Category: 7287-81-2

Electric Literature of 7287-81-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7287-81-2, name is 1-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 2,2,6,6-Tetramethylpiperidine 1-oxyl (TEMPO, 9.4 mg,0.06 mmol, 3 mol %), 2,2?-bipyridyl (9,4 mg, 0.06 mmol,3 mol %), [Cu(CN)4]OTf (22.6 mg, 0.06 mmol, 3 mol %) and1-methylimidazole (NMI, 11.5 mg, 11.2 muL, 0.14 mmol,7 mol %) were placed in a zirconia-milling beaker (45 mL)equipped with four balls (two balls × 5 mm , two balls ×12 mm ) of the same material. The jar was sealed and ballmilled for 1 min. Then, benzyl alcohol (216.3 mg, 207 muL,2.0 mmol), NaCl (1.0 g) together with other two zirconia balls(12 mm ) were added and the reaction mixture was subjectedto grinding for further 10 minutes overall (two cycles of5 minutes each). The first milling cycle was followed by a breakof 2 min leaving in the meantime the uncovered jar in open air.The progress of the reaction was monitored by TLC analysis(heptane/AcOEt 9:1 v/v) and GC-MS analysis on an aliquot ofthe crude. Upon completion of the ball milling process, the jarwas opened, the milling balls were removed and the resultingcrude product (adsorbed on NaCl) was then easily transferredinto a separating funnel filled with an aqueous 10% citric acidsolution (20 mL). The aqueous phase was extracted withcyclopentyl methyl ether (or alternatively with AcOEt)(3 × 15 mL). The combined organic fractions were washed withH2O (25 mL) and brine (25 mL), then dried over Na2SO4, andconcentrated in vacuo to give benzaldehyde in high yield (195 mg, 92%) and good purity (>93% by GC analysis). Alternatively, after completion of the reaction, the resulting crudeproduct (adsorbed on NaCl) can be also easily purified by ashort column chromatography on silica gel using heptane/ethylacetate (9:1 v/v) as the eluents to afford pure aldehyde 2b inhigh yield (202 mg, 95%) as a colourless liquid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Porcheddu, Andrea; Colacino, Evelina; Cravotto, Giancarlo; Delogu, Francesco; De Luca, Lidia; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2049 – 2055;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-81-2, name is 1-(m-Tolyl)ethanol. A new synthetic method of this compound is introduced below., Safety of 1-(m-Tolyl)ethanol

General procedure: A 1,2-dichloroethane (2.0 or 5.0 mLmL) solution of alcohol 1 (0.3mmol), enol acetate 2 (0.3mmol), and ReBr(CO)5 (5mol%) was stirred under an atmosphere of nitrogen at 80C for 5h. After the reaction was complete, H2O was added to the reaction mixture and extracted with ethyl acetate. The organic layer was dried with MgSO4. The resulting mixture was filtered, and the filtrate was concentrated. Purification of the residue by silica gel column chromatography afforded carbonyl compounds. Further purification was carried out by recyclable preparative HPLC, if necessary. The structures of the products were assigned by their 1H and 13C NMR, and mass spectra. The product was characterized by comparing its spectral data with those of authentic sample or previous reports 3a [23], 3b [24], 3c [24a], 3e [25], 3f [24a,26], 3h [27], 3i [28], 3j [29], 3k [25], 3l [30], 3m [31], 4b [27], 4d [32], 4g [24a,33], 4h [34], 6a [35], 6g [24a], 6h [36], 8e [37], and 8e? [38]. The structures of the products (3d, 4c, 4e, 4f, 4i, 6b, 6c, 6d, 6e, 6f, 6i, 6j, 6k, 6l, 8a, 8a?, 8b, 8b?, 8c, 8c?, 8d, 8d?, 8f, 8f?, 8g, and 8g?) were assigned by their 1H and 13C NMR, IR, and high resolution mass spectra analysis.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Umeda, Rui; Takahashi, Yuuki; Yamamoto, Takaaki; Iseki, Hideki; Osaka, Issey; Nishiyama, Yutaka; Journal of Organometallic Chemistry; vol. 877; (2018); p. 92 – 101;,
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Application of 7287-81-2 ,Some common heterocyclic compound, 7287-81-2, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Dissolve 1- (3-METHYLPHENYL)-1-ETHANOL (1.36 g, 10 mmol) in dry toluene. Cool to 0 C and add DPPA (diphenylphosphoryl azide, 3.3 g, 12 mmol) followed by 1,8- diazabicyclo [5.4. 0] undec-7-ene (DBU, 1. 8 mL, 12 mmol). Warm the resulting mixture to RT and stir overnight, then dilute with H2O, and extract with ether. Wash the organic layer with 1 N HCI, saturated NaHC03, and brine. Dry over MGS04, filter, and concentrate to give the title compound (1.3 g, 81%) as a pale yellow oil. Use without further purification. RIF= 0. 66 (20: 1 hexanes/EtOAc) ; H NMR (CDC13, 250 MHz) 8 7.1- 7.4 (m, 4H), 4.61 (q, 1H), 2.42 (2, 3H), 1. 56 (d, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7287-81-2, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/821; (2005); A1;,
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Adding a certain compound to certain chemical reactions, such as: 7287-81-2, 1-(m-Tolyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-(m-Tolyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 1-(m-Tolyl)ethanol

In the glove box, the -1 – methyl methyl phenyl ethyl alcohol (1.0 mmol), [Cu6 (Pyt)6 ] (0.1 mmol), KOH (1.0 mmol) is added to the test tube with the magnetic coil in the has, then adding 2.0 ml dry toluene solvent. After the sealed reaction tube, is taken out of the glove box. Toward the nozzle leads into the small and stable and low production, stable air flow after such as, for 70 C reaction under 24 h; after the reaction, extracted with ethyl acetate (3 ¡Á 5 ml), the combined organic phase, dried with anhydrous sodium sulfate, filtered, concentrated filtrate for rotary evaporator, and then separating and purifying column law silica gel chromatography, to obtain the target product methyl methyl acetophenone (yield 93%).

The synthetic route of 7287-81-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Soochow University; Li, Hongxi; Tan, Dawei; Li, Haiyan; Lang, Jianping; (15 pag.)CN106588957; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-81-2, name is 1-(m-Tolyl)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(m-Tolyl)ethanol

General procedure: A 20 ml vial equipped with a magnetic stirring bar was charged with secondary alcohols (0.3 mmol, 1 equiv.), NaN3 (0.75 mmol, 2.5 equiv.), n-hexane (1.0 ml, 0.3 M) and TFA (5.4 mmol, 18 equiv.) or a mixture of TFA (3.6 mmol,12 equiv.) and MeSO3H (1.8 mmol, 6 equiv.). The vial was sealed and stirred under air at 40 C for 4 h. On completion, the reaction mixture was quenched by 2 M NaOH (5 m), extracted by ethyl acetate (5 ¡Á 2 m) and the combined organic phase was washed with brine and dried over Na2SO4. Then the mixture was concentrated and purified by flash chromatography on a short silica gel column.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Liu, Jianzhong; Qiu, Xu; Huang, Xiaoqiang; Luo, Xiao; Zhang, Cheng; Wei, Jialiang; Pan, Jun; Liang, Yujie; Zhu, Yuchao; Qin, Qixue; Song, Song; Jiao, Ning; Nature Chemistry; vol. 11; 1; (2019); p. 71 – 77;,
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Reference of 7287-81-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-81-2, name is 1-(m-Tolyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: In a flask under argon atmosphere, iridium catalyst 5 (0.50 or 1.0 mol %), sodium hydroxide (0.50 or 1.0 mol %), water (2 mL), and alcohol (2.0 mmol) were placed. The mixture was stirred under vigorous reflux (temperature of the oil bath was set at 140 C) for 20-96 h. After cooling to room temperature, water (4 mL) was added and the mixture was transferred to a separate funnel. Extraction of the organic compounds with dichloromethane (15 mL x 3), dehydration with sodium sulfate, followed by evaporation under vacuum gave crude mixture. For entries 2-11,the conversion of starting alcohol and the yield of ketone were determined by 1H NMR analysis in chloroform-d using triphenylmethane as an internal standard. For entries 1 and 12-14, the conversion of starting alcohol and the yield of ketone were determined by GC analysis using biphenyl as an internal standard. For entries 2-8, 10, and 11, the product was isolated by silica-gel column chromatography (eluent:ethyl acetate/ hexane).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7287-81-2, 1-(m-Tolyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Toyomura, Kazuki; Fujita, Ken-Ichi; Chemistry Letters; vol. 46; 6; (2017); p. 808 – 810;,
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Reference of 7287-81-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7287-81-2, name is 1-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of alcohol 1 (0.50 mmol), immobilized lipase (200 mg, 0.5%(w/w) enzyme/Toyonite-200M), and molecular sieves 3A (three pieces) in dry i-Pr2O (5.0mL) in a test tube with a rubber septum was stirred at 30 C for 30 min. The reaction wasstarted by addition of vinyl acetate (93 muL, 1.0 mmol) via a syringe. The progress of thereaction was monitored by TLC. The reaction was stopped by filtration at an appropriateconversion, and the filtrate was concentrated under reduced pressure. Alcohol 1 and ester 2were separated by silica gel column chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Ema, Tadashi; Inoue, Hiroki; Chemistry Letters; vol. 44; 10; (2015); p. 1374 – 1376;,
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7287-81-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7287-81-2, name is 1-(m-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 37. Synthesis of (¡À)(1 hromoethyfl-3-methylbenzene,Phosphorus tribromide (4.28 g, 15.9 mmoi) was added drop-wise to a stirred neat solution of 1- (m-toiyi)ethanoi (0.9 g, 6.6 mmoi) at 0C. After being stirred to room temperature over 12 h, the reaction was carefully? quenched with sat?d saturated aqueous NaHCO3 solution an( the mixture was extracted with EtOAc, The organic extract was washed with water, dried with MgSO, and cone, in vacuo to afford the title compound (i.2 g. 91%) as a colorless oil, that was used directly in the next step without tiirther purification. LCMS 200 (M + Kj.

The chemical industry reduces the impact on the environment during synthesis 7287-81-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew, S.; DAKIN, Les, A.; DUPLESSIS, Martin; GEHLING, Victor, S.; HARMANGE, Jean-Christophe; NAVESCHUK, Christopher, G.; VASWANI, Rishi, G.; WO2013/120104; (2013); A2;,
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7287-81-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7287-81-2, name is 1-(m-Tolyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: A 1,2-dichloroethane (2.0 mL) solution of alcohol 1 (0.3 mmol), enol acetate 2 (0.3 mmol), andReBr(CO)5 (5 mol%) was stirred under an atmosphere of nitrogen at 80 C for 5 h. After the reactionwas complete, H2O was added to the reaction mixture and extracted with ethyl acetate. The organiclayer was dried with MgSO4. The resulting mixture was filtered, and the filtrate was concentrated.Purification of the residue by silica gel column chromatography afforded carbonyl compounds.Further purification was carried out by recyclable preparative HPLC, if necessary. The structures ofthe products were assigned by their 1H and 13C-NMR, and mass spectra. The product was characterizedby comparing its spectral data with those of authentic sample or previous reports 3a,S1 3b,S2 3c,S2a3d,S2a,S3 3f,S4 3h,S5 3i,S6 3j,S7 3k,S4 3l,S8 3m,S9 3n,S2a 3o,S5 3q,S10 3t,S2a,S11 and 3u. S12 The structures of theproducts (3g, 3o, 3p, 3q, 3r, 3s, and 3v) were assigned by their 1H and 13C NMR, IR and mass spectra

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7287-81-2, 1-(m-Tolyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Umeda, Rui; Takahashi, Yuuki; Nishiyama, Yutaka; Tetrahedron Letters; vol. 55; 44; (2014); p. 6113 – 6116;,
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