Category: 7250-55-7

Synthetic Route of 7250-55-7 ,Some common heterocyclic compound, 7250-55-7, molecular formula is C7H12O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of scheme 5-8 compound S1 (24 g, 0.136 mol) and benzyl 2,2,2-trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 mL) at room temperature was added trifluoromethanesulfonic anhydride (cat.1.2 mL) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHCO3 and brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (35 g, 93.3% yield) as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7250-55-7, its application will become more common.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (508 pag.)WO2017/35409; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7250-55-7, name is Dimethyl 3-hydroxypentanedioate, the common compound, a new synthetic route is introduced below. Product Details of 7250-55-7

Preparation 29: (l-methyl-5-oxo-pyrtOlidin-3-yl)-acetic acidStep A: 3-methanesulfonyloxy-pentanedioic acid dimethyl esterCommercially available methyl 3-hydroxy-pentanedioic acid dimethyl ester (3.5 g, 20 mmol) was dissolved in DCM (50 mL) and Et3N (5.6 mL, 40 mmol) was added thereto. The reaction solution was cooled to 0C, and MsCl (2.75 g, 24 mmol) was added dropwise thereto, followed by stirring at room temperature for 2 hours. After the reaction was complete, NH4Cl was added to the reaction solution, followed by extraction with EtOAc. The organic extract was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc: n-Hex = 1/5) to afford the title compound (4.77 g, 94%).MS[M+1] = 241 (M+l)

The synthetic route of 7250-55-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2009/38412; (2009); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 7250-55-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7250-55-7 as follows.

To a stirred solution of dimethyl 3-hydroxyglutarate (19.98 g, 113.4mmol) in THF (340 mL) under argon at room temperature was added BH3·Me2S (3 equiv., 32.26 mL, 340.1 mmol) drop to drop. After 48 h the reaction mixture was diluted with MeOH (340 mL) with intense formation of bubbles, and stirred morefor 1 h. The solvent was distilled off and the residue purified by column chromatography on silica gel (EtOAc to MeOH/EtOAc, 1:9) to afford pentane-1,3,5-triol (2) (12.30g, 90%) as a colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7250-55-7, its application will become more common.

Reference:
Article; Kang, Young-Goo; Park, Chan-Yong; Shin, Hongsuk; Singh, Ramandeep; Arora, Garima; Yu, Chan-Mo; Lee, Ill Young; Bioorganic and Medicinal Chemistry Letters; vol. 25; 17; (2015); p. 3650 – 3653;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 7250-55-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7250-55-7, name is Dimethyl 3-hydroxypentanedioate, molecular formula is C7H12O5, molecular weight is 176.17, as common compound, the synthetic route is as follows.

Example 1 (Synthesis of dimethyl 3-benzyloxycarbonyloxyglutarate) In 10 ml of 1,2-dichloromethane was dissolved 1.01 g (5.78 mmol) of dimethyl 3-hydroxyglutarate, 847 mg (6.93 mmol) of 4,4-dimethylaminopyridine and 990 mul (6.93 mmol) of benzyloxycarbonyl chloride were added to the solution at room temperature, and the mixture was reacted at 0C for 30 minutes, and at room temperature for 1 hour under stirring. After completion of the reaction, the obtained reaction mixture was concentrated under reduced pressure, and the organic layer was extracted by adding 20 ml of ethyl acetate and 10 ml of water. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to obtain an oily substance.

Statistics shows that 7250-55-7 is playing an increasingly important role. we look forward to future research findings about Dimethyl 3-hydroxypentanedioate.

Reference:
Patent; Ube Industries, Ltd.; EP1500642; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 7250-55-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7250-55-7, name is Dimethyl 3-hydroxypentanedioate, molecular formula is C7H12O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of dimethyl 3-hydroxypentanedioate (20 g, 114 mmol) in CH2CI2 (100 mL) was added lH-imidazole (15.46 g, 227 mmol) and TBDPSC1 (46.8 g, 170 mmol) at 25C. The solution was stirred at 25C for 3 h, and the mixture was filtrated and the filter cake was washed by CH2CI2 (100 mL). The filtrate was concentrated in vacuo to afford the crude product, which was purified by gradient elution on S1O2 (ISCO, 120 g RediSep Gold column, 0 to 10% EtO Ac/Pet. ether over 90 min, dry-loaded) to afford the title compound. LRMS (M+H)+: 437.2.

According to the analysis of related databases, 7250-55-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; EMBREY, Mark, W.; HARTINGH, Timothy John; LABROLI, Marc; RAHEEM, Izzat, T.; (75 pag.)WO2019/160783; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts