Category: 756520-66-8

Synthetic Route of 756520-66-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

In a 100 mL single-necked flask,1- (3-fluoro-2,6-dichlorophenyl) ethanol 2.71g (0.013mol),15 mL of 1,4-dioxane,Ice bath in the cooling,Controlled at 1-5 C,1.2 g of sodium hydride (60% 0.03 mol) was added,About 15min,2.43 g (0.01 mol) of 4-chloro-6-bromo-quinazoline was added,After about 1 h at room temperature, the reaction solution was poured into 100 mL of H2O,With 10% hydrochloric acid transferred to neutral,filter,50% ethanol wash,3.3 g of a white solid,Yield 80%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.

Reference:
Patent; Southern Medical University; Wan Shanhe; Wang Guangfa; Wu Xiaoyun; Tian Yuanxin; Ye Ling; Li Zhonghuang; Zhang Tingting; Zhu Zhengguang; Jin Hong; Zhang Jiajie; (27 pag.)CN106565684; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

To a stirred mixture of D8 (65.5mg, 0.43mmol) and A5 (81mg, 0.39mmol) in THF (5mL), was added Ph3P (152mg, 0.58mmol) under the protection of nitrogen. After being stirred at r.t. for Ih, the mixture was added DIAD (1 17mg, 0.58mmol) at 00C. The resulting mixture was stirred at r.t. for two days and evaporated. The residue was purified by column chromatography (PE:EA=20: l) to afford D9 (1 13mg, 86%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; XCOVERY, INC.; WO2008/88881; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 756520-66-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

2. To a stirred solution of triphenyl phosphine (8.2 g, 0.03 mol) and DEAD (13.65 mL of a 40% solution in toluene) in THF (200 mL) at 0C was added a solution of 1-(2,6- dichloro-3-fluoro-phenyl)-ethanol (4.55 g, 0.021 mol) and 3-hydroxy-nitropyridine (3.35 g, 0.023 mol) in THF (200 mL). The resulting bright orange solution was stirred under a nitrogen atmosphere at ambient temperature for 4 hours at which point all starting materials had been consumed. The solvent was removed, and the crude material was dry loaded onto silica gel, and eluted with ethyl acetate-hexanes (20:80) to yield 3-(2,6- dichloro-3-fluoro-benzyloxy)-2-nitro-pyridine (6.21 g, 0.02 1 mol, 98%) as a pink solid. 1H NMR (CDCI3, 300 MHz) 61.8-1.85 (d, 3H), 6.0-6.15 (q, 1H), 7.0-7.1 (t, 1H), 7.2-7.21 (d, 1H), 7.25-7.5 (m, 2H), 8.0-8.05 (d, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Patent; PFIZER INC.; CHRISTENSEN, James Gail; ZOU, Yahong; WO2013/17989; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1-(2,6-Dichloro-3-fluorophenyl)ethanol

182 g of Compound 2 and 135 g of phthalic anhydride were dissolved in 124 mL of triethylamine, and 2 g of 4-dimethylaminopyridine (DMAP) was added.After refluxing for 2 hours, the heating was stopped.Cool to about 50 C and add 40 mL of ethyl acetate.Then adjust the pH to about 1.5 with 2N hydrochloric acid.Stir for another half an hour,a lot of white solids appear,Filter and wash twice with water,Compound 3 was obtained in a yield of 93%.The content is 98.5%.

With the rapid development of chemical substances, we look forward to future research findings about 756520-66-8.

Reference:
Patent; Kairuiside Biochemical (Suzhou) Co., Ltd.; Wu Shengwen; Wu Lei; Song Qianqian; (6 pag.)CN109438180; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 756520-66-8

A slurry of l-(2,6-dichloro-3-fluorophenyl)ethanol (4.6 g, 22 mmol) and P2O5 (17.5 g, 0.12 mol) in DCM (200 mL) was stirred at rt for 16 hours. The solid was filtered off through a pad of CELITE, and washed with DCM (200 mL) for several times. The filtrate was washed with saturated Na2C03 aqueous solution (100 mL x 2). The separated organic layer was dried over anhydrous Na2S04, and concentrated in vacuo. The white solid precipitated during concentration was discarded. The remained oil was dried in vacuo, and used directly in the next step without further purification (3.5 g, 83%). MS (ESI, pos. ion) m/z: 191.0 (M+l); 1H NMR (400 MHz, DMSO- e): delta 7.60-7.50 (m, 1H), 7.45-7.35 (m, 1H), 6.75-6.63 (m, 1H), 5.90-5.75 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Xiaobo; WO2014/193647; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. name: 1-(2,6-Dichloro-3-fluorophenyl)ethanol

Dissolve triphenylphosphine (17.50g, 66.73mmol) in THF,Argon protection, injection under ice bathDEAD (10.57mL, 66.73mmol),Add 1-(2,6-dichloro-3-fluorophenyl)ethanol (9.30g, 44.49mmol)And m-bromophenol (5.19mL, 48.94mmol) in THF,Move to room temperature and react overnight. TLC monitors the reaction is complete,The solvent was distilled off under reduced pressure,Separation and purification by silica gel column chromatography (petroleum ether / dichloromethane =200: 1, v / v) to obtain a transparent oil (8.51g, yield 52.84%).

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Chinese Academy Of Sciences Shanghai Life Sciences Institute; Liu Hong; Yang Chenghua; Li Chunpo; Sun Chenxia; Liang Xuewu; Gao Yang; Shi Yuqiang; Zhao Sen; Jiang Hualiang; Chen Kaixian; (34 pag.)CN110950807; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 756520-66-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Bromo-3-[1 -(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyrazin-2-ylamine was prepared following procedure 2 below, from 1-(2,6-dichloro-3-fluoro-phenyl)-ethanol and 3,5-dibromo-pyrazin-2-ylamine. 1H NMR (400 MHz, DMSO-d6) 6 1.74 (d, 3H), 6.40 (m, 1H), 6.52 (br s, 2H), 7.30 (m, 1H), 7.48 (m, 1H), 7.56 (s, 1H); MS m/z 382 (M+1); To an ice cooled solution of substituted benzyl alcohol (1.0 molar equivalent) and anhydrous tetrahydrofuran (0.14 M) was added sodium hydride (1.0 molar equivalent) slowly under nitrogen atmosphere. After stirring for 30 minutes, 3,5-dibromopyrazin-2-ylamine (1.0 molar equivalent) in tetrahydrofuran (0.56 M) was added via an addition funnel at a fast dropwise rate. Once the addition wascomplete the ice bath was removed and the reaction was refluxed under nitrogen and monitored by reversed phase HPLC. After 18 hr HPLC showed that the majority of the starting 3,5-dibromopyrazin-2-ylamine had been consumed and the reaction was allowed to cool to room temperature. The reaction mixture was concentrated, diluted with ethyl acetate, and washed with brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuum. The crude product was purified using a silica gel eluting with 1:1 ethyl acetate/dichloromethane to yield the 5-bromo-3-(substituted-benzyloxy)-pyrazin-2-ylamine as a white solid in 60-90% yield

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Patent; PFIZER INC.; WO2006/21886; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

General procedure: A CH3CN solution of alcohol (1 mmol), ZnBr2 (45 mg, 0.2 mmol), and chloramine-T (282 mg, 1 mmol) was placed in a three necked flask with a reflux condenser. After the mixture was stirred under reflux for 1.5-5 h. After cooling to room temperature, the solution was quenched by adding water and the resulting mixture was extracted with AcOEt. Removal of the solvent under reduced pressure gave the crude product, which was purified by column chromatography on silica gel to give the corresponding carbonyls.

According to the analysis of related databases, 756520-66-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wang, Peng; Cai, Jin; Yang, Jiabin; Sun, Chunlong; Li, Lushen; Hu, Huayou; Ji, Min; Tetrahedron Letters; vol. 54; 6; (2013); p. 533 – 535;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. Quality Control of 1-(2,6-Dichloro-3-fluorophenyl)ethanol

To a solution of A5 (147.6g, 0.71mol) in THF (3L) was added 60% NaH (28.4g, 0.71mol) at 0C, the resulting mixture was stirred at that temperature for 30min, was then added A3 (147g, 0.71mmol) quickly. The resulting mixture was heated under reflux overnight and evaporated. The residue was purified by column chromatography (PE:EA=4:1) to provide the advanced intermediate A6 (89.3g, 37.6%).

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48259; (2012); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 756520-66-8

To a solution of 1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol 18 (19.00 g, 90.89 mmol) in 150 ml of CH2Cl2 was added Et3N (13.27 ml, 95.43 mmol) and catalytic amount of DMAP. The resulting solution was cooled in an ice bath and added dropwise MsCl (7.39 ml, 95.43 mmol). After complete addition of MsCl, the reaction mixture was maintained in the ice bath for 1 h and then 30 ml of water was added to the reaction mixture. The organic phase was washed with brine, dried over anhydrous Na2SO4 and concentrated under vacuum. The crude product was pure enough for use in the next step. 1H NMR (300 MHz, CDCl3) delta 7.33 (dd, J = 4.8, 9.0 Hz, 1H), 7.12 (dd, J = 8.1, 9.0 Hz, 1H), 6.45 (q, J = 6.9 Hz, 1H), 2.91 (s, 3H), 1.84 (d, J = 6.9 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol.

Reference:
Article; Zhang, Dengyou; Ai, Jing; Liang, Zhongjie; Li, Chunpu; Peng, Xia; Ji, Yinchun; Jiang, Hualiang; Geng, Meiyu; Luo, Cheng; Liu, Hong; Bioorganic and Medicinal Chemistry; vol. 20; 17; (2012); p. 5169 – 5180;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts