Category: 72364-46-6

On January 10, 2013, Liu, Xingjin; Zhang, Xuke published a patent.Safety of (2-Fluorophenyl)methanethiol The title of the patent was Preparation of C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives for treating bacteria and protozoan infection. And the patent contained the following:

The title C-3 substituted 9-deoxo-9伪-aza-9伪-erythromycin A derivatives I [wherein wherein R1 = H, OH, or OMe; R2 = OH; R3 = organic substituent with optional heteroatom(s); R4 = H, Cbz, Bz, or Ac] or pharmaceutically acceptable salts thereof were prepared for treating bacteria and protozoan infections. For example, II was prepared in a multi-step synthesis. Some title compounds showed antibacterial activity with MIC of 0.125 pg/mL, which is 32 times better than Azithromycin and Clarithromycin. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Safety of (2-Fluorophenyl)methanethiol

The Article related to preparation erythromycin a antibacterial agent human, Carbohydrates: Amines and other aspects.Safety of (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mavel, Sylvie; Renou, Jean Louis; Galtier, Christophe; Snoeck, Robert; Andrei, Graciela; Balzarini, Jan; De Clercq, Erik; Gueiffier, Alain published an article in 2001, the title of the article was Synthesis of imidazo[1,2-a]pyridine derivatives as antiviral agents.SDS of cas: 72364-46-6 And the article contains the following content:

The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain was reported. Mol. modeling was used to identify biophoric structural patterns that are common to the 16 compounds Structure-activity relationship (SAR) studies identified hydrophobicity as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).SDS of cas: 72364-46-6

The Article related to imidazopyridine derivative formation antiviral activity, Pharmacology: Structure-Activity and other aspects.SDS of cas: 72364-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 1, 2006, Sakya, Subas M.; Cheng, Hengmiao; Lundy DeMello, Kristin M.; Shavnya, Andrei; Minich, Martha L.; Rast, Bryson; Dutra, Jason; Li, Chao; Rafka, Robert J.; Koss, David A.; Li, Jin; Jaynes, Burton H.; Ziegler, Carl B.; Mann, Donald W.; Petras, Carol F.; Seibel, Scott B.; Silvia, Annette M.; George, David M.; Hickman, Anne; Haven, Michelle L.; Lynch, Michael P. published an article.Recommanded Product: 72364-46-6 The title of the article was 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers. And the article contained the following:

Structure-activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine COX enzymes are described. The 4-cyano-5-alkyl ethers were found to have excellent potency and selectivity, whereas the 5-thioethers were potent but less selective than the ether analogs in a canine whole blood (CWB) COX-2 assay. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Recommanded Product: 72364-46-6

The Article related to canine cox2 inhibitor heterocyclic pyrazole preparation sar, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 72364-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 22, 2016, Jones, Stuart; Ahmet, Jonathan; Ayton, Kelly; Ball, Matthew; Cockerill, Mark; Fairweather, Emma; Hamilton, Nicola; Harper, Paul; Hitchin, James; Jordan, Allan; Levy, Colin; Lopez, Ruth; McKenzie, Eddie; Packer, Martin; Plant, Darren; Simpson, Iain; Simpson, Peter; Sinclair, Ian; Somervaille, Tim C. P.; Small, Helen; Spencer, Gary J.; Thomson, Graeme; Tonge, Michael; Waddell, Ian; Walsh, Jarrod; Waszkowycz, Bohdan; Wigglesworth, Mark; Wiseman, Daniel H.; Ogilvie, Donald published an article.HPLC of Formula: 72364-46-6 The title of the article was Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells. And the article contained the following:

A collaborative high throughput screen of 1.35 million compounds against mutant (R132H) isocitrate dehydrogenase IDH1 led to the identification of a novel series of inhibitors. Elucidation of the bound ligand crystal structure showed that the inhibitors exhibited a novel binding mode in a previously identified allosteric site of IDH1 (R132H). This information guided the optimization of the series yielding submicromolar enzyme inhibitors with promising cellular activity. Encouragingly, one compound from this series was found to induce myeloid differentiation in primary human IDH1 R132H AML cells in vitro. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).HPLC of Formula: 72364-46-6

The Article related to preparation allosteric inhibitor isocitrate dehydrogenase leukemia, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 72364-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 31, 2011, Chai, Hui-fang; Liang, Xin-xia; Li, Lin; Zhao, Chun-shen; Gong, Ping; Liang, Zhong-jie; Zhu, Wei-liang; Jiang, Hua-liang; Luo, Cheng published an article.HPLC of Formula: 72364-46-6 The title of the article was Identification of novel 5-hydroxy-1H-indole-3-carboxylates with anti-HBV activities based on 3D QSAR studies. And the article contained the following:

Infection with hepatitis B virus (HBV) is a major cause of liver diseases such as cirrhosis and hepatocellular carcinoma. In our previous studies, we identified indole derivatives that have anti-HBV activities. In this study, we optimize a series of 5-hydroxy-1H-indole-3-carboxylates, which exhibited potent anti-HBV activities, using three-dimensional quant. structure-activity relationship (3D QSAR) studies with comparative mol. field anal. (CoMFA) and comparative mol. similarity indexes anal. (CoMSIA). The lowest energy conformation of compound 3, which exhibited the most potent anti-HBV activity, obtained from systematic search was used as the template for alignment. The best predictions were obtained with the CoMFA standard model (q 2 = 0.689, r 2 = 0.965, SEE = 0.082, F = 148.751) and with CoMSIA combined steric, electrostatic, hydrophobic and H-bond acceptor fields (q 2 = 0.578, r 2 = 0.973, SEE = 0.078, F = 100.342). Both models were validated by an external test set of six compounds giving satisfactory prediction. Based on the clues derived from CoMFA and CoMSIA models and their contour maps, another three compounds were designed and synthesized. Pharmacol. assay demonstrated that the newly synthesized compounds possessed more potent anti-HBV activities than before (IC50: compound 35a is 3.1 μmol/l, compound 3 is 4.1 μmol/l). Combining the clues derived from the 3D QSAR studies and from further validation of the 3D QSAR models, the activities of the newly synthesized indole derivatives were well accounted for. Furthermore, this showed that the CoMFA and CoMSIA models proved to have good predictive ability. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).HPLC of Formula: 72364-46-6

The Article related to hydroxy indole carboxylate hepatitis b virus antiviral qsar hepatoblastoma, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 72364-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 26, 2003, Watanabe, Yukiyoshi; Yamazaki, Daiei; Otsu, Yuichi; Shibuya, Katsuhiko published a patent.COA of Formula: C7H7FS The title of the patent was Preparation of isothiazolylaminocarbonyl derivatives as insecticides. And the patent contained the following:

The isothiazolylaminocarbonyl derivatives I (R = halo, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, Ph, phenoxy, cyano, nitro or alkoxycarbony; X = NH, O or S; R1 = H or alkyl; a = 0-5; m = 0 or 1; n = 0 or 1) are prepared as insecticides. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).COA of Formula: C7H7FS

The Article related to isothiazolylaminocarbonyl derivative preparation insecticide, Agrochemical Bioregulators: Invertebrate and other aspects.COA of Formula: C7H7FS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 9, 2015, Wang, Lin; Tang, Lin; Chen, Zhiwu; Peng, Tao; Zhang, Shouguo; Wen, Xiaoxue; Yan, Haiyan; Wang, Gang; Liu, Shuchen; Sun, Yunbo; Li, Lu published a patent.Application In Synthesis of (2-Fluorophenyl)methanethiol The title of the patent was Substances having protein tyrosine kinase inhibiting activity, and preparation method and application thereof. And the patent contained the following:

The title substances are compounds represented by formula I, wherein X is sulfonyl (SO2) or sulfinyl (SO); R1 is selected from hydrogen, halogen, C1-C6 alkyl, and C1-C6 alkoxy; R is selected from substituted 2-indolinone-3-methylene or substituted 2-naphthyl. These compounds have better protein tyrosine kinase inhibiting activity than pilot compound (data given). ExRad, and can be used as candidate drugs for prevention and treatment of neoplastic diseases. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application In Synthesis of (2-Fluorophenyl)methanethiol

The Article related to protein tyrosine kinase inhibitof antitumor, Aliphatic Compounds: Sulfoxides and Sulfones and other aspects.Application In Synthesis of (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 8, 2014, Robl, Jeffrey A.; Wu, Shung C.; Yoon, David S. published a patent.Application In Synthesis of (2-Fluorophenyl)methanethiol The title of the patent was Preparation of pyridone/hydroxypyridine compounds as 11β-hydroxysteroid dehydrogenase h type I inhibitors. And the patent contained the following:

Title compounds I [A = (un)substituted 4- to 15-membered mono, bi- or tricyclic aliphatic or aromatic ring, X = halo, cyano, haloalkyl, etc.; Y = bond, (un)substituted alkylene or cycloalkyl, etc.; R1 = (un)substituted alkyl, heteroaryl, aryl, heterocyclyl, etc.; W = bond, alkyl, O, S, SO, SO2, etc.], and their enantiomers, diastereomers, solvates, salts, tautomers or prodrugs, are prepared as 11-beta-hydroxysteroid dehydrogenase type I inhibitors. Thus, e.g., II was prepared by reaction of cyclohexanone with malononitrile followed by reaction with 2-chlorobenzyl bromide. Compound II showed IC50 value of 2.95 nM at the in vitro inhibition of recombinant human 11β-HSD1 assay. The invention compounds are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy, such as diabetes, hyperglycemia, obesity, dislipidemia, hypertension, cognitive impairment, rheumatoid arthritis, osteoarthritis, glaucoma, Cushing’s disease and metabolic syndrome. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application In Synthesis of (2-Fluorophenyl)methanethiol

The Article related to pyridone hydroxypyridine preparation beta hydroxysteroid dehydrogenase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 1, 2013, Greco, M. N.; Connelly, M. A.; Leo, G. C.; Olson, M. W.; Powell, E.; Huang, Z.; Hawkins, M.; Smith, C.; Schalk-Hihi, C.; Darrow, A. L.; Xin, H.; Lang, W.; Damiano, B. P.; Hlasta, D. J. published an article.Name: (2-Fluorophenyl)methanethiol The title of the article was A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice. And the article contained the following:

By screening directed libraries of serine hydrolase inhibitors using the cell surface form of endothelial lipase (EL), the authors identified a series of carbamate-derived (EL) inhibitors. Compound (I) raised plasma HDL-C levels in the mouse, and a correlation was found between HDL-C and plasma compound levels. Spectroscopic and kinetic studies support a covalent mechanism of inhibition. The authors’ findings represent the first report of EL inhibition as an effective means for increasing HDL-C in an in vivo model. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Name: (2-Fluorophenyl)methanethiol

The Article related to thiocarbamate endothelial lipase hdl cholesterol preparation, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Name: (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 23, 2005, Scott, Ian L.; Ralph, Jeffrey M.; Voss, Matthew E. published a patent.Electric Literature of 72364-46-6 The title of the patent was Preparation of vinorelbine derivatives as antitumor agents. And the patent contained the following:

Vinorelbine derivatives of formula I [R1 = alkyl, aryl, heterocyclyl, halo, CN, CHO, acyl, (substituted) SH, alkylsulfonyl, etc.; R2 = alkyl, CHO; R3 = H, alkyl, acyl; R4 = H, acyl; X = alkoxy, (substituted) NH2, etc.] are prepared Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed. Thus, 11′-bromovinorelbine (II) was prepared from vinorelbine tartrate. II inhibited growth of HeLa and MCF-7 cells with GI50 values of 5 nM and 3 nM, resp. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Electric Literature of 72364-46-6

The Article related to vinorelbine derivative preparation antitumor, Alkaloids: Alkaloids Containing Three Or More Nitrogen Atoms and other aspects.Electric Literature of 72364-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts