Category: 70445-33-9

Dissette, Valeria published the artcileEvaluation of the transepidermal penetration of a carnosine complex in gel formulation by 3D skin models, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Cosmetics (2018), 5(4), 67, database is CAplus.

Carnosine has several physiol. roles, from intracellular pH buffering to antioxidant activities, which all depend on bioavailability. This study was conducted in a human skin 3D model and focuses on the effects of the topical delivery of carnosine, from a dermo-cosmetic gel, through the stratum corneum in the presence of a magnesium ion as a complexing agent. To evaluate possible enhancement for small peptide delivery to the skin from simple cosmetic formulations, we discovered that complexation was able to improve the delivery of carnosine into human skin 3D models by application in gel formulation. The concentrations of carnosine released in the underlying media and those that remained in the reconstructed human epidermis (RHE) tissues after 24 and 48 h exposure were measured. Moreover, the influence of magnesium ions was also evaluated comparing the same formulation with and without the salt. The results obtained in this study support hypothesis that magnesium can influence the delivery of small peptides and that the gel formulation based on the carnosine-magnesium complex allows for superior delivery of carnosine in the lower skin layer at a concentration up to 60% more than carnosine alone.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wiechers, S. published the artcileTitanium dioxide particle size vs. sun protection performance, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Cosmetics & Toiletries (2013), 128(5), 332, 334, 336, 338-339, database is CAplus.

The article compares the performance of titanium dioxide as a UV filter in cosmetic formulations as a function of its primary particle size. It was found that with increasing primary particle size, even below 100 nm, the effectiveness of the inorganic (mineral) UV filter was clearly reduced.

Cosmetics & Toiletries published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C4H6BrFO2, Application of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Johnson, Wilbur Jr. published the artcileSafety assessment of alkyl glyceryl ethers as used in cosmetics, Formula: C11H24O3, the publication is International Journal of Toxicology (2013), 32(5S), 5S-21S, database is CAplus and MEDLINE.

A review. Alkyl glyceryl ethers function mostly as skin-conditioning agents in cosmetic products applied to the skin and hair. The Cosmetic Ingredient Review expert panel reviewed the available animal toxicity and clin. data, including the low dermal absorption, and concluded that the alkyl glyceryl ethers are safe in the present practices of use and concentration described in this safety assessment.

International Journal of Toxicology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Xin published the artcilePolyols with several kinds of Chinese herbal medicine extracts of the anticorrosion composite applied in cosmetics, Formula: C11H24O3, the publication is Guangzhou Huagong (2013), 41(24), 70-72, database is CAplus.

A kind of the anti-corrosion composite containing polyols and several kinds of extracts of Chinese herbal medicine in combination were studied. By use of this kind of compound with combination, a novel cosmetics using antiseptic combination was provided, and the results showed that the combination and the vast majority of cosmetics raw material compatibility were very good, with broad-spectrum antimicrobial activity, which can effectively inhibit gram neg. bacteria, gram-pos. bacteria, yeast and mold, and its bacteriostatic ability was not influenced by surface active agent in cosmetics.

Guangzhou Huagong published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C15H14O3, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alam, Shoaib published the artcileInvestigation utilizing the HLB concept for the development of moisturizing cream and lotion: in-vitro characterization and stability evaluation, SDS of cas: 70445-33-9, the publication is Cosmetics (2020), 7(2), 43, database is CAplus.

The current study aims to utilize the concept of the hydrophilic-lipophilic balance (HLB) value of ingredients for the development of a stable emulsion-based moisturizing cream and lotion for cosmetic application. The combination of a hydrophilic and lipophilic emulsifier such as glyceryl stearate (HLB value 3.8) and PEG-100 stearate (HLB value 18.8) were found to be effective to emulsify the chosen oil phase system at a specific concentration to achieve the required HLB for the development of the stable emulsion-based system. The developed formulation was characterized for pH, viscosity, spreadability, rheol., and droplet morphol. The influence of carbopol ETD 2020 and the concentration of the oil phase on the rheol. of the product was investigated and found to be significant to achieve the required thickening to convert the lotion into a cream. The formulation system developed through utilizing the concept of HLB was compared to a product developed through the conventional approach. It was observed that the utilization of the HLB method for the development of an emulsion-based product is a promising strategy compared to the conventional method. The phys. stability and thermodn. stability tests were carried out under different storage conditions. It was observed that the developed formulation was able to retain its integrity without showing any signs of instability during storage.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ikawa, Kurumi published the artcileNew in vitro SPF evaluation method for hydrophilic sunscreen samples, COA of Formula: C11H24O3, the publication is Journal of Oleo Science (2022), 71(2), 321-331, database is CAplus and MEDLINE.

A new method was developed for the in vitro sun protection factor (SPF) evaluation of sunscreen samples. A new type of substrate, a hydroxyalkyl cellulose-coated plate, was also prepared specifically for hydrophilic samples. This new substrate was required because hydrophilic samples would be unlikely to wet the surface of the standard cosmetic PMMA UV evaluation plate. A super-hydrophilic quartz plate was prepared by corona-discharge treatment before an aqueous solution of hydroxyalkyl cellulose was spread on it. A flat and uniform hydroxyalkyl cellulose film was subsequently formed through the evaporation of water. Special care was taken to inhibit the generation of spatial non-uniformity. Six hydrophilic sunscreen samples with in vivo SPF values of 56, 55, 52, 25, 15, and 4, were then applied to the prepared hydroxyalkyl cellulose-coated plate, as well as a super-hydrophilic quartz plate and a flat hydrophobic PMMA plate. The thicknesses of the applied layers were determined using a wheel-shaped wet film thickness gauge immediately after the application, and UV transmission was measured using an SPF analyzer. The value of in vitro SPF was calculated from the UV absorbance and the thickness of the layer. For two out of the six samples, PMMA plate could not be available, as the samples were unable to wet the PMMA surface. Relatively small differences were observed between the in vitro SPF values when the super-hydrophilic and hydroxyalkyl cellulose-coated plates were used. Samples exhibiting higher in vivo SPF were also associated with higher in vitro SPF values, although a linear relationship was not observed In contrast to the super-hydrophilic plate whose half-life of the super-hydrophilicity is only approx. five days, the hydrophilicity of the hydroxyalkyl cellulose-coated plate scarcely varied during six months of storage. Finally, a simplified evaluation method was also proposed. The validity of the method was verified through a ring test where three researchers employed this method in different laboratories at three independent organizations.

Journal of Oleo Science published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beck, R. published the artcileA Novel L₃-Phase from a Ca-Salt of an Anionic Surfactant and a Cosurfactant, COA of Formula: C11H24O3, the publication is Journal of Physical Chemistry B (2002), 106(13), 3335-3338, database is CAplus.

An L₃-phase is observed for the first time in a ternary phase diagram of a Ca-salt of an α-sulfonated alkyl fatty acid Me ester, the cosurfactant (2-ethylhexyl)monoglyceride and water. As for other ternary surfactant/cosurfactant systems, the L₃-phase occurs with increasing cosurfactant/surfactant ratios after the L_α-phase. Some properties of the newly observed L₃-phases are the same as for other known L₃-phases. It is a low viscosity, optically isotropic fluid with a low flow birefringence. The time constants τ of the elec. birefringence results scale with τ ∼ O^-3. Its conductivity is very much higher than that of the neighboring L_α-phase, but there are some marked differences from known L₃-phases. This novel L₃-phase is thermodynamically stable despite ionic structure of the surfactant. We found no two phase region between the L_α and the L₃-phase, and the L₃-phase is stable over a wide cosurfactant/surfactant ratio between one and two. In SANS measurements it shows a broad correlation peak that occurs at about the same position as the sharper peak in the L_α-phase. The structure of the L₃-phase is demonstrated by FF-TEM micrographs.

Journal of Physical Chemistry B published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts