Category: 748805-85-8

Electric Literature of 748805-85-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 748805-85-8, name is (2-Amino-5-fluorophenyl)methanol. A new synthetic method of this compound is introduced below.

14.5 g of potassium monoethyl malonate was added to 20 mL of 6 mol/L cold hydrochloric acid and then the mixture was extracted with diethyl ether. The extract was washed with saturated brine and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and then 20 mL of acetonitrile, 1.9 g of magnesium chloride, and 4.1 g of triethylamine were added to the resulting residue under ice cooling. The mixture was stirred at room temperature for 4 hours to obtain a suspension. 15 mL of acetonitrile and 2.8 g of carbonyldiimidazole were added to 3.5 g of 3-methyl-2,4,5-trifluorobenzoic acid and the mixture was stirred at room temperature for 4 hours. The reaction solution was added to the aforementioned suspension at room temperature and the mixture was stirred at 80 C. for 3 hours. 100 mL of 1 mol/L hydrochloric acid was added and then the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was subjected to silica gel column chromatography (n-hexane/ethyl acetate=200) to obtain 3.9 g of ethyl 2-(3-methyl-2,4,5-trifluoro)benzoylacetate. 3 mL of the acetic anhydride and 3 mL of ethyl orthoformate were added to the obtained compound and the mixture was stirred at 130 C. for 6 hours. The solvent was evaporated under reduced pressure. The residue was subjected to azeotropic distillation twice with toluene and the resulting residue was dissolved in dichloromethane to prepare a 1 mol/L solution for use in the following reaction. 29.7 mL of N,N-dimethylformamide and 29.7 mL of the dichloromethane solution of ethoxyacrylate prepared earlier were added to 4.19 g of 2-amino-5-fluorophenylmethanol and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and ethyl acetate was added to the residue. The mixture was washed with water. The organic layer was dried using anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The resulting residue was dispersed in hexane, collected by filtration, and dried under reduced pressure to obtain 10.4 g of the title compound. 1H-NMR (DMSO-d6): delta 0.91 (0.9H, t, J=7.1 Hz), 1.00 (2.1H, t, J=7.2 Hz), 2.21 (3H, brs), 3.97-4.03 (2H, m), 4.60 (2H, d, J=4.6 Hz), 5. 79-5.83 (1H, m), 7.20-7.29 (2H, m), 7.36-7.45 (1H, m), 7.58 (0.3H, dd, J=4.5, 8.6 Hz), 7.65 (0.7H, dd, J=4.8, 8.7 Hz), 8.36 (0.3H, d, J=14.3 Hz), 8.46 (0.7H, d, J=13.8 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,748805-85-8, its application will become more common.

Reference:
Patent; WAKUNAGA PHARMACEUTICAL CO., LTD.; KINOSHITA, Tomohiko; KURAMOTO, Yasuhiro; INOUE, Satoshi; NISHIMURA, Kouji; HIRANO, Tatsuya; ARAI, Mai; SAKURAI, Asuka; KAZAMORI, Daichi; SASAKI, Ayuka; (105 pag.)US2019/276407; (2019); A1;,
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Synthetic Route of 748805-85-8 ,Some common heterocyclic compound, 748805-85-8, molecular formula is C7H8FNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Acetophenone (144 mg, 1.2 mmol),[Cp * Ir (6,6 ‘- (OH) 2bpy) (H2O)] [OTf] 2 (8.3 mg,0.01 mmol, 1 mol%), potassium hydroxide (56 mg, 1.0 mmol, 1.0 equiv.),Amino-5-fluorobenzyl alcohol (141 mg, 1.0 mmol) and water (1 mL) were sequentially added to a 5 mL round bottom flask.The reaction mixture was refluxed in air for 12 hours and then cooled to room temperature.Extraction with ethyl acetate, removal of the solvent by rotary evaporation, and purification of the target compound by column chromatography (developing solvent: petroleum ether / ethyl acetate) yielded 93%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 748805-85-8, (2-Amino-5-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing University of Science and Technology; Li Feng; Wang Rongzhou; (15 pag.)CN107400084; (2017); A;,
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Synthetic Route of 748805-85-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 748805-85-8 as follows.

General procedure: Benzyl alcohol derivative 11 (1 eq.) was dissolved in CH2Cl2 (0.4 M). Manganese (IV) oxide (2.1 eq.)was added under argon and the solution was left to stir at room temperature for 48 h. The progress ofthe reaction was monitored by TLC analysis. After completion, manganese oxide was filtered off andthe resulting filtrate was concentrated under reduced pressure. The crude product was purified by silicacolumn chromatography employing mixtures of n-hexane and ethyl acetate as eluents to obtain thedesired product 10.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,748805-85-8, its application will become more common.

Reference:
Article; Jarrige, Lucie; Merad, Jeremy; Zaied, Siwar; Blanchard, Florent; Masson, Geraldine; Synlett; vol. 28; 14; (2017); p. 1724 – 1728;,
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Electric Literature of 748805-85-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 748805-85-8 as follows.

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,748805-85-8, its application will become more common.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
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Adding a certain compound to certain chemical reactions, such as: 748805-85-8, (2-Amino-5-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 748805-85-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 748805-85-8

To a Schlenk tube were added (2-aminophenyl)methanols 1 (0.2 mmol), aldehydes 2 (0.3 mmol), CAN (0.3 mmol), CuCl (0.02 mmol), 2,2′-bipyridine (0.02 mmol), TEMPO (0.02 mmol), CsOH(0.5 mmol), and CH3CN (2 mL). Next the tube was charged with O2 (1 atm), and was stirred constantly at 30 C for 24 h, then at 60 C for 24 h. After the completion of the reaction, the reaction mixture was cooled to room temperature, diluted with ethyl acetate, and washed with brine. After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous MgSO4 and evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products 3.

The synthetic route of 748805-85-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ye, Leping; Yu, Lin; Zhu, Lijun; Xia, Xiaodong; Molecules; vol. 18; 11; (2013); p. 13860 – 13869;,
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