Category: 722-92-9

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 722-92-9

To a solution of 4( 1 hydroxy-1 rifluoromethyl2,2,24ritiuoroethyl)aniline (60mg, 0.232 mmol) in CH2CI2 (2 mL) were successively added at RT N,Ndiisopropylethylamine (80 pL, 0.463 mmol) and 2chlorobenzoyl chloride (41 pL, 0.324 mmd). The mixture was stirred for 3 h and concentrated under reduce pressure. The crude residue was directly purified by cdumn chromatography on siNca gel without any workup by hexane/AcOEt (812) to obt&n 65 mg (71percent) 0 SR987 as a white powder: FTR cm1 3338. 3028, 1643, 1521, 1410; 1254. 1219, 1188, 1112, 968, 944, 826; 1H NMR (400 MHz, MeODd4) S =797 (t, J = 1.8 Hz, 1 H), 7.91 7.86 (m, I H), 7.85 7.80 (m, 2 H), 7.75 7.70 (m, 2 H),7.63 7.58 (m, I H), 7.51 (t, J 7.8 Hz, 1 H); 13C NMR (101 MHz, MeODd4) S = 167.5,141.5, 138.2, 135.9, 133.1, 131.4, 129.0 (2C), 128.9, 128.5, 127.3 (2C), 121.7 Thereare tree carbons msshg for the descdpton of SR1078. They correspond to the three carbons of the (1 hydroxy- 1 trmuoromethy2 2 ,24fiuoroethy) moety. The fluodne coupng with these carbons gkte muWpets that are very dUflcuft to see on the ?3C spectrum even with a proonged number of scans. HRMS (ES) m/z [M+H] c&cd for C16H10CF6NO2, 398.0377; found, 398.0395; Mp = 170A72C.

The synthetic route of 722-92-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; GRIFFIN, Patrick; KAMENECKA, Theodore; CHANG, Mi, Ra; DOEBELIN, Christelle; (58 pag.)WO2017/79120; (2017); A1;,
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Reference of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

Example 500 2-Acetyl-5-(cyclopropylsulfamoyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2,3-dihydro-1H-isoindole-1-carboxamide DIPEA (0.162 mL, 0.92 mmol) was added to 2-acetyl-5-(cyclopropylsulfamoyl)-2,3-dihydro-1H-isoindole-1-carboxylic acid (100 mg, 0.31 mmol), 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (88 mg, 0.34 mmol) and HATU (129 mg, 0.34 mmol) in DCM (5 mL) under nitrogen. The resulting solution was stirred at room temperature for 1 hour. The reaction mixture was quenched with saturated NH4C1 (20 mL), extracted with DCM (3*20 mL), the organic layer was dried over Na2SO4, filtered and evaporated to afford dark solid. The crude product was purified by flash silica chromatography, elution gradient 0 to 100percent EtOAc in petroleum ether. Pure fractions were evaporated to dryness to afford 2-acetyl-5-(cyclopropylsulfamoyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2,3-dihydro-1H-isoindole-1-carboxamide (40.0 mg, 22.94percent) as a colorless solid. LC/MS: m/z=566 [M+H]+. HRMS: calculated for (C23H21F6N3O5S+H)+566.1184. found (ESI [M+H]+) 566.1185. 1H NMR (400 MHz, DMSO-d6, mixture of rotamers, 4.5*:1) delta 0.36-0.54 (m, 4H), 1.99, 2.15*(s, 3H), 2.08-2.10 (m, 1H), 4.76-4.93, 5.00-5.09*(m, 2H), 5.71*, 5.91 (s, 1H), 7.61-7.70 (m, 3H), 7.71-7.82 (m, 3H), 7.84-7.92 (m, 1H), 8.00, 8.02*(d, 1H), 8.67*, 8.69 (s, 1H), 10.71*, 10.94 (s, 1H).

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AstraZeneca AB; NARJES, Frank; OLSSON, Roine Ingemar; VON BERG, Stefan; LEVER, Sarah; (112 pag.)US2017/166527; (2017); A1;,
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Reference of 722-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, molecular weight is 259.15, as common compound, the synthetic route is as follows.

i) To a solution of 2-(5-bromopyridin-2-yl)acetic acid (500 mg) in DCM (4 mL) were added 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (625 mg), EDCl (476 mg) and DMAP (57 mg). The reaction mixture was stirredat RT for 1 hour, poured into water, filtered on a water repellent filter cartridge and concentrated under reducedpressure. The residue was purified by column chromatography on silica gel, using 10percent EtOAc in heptane as theeluent, followed by trituration with ether/pentane to obtain 820 mg of the expected compound. MS(ES+) m/z 456.9[M+H]+.

Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; Lead Pharma Cel Models IP B.V.; SANOFI; CALS, Joseph Maria Gerardus Barbara; NABUURS, Sander Bernardus; MACHNIK, David; SABUCO, Jean-Francois; SCHIO, Laurent; (49 pag.)EP3101005; (2016); A1;,
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Reference of 722-92-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 722-92-9 as follows.

A solution of [2- (4-AMINOPHENYL)-1,] 1,1, 3,3, 3-hexafluoropropan-2-ol (Oakwoood, [1] g, 3.9 [MMOL)] and 2, [4-DICHLOROBENZALDEHYDE] in methanol (21 mL) was stirred at ambient temperature. After 18 hours, glacial acetic acid (0.24 mL, 4.25 [MMOL)] and sodium [CYANOBOROHYDRIDE] (388 mg, 4.25 [MMOL)] were added. After stirring an additional 18 hours, the mixture was [CONCENTRATED IN VACUO] and the residue dissolved in EtOAc. The organic layer was washed several times with brine, dried [(NA2SO4),] filtered, and concentrated. Purification by flash chromatography (4: 1 hexanes/EtOAc) afforded the title compound as a white waxy solid (1.6 g, 99percent). MS (ES+) [M/Z] 418 (M+), 420 (M+2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
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Electric Literature of 722-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, molecular weight is 259.15, as common compound, the synthetic route is as follows.

A mixture of 2-(4-amino-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol (1 eq.), DIAD(1.96 eq.), PPh3(polymer-bound, 2.36 eq) and MeOH (1.1 eq) in THF (100 mL)was stirred at reflux for 16 h. After filtration andconcentration, the crude was purified by flashchromatography (20percent EtOAc/CH2Cl2) to give the title compoundas a white solid. MS (ES+) : 274 (M+H)+. Calc’d forCioH9F6NO- 273.06.

The chemical industry reduces the impact on the environment during synthesis 722-92-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AMGEN INC.; WO2006/12374; (2006); A1;,
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Electric Literature of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

The product from step 1 (500 mg, 1.9 [MMOL)] and ethyl acetoacetate [(0. 27] mL, 2.1 [MMOL)] were combined and dissolved in methanol (10 mL) at ambient temperature. To this solution was added glacial acetic acid (0.13 mL, 2.1 [MMOL)] followed by sodium [CYANOBOROHYDRIDE] (194 mg, 3.1 [MMOL).] After stirring 18 h, the solution was [CONCENTRATED IN VACUO] and the resultant oil dissolved in ethyl acetate. The organics were washed with brine, dried over [MGS04,] and concentrated. Purification by reverse phase HPLC using a gradient elution of 60: 40 H20/TFA : CH3CN to 0: 100 H20/TFA : CH3CN at 254 nm afforded the title compound as a white solid (440 mg, [61 percent)] : mp = 103 [¡ãC.] H NMR [(CDC . S) 8] 7.43 (d, 2H), 6.64 (d, 2H), 4.07 (q, 2H), 3.90 (m, 1H), 3.43 (br s, 1 H), 2.58 (dd, 1 H), 2.41 (dd, [1 H),] 1.23 (d, 3H), 1.17 (t, 3H). MS (ES+) m/z 374 [(MH+).] [ANAL. CALC.] for C15H17NO3F6: C, 48.26 ; H, 4.59 ; N, 3.75. Found: C, 47.95 ; H, 4.45 ; N, 3.58.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 722-92-9, Adding some certain compound to certain chemical reactions, such as: 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C9H7F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 722-92-9.

The product from step 1 (500 mg, 1.9 [MMOL)] and ethyl acetoacetate [(0. 27] mL, 2.1 [MMOL)] were combined and dissolved in methanol (10 mL) at ambient temperature. To this solution was added glacial acetic acid (0.13 mL, 2.1 [MMOL)] followed by sodium [CYANOBOROHYDRIDE] (194 mg, 3.1 [MMOL).] After stirring 18 h, the solution was [CONCENTRATED IN VACUO] and the resultant oil dissolved in ethyl acetate. The organics were washed with brine, dried over [MGS04,] and concentrated. Purification by reverse phase HPLC using a gradient elution of 60: 40 H20/TFA : CH3CN to 0: 100 H20/TFA : CH3CN at 254 nm afforded the title compound as a white solid (440 mg, [61 percent)] : mp = 103 [¡ãC.] H NMR [(CDC . S) 8] 7.43 (d, 2H), 6.64 (d, 2H), 4.07 (q, 2H), 3.90 (m, 1H), 3.43 (br s, 1 H), 2.58 (dd, 1 H), 2.41 (dd, [1 H),] 1.23 (d, 3H), 1.17 (t, 3H). MS (ES+) m/z 374 [(MH+).] [ANAL. CALC.] for C15H17NO3F6: C, 48.26 ; H, 4.59 ; N, 3.75. Found: C, 47.95 ; H, 4.45 ; N, 3.58.

According to the analysis of related databases, 722-92-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 722-92-9, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H7F6NO

2-(tert-Butoxycarbonyl)-5-(methylsulfonyl)isoindoline- 1 -carboxylic acid (4.40 g, 12.89 mmol) and 2-(4-aminophenyl)- 1,1,1,3,3,3 -hexafluoropropan-2-ol (3.34 g, 12.89 mmol)were combined in EtOAc (50 mL) to give a suspension, before the addition of triethylamine (5.39 mL, 38.67 mmol) gave a dark brown solution. The solution was chilled by stirring on an ice I water bath before the addition of T3P (50percent in EtOAc, 15.35 mL, 25.78 mmol) through a dropping funnel. The addition was controlled to ensure that the temperature did not exceed 5 ¡ãC. After one hour the reaction solution was washed withwater (2 x 5OmL). The combined water washes were extracted with EtOAc (5OmL). The combined organic extracts were washed with 0. 1M aq HC1 (2 x 5OmL) and brine (25mL) before being dried over MgSO4. Filtration and concentration in vacuo gave a residue, which was purified by flash chromatography eluting with 0 ? 60percent EtOAc in n-heptane to give the title compound (4.95 g, 66percent) as a solid.LCIMS: mlzrr 581 EM-H]-. ?H NMR (400 MHz, DMSO-d6, mixture of rotamers, 1.8*:1) 151.35*, 1.47 (s, 9H), 3.20, 3.21* (s, 3H), 4.69? 4.88 (m, 2H), 5.61*, 5.63 (s, 1H), 7.6?7.76 (m, 5H), 7.86?7.92 (m, 1H), 7.98, 8.01* (s, 1H), 8.63*, 8.65 (s, 1H), 10.75 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; LEVER, Sarah; NARJES, Frank; OLSSON, Roine, Ingemar; VON BERG, Stefan; (124 pag.)WO2018/229155; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 722-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (10.0 g, 38.6 mmol) in DMF (50 mL) was dropwise added a solution of sodium nitrite (2.8 g, 40.5 mmol) in water (15.5 mL) and a 6M solution of hydrochloric acid (19.3 mL, 115.7 mmol), while maintaining the reaction temperature at 0?5 C. The reaction mixture was stirred for 30 min, and then potassium iodide (6.4 g, 38.6 mmol) was added portionwise at 0?5 C. The resulting reaction mixture was stirred overnight at rt. The reaction mixture was extracted with EtOAc, and the combined organic layers were washed with saturated sodium thiosulphate and dried over Na2SO4. The solvent was evaporated in vacuo to obtain the crude, which was purified by flash chromatography on silica gel (?5% EtOAc/Hex) to obtain the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; The Scripps Research Institute; Kamenecka, Theodore Mark; Griffin, Patrick R.; Shin, Youseung; He, Yuanjun; Blayo, Anne-Laure; Lyda, Brent R.; Koenig, Marcel; Kumar, Naresh; Burris, Thomas; (119 pag.)US9586928; (2017); B2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 722-92-9

Step A: 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol To a stirred solution of copper(II) bromide (1.293 g, 5.79 mmol) in acetonitrile (15 mL) was added tert-butyl nitrite (0.764 mL, 5.79 mmol) in one portion at 60¡ã C. A solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1 g, 3.86 mmol) in acetonitrile (3 mL) was then added dropwise at 60¡ã C. After stirring for 15 min at 60¡ã C., the mixture was concentrated. The residue was diluted with water (20 mL) and extracted with EtOAc (10 mL, 2*4 mL). The combined organic solutions were dried over anhydrous sodium sulfate and concentrated. Flash chromatography purification using (24 g silica gel column, gradient elution from 0 to 30percent of ethyl acetate in hexanes) afforded 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1.3 g, 4.02 mmol, 104percent yield) as a liquid.

Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; Duan, Jingwu; Dhar, T. G. Murali; Jiang, Bin; Lu, Zhonghui; Xiao, Hai-Yun; US2015/191483; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts