Category: 7073-69-0

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO

2-(2-Bromophenyl)propene (6b) was synthesized in a similar way by dehydration of 65.00 g (0.33 mol) of compound 5b with 49.50 g (0.36 mol) of phthalic anhydride. The oily crude product, 49.50 g, was distilled under reduced pressure. Yield 46.50 g (77%), purity 98% (GLC), bp 64-65C (1 mm), d420 = 1.5365,nD20 = 1.5595; MRD 47.50, calcd. 47.46; published data [21]: bp 55-65C (0.9 mm), nD27 = 1.553. IR spectrum,nu, cm-1: 3090, 1648, 910 (C=CH2), 740 (C-Br).1H NMR spectrum, delta, ppm: 2.07 m (3H, CH3), 4.95 mand 5.23 m (2H, =CH2), 7.03-7.37 m (3H, Harom),7.58 d (1H, 3-H, J = 7 Hz). 13C NMR spectrum, deltaC,ppm: 145.5 (C1), 128.1 (C2), 129.5 (C3, C4), 126.9(C5), 132.8 (C6), 121.7 (C7), 116.0 (C8), 23.5 (CH3).Found, %: C 54.51; H 4.40; Br 40.35. C9H9Br. Calculated,%: C 54.85; H 4.60; Br 40.55.

With the rapid development of chemical substances, we look forward to future research findings about 7073-69-0.

Reference:
Article; Fedorov; Fedorova; Sheverdov; Pavlov; Eremkin; Russian Journal of Organic Chemistry; vol. 52; 6; (2016); p. 806 – 812; Zh. Org. Khim.; vol. 52; 6; (2016); p. 806 – 812,7;,
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Reference of 7073-69-0 ,Some common heterocyclic compound, 7073-69-0, molecular formula is C9H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

C. 3,3-dimethyl-3H-benzo[c][1,2]oxaborol-1-ol To a solution of 2-(2-bromo-phenyl)-propan-2-ol (4.0 g, 18.6 mmol, prepared as described in Egan, W. et al. J. Am. Chem. Soc., 1971, 93, 6205) in 60 mL of anhydrous THF under argon at -78 C. was slowly added n-butyl lithium (15 mL, 2.5 M). The mixture was stirred at -78 C. for 2 h, and then triisopropylborate (5.5 mL, 24.2 mmol) was added to the mixture. The mixture was allowed to warm to room temperature and stirred at room temperature for 12 h. The mixture was then cooled to 0 C. and hydrochloric acid (10 mL, 1N) was added to the mixture until pH was <5. The mixture was then stirred at room temperature for 1 h. The two layers were separated. The aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to afford a yellow oil. The oil was purified by chromatography (silica, EtOAc: hexanes,1:3) to afford a white solid (1.16 g, 40%). 1H NMR (400 MHz, CDCl3) delta (ppm): 7.53 (m, 1H), 7.36 (m, 2H), 7.28 (m, 1H), 1.62 (s, 3H), 1.61 (s, 3H). In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7073-69-0, 2-(2-Bromophenyl)propan-2-ol, other downstream synthetic routes, hurry up and to see. Reference:
Patent; Cheung, Wing S.; Parks, Daniel J.; Parsons, William H.; Patel, Sharmila; Player, Mark R.; US2008/146637; (2008); A1;,
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Reference of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

In a 250 mL three-necked flask, 0.03 mol of dibenzofuran-3-amine, 0.04 mol of 2-(2-bromophenyl)propan-2-ol, and 150 mL of toluene were stirred and mixed under a nitrogen atmosphere.Then adding 0.05 mol of sodium t-butoxide, 0.0015 mol of Pd2 (dba) 3, 0.0015 mol of tri-tert-butylphosphine, heating to 115 C, refluxing reaction for 24 hours;Naturally cooled to room temperature, filtered, and the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C).Passing through a neutral silica gel column to give 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;

The chemical industry reduces the impact on the environment during synthesis 7073-69-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (37 pag.)CN108203427; (2018); A;,
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