Category: 72995-94-9

Related Products of 72995-94-9 ,Some common heterocyclic compound, 72995-94-9, molecular formula is C14H29BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

14-Bromo-1-tetradecanol (10.00 g, 34.1 mmol) was dissolved in 6 dichloromethane (34.1 mL), and 7 imidazole (5.11 g, 75.0 mmol) was added to the solution. 8 TIPSCl (7.95 mL, 37.5 mmol) was dropwise added to the mixture, followed by stirring at room temperature for 3 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was dissolved in 11 heptane (136 mL), followed by liquid-liquid extraction with water (34 mL) once, 1 N 9 hydrochloric acid (34 mL) once, 10 water (34 mL) twice, and 39 acetonitrile (34 mL) once. Heptane (34 mL) was added to the resulting heptane layer, followed by liquid-liquid extraction with acetonitrile (34 mL). The liquid-liquid extraction with heptane and acetonitrile was further repeated once, and the heptane layer was then concentrated under reduced pressure to obtain 92 Br-(CH2)14-O-TIPS (15.41 g). (0161) 1H-NMR (400 MHz, CDCl3) delta 1.04-1.08 (m, 21H), 1.24-1.38 (m, 18H), 1.42 (quin., 2H), 1.53 (quin., 2H), 1.85 (quin., 2H), 3.40 (t, 2H), 3.67 (t, 2H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72995-94-9, 14-Bromotetradecan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SEKISUI MEDICAL CO., LTD.; YANO, Shinya; WAKASUGI, Yuki; IWANAGA, Yosuke; (32 pag.)US2019/23726; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72995-94-9, name is 14-Bromotetradecan-1-ol, molecular formula is C14H29BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C14H29BrO

(5) A solution of n-butyl lithium (1.8 ml) was added dropwise to a 5 ml THF solution of 560 mg of 1,1-(ethylenedioxy)-4-methyl-3-(phenylsulfonyl)-cyclohexane and 4 mg of triphenylmethane under an argon stream at -78 C. The resulting mixture was stirred for 10 minutes and then reacted at room temperature for one hour. HMPT (1 ml) was added and the resulting mixture was cooled again to -78 C., followed by the dropwise addition of a 2 ml THF solution of 205 mg of 14-bromo-1-tetradecanol. After the reaction at -20 C. for 2 hours, the reaction mixture was poured into a saturated solution of ammonium chloride. The resulting mixture was extracted with diethyl ether. The organic layer was washed with water and saturated saline, dried over magnesium sulfate and distilled under reduced pressure to remove the solvent. The residue was purified by chromatography on a silica gel column while using hexane-ethyl acetate, whereby 1,1-(ethylenedioxy)-3-(14-hydroxytetradecyl)-4-methyl-3-(phenylsulfonyl)-cyclohexane was obtained in the form of a colorless oil (yield: 98%).

With the rapid development of chemical substances, we look forward to future research findings about 72995-94-9.

Reference:
Patent; Luu, Bang; Mohier, Eliane; Yamada, Masashi; Suma, Yukie; Suzuki, Hiroto; US2004/115810; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 72995-94-9, name is 14-Bromotetradecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 72995-94-9

Synthesis Example D-(27) 2,5-Dimethoxyphenol (287.1 mg) was dissolved in 30 ml of acetone, and to this solution, potassium carbonate and a solution of 14-bromotetradecan-1-ol (599.5 g) in 2 ml of acetone were added. The reaction mixture was stirred at reflux temperature (56C) for 24 hours, and then neutralized with saturated ammonium chloride solution. It was then extracted three times with diethyl ether. The organic layer was washed with saline solution and dried over magnesium sulfate, and then the solvent was distilled off under reduced pressure. Purification of the residue by silica gel chromatography (eluting with dichloromethane) gave 14-(2,5-dimethoxyphenoxy)tetradecan-1-ol as white crystals at a 65% yield. Molecular weight: 366.53 (C22H38O4) TLC: (CH2Cl2100%) Rf value=0.2 1H-NMR: (300MHz, CDCl3) delta:1.26 (s large, 20H, -(CH2)10-); 1.54 (qt, 2H, J=6.9Hz, -CH2-); 1.81 (qt, 2H, J=7.2Hz, -CH2-); 3.63 (t, 2H, J=6.6Hz, -CH2-OH); 3.76 (s, 3H, -OCH3); 3.81 (s, 3H, -OCH3); 3.97 (t, 2H, J=6.9Hz, -CH2-O-Ph); 6.38 (dd, 1H, J3=8.7Hz, J5=2.8Hz, aromatic-CH); 6.50 (d, 1H, J5=2.8Hz, aromatic-CH); 6.78 (d, 1H, J3=8.7Hz, aromatic-CH) 13C-NMR: (75MHz, CDCl3) delta: 25.75; 25.97-32.5; 32.83; 55.67; 56.81; 63.12; 68.96; 101.66; 103.01; 112.66; 144.41; 151.08; 155.44

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Reference:
Patent; Meiji Dairies Corporation; EP1854777; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 72995-94-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72995-94-9, name is 14-Bromotetradecan-1-ol, molecular formula is C14H29BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 14-bromotetradecan-1-ol (700 mg, 2.38 mmol) and DAST (0.63 ml_, 4.76 mmol) was heated at 35 C for 4h. The reaction mixture was poured into water and extracted with DCM (x3). The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered and the solvent was removed under reduced pressure. The residue was purified by flash chromatography (hexanes/diethyl ether) to yield the title compound (422 mg, 60%) as a colourless oil. 1 H NMR d (400 MHz, CDCI3): 1.21-1.34 (m, 16H), 1.35-1.47 (m, 4H), 1.60-1 .78 (m, 2H), 1.80-1 .92 (m, 2H), 3.41 (t, J=6.9 Hz, 2H), 4.38 (t, J=6.2 Hz, 1 H), 4.50 (t, J=6.2 Hz, 1 H).

According to the analysis of related databases, 72995-94-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALMIRALL, S.A.; BACH TANA, Jordi; ESTEVE TRIAS, Cristina; MIR CEPEDA, Marta; (187 pag.)WO2019/115405; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts