

Bioinspired chiral iron(II) complex [((R)-(-)-N4Py*)FeII(MeCN)]2+ (1) (N4Py* = N,N-bis(2-pyridylmethyl)-1,2-di(2-pyridyl)ethylamine) has been shown to efficiently catalyze the benzylic C-H oxidation of ethylbenzene with tert-Bu hydroperoxide (TBHP), H2O2, and meta-chloroperoxybenzoic acid (mCPBA) resulting in enantiomerically enriched 1-phenylethanol up to 12.5% ee and the corresponding acetophenone, where the [FeIV(N4Py*)(O)]2+ (2) intermediate has been detected by UV/visible spectrometry. The stoichiometric oxidation of benzyl alc. and various hydrocarbon derivatives including the asym. hydroxylation of ethylbenzene with 2 has also been investigated. Detailed kinetic, and mechanistic studies (kinetic isotope effect (KIE) of 31 and 38, and Hammett correlation with ρ = -0.32 and -0.98 for PhCH2OH and PhCH3, resp., and the linear correlation between the normalized bimol. reaction rates and bond dissociation energies (BDECH)) indicated that the rate-determining step in these reactions above involves hydrogen-atom transfer between the substrate and the Fe(IV)-oxo species. The stoichiometric 2-mediated hydroxylation of ethylbenzene affords 1-phenylethanol in up to 33% ee, suggesting clear evidence for the involvement of the oxoiron(IV) species in the enantioselective step. The moderate enantioselectivity may be explained by the epimerization of the long-lived substrate radical before the rebound step (non-rebound mechanism, where kep > kreb). The kinetic resolution of the resulting chiral alc. due to its metal-based overoxidn. process into acetophenone in the catalytic metal-based ethylbenzene oxidation can be excluded.

Inorganic Chemistry Communications published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (benzylalcs.). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Beni, Ryan; Boadi, William; Karim, Kaleh; Alnakhli, Jawzah; Alhamed, Samiyah published the artcile< Synthesis and antiproliferative activities of triphenylmethanol conjugates of leuprorelin>, Formula: C19H16O, the main research area is leuprorelin triphenylmethanol conjugate antiproliferative invasive ductal prostate carcinoma adipocyte.

Leuprorelin (LEP) is an FDA drug for breast cancer and prostate cancer treatment. There are several reported adverse effects such as transient hypertension, excessive salivation, and increased dysuria during treatment with LEP. In this study, the efficacy and toxicity of LEP were modified by using a drug delivery system to adjust the physicochem. properties. In this regard, Leuprorelin conjugates of triphenylmethanol derivatives (TPMs) were synthesized as prodrugs. Comparative antiproliferative assays showed that LEP-TPMs conjugates had significantly higher antiproliferative activities than the corresponding non-covalent phys. mixtures of the TPMs and LEP against human invasive ductal carcinoma (BT549), human prostate carcinoma (PC3), human lung cancer (A549) and mouse pre-adipocytes (3T3-L1) cells.

Open Journal of Medicinal Chemistry published new progress about Adipocyte, preadipocyte. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Liangzhen; Hussain, Muhammad Ijaz; Deng, Qingfu; Liu, Qing; Feng, Yangyang; Zhang, Xiaohui; Xiong, Yan published the artcile< I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process>, Safety of Triphenylmethanol, the main research area is unsaturated nitrile phenylnitirile preparation dual activated cyanation diarylalc.

One-step base promoted strategy for cyanation of α,α-diaryl alcs. has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, resp., up to 99% yield. Moreover, various azides and ethers could also be accessed from their resp. nucleophiles under standard reaction conditions.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (α,α-diaryl). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Si-Xuan; Ding, Yan; Wang, Jun-Jie; Shen, Chuanji; Zhou, Xiaocong; Chu, Xue-Qiang; Ma, Mengtao; Shen, Zhi-Liang published the artcile< Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives>, Safety of Triphenylmethanol, the main research area is diaryl ester preparation; ethoxycyclopropoxy trimethylsilane diaryl methanol ring opening dehydroxylative cross coupling.

A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl-substituted methanols R(R1)C(OH)R2 (R = Ph, 2-methylphenyl, 4-iodophenyl, naphthalen-1-yl, etc.; R1 = H, Ph, 4-methylphenyl, 4-chlorophenyl; R2 = Ph, 4-methoxyphenyl, 4-fluorophenyl, etc.) with a (1-ethoxycyclopropoxy)trimethylsilane was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters R(R1)C((CH2)2C(O)OCH2CH3)R2 in moderate to good yields, which could be applied to the functionalization of complex mols. I and II derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft III.

Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Afewerki, Samson; Palo-Nieto, Carlos; Cordova, Armando published the artcile< Efficient Heterogeneous Palladium-Catalyzed Transfer Hydrogenolysis of Benzylic Alcohols by Formic Acid>, Product Details of C19H16O, the main research area is benzylic alc formic acid palladium catalyst chemoselective transfer hydrogenolysis; alkyl benzene preparation.

An efficient heterogeneous palladium-catalyzed transfer hydrogenolysis of primary, secondary and tertiary benzylic alcs. using formic acid as hydrogen source was developed. The resulting hydrocarbon products were obtained in excellent yields. Moreover, the system exhibited high chemoselectivity, reacting only with the hydroxy groups in the presence of other functional groups and excellent recyclability.

Synthesis published new progress about Alkylbenzenes Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uehara, Tomoya; Kanazawa, Naoki; Suzuki, Chie; Mizuno, Yuki; Suzuki, Hiroyuki; Hanaoka, Hirofumi; Arano, Yasushi published the artcile< Renal Handling of 99mTc-Labeled Antibody Fab Fragments with a Linkage Cleavable by Enzymes on Brush Border Membrane>, Related Products of 76-84-6, the main research area is technetium 99m Fab fragment linkage cleavage renal brush border.

The high and persistent renal radioactivity levels after injection of radiolabeled low-mol.-weight polypeptides constitute a significant problem for their diagnostic and therapeutic applications, especially when they are labeled with metallic radionuclides. To improve the renal radioactivity levels of technetium-99m (99mTc)-labeled Fab fragments, a mercaptoacetyltriglycine (MAG3)-based new bifunctional chelating agent with a cleavable glycyl-phenylalanyl-lysine (GFK) linkage, MAG3-GFK-suc-TFP, was designed, synthesized, and evaluated. 99mTc-labeled Fab was obtained by reacting MAG3-GFK-Fab conjugate with 99mTc-glucarate. The GFK linkage remained stable in plasma but was cleaved by enzymes on the renal brush border membrane. The comparative biodistribution studies with indium-111 (111In)-labeled Fab using SCN-CHX-A”-DTPA showed that while both radiolabeled Fabs exhibited similar elimination rates from the blood, [99mTc]Tc-MAG3-GFK-Fab registered much lower renal radioactivity levels from 30 min post-injection onward due to the release and subsequent urinary excretion of [99mTc]Tc-MAG3-Gly. However, [99mTc]Tc-MAG3-GFK-Fab showed an increase in the intestinal radioactivity levels with the time that was not observed with 111In-labeled Fab. The anal. of the intestinal contents suggested the redistribution of [99mTc]Tc-MAG3-Gly to the intestine. The retrospective comparison of [99mTc]Tc-MAG3-GFK-Fab with the radiolabeled Fabs so far prepared under the identical concept suggested that some portion of [99mTc]Tc-MAG3-Gly was generated after the coated vesicle formation and they were excreted into the blood, and subsequently redistributed in the intestine via hepatobiliary excretion. In conclusion, MAG3-GFK-suc-TFP provided 99mTc-labeled Fabs that exhibit low renal radioactivity shortly after injection by the post-labeling procedure. The present study indicated that, contrary to our earlier proposal, the generation of the radiometabolites would proceed not only during the internalization process of the parental antibody fragments but also after coated vesicle formation. This study also showed that the intracellular behaviors of radiometabolites played crucial roles in the elimination rates and the routes of the radioactivity from the kidney.

Bioconjugate Chemistry published new progress about Brush border. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Related Products of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Ashima; Gupta, Shruti; Khurana, Jitender M. published the artcile< Zinc Chloride Mediated Nucleophilic Substitution: Amination and Thioetherification of Alcohols at Room Temperature>, SDS of cas: 76-84-6, the main research area is zinc chloride catalyst nucleophilic substitution amination thioetherification alc.

The authors report a high yielding, waste-free, efficient synthesis of thioethers and amines from secondary or tertiary alcs. and anilines or thiophenols in dichloromethane in the presence of ZnCl2 at room temperature

Organic Preparations and Procedures International published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, SDS of cas: 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts