Category: 7073-69-0

Related Products of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

To a mixture of methyl 2-bromobenzoate (20 g, 93.00 mmol, 13.07 mL, 1 eq) in THF (200 mL) was added dropwise MeMgBr (3 M, 65.10 mL, 2.1 eq) at 5C under N2. The mixture was stirred at 25C for 2 h and then quenched with aqueous NH4CI (200 mL). The aqueous phase was extracted with ethyl acetate (100 mL x 3). The combined organic phase was washed with brine (150 mL), dried with anhydrous Na2S04, filtered and concentrated in vacuum. The residue was purified by flash silica gel chromatography (ISCO; 120 g SepaFlash Silica Flash Column, Eluent of 0- 30% Ethyl acetate/Petroleum ethergradient, 80 mL/min) to afford 2-(2- bromophenyl)propan-2-ol (13 g, 60.44 mmol, 64.99% yield) as light-yellow oil. 1H NMR (CDCIs, 400 MHz): d 7.67 (d, J = 7.6 Hz, 1 H), 7.59 (d, J = 7.6 Hz, 1 H), 7.31 (t, J = 7.6 Hz, 1 H), 7.12 (t, = 7.6 Hz, 1 H), 1.77 (s, 6H) ppm. To a mixture of 2-(2- bromophenyl)propan-2-ol (12 g, 55.79 mmol, 1 eq) in THF (120 ml_) was added n- BuLi (2.5 M, 55.79 ml_, 2.5 eq) in one portion at -70C. The mixture was stirred at – 70C for 2 h. Then triisopropyl borate (20.99 g, 111.58 mmol, 25.65 ml_, 2 eq) was added to the mixture. The mixture was warmed to 20C and stirred for 15 h. The residue was poured into ice-water (w/w = 1/1) (10 ml_) and adjust to pH 5. The aqueous phase was extracted with ethyl acetate (10 mL x 3). The combined organic phase was washed with brine (15 mL), dried with anhydrous Na2S04, filtered and concentrated in vacuum. The residue was purified by flash silica gel chromatography (ISCO; 80 g SepaFlash Silica Flash Column, Eluent of 0-100% Ethyl (0480) acetate/Petroleum ethergradient, 100 mL/min) to afford 3,3-dimethylbenzo (0481) [c][1 ,2]oxaborol-1 (3H)-ol (9 g, 55.56 mmol, 99.6% yield) as crude yellow oil. 1H NMR (CDCIs, 400 MHz): d 9.00 (s, 1 H), 7.67 (d, J = 7.2 Hz, 1 H), 7.47-7.41 (m, 2H), 7.33- 7.31 (m, 1 H), 1.45 (s, 6H) ppm. To a mixture of 3,3-dimethylbenzo[c][1 ,2]oxaborol- 1 (3H)-ol (9 g, 55.56 mmol, 1 eq) in H2S04 (100 mL) was added HNOs (10.50 g, 166.67 mmol, 7.50 mL, 3 eq) at -20C. The mixture was stirred at -15C for 10 min. Ice-water (100 mL) was added to the mixture at -10C and stirred for 10 min. It was filtered and then the solid was washed by petroleum ether (50 mL) to afford crude 3,3-dimethyl-6-nitrobenzo[c][1 ,2]oxaborol-1 (3H)-ol (8 g, 38.65 mmol, 69.6% yield) as yellow solid. 150 mg of crude product was purified by pre-HPLC (column: Xtimate C18 150*25mm*5um; mobile phase: [water (10mM NH4HC03)-ACN]; B%: 10%-40%, 10.5 min) to afford the purified material of 3,3-dimethyl-6-nitrobenzo[c][1 ,2]oxaborol- 1 (3H)-ol (91 mg) as yellow solid. 1H NMR (DMSO-cfe, 400 MHz): d 9.47 (s, 1 H), 8.52 (d, J = 2.4 Hz, 1 H), 8.32 (dd, J = 8.4, 2.4 Hz, 1 H), 7.73 (d, J = 8.4 Hz, 1 H), 1.49 (s, 6H) ppm. MS (ESI): mass calcd. For C9HI0BNO4 207.07, m/z found 206.1 [M-H] HPLC purity: 100% (220 nm) and 100% (254 nm). To a solution of 3,3-dimethyl-6- nitrobenzo[c][1 ,2]oxaborol-1 (3H)-ol (2 g, 9.66 mmol, 1 eq) in EtOAc (70 mL) was added Pd/C (0.5 g, 10% purity) under N2. The suspension was degassed under vacuum and purged with H2 several times. The mixture was stirred under H2 (15 psi) at 20C for 15 h. The reaction mixture was filtered, and the filtrate was concentrated to affrord 6-amino-3,3-dimethylbenzo[c][1 ,2] oxaborol-1 (3H)-ol (1.5 g, 8.47 mmol, 87.70% yield) as red solid. 100 mg of the crude product was purified by pre-HPLC (column: Xtimate C18 150*25mm*5um; mobile phase: [water (10mM NH4HC03)- ACN]; B%: 10%-40%, 10.5 min) to afford 6-amino-3,3-dimethylbenzo[c][1 ,2]oxaborol- 1 (3H)-ol (51 mg) as yellow solid. 1H NMR (DMSO-cfe, 400 MHz): d 8.73 (s, 1 H), 7.02 (d, J = 8.0 Hz, 1 H), 6.79 (d, J = 2.0 Hz, 1 H), 6.67 (dd, J = 8.0, 2.4 Hz, 1 H), 4.95 (s, 2H), 1.37 (s, 6H) ppm. MS (ESI): mass calcd. For C9Hi2BN02 177.10, m/z found 176.1 [M-H]-. HPLC: 99.4% (220 nm), 98.6% (254 nm). To a mixture of 6-amino-3,3- dimethylbenzo[c][1 ,2]oxaborol-1 (3H)-ol (1 g, 5.65 mmol, 1 eq) in t-BuOH (20 mL) was added (Boc)20 (3.70 g, 16.95 mmol, 3.89 mL, 3 eq) in one portion at 20C under N2. The mixture was stirred at 50C for 12 h and concentrated under reduced pressure. The residue was purified by flash silica gel chromatography (ISCO; 12 g SepaFlash Silica Flash Column, Eluent of 0-80% Ethyl acetate/Petroleum ethergradient: 30 mL/min) to afford tert-butyl (1-hydroxy-3,3-dimethyl-1 ,3-dihydrobenzo[c][1 ,2]oxaborol- 6- yl)carbamate (0.6 g, 2.17 mmol, 38.32% yield) as yellow oil. 1H NMR (CDCh, 400 MHz): d 7.60 (s, 1 H), 7.54 (d, J = 8.0 Hz, 1 H), 7.21 (d, J = 8.0 Hz, 1 H), 6.53 (s, 1 H), 1.55 (s, 9H), 1.54 (s, 6H). To a mixture of tert-butyl (1 -hydroxy-3, 3-dimethyl-1 , 3- dihydrobenzo[c][1 ,2]oxaborol-6-yl)carbamate (0.5 g, 1.80 mmol, 1 eq) in DMF (10 mL) was added NCS (240.93 mg, 1.80 mmol, 1 eq) in one portions at 0C. The mixture was stirred at 50C for 15 h and then poured into water (10 mL). The aqueous phase was extracted with ethyl acetate (10 mL x 3). The combined organic phase was washed with brine (10 mL),…

The chemical industry reduces the impact on the environment during synthesis 7073-69-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BORAGEN, INC.; LIU, Chunliang; ZHANG, Yong-Kang; LIU, Chun, Yu; ZHOU, Yasheen; (372 pag.)WO2020/51575; (2020); A1;,
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Application of 7073-69-0 , The common heterocyclic compound, 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 2[00253] To a solution of n-BuLi (21.2ml, 0.053 mol) in anhydrous THF (160 mL) at – 78C under argon was slowly added a solution of 2-(2-bromophenyl)propan-2-ol (XCV) (0.0212 mol, 4.55 g) in anhydrous THF (50 mL) while maintaining the temperature below -65C. After addition was complete, the reaction mixture was stirred at -75C for 30 min. To this mixture was added in portions trimethyl borate (0.032mol, 3.3 g), and the reaction mixture was stirred at – 78C for 30 min and then at room temperature overnight. The mixture was cooled to 0C, carefully quenched with 1M aqueous HCl, and stirred at room temperature for 15 min. The mixture was acidified to pH 3 with 2M HCl and stirring was continued for 1 hour. The two phases were separated and the aqueous layer was extracted with EtOAc. The combined organic phases were dried over MgS04. The crude product was purified by silica gel chromatography using DCM followed by DCM/MeOH 300/1 to give 3,3-dimethylbenzo[c][l,2]oxaborol-l(3H)- ol (XCVI) as a light yellow oil (1.37 g; 8.5 mmol, 40% yield). 1H NMR (CDC13) delta ppm 1.54 (s, 6H), 7.25-7.29 (m, 1H), 7.33 (d, J=7Hz, 1H), 7.45 (td, J=7Hz, J=lHz, 1H), 7.68 (d, J=7Hz, 1H).

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REMPEX PHARMACEUTICALS, INC.; GLINKA, Tomasz; HIGUCHI, Robert; HECKER, Scott; EASTMAN, Brian; RODNY, Olga; WO2012/109164; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 7073-69-0, 2-(2-Bromophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(2-Bromophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Safety of 2-(2-Bromophenyl)propan-2-ol

2-(2-Bromophenyl)propene (6b) was synthesized in a similar way by dehydration of 65.00 g (0.33 mol) of compound 5b with 49.50 g (0.36 mol) of phthalic anhydride. The oily crude product, 49.50 g, was distilled under reduced pressure. Yield 46.50 g (77%), purity 98% (GLC), bp 64-65C (1 mm), d420 = 1.5365,nD20 = 1.5595; MRD 47.50, calcd. 47.46; published data [21]: bp 55-65C (0.9 mm), nD27 = 1.553. IR spectrum,nu, cm-1: 3090, 1648, 910 (C=CH2), 740 (C-Br).1H NMR spectrum, delta, ppm: 2.07 m (3H, CH3), 4.95 mand 5.23 m (2H, =CH2), 7.03-7.37 m (3H, Harom),7.58 d (1H, 3-H, J = 7 Hz). 13C NMR spectrum, deltaC,ppm: 145.5 (C1), 128.1 (C2), 129.5 (C3, C4), 126.9(C5), 132.8 (C6), 121.7 (C7), 116.0 (C8), 23.5 (CH3).Found, %: C 54.51; H 4.40; Br 40.35. C9H9Br. Calculated,%: C 54.85; H 4.60; Br 40.55.

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fedorov; Fedorova; Sheverdov; Pavlov; Eremkin; Russian Journal of Organic Chemistry; vol. 52; 6; (2016); p. 806 – 812; Zh. Org. Khim.; vol. 52; 6; (2016); p. 806 – 812,7;,
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Electric Literature of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

General procedure: Using diaryl acetylenesA 5-mL two-necked flask equipped with a stir bar was charged with [RhCl(cod)]2 (0.0125 mmol,6.16 mg), BINAP (0.0125 mmol, 7.78 mg), 1a-c (0.25 mmol), KI (0.25 mmol, 41.5 mg), and Na2CO3(1.0 mmol, 106.0 mg). The central neck of the flask was equipped with a reflux condenser havinga N2 gas-bag (2 L), which was connected by a three-way stopcock at its top, and a rubber septumwas inserted i n to the side neck. The flask was evacuated and backfilled with N2 (three times).Xylene (1.0 mL), 2a (0.75 mmol, 161.3 mg), and furfural (1.75 mmol, 168.2 mg), were then added.After degassing the reaction mixture three times by the freeze-pump-thaw method, the flask wasfilled with N2. The mixture was placed in an oil bath that had been preheated to 140 C for 20 h.After cooling to room temperature, the resulting solution was filtered through a pad of celite, andthe filtrate was concentrated in vacuo. The resulting crude product was purified by flash columnchromatography on silica-gel to afford 3aa-3ac.

Statistics shows that 7073-69-0 is playing an increasingly important role. we look forward to future research findings about 2-(2-Bromophenyl)propan-2-ol.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
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Electric Literature of 7073-69-0 ,Some common heterocyclic compound, 7073-69-0, molecular formula is C9H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 250 mL three-necked flask, 0.03 mol of dibenzofuran-3-amine, 0.04 mol, was added under nitrogen protection.2-(2-Bromophenyl)propan-2-ol, 150 mL of toluene was stirred and mixed, then 0.05 mol of sodium t-butoxide, 0.0015 mol of Pd2 (dba) 3, 0.0015 mol of tri-tert-butylphosphine, and heated to 115 C, Reflow reaction for 24 hours; naturally cool to room temperature, filter, filterThe liquid was subjected to vacuum distillation (-0.09 MPa, 85 C), and passed through a neutral silica gel column.Obtaining 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7073-69-0, its application will become more common.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (43 pag.)CN108164470; (2018); A;,
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Synthetic Route of 7073-69-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: Using diaryl acetylenesA 5-mL two-necked flask equipped with a stir bar was charged with [RhCl(cod)]2 (0.0125 mmol,6.16 mg), BINAP (0.0125 mmol, 7.78 mg), 1a-c (0.25 mmol), KI (0.25 mmol, 41.5 mg), and Na2CO3(1.0 mmol, 106.0 mg). The central neck of the flask was equipped with a reflux condenser havinga N2 gas-bag (2 L), which was connected by a three-way stopcock at its top, and a rubber septumwas inserted i n to the side neck. The flask was evacuated and backfilled with N2 (three times).Xylene (1.0 mL), 2a (0.75 mmol, 161.3 mg), and furfural (1.75 mmol, 168.2 mg), were then added.After degassing the reaction mixture three times by the freeze-pump-thaw method, the flask wasfilled with N2. The mixture was placed in an oil bath that had been preheated to 140 C for 20 h.After cooling to room temperature, the resulting solution was filtered through a pad of celite, andthe filtrate was concentrated in vacuo. The resulting crude product was purified by flash columnchromatography on silica-gel to afford 3aa-3ac.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7073-69-0, 2-(2-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO

In a 250mL three-neck bottle,Under the protection of nitrogen,Add 0.03 mol of dibenzofuran-3-amine,0.04 mol of 2-(2-bromophenyl)propan-2-ol,150mL toluene was stirred and mixed,Then add 0.05 mol of sodium t-butoxide,0.0015mol Pd2 (dba)3,0.0015 mol of tri-tert-butylphosphine, heated to 115 C,Reflow reaction for 24 hours;Naturally cooled to room temperature, filtered, and the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C), and passed through a neutral silica gel column.Obtaining 2-(2-(dibenzofuran-3-ylamino)phenyl)propan-2-ol;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7073-69-0, 2-(2-Bromophenyl)propan-2-ol.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Miao Kangjian; Zhang Zhaochao; Zhang Xiaoqing; Li Chong; (48 pag.)CN108203428; (2018); A;,
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Application of 7073-69-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

0.8 g (0.0037 mol) of palladium(II) acetate, 20.5 g (0.25 mol) of sodium acetate, 64.5 g (0.20 mol) of tetrabutylammonium bromide were placed under an argon atmosphere and 23.7 g (0.1 1 mol) of bromo-carbinol (III, X=Br) dissolved in 170 cm3 of toluene was added. The mixture was heated to 120C and then 32.2 g (0.10 mol) of chloroquinaldine-alcohol (II) dissolved in 70 cm3 of N-methyl-2-pirrolidone (NMP) was added. The mixture was stirred at 120 C until the reaction was complete. 100 cm3 of saturated NaHC03 solution, 100 cm3 of distilled water and 200 cm3 of ethyl acetate were then added. The mixture was stirred for 5 minutes. The layers were separated. The organic phase was washed three times with 200 cm3 of distilled water and with 200 cm3 of brine. The organic solution was dried over 30 g of sodium sulfate. The drying agent was filtered, washed with 200 cm3 of ethyl acetate and the filtrate was evaporated in vacuum. Yield: 54.7 g crude 1-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(l-hydroxy-l- methyl-ethyl)-phenyl]-propan-l-one (IV) as a brown oil. A small amount of the product was purified by chromatography; the structure was checked by NMR spectroscopy: 1H NMR (DMSO-i/6) delta 1.57 (s, 6H, Me2C), 3.26-3.35 (m, 2H, CH2Ar), 3.40-3.48 (m, 2H, CH2CO), 5.04 (s, 1H, OH), 7.11-7.22 (m, 2H), 7.27-7.32 (m, 1H), 7.36-7.42 (m, 1H), 7.55-7.64 (m, 3H), 7.89-8.04 (m, 6H), 8.32-8.36 (m, 1H), 8.41 (d, 1H, J= 8.6 Hz) ppm.13C NMR (DMSO-i? delta 28.5 (CH2Ar), 2 31.8 ( e2C), 41.7 ( H2CO), 72.0 (Me2Q, 120.3, 125.5, 125.5, 125.6, 126.5, 126.8, 127.0, 127.2, 128.0, 129.3, 129.4, 129.7, 131.4, 131.5, 134.1, 134.4, 136.6, 136.6, 137.3, 139.8, 146.8, 148.0, 156.6, 199.6 (CO) ppm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7073-69-0, 2-(2-Bromophenyl)propan-2-ol.

Reference:
Patent; RICHTER GEDEON NYRT.; BODI, Jozsef; FARAGO, Janos; SZOeKE, Katalin; UJVARI, Viktor; TEMESVARI, Krisztina; ARANYI, Antal; SANTA, Zsuzsanna; NAGY, Melinda Magdolna; WO2012/20271; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 7073-69-0, 2-(2-Bromophenyl)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(2-Bromophenyl)propan-2-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(2-Bromophenyl)propan-2-ol

A 12-Liter 4-neck round bottom flask equipped with a thermocouple, condenser, addition funnel and overhead mechanical stirrer under dry Argon was charged with anhydrous THF, (3 L) and chilled to -70 to -78 C. via a dry ice/acetone bath. n-Butyl lithium (2.5N in hexanes, 860 mL, 2.15 mol) was slowly added via addition funnel. An exotherm was observed as the temperature rose from -78 to -70 C. To the addition funnel was added a solution of Compound 10d (220 g, 979.97 mmol) in anhydrous THF (1 L). The 2-(2-bromophenyl)propan-2-ol solution was slowly added to the n-BuLi solution. The addition took 90 min in order to maintain a reaction temperature below -70 C. After the addition was complete, the reaction mixture was stirred at -70 to -75 C. for 30 min. The triethylborate (230 mL, 1.35 mol) was quickly added in 3 portions at -70 C. An exotherm was observed, the batch temperature rose from -70 to -64 C. The reaction was stirred at -70 C. and slowly warmed to room temperature over night. After the reaction was cooled to 0-5 C., the reaction was slowly quenched with 2 M HCl (1 L, 2.00 mol) added via the addition funnel while maintaining the batch temperature 0-5 C. The reaction mixture was stirred for 1 h. The aqueous phase pH was 9-10. The pH was then adjusted to acidic (4-5) with 2 M HCl (200 mL). The two phases were separated and the aqueous layer was extracted with MTBE (2¡Á500 mL). The combined organic phases were dried with anhydrous magnesium sulfate. The solution was filtered and concentrated to yield a yellow oil. The yellow oil was diluted with MTBE (1.5 L) and washed with 1M NaOH (3¡Á500 mL). The product containing basic aqueous phases were combined and acidified with 2 M HCl (800 mL) (the clear solution turns turbid with the addition of acid). After stirring the turbid solution for 15 min (pH=4-5) (Note 1), it was extracted with MTBE (2¡Á500 mL). The organic phases were combined and dried over MgSO4. The solution was filtered and the filtrate was concentrated to yield the title Compound 10e as a clear yellow oil (121.78 grams, 77% yield).

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Player, Mark R.; Dax, Scott L.; Parsons, William H.; Brandt, Michael Richard; Calvo, Raul R.; Patel, Sharmila; Liu, Jian; Cheung, Wing S.; Jetter, Michele C.; Lee, Yu-Kai; Youngman, Mark A.; Pan, Wenxi; Weils, Kenneth M.; Beauchamp, Derek A.; US2007/259936; (2007); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. A new synthetic method of this compound is introduced below., Computed Properties of C9H11BrO

Step 1: 1-Bromo-2-(2-fluoropropan-2-yl)benzene Into a 100 mL round-bottom flask equipped with a magnetic stir bar was dissolved 2-(2-bromophenyl)propan-2-ol (1.0 g, 4.7 mmol) in CH2Cl2 (15 mL) and it was cooled to -78 C. DAST (1.1 g, 7.0 mmol) was added and the reaction was monitored by TLC. After disappearance of the starting material, the reaction mixture was quenched over 50 mL of a sat aq. NaHCO3 solution in a beaker. It was then transferred into a 250 mL separatory funnel and extracted with ethyl acetate (2*70 mL). Combined organic layers were washed with brine, dried over MgSO4, filtered and the solvent was evaporated under reduced pressure. Purification by column chromatography through silica gel, eluting with 100% hexanes afforded the title compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7073-69-0, 2-(2-Bromophenyl)propan-2-ol.

Reference:
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
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