Category: 7589-27-7

Reference of 7589-27-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7589-27-7 as follows.

To a stirring solution of 4-fluorophenylethyl alcohol (110 g, 184.8 mmol) in dry DMSO (800 mL) triethylamine (220 mL, 1589.2 mmol) was added dropwise. The temperature was maintained at 15 C. stirring under N2. A solution of pyridine sulfur trioxide (253 g, 1589.2 mmol) in dry DMSO (900 mL) was added dropwise to the reaction keeping the temperature below 25 C. The subsequent mixture was stirred at 15 C. for 1.5 h. After this time, 1N HCl (aqueous) was added carefully until the mixture reached pH 4.3. The reaction mixture was extracted with MTBE, the organic layer dried and evaporated to give 4-fluorophenylacetaldehyde (110.8 g) as yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7589-27-7, its application will become more common.

Reference:
Patent; Callahan, James Frances; Li, Yue Hu; US2006/116419; (2006); A1;,
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Synthetic Route of 7589-27-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

Example 316 Synthesis of 2-(4-fluorophenyl)acetaldehyde To a stirred suspension of pyridinium chlorochromate (6.9 g, 21.4 mmol) in CH2Cl2 (100 ml) was added a solution of 2-(4-fluorophenyl)ethanol (3.0 g, 21.4 mmol) in CH2Cl2 (10 ml). The resulting suspension was stirred for 2 hours at room temperature and was then diluted with ether. The resulting suspension was filtered through a pad of Celite and washed with ether. The solvents were removed under reduced pressure to yield the crude title compound as a green oil (2.6 g, 86%), which was used as such for further reaction. 1H NMR (300 MHz, CDCl3, 25 C.): b=9.75 (s, 1H, CH), 7.19-7.22 (m, 2H, PhH), 7.06 (t, J=8.5 Hz, PhH), 3.68 (s, 2H, CH2) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7589-27-7, 2-(4-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D; De Jonghe, Steven; Gao, Ling-Jie; Herdewijn, Piet; Herman, Jean; Jang, Miyeon; Leyssen, Pieter; Louat, Thierry; Neyts, Johan; Pannecouque, Christophe; Vanderhoydonck, Bart; US2013/190297; (2013); A1;,
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Related Products of 7589-27-7, Adding some certain compound to certain chemical reactions, such as: 7589-27-7, name is 2-(4-Fluorophenyl)ethanol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7589-27-7.

Step 1: Preparation of 1-(2-bromoethy -4-fluorobenzenePhosphorus tribromide (19.3 g, 71.3 mmol) was added slowly into a solution of 2-(4- fluorophenyl)ethanol (5.0 g, 35.7 mmol) in hexane at 0 ‘C. After 12 hours under stirring, the reaction mixture was diluted with a 10% aqueous solution of NaHC03 and ethyl acetate. The organic layer was washed with water and brine, dried (Na2S04) and concentrated under vacuum to give the title compound (5.7 g, 78 %). TLC: ethylacetate/ Hexane (3/7): R, : 0.85. 1H NMR (CDCI3, 400 MHz): delta 7.20-7.16 (m, 2H), 7.03-6.99 (m, 2H), 3.56 (t, J=7.40 Hz, 2H), 3.15 (t, J=7.44 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7589-27-7, 2-(4-Fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh; WO2012/130915; (2012); A1;,
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Application of 7589-27-7, Adding some certain compound to certain chemical reactions, such as: 7589-27-7, name is 2-(4-Fluorophenyl)ethanol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7589-27-7.

A mixture of 2,5-dichloronicotinic acid (0.30 g, 1.6 mmol), 2-(4- fluorophenyl)ethanol (0.23 mL, 1.9 mmol), and sodium hydride in oil (0.15 g, 3.7 mmol) in N, N-dimethylforamide (2 mL) was heated at 90 ¡ãC in an oil bath for 3 hours. The reaction mixture was poured into 10percent citric acid aqueous solution (50 mL), and extracted with ethyl acetate (50 mL x 2). The combined organic layers were washed with water (50 mL x 2) and brine (50 mL), dried (magnesium sulfate), and evaporated. The crude solids were washed with hexane/ether (10/1), and dried in vacuo to afford 0.31 g (68percent) of the title compound as white solids: (at)H-NMR (CDCI3) 8 8.41 (1 H, d, J = 2.8 Hz), 8.31 (1 H, d, J = 2.8 Hz), 7.27-7.20 (2H, m), 7.08-6.98 (2H, m), 4.78 (2H, t, J = 6.8 Hz), 3.15 (2H, t, J = 6.8 Hz) ; MS (ESI) m/z 294 (M – H)-

According to the analysis of related databases, 7589-27-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/102389; (2005); A2;,
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Adding a certain compound to certain chemical reactions, such as: 7589-27-7, 2-(4-Fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(4-Fluorophenyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 2-(4-Fluorophenyl)ethanol

NaH 60percent suspension in mineral oil (2.400 g, equivalent to 1 .440 g of NaH, 60 mmol, 2 eq) was weighed into a flame-dried flask and suspended in dry D F (60 mL) with stirring, under a nitrogen atmosphere. To this was added 4 (4.205 g, 3.751 mL, 30 mL) and the temperature raised to 60 ¡ãC with stirring for 15 minutes. Chloroacetic acid (2.835 g, 30 mmol, 1 eq) was added to the flask and the mixture allowed to stir at 60 ¡ãC for a further 2.5 h. After cooling and removal of solvent, the residue was suspended in Et20 (30 mL) and extracted with water (2 x 30 mL). The combined aqueous layers were acidified with aqueous 2 HCI (to around pH 3) before extraction with EtOAc (3 x 30 mL). After removal of solvent, the crude solid was recrystallised from cyclohexane to yield 3.000g of pink crystals.

The synthetic route of 7589-27-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda; WO2012/4549; (2012); A1;,
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Electric Literature of 7589-27-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

To a 40 mL vial equipped with a stir bar was added 4-bromo-2,5-difluorophenol (1.04 g, 5.00 mmol), 2-(4-fluorophenyl)ethanol (700 mg, 5.00 mmol), triphenylphosphine (1.57 g, 6.00 mmol) and THF (25 mL). To the stirred solution was added DIAD (1.17 mL, 6.00 mmol). The solution warmed to a mild reflux, then cooled within 5 minutes. The solution was stirred at r.t. for 18h. The reaction solution was concentrated in vacuo and the resulting oil was diluted with a mm. of acetone, then concentrated onto Celite invacuo. The resulting powder was subjected to Si02 purification (80g column, hexanes:EtOAc 100:0-90: 10) to afford 1-bromo-2,5-difluoro-4-(4- fluorophenethoxy)benzene as a colorless oil (1.562 g, 94percent). ?H NMR (500MHz, CDC13) 7.28 – 7.21 (m, 3H), 7.04 – 6.96 (m, 2H), 6.73 (dd, J=9.5, 7.2 Hz, 1H), 4.16 (t, J=6.9 Hz, 2H), 3.09 (t, J=6.9 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7589-27-7, 2-(4-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7589-27-7, name is 2-(4-Fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 7589-27-7

To a stirred solution of 4-bromophenol (81.7 g,472 mmol), 2-(4-fluorophenyl)ethanol (79 g, 567 mmol) and Ph3P (149 g, 567 mmol) in THF (100 mL) cooled in an ice-water bath was added drop wise DEAD (93 ml, 590 mmol) over 20 mm. Note: The reaction is exothermic and efficient cooling is highly recommended before initiating large scale reaction. After 1 h, cold bath was removed andstirred overnight (17 h) at rt. Then, the reaction mixture was concentrated, the resulting residue triturated with hexanes, filtered and the filter cake washed with 10percent ether/hexanes (2-lit). The filtrate was concentrated and purified by flash chromatography (silica gel column 3? x 11?) using 4-lit hexanes and 2-lit 2percent EtOAc/Hex to afford 1- bromo-4-(4-fluorophenethoxy)benzene (142 g, 469 mmol, 99 percent yield) as colorless liquid(contaminated with 2.5percent Ph3P by ?HNIVIR). ?H NIVIR (5001V11{z, CDC13) oe 7.41 – 7.36 (m, 2H), 7.28 – 7.22 (m, 2H), 7.05 – 6.99 (m, 2H), 6.82 – 6.76 (m, 2H), 4.14 (t, J=6.9 Hz, 2H), 3.08 (t, J=6.9 Hz, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7589-27-7, 2-(4-Fluorophenyl)ethanol.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; EASTMAN, Kyle J.; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PATEL, Manoj; SIVAPRAKASAM, Prasanna; TU, Yong; (275 pag.)WO2017/25915; (2017); A1;,
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