Category: 7287-82-3

Synthetic Route of 7287-82-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-82-3, name is 1-(2-Methylphenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: The preparative electrolysis experiments were conducted with in an undivided cell containing0.1 M NaClO4-CH3CN solution (15 mL), alcohol substrate (1.0 mmol), ABNO (0.1 mmol),and 2,6-lutidine (1.0 mmol) at a constant current of 10.0 mA with moderate magnetic stirring for8.5 h in the atmosphere. Two square platinum sheets were employed as the anode and cathode,respectively. The electrolytic reaction was monitored by gas chromatography (GC) on a GC-2010system (Shimadzu, Kyoto, Japan) equipped with a SH-Rtx-Was polar column and a flame ionizationdetector (FID). Both the injector and detector were maintained at 220 C, the carrier gas is nitrogen,and the flow rate is 1.2 mL/min. The initial oven temperature of 100 C was held for 2 min andthen ramped up at 15 C per min to 220 C. This final temperature was held for 8 min. After thereaction was finished, the resulting mixture was concentrated in a rotary evaporator (Heidolph,Schwabach, Germany) and purified by column chromatography on silica gel using petroleum andethyl acetate 15:1) as eluent to afford the products. The products were confirmed by GC-MS, 1H-NMR,and 13C-NMR. NMR spectroscopy was carried out on a Bruker Avance III spectrometer (Bruker,Faellanden, Switzerland). The GC-MS analysis was measured on Thermo Trace ISQ instrument (ThermoFisher Nicolet,Waltham, MA, USA) with TG 5MS capillary column.Acetophenone (colorless oil, yield 80%):

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7287-82-3, its application will become more common.

Reference:
Article; Niu, Pengfei; Liu, Xin; Shen, Zhenlu; Li, Meichao; Molecules; vol. 24; 1; (2019);,
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Electric Literature of 7287-82-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7287-82-3, name is 1-(2-Methylphenyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a flask under argon atmosphere, iridium catalyst 5 (0.50 or 1.0 mol %), sodium hydroxide (0.50 or 1.0 mol %), water (2 mL), and alcohol (2.0 mmol) were placed. The mixture was stirred under vigorous reflux (temperature of the oil bath was set at 140 C) for 20-96 h. After cooling to room temperature, water (4 mL) was added and the mixture was transferred to a separate funnel. Extraction of the organic compounds with dichloromethane (15 mL x 3), dehydration with sodium sulfate, followed by evaporation under vacuum gave crude mixture. For entries 2-11,the conversion of starting alcohol and the yield of ketone were determined by 1H NMR analysis in chloroform-d using triphenylmethane as an internal standard. For entries 1 and 12-14, the conversion of starting alcohol and the yield of ketone were determined by GC analysis using biphenyl as an internal standard. For entries 2-8, 10, and 11, the product was isolated by silica-gel column chromatography (eluent:ethyl acetate/ hexane).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-82-3, 1-(2-Methylphenyl)ethanol.

Reference:
Article; Toyomura, Kazuki; Fujita, Ken-Ichi; Chemistry Letters; vol. 46; 6; (2017); p. 808 – 810;,
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Adding a certain compound to certain chemical reactions, such as: 7287-82-3, 1-(2-Methylphenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-(2-Methylphenyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 1-(2-Methylphenyl)ethanol

General procedure: In a typical process, into a 5ml two-necked, round-bottom flask equipped with a magnetic stirrer and a thermometer were added the ruthenium complex [Ru(pymieb)(pydic)] (0.002mmol) and the substrate alcohol (2mmol) successively. The mixture was heated to 40C under stirring. Then t-butyl hydroperoxide (TBHP) was added dropwise to the mixture and the temperature was kept at 40C until completion of the reaction. The reaction samples were analyzed on a Shandong Lunan Ruihong Gas Chromatograph (SP-6800A) equipped with a FID detector and a SE 30 column (30m×0.5mm). The conditions used in gas chromatography were temperature of the detector 280C, column temperature 130-220C (varying with alcohols), pressure of the carrier gas 0.05-0.07MPa (varying with alcohols).

The synthetic route of 7287-82-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Yuecheng; Liu, Liu; Cao, Xiaohui; Zhao, Jiquan; Polyhedron; vol. 105; (2016); p. 170 – 177;,
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Related Products of 7287-82-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7287-82-3, name is 1-(2-Methylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

1-(o-Tolyl)ethanol (513 mg, 3.77 mmol, commercially available from, for example, Alfa Aesar) was dissolved in DCM (5 mL) and stirred at 0 C under N2. PBr3 (0.142 mL, 1.507 mmol) wasadded dropwise and the reaction stirred for 30 mm at 0 C, then allowed to slowly warm to rt. A further portion of PBr3 (0.355 mL, 3.77 mmol) was added dropwise at rt and the reaction stirred for1.5 h. The solution was quenched with sat. aq. sodium bicarbonate (20 mL), the aqueous layer was extracted with DCM (3 x 20 mL) and the combined organic layers were dried over a hydrophobic frit and concentrated to give (+/-)-1-(1-bromoethyl)-2-methylbenzene (670 mg, 2.69 mmol, 71.5 %yield) as a colourless oil.1H NMR (400 MHz, DMSO-d6) O ppm 7.54 – 7.60 (m, 1 H) 7.15 – 7.27 (m, 3 H) 5.62 (q, J=6.8 Hz, 1 H) 2.37 (5, 3 H) 2.03 (d, J=6.8 Hz, 3 H)

According to the analysis of related databases, 7287-82-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
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Reference of 7287-82-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-82-3, name is 1-(2-Methylphenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: In a typical process, into a 5-ml two-necked round-bottomflask equipped with a magnetic stirrer were addedRu(pbbp)(pydic) (0.002 mmol) and alcohol (2 mmol)successively at room temperature. The mixture washeated to 60 C under stirring, and then TBHP (70%aqueous solution) was slowly dropped in 0.5 h. Thereaction was monitored by GC equipped with a SE 54column (30 m 9 0.5 lm). After reaction, the product waspurified by column chromatography over silica gel (eluent:n-hexane/ethyl acetate) and characterized by 1HNMR.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7287-82-3, 1-(2-Methylphenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Yuecheng; Chu, Ruosi; Zhang, Hongyu; Zhao, Jiquan; Transition Metal Chemistry; vol. 42; 2; (2017); p. 105 – 116;,
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