Category: 756520-66-8

Reference of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

General procedure: The reaction mixture was composed by a 3 mL solution of0.048 mmol 1-(2,6-dichloro-3-fluoro-phenyl)-ethanol, 0.096 mmolacyl donor and 60 mg of enzyme (20% w/v) in solvent. The screeningreactions were performed in silicon carbide plates at temperaturesof 60-80 C, under magnetic stirring to obtain 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate (1H NMR (300 MHz, CDCl3)d 7.26 (dd, J = 8.3, 5.6 Hz, 5H), 7.03 (t, J = 8.5 Hz, 3H), 6.39 (q,J = 7.1 Hz, 3H), 2.09 (s, 3H), 1.66 (d, J = 6.9 Hz, 3H). In order toscreen the influence of the different reaction medium?s components,enzymes, solvent, acyl donor and temperature were evaluated.A 20 mL aliquot was transferred to a new vial and 980 mL ofethyl acetate was added and analyzed in the GC-FID.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; de Franca, Alexandre da S.; Silva, Marcus V.M.; Neves, Rebeca V.; de Souza, Stefania P.; Leao, Raquel A.C.; Monteiro, Carlos M.; Rocha, Angelo; Afonso, Carlos A.M.; de Souza, Rodrigo O.M.A.; Bioorganic and Medicinal Chemistry; vol. 26; 7; (2018); p. 1333 – 1337;,
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Adding a certain compound to certain chemical reactions, such as: 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 756520-66-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1-(2,6-Dichloro-3-fluorophenyl)ethanol

General procedure: 1-(2-chloro-5-fluorophenyl)ethan-1-ol (2.200 g, 12.6 mmol),triphenylphosphine (3.976 g, 15.1 mmol) and 5-bromo-2-nitropyridin-3-ol(2.755 g, 12.6 mmol) was dissolved in anhydrous THF(20 mL) and stirred for 30 minutes in an ice bath. The diisopropylazodiformate (3.057 g, 15.1 mmol) was added to the reaction solutionslowly at 0 oC and the mixture was stirred for4 h at room temperature. Then, the solution was concentrated with a rotaryevaporator. The crude product was purified by silica gelchromatography (petroleum ether/ethyl aceate = 100: 1, v/v) to obtain the titleproduct as white solid (4.232 g, 89.5 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.

Reference:
Article; Wang, Wanqi; Diao, Yanyan; Li, Wenjie; Luo, Yating; Yang, Tingyuan; Zhao, Yuyu; Qi, TianTian; Xu, Fangling; Ma, Xiangyu; Ge, Huan; Liang, Yingfan; Zhao, Zhenjiang; Liang, Xin; Wang, Rui; Zhu, Lili; Li, Honglin; Xu, Yufang; Bioorganic and Medicinal Chemistry Letters; vol. 29; 12; (2019); p. 1507 – 1513;,
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Synthetic Route of 756520-66-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

Acetic anhydride (1.42 mL, 15 mmol) and pyridine (1.7 mL, 21 mmol) were added sequentially to a solution of compound A1 (2.2 g, 10.5 mmol) in 20 mL of CH2CI2. The reaction mixture was stirred at room temperature for 12h and then evaporated to give a yellowish oil residue. The residue was purified by flash chromatography (eluting with 7->9% EtOAc in hexanes) to give compound A2 as a colorless oil (2.26 g; 9.0 mmol; 85.6% yield); 1H NMR (400 MHz, chloroform-D) 8 ppm 1.88 (d, J=6.82 Hz, 3 H) 2.31 (s, 3 H) 6.62 (q, J^6.82 Hz, 1 H) 7.25 (t, J=8.46 Hz, 1 H) 7.49 (dd, ^=8.84, 5.05 Hz, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; WO2006/21886; (2006); A1;,
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Synthetic Route of 756520-66-8 , The common heterocyclic compound, 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 100mL single-necked flask,1.2 g (0.005 mol) of 2-amino-4-hydroxy-6-bromo-quinazoline was added,(0.0065 mol, 1.3 equiv) of benzotriazol-1-yloxytris (dimethylamino) phosphonium hexafluorophosphate (BOP)Acetonitrile 20 mL,Stirred at room temperature,A solution of 1.1 mL (0.0075 mol, 1.5 equiv) of 1,8-diazabicycloundecyl-7- (DBU) was added to clarify the solution,After 10min reaction with solid precipitation,Join again1.56 g of 1- (3-fluoro-2,6-dichloro-phenyl) ethanol (0.0075 mol,1.5 equiv),0.4 g of NaH (60%) and 10 mL of acetonitrile,After stirring at room temperature overnight,Add 200mL H2O,Extract three times with 90 mL of ethyl acetate,Combine ethyl acetate,Evaporation of ethyl acetate,Got a white solid.The residue was purified by silica gel column chromatography (petroleum ether: dichloromethane: ethyl acetate = 2: 1: 2)Yield 55%.

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Southern Medical University; Wan Shanhe; Wang Guangfa; Wu Xiaoyun; Tian Yuanxin; Ye Ling; Li Zhonghuang; Zhang Tingting; Zhu Zhengguang; Jin Hong; Zhang Jiajie; (27 pag.)CN106565684; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 756520-66-8, blongs to alcohols-buliding-blocks compound. SDS of cas: 756520-66-8

To a solution of A5 (219g, 1.05mol) in 1,2-dichloroethane (3500mL) was added Boc-D-Pro (141g, 0.65mol) followed by EDCI (163g, 0.85mol) and DMAP (21.57g, 0.18mol) at 0 C. The resulting mixture was stirred at r.t. overnight and then water (3500mL) was added and separated, the water phase was extracted withDCM(1500mLx3), dried over MgS04, concentrated and purified by column chromatography to (PE:EA=30:1) to give Bl (55.96g, yield: 51.1%)

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48259; (2012); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

To a solution of A5 (219g, 1.05mol) in 1,2-dichloroethane (3500mL) was added Boc-D-Pro (141g, 0.65mol) followed by EDCI (163g, 0.85mol) and DMAP (21.57g, 0.18mol) at 0 C. The resulting mixture was stirred at r.t. overnight and then water (3500mL) was added and separated, the water phase was extracted withDCM(1500mLx3), dried over MgS04, concentrated and purified by column chromatography to (PE:EA=30:1) to give Bl (55.96g, yield: 51.1%)

The synthetic route of 756520-66-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin; WO2012/48258; (2012); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 756520-66-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

Step 2 (±)3-(1-(2,6,-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine [00161] To a solution of triphenylphosphine (24.29 g, 92.6 mmol) in THF (dry, 160 ml_) was added DIAD (18.23 ml_, 92.6 mmol) dropwise at 0 C under N2. After addition of DIAD, a solution of 1-(2,6-dichloro-3-fluorophenyl)ethanol (13.35 g, 63.86 mmol) and 3-hydroxy-2-nitropyridine (10.29 g, 73.44 mmol) in THF (anhydrous, 160 ml_) was added dropwise. The ice-bath was removed and the reaction mixture was allowed to warm to room temperature and stirred at room temperature for 4 hrs. The reaction mixture was concentrated by evaporator to give a yellow residue. A saturated solution of NH4CI (200 ml_) was added. The aqueous phase was extracted with EtOAc (3^150 mL). The combined organic phase was washed with brine (2*80 mL), dried over anhydrous Na2S04, concentrated by evaporation in vacuo to give a yellow residue which was purified by CombiFlash (220 g silica gel column, Hexane/EtOAc) to afford (±)-3-(1-(2,6,- dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (21.1 g, 100%) as a white solid. [00162] 1HNMR (300 MHz, CDCI3): delta 8.04 (d, 1 H), 7.37 (m, 1 H), 7.30 (dd, 1 H), 7.21 (d, 1 H), 7.09 (t, 1 H), 6.10 (q, 1 H), 1.85 (d, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; BETA PHARMA CANADA INC.; WANG, Zhaoyin; LI, Lianhai; WANG, Zhigang; WO2013/13308; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 756520-66-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To the solution of compound 6 (17 mg, 0.13 mmol), 3-morpholinopropan-1-ol (19 mg, 0.13 mmol) and PPh3 (51 mg, 0.19 mmol) in anhydrous THF (5 mL) was added 33 uL DEAD (0.19 mmol) dropwise. The reaction mixture was stirred at room temperature for 3h. After completion of reaction, the reaction mixture was concentrated and the residue was purified by silica gel column chromatography using DCM: MeOH=60:1 as eluents.

According to the analysis of related databases, 756520-66-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; An, Xiao-De; Liu, Hongyan; Xu, Zhong-Liang; Jin, Yi; Peng, Xia; Yao, Ying-Ming; Geng, Meiyu; Long, Ya-Qiu; Bioorganic and Medicinal Chemistry Letters; vol. 25; 3; (2015); p. 708 – 716;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 756520-66-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol, molecular formula is C8H7Cl2FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of triphenyl phosphine (8.2 g, 0.03 mol) and DEAD (13.65 mL of a 40% solution in toluene) in THF (200 mL) at 0 C. was added a solution of 1-(2,6-dichloro-3-fluoro-phenyl)-ethanol (4.55 g, 0.021 mol) and 3-hydroxy-nitropyridine (3.35 g, 0.023 mol) in THF (200 mL). The resulting bright orange solution was stirred under a nitrogen atmosphere at ambient temperature for 4 hours at which point all starting materials had been consumed. The solvent was removed, and the crude material was dry loaded onto silica gel, and eluted with ethyl acetate-hexanes (20:80) to yield 3-(2,6-dichloro-3-fluoro-benzyloxy)-2-nitro-pyridine (6.21 g, 0.021 mol, 98%) as a pink solid. 1H NMR (CDCl3, 300 MHz) delta1.8-1.85 (d, 3H), 6.0-6.15 (q, 1H), 7.0-7.1 (t, 1H), 7.2-7.21 (d, 1H), 7.25-7.5 (m, 2H), 8.0-8.05 (d, 1H).

According to the analysis of related databases, 756520-66-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER INC.; US2008/293769; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 756520-66-8, Adding some certain compound to certain chemical reactions, such as: 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol,molecular formula is C8H7Cl2FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 756520-66-8.

General procedure: The reaction mixture was composed by a 3 mL solution of0.048 mmol 1-(2,6-dichloro-3-fluoro-phenyl)-ethanol, 0.096 mmolacyl donor and 60 mg of enzyme (20% w/v) in solvent. The screeningreactions were performed in silicon carbide plates at temperaturesof 60-80 C, under magnetic stirring to obtain 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate (1H NMR (300 MHz, CDCl3)d 7.26 (dd, J = 8.3, 5.6 Hz, 5H), 7.03 (t, J = 8.5 Hz, 3H), 6.39 (q,J = 7.1 Hz, 3H), 2.09 (s, 3H), 1.66 (d, J = 6.9 Hz, 3H). In order toscreen the influence of the different reaction medium?s components,enzymes, solvent, acyl donor and temperature were evaluated.A 20 mL aliquot was transferred to a new vial and 980 mL ofethyl acetate was added and analyzed in the GC-FID.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; de Franca, Alexandre da S.; Silva, Marcus V.M.; Neves, Rebeca V.; de Souza, Stefania P.; Leao, Raquel A.C.; Monteiro, Carlos M.; Rocha, Angelo; Afonso, Carlos A.M.; de Souza, Rodrigo O.M.A.; Bioorganic and Medicinal Chemistry; vol. 26; 7; (2018); p. 1333 – 1337;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts