Category: 7314-44-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of (2,4-Dimethoxyphenyl)methanol

General procedure: A series of catalytic oxidation reactions was performed in 5 ml/3 mlMeCN solutions at room temperature under open air. The reaction wasset up by adding 1 mmol of 1-octanol, 5 mol % of copper(I)catalyst,5 mol % of TEMPO and 10 mol % of NMI into a 20 ml test tube, whichwas equipped with a magnetic stirrer bar. The reaction was stirred1500 rpm for 24 h for 1-octanol, 3 h for cinnamyl alcohol and 3-phenyl-1-propanol and 1 h for benzyl alcohol. After the reaction, 0.7 ml of thereaction solution and an internal standard (acetophenon 40 mul or 1,2-dichlorobenzene 40 mul, more information see ESI) were diluted withEtOAc (100 ml). GC samples (1.5 ml) were prepared by filtrating thesolution through a layer of silica gel (1 cm thick). The yields were determinedusing GC-MS with calibration curves.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7314-44-5, (2,4-Dimethoxyphenyl)methanol.

Reference:
Article; Lagerspets, Emi; Lagerblom, Kalle; Helioevaara, Eeva; Hiltunen, Otto-Matti; Moslova, Karina; Nieger, Martin; Repo, Timo; Molecular catalysis; vol. 468; (2019); p. 75 – 79;,
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Synthetic Route of 7314-44-5, Adding some certain compound to certain chemical reactions, such as: 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol,molecular formula is C9H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7314-44-5.

Preparation 74 2-(2,4-Dimethoxybenzyl)-1,2-thiazinane-1,1-dioxide To a 0.5 M solution of 2,4-dimethoxybenzyl alcohol (4.94 g, 29.3 mmol) in anhydrous diethyl ether was added anhydrous pyridine (4.75 mL, 58.7 mmol). The mixture was cooled to 0 C. and thionyl chloride (5.98 mL, 80.7 mmol) was added slowly over 5-10 mins and the reaction stirred at 0 C. for 1.5 hrs. The reaction mixture was poured into ice water (120 mL) and the layers separated. The aqueous layer was extracted with diethyl ether (2*60 mL) and the combined organic layers washed with ice water (60 mL) and a solution of 5:1 saturated aqueous sodium chloride:saturated aqueous sodium bicarbonate (2*60 mL), dried (anhydrous sodium sulfate), filtered, and concentrated to ?5 mL of liquid. The crude solution was dissolved in benzene (200 mL) and re-concentrated to 10-15 mL of liquid, which was used immediately in the next step. 1,4-butanesultam (2.800 g, 20.7 mmol) in anhydrous N,N-dimethylformamide (50 mL) was cooled to 0 C. and sodium hydride was added in small portions, stirring for 5 min at 0 C. and 1 hr at room temperature. The reaction became a slurry, and was cooled to 0 C. and a solution of 1-(chloromethyl)-2,4-dimethoxybenzene in benzene was added, stirring at 0 C. and slowly warming to room temperature and stirring for 16 hrs. The mixture was poured into water (300 mL) and extracted with ethyl acetate (3*). The combined organic layers were washed with water, saturated aqueous sodium chloride, dried (anhydrous sodium sulfate), filtered, and concentrated in vacuo. The crude material was purified by silica gel chromatography (15-60% ethyl acetate/hexanes) to give a white solid (4.78 g). 1H NMR (300 MHz, CDCl3) delta 7.28-7.25 (d, 1H, J=8.4 Hz), 6.48-6.45 (dd, 1H, J=2.4, 8.1 Hz), 6.43-6.42 (d, 1H, J=2.1 Hz), 4.29 (s, 2H), 3.79 (s, 6H), 3.31-3.27 (m, 2H), 3.04-3.00 (m, 2H), 2.18-2.15 (m, 2H), 1.60-1.56 (m, 2H). HPLC analysis: (C18, 25-99% acetonitrile in water+0.1% trifluoroacetic acid over 10 mins: retention time, % area at 254 nm): 6.93 min, 98%.

According to the analysis of related databases, 7314-44-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bersot, Ross; Humphries, Paul; US2013/303524; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: (2,4-Dimethoxyphenyl)methanol

General procedure: In a 10 cm3 flask, 50 mg of phosphine-polyphosphazene(0.094 mmol) was dissolved in 3 cm3 anhydrous CH2Cl2 under an argon atmosphere. The resulting solution was cooled to 0 C and a solution of 0.384 mmol C2Cl6 In a 10 cm3 flask, 50 mg of phosphine-polyphosphazene(0.094 mmol) was dissolved in 3 cm3 anhydrous CH2Cl2 under an argon atmosphere. The resulting solution was cooled to 0 C and a solution of 0.384 mmol C2Cl6 in 1 cm3 anhydrous CH2Cl2 was added followed by 0.094 mmol ofthe alcohol after 5 min. After further stirring for 15 min the solvent was removed, the residue was taken up in a minimum amount of CHCl3 and the oxidized polymer was precipitated in an appropriate solvent. The polymer was removed by filtration, and washed with the precipitation solvent. The combined filtrates were evaporated to dryness and dried under high vacuum to yield the corresponding alkyl orbenzyl chlorides. in 1 cm3 anhydrous CH2Cl2 was added followed by 0.094 mmol ofthe alcohol after 5 min. After further stirring for 15 min the solvent was removed, the residue was taken up in a minimum amount of CHCl3 and the oxidized polymer was precipitated in an appropriate solvent. The polymer was removed by filtration, and washed with the precipitation solvent. The combined filtrates were evaporated to dryness and dried under high vacuum to yield the corresponding alkyl orbenzyl chlorides.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7314-44-5, (2,4-Dimethoxyphenyl)methanol.

Reference:
Article; Koenig, Michael; Linhardt, Anne; Brueggemann, Oliver; Teasdale, Ian; Monatshefte fur Chemie; vol. 147; 9; (2016); p. 1575 – 1582;,
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Synthetic Route of 7314-44-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

TMS protected treprostinil was dissolved in DCM (2.5 mE) and H20 (60 pL). DMAP (76 mg, 0.624 mmol),EDC.HC1 (119 mg, 0.624 mmol) and Dmob-alcohol (105 mg, 0.624 mmol) dissolved in DCM (1 ml) were added. Thereaction mixture was stirred at RT until reaction was com25 plete (EC/MS). The solution was diluted with DCM andquenched by addition of 0.1 N HC1 solution saturated withNaC1. The aqueous phase was extracted several times withDCM. Combined organic layers were dried with Mg504 andthe solvent was removed in vacuo obtaining crude product8. Crude product was purified using RP-HPEC (solvent A:H20 with 0.05% TFA, solvent B: MeCN with 0.05% TFA, gradient: 35-85% B over 16 mm, flow: 40 ml/min). Combined HPEC fractions were adjusted to a pH of approx. 7 by adding sat. NaHCO3 soln. MeCN was removed in vacuo. The remaining H20 layer was extracted several times with DCM and the combined organic phases were dried with Mg504, filtered and the solvent was removed in vacuo obtaining product 8 as colorless solid.Yield: 69 mg (82%).MS: mlz 563.20 g/mol=[M+Na] (MW+Na calculated=563.67 g/mol).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7314-44-5, (2,4-Dimethoxyphenyl)methanol.

Reference:
Patent; Ascendis Pharma A/S; Hersel, Ulrich; Rau, Harald; Lessmann, Torben; Bisek, Nicola; Maitro, Guillaume; Sprog°e, Kennett; Wegge, Thomas; Keil, Oliver; Zettler, Joachim; (89 pag.)US9561287; (2017); B2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C9H12O3

EXAMPLE 2 5-Chloro-3-cyclohexyl-1,3-dihydro-1-(2,4-dimethoxybenzyl)-2H-benzimidazol-2-one A solution of 0.537 g of 1-hydroxymethyl-2,4-dimethoxybenzene in 5 ml of ether is cooled to -10 C., under a nitrogen atmosphere, and a solution of 0.1 ml of phosphorus tribromide in 2 ml of ether is added dropwise. The 1-bromomethyl-2,4-dimethoxybenzene thus obtained is stored in solution at -30 C.

The synthetic route of 7314-44-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; US5661169; (1997); A;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7314-44-5, name is (2,4-Dimethoxyphenyl)methanol, molecular formula is C9H12O3, molecular weight is 168.19, as common compound, the synthetic route is as follows.Recommanded Product: (2,4-Dimethoxyphenyl)methanol

N-(Fmoc)-M1-(Boc)-D-Tryptophan (1 eq., 4.5 g, 8.55 mmol), TBTU (1 eq., 2.74 g, 8.55 mmol) and di-iso-propylethylamine (DIEA, 2 eq., 2.82 mL, 17.1 mmol) were dissolved in DMF (20 mL), stirred at rt for 30 mm under argon atmosphere, treated with an injection of a solutionof 2,4-dimethoxybenzyl alcohol (1.1 eq., 1.58 g, 9.4 mmol, prepared according to Feng, L.; Lv, K.; Liu, M.; Wang, S.; Zhao, J.; You, X.; Li, S.; Cao, J.; Guo, H. Eur. J. Med. Chem. 2012, 55, 125-136) in DMF (5 mL), and stirred at rt for 4h. The reaction mixture was diluted with EtOAc and washed with water (2 x 100 mL) and brine (2 x 100 mL). The organic phases were combined, dried over Na2SO4, filtered and evaporated to a residue that was purified by flashchromatography on silica gel eluting with 20% EtOAc in hexane to afford ester 6 (4.97 g, 7.35 mmol, 86 %) as white solid: mp 67-68 C; Rf 0.29 (20% EtOAc in hexane); 1H NMR (500 MHz, CDCI3) oe 8.11 (brs, 1H), 7.76 (d, J= 7.6 Hz, 2H), 7.58-7.48 (m, 3H), 7.44 (s, 1H), 7.42-7.36 (m, 2H), 7.33 – 7.26 (m, 3H), 7.21 (t, J 7.3 Hz, 1 H), 7.11 (d, J = 8.0 Hz, 1 H), 6.46 – 6.39 (m, 2H), 5.44 (d, J= 8.0 Hz, 1H), 5.12 (s, 2H), 4.78 (dd, J= 13.6, 5.4 Hz, 1H), 4.40-4.28 (m, 2H),4.19 (t, J= 7.3 Hz, 1H), 3.80 (s, 3H), 3.79 (s, 3H), 3.33-3.20 (m, 2H), 1.65 (s, 9H); 13C NMR(125 MHz, CDCI3) 6 171.7, 161.7, 159.2, 155.8, 149.7, 144.0, 143.9, 141.4 (2C), 131.7 (2C),127.8 (2C), 127.2 (2C), 125.3 (2C), 124.6 (2C), 124.5, 124.4, 122.8, 120.1, 119.0, 115.8, 115.4,115.1, 104.2, 98.7, 83.8, 67.3, 63.4, 55.5 (2C), 54.4, 47.3, 28.3 (3C), 28.0; HRMS m/zcalculated for C40H41N208 [M+H] 677.2857; found 677.2859.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7314-44-5, (2,4-Dimethoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; VALORISATION-RECHERCHE, LIMITED PARTNERSHIP; LUBELL, William D.; ONG, Huy; ZHANG, Jinqiang; MULUMBA, Dilan Mukandila; MARLEAU, Sylvie; OHM, Ragnhild Gaard; AHSANULLAH, -; OMRI, Samy; CHINGLE, Ramesh; (157 pag.)WO2018/79; (2018); A1;,
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Application of 7314-44-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

EXAMPLE 2 1,3-Dihydro-1-(2,4-dimethoxybenzyl)-3-spiro(N-methylpiperidine-4)indol-2-on A solution of 2.08 g of 1-hydroxymethyl-2,4-dimethoxybenzene in 20 ml of ether is cooled to -10 C. under nitrogen and a solution of 0.4 ml of phosphorus tribromide in 8 ml of ether is added dropwise; the resulting 1-bromomethyl-2,4-dimethoxybenzene is kept at -30 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7314-44-5, its application will become more common.

Reference:
Patent; Sanofi; US5618833; (1997); A;,
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Related Products of 7314-44-5 , The common heterocyclic compound, 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol, molecular formula is C9H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of alcohol (0.75 mmol), and catalyst Mo1 (13 mg,3.0 mol%) taken in 0.5 mL of water was stirred at 100 C under oxygenatmosphere (O2 bladder) and the stirring was continued for16-24 h as per requirement. The progress of reaction was monitoredby TLC. After completion of the reaction, ethyl acetate was added to the mixture. The aqueous phase was extracted with ethyl acetate 2-3 times. Then the combined organic extracts were driedover anhydrous sodium sulfate and the solvent was removed under reduced pressure. The crude product so obtained was purified by column chromatography using hexane-ethyl acetate as eluent. While the known products were characterized by spectroscopic techniques and compared with reported data and the new products 22b and 36b were characterized completely. The characterization detail is provided in supporting information section.

The synthetic route of 7314-44-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Thiruvengetam, Prabaharan; Chakravarthy, Rajan Deepan; Chand, Dillip Kumar; Journal of Catalysis; vol. 376; (2019); p. 123 – 133;,
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