Category: 75476-86-7

Synthetic Route of 75476-86-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75476-86-7 as follows.

(a) A solution of 6-bromo-indan-1 -ol (1 mmol) and NEt3 (4 mmol) in dry THF (5 ml_) was stirred at -15 5C under argon. A solution of methanesulfonyl chloride (2 mmol) in dry THF (1 ml_) was cooled to -78 5C and then slowly added to the alcohol solution maintaining the temperature below 0 5C. The reaction mixture was stirred for 2h at -15 5C and then purged with dimethylamine gas (12 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. Then, it was filtered to remove salts and solvent was evaporated. Crude was dissolved in CH2CI2 and extracted with HCI 1 M (3x). The aqueous phase was basified withNaOH 6M to pH 8-9 and extracted with CH2CI2. The combined organic extracts were dried over MgS04 and concentrated to dryness. The crude was used in next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; GARCIA-LOPEZ, Monica; TORRENS-JOVER, Antoni; ALONSO-XALMA, Monica; WO2011/42343; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 75476-86-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75476-86-7 as follows.

A mixture of 15A (11 g, 51.6 mmol) and Ph3P-HBr (17.7 g, 51.6 mmol) in benzene (35 ml_) was heated at 90 9C overnight. After cooling to RT, the solid was filtered and dried in vacuo. The solid was washed with Et2O and acetone, and then vacuum dried to afford 15B (18.9 g, 68%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; WO2008/100480; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H9BrO, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H9BrO

(1) 6-Bromoindan-1-ol (3.01 g) and dihydropyrane (1.78 g) are dissolved in dichloromethane (50 ml), and thereto is added pyridinium p-toluenesulfonate (178 mg), and the mixture is stirred at room temperature for 1.5 hour. The reaction solution is washed with a saturated aqueous sodium hydrogen carbonate solution, dried, and evaporated to remove the solvent. The residue is purified by silica gel column chromatography (solvent; hexane/ethyl acetate) to give 6-bromo-1-tetrahydropyranyloxyindane (4.10 g). MS (m/z): 296, 298 (M+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tanabe Seiyaku Co., Ltd.; US5830873; (1998); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 75476-86-7, blongs to alcohols-buliding-blocks compound. SDS of cas: 75476-86-7

A solution of 6-bromo-indan-1-ol (1 mmol) and NEt3 (4 mmol) in dry THF (5 mL) was stirred at -15 C under argon. A solution of methanesulfonyl chloride (2 mmol) in dry THF (1 mL) was cooled to -78 C and then slowly added to the alcohol solution maintaining the temperature below 0 C. The reaction mixture was stirred for 2h at -15 C and then purged with dimethylamine gas (12 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. Then, it was filtered to remove salts and solvent was evaporated. Crude was dissolved in CH2Cl2 and extracted with HCl 1 M (3x). The aqueous phase was basified with NaOH 6M to pH 8-9 and extracted with CH2Cl2. The combined organic extracts were dried over MgSO4 and concentrated to dryness. The crude was used in next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; EP2308849; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 75476-86-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75476-86-7, name is 6-Bromo-2,3-dihydro-1H-inden-1-ol. A new synthetic method of this compound is introduced below.

To a solution of 6-bromo-2,3-dihydro-1 H-inden-1 -ol (1 .50 g, 7.04 mmol) in DOM (3.5 mL) wasadded thionyl chloride (1.028 mL, 14.08 mmol). The resulting reaction mixture was stirred atambient temperature for 1 h. The reaction mixture was evaporated under vacuum to afford product 6-bromo-1-chloro-2,3-dihydro-1 H-indene (1.6225 g, 7.01 mmol, 100% yield). 1H NMR (400 MHz, CHLOROFORM-d) ppm 2.33- 2.44 (m, 1 H) 2.63 (dq, J=14.24, 7.22 Hz, 1 H) 2.86 (ddd, J=1 6.00, 7.97, 4.14 Hz, 1 H) 3.13 (dt, J=1 5.81, 7.65 Hz, 1 H) 5.37 (dd, J=6.53, 3.51 Hz, 1H) 7.14 (d, J=8.03 Hz, 1 H) 7.39 (d, J=8.03 Hz, 1 H) 7.57 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; YAN, Hongxing; CALLAHAN, James Francis; HEIGHTMAN, Thomas Daniel; BOEHM, Jeffrey Charles; WOOLFORD, Alison Jo-Anne; (250 pag.)WO2016/203401; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 75476-86-7, blongs to alcohols-buliding-blocks compound. SDS of cas: 75476-86-7

Example 10-A. (±)-Methyl 2-(2-((6-bromo-2,3-dihydro-1 H-inden-1 -yl)oxy)phenyl)acetate DIAD (1 .165 mL, 5.99 mmol) was added dropwise to a solution of PPh3 (1 .571 g, 5.99 mmol), 6-bromo-2,3-dihydro-1 H-inden-1 -ol (CAS 75476-86-7) (1 .1 1 g, 5.21 mmol) and methyl 2-(2-hydroxyphenyl)acetate (0.996 g, 5.99 mmol) in THF (1 5 mL) at 0 C. The reaction mixture was allowed to stir for 15 minutes at 0 C and then warmed to room temperature. The reaction mixture was stirred at room temperature overnight, partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc . The combined organics were washed with brine, dried (Na2S04) and concentrated. The residue was purified by silica gel chromatography (30% EtOAc- heptane) tor provide the title compound. MS (ESI ) m/z 359.0, 361 .0 (M-H)~.

The synthetic route of 75476-86-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BELANGER, David; FLOHR, Stefanie; GELIN, Christine Fang; JENDZA, Keith; JI, Nan; KARKI, Rajeshri Ganesh; LIU, Donglei; LORTHIOIS, Edwige Liliane Jeanne; MAINOLFI, Nello; POWERS, James J.; VULPETTI, Anna; (100 pag.)WO2016/88082; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H9BrO, blongs to alcohols-buliding-blocks compound. Formula: C9H9BrO

To a solution of 6-bromo-2,3-dihydro-1 H-inden-1 -ol (12 g, 56.3 mmol) in 1 ,4-dioxane (100 mL) was added bis(pinacolato)diboron (18.59 g, 73.2 mmol), potassium acetate (13.82 g, 141 mmol) and the mixture was degassed with argon for 20 mm in a sealed tube. PdCI2(dppf) (2.060 g, 2.82 mmol) was added and the reaction mixture was stirred at 90 00 for 2 h. The reaction mixture was filtered through celite and washed with ethyl acetate. The filtrate wasconcentrated under reduced pressure to afford a crude residue. The crude residue was purified by column chromatography using 20% ethyl acetate in n-hexane as eluent. The eluted fractions were concentrated under reduced pressure to afford the title compound (12 g, 82% yield). 1H NMR (400MHz, ODd3) 5 ppm = 7.88 (s, I H), 7.72 (d, J=7.7 Hz, 1 H), 7.28 (s, 1 H), 5.25 (br t, J=5.8 Hz, 1 H), 3.08 (ddd, J=5.0, 8.4, 16.4 Hz, 1 H), 2.88 – 2.78 (m, 1 H), 2.51 – 2.41 (m, 1 H), 2.01-1.91 (m, 1H), 1.68 (br s, 1H), 1.37-1.27 (m, 12H).

The synthetic route of 75476-86-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; YAN, Hongxing; CALLAHAN, James Francis; HEIGHTMAN, Thomas Daniel; BOEHM, Jeffrey Charles; WOOLFORD, Alison Jo-Anne; (250 pag.)WO2016/203401; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 75476-86-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 75476-86-7

A suspension of 6-bromoindan-1-ol (240 mg, 1.1 mmol), potassium acetate (550 mg, 5.6 mmol) and 4,4,5,5,4′,4′,5′,5′-octamethyl-[2,2′]bi[[1,3,2]dioxaborolanyl](430 mg, 1.7 mmol) in 1,4-doxane (3.3 mL) was first degassed with stream of nitrogen for ?5 min, then [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1:1) (92 mg, 0.11 mmol) was added and the mixture was heated to 90 C. overnight. The reaction mixture was then diluted with EtOAc, filtered through celite, and concentrated. The residue was purified by flash chromatography on a silica gel column eluting with 0 to 25% EtOAc/hexanes to provide the desired product (256 mg, 87%). LC-MS calculated for C15H20BO2 (M+H-H2O)+: m/z=243.2. found 243.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Incyte Corporation; Wu, Liangxing; Courter, Joel R.; He, Chunhong; Li, Jingwei; Lu, Liang; Sun, Yaping; Wang, Xiaozhao; Yao, Wenqing; Zhang, Colin; Zhuo, Jincong; (87 pag.)US2016/9720; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts