Category: 70445-33-9

Draelos, Zoe Diana published the artcileThe effect of an anti-inflammatory botanical cleanser/night mask combination on facial redness reduction, SDS of cas: 70445-33-9, the publication is Journal of Drugs in Dermatology (2018), 17(6), 671-676, database is CAplus and MEDLINE.

Facial redness is a common difficult to control cosmetic problem representing various phases of rosacea. Using anti-inflammatory/antioxidant botanicals in moisturizer formulations is a possible approach to minimizing the erythema.This research utilized a common facial cleanser, but only applied the botanically based moisturizer to one half face to properly assess efficacy. 30 female subjects Filzpatrick skin types l-IV 30-55 years of age with mild to moderate chronic facial redness, defined as a redness score of 3-6 on a 10-point scale, were enrolled. By the end of week 4, statistically significant improvement was seen on the cleanser/mask treated side in scaling (P<0.001), flaking (P<0.001), tactile smoothness (P<0.001), textural smoothness (P<0.001), firmness (P<0.001), radiance (Pc0.001), luminosity (P<0.001), and overall appearance (P<0.001).Thus, cosmetic moisturizers may be useful in reducing facial redness.

Journal of Drugs in Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lewinska, Agnieszka published the artcileTargeted hybrid nanocarriers as a system enhancing the skin structure, Safety of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Molecules (2021), 26(4), 1063, database is CAplus and MEDLINE.

The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The anal. showed that nanoemulsion has a spherical morphol. and size 220- 300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130-260 nm). Addnl., we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, resp. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, addnl. consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions.

Molecules published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Safety of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arvand, Majid published the artcileElectrochemical study on the natural and chemical preservatives antibacterial effect against S. aureus PTCC 1112 and its determination at low levels, Computed Properties of 70445-33-9, the publication is Journal of the Iranian Chemical Society (2020), 17(1), 195-203, database is CAplus.

Pathogen microorganisms detection, such as Staphylococcus aureus (S. aureus), is so critical because it can be dangerous for public health. In this research, we have tried to introduce a simple and sensitive modified biosensor by multiwalled carbon nanotubes (MWCNTs) for S. aureus PTCC 1112 detection which was inoculated in PBS (pH 7.4). The pulsed amperometric detection (PAD) method showed that by increasing the concentration of S. aureus suspension, the related current will increase linearly in a dynamic range of 1.88 × 10⁷-3.00 × 10⁸ cfu mL^-1, with a detection limit of 4.85 × 10⁵ cfu mL^-1. The antibacterial effect of three herbal essential oils, tea, bergamot and lemon, and three common chem. cosmetic preservatives, euxyl (phenoxyethanol:ethylhexylglycerin), benzyl alc. and benzalib (alkyl benzyl di-Me ammonium chloride), was compared by electrochem. and biol. methods. The results based on disk diffusion agar method and PAD revealed that this biosensor can be used for comparing the effectiveness of natural and chem. preservatives to inhibit the growth of bacteria. By adding the essential oils into the S. aureus suspension in PBS, the related currents were largely decreased about 65.83% (green tea), 80.49% (bergamot) and 93.30% (lemon) that are in agreement with the inhibition zones of microbial test and comparable to chem. preservatives of euxyl (73.52%), benzyl alc. (90.65%) and benzalib (93.81%). It demonstrates the comparative antibacterial effect of these essential oils vs. chem. preservatives and the ability of MWCNTs/GCE to detect the presence or absence of S. aureus in a few minutes.

Journal of the Iranian Chemical Society published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutter, Marc published the artcileSelective Synthesis of 1-O-Alkyl(poly)glycerol Ethers by Catalytic Reductive Alkylation of Carboxylic Acids with a Recyclable Catalytic System, SDS of cas: 70445-33-9, the publication is ChemSusChem (2012), 5(12), 2397-2409, database is CAplus and MEDLINE.

(Poly)glycerol monoethers were synthesized in good yield and selectivity by the catalytic reductive alkylation of glycerol, diglycerol, and triglycerol with readily available, cheap and/or bio-sourced carboxylic acids. The reaction was catalyzed by 1 mol % of Pd/C under 50 bar H₂ using an acid ion-exchange resin as a recyclable cocatalyst. The catalytic system was recycled several times, and a mechanism is proposed for this transformation.

ChemSusChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C10H9ClN2O, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutter, Marc published the artcile1,2,3-Trimethoxypropane and Glycerol Ethers as Biosource Solvents from Glycerol. Synthesis by Solvent-Free Phase-Transfer Catalysis and Utilization as an Alternative Solvent in Chemical Transformations, Quality Control of 70445-33-9, the publication is ChemCatChem (2013), 5(10), 2893-2904, database is CAplus.

1,2,3-Trimethoxypropane, 1-alkoxy-2,3-dimethoxypropane and 1-aryloxy-2,3-dimethoxypropane were prepared in good yields and selectivity by a solid-liquid phase-transfer catalysis in the presence of an inorganic base and an ammonium salt as a phase-transfer catalyst with no addnl. solvent. No heating was required and the synthesis of the target compounds was achieved easily under atm. pressure on a 150 g scale. For the preparation of 1,2,3-trimethoxypropane, the conversion of glycerol was complete and the selectivity for the expected glycerol tri-Me ether was above 95%. This product was used as a solvent in organic reactions such as a transesterification between glycerol and vegetable oil, organometallic reactions (Grignard- and Barbier-type reactions), carbon-carbon coupling reactions (Suzuki, Sonogashira, Heck) and in etherification reactions by dehydrogenative alkylation. The solvent showed interesting properties for the solubilization of polymers.

ChemCatChem published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C6H12Br2, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Travassos, Ana Rita published the artcileNon-fragrance allergens in specific cosmetic products, Category: alcohols-buliding-blocks, the publication is Contact Dermatitis (2011), 65(5), 276-285, database is CAplus and MEDLINE.

Objectives. Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce. Methods. Between Jan. 2000 and Dec. 2010, the specific cosmetic products having caused allergic contact dermatitis, as well as the individual allergenic cosmetic ingredients present in them, were recorded by use of a standardized form. Results. Among 11 different categories of cosmetic product, skin care products, followed by hair care and body-cleansing products, were most often involved. The presence of the allergenic ingredient(s) in a specific cosmetic product was confirmed according to the ingredient label in 959 of 1448 records. Six hundred and twenty-one of 959 concerned non-fragrance components, preservatives being responsible for 58% of them. Reactions to formaldehyde and formaldehyde-releasers were most often correlated with body-cleansing products, particularly 2-bromo-2-nitropropane-1,3-diol and skin care products. They were followed by the methylchloroisothiazolinone/methylisothiazolinone mixture, most frequently found as allergens in hair care and intimate hygiene products, and facial cleansers (in the last category together with diazolidinyl urea). Octocrylene was by far the most frequent (photo)allergen in sun care products. Conclusions. This study provides information on the presence and frequency of allergens in specific causal cosmetic products.

Contact Dermatitis published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C20H28B2O4S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Youenou, Benjamin published the artcileIn vitro study to evaluate the antimicrobial activity of various multifunctional cosmetic ingredients and chlorphenesin on bacterial species at risk in the cosmetic industry, Computed Properties of 70445-33-9, the publication is Journal of Applied Microbiology (2022), 132(2), 933-948, database is CAplus and MEDLINE.

We evaluated the activity of the preservative chlorphenesin and of four antimicrobial cosmetic multifunctional ingredients against various strains of gram-neg. and gram-pos. human opportunistic pathogens. Growth kinetics, modeling growth parameters and statistical analyses enabled comparing bacterial behavior in the presence and in the absence of the compound Whatever compound tested (i.e. chlorphenesin, phenylpropanol, hexanediol, ethylhexylglycerin, hydroxyacetophenone) and strain origin (i.e. clin. vs. industrial), the growth of 42 strains belonging to Acinetobacter spp., Burkholderia cepacia complex and Stenotrophomonas maltophilia, was totally inhibited. On the opposite all of the P. aeruginosa strains (n = 13) as well as 4 and 6 out of 10 strains of Pluralibacter gergoviae grew in the presence of chlorphenesin and ethylhexylglycerin, resp. Some P. gergoviae and Staphylococcus hominis strains withstand hydroxyacetophenone. Within a species, the different strains show variable latency phase, growth rate (r) and carrying capacity (K). They can be similar, lower or higher than those measured in control conditions. Data showed differences in the antimicrobial activity of compounds Upon exposure, strains differed in their behavior between and within species. Whatever species and strains, compound sensitivity could not be related to antibiotic resistance. Most multifunctional ingredients showed significant antimicrobial properties against the wide panel of species and strains evaluated. This will help adjusting preservation strategies in the cosmetic industry.

Journal of Applied Microbiology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C13H18BFO3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ionescu, Andrei C. published the artcileSubstituted Nano-Hydroxyapatite Toothpastes Reduce Biofilm Formation on Enamel and Resin-Based Composite Surfaces, Category: alcohols-buliding-blocks, the publication is Journal of Functional Biomaterials (2020), 11(2), 36, database is CAplus and MEDLINE.

Toothpastes containing nano-hydroxyapatite (n-HAp) substituted with metal ions provide calcium and phosphate ions to dental hard tissues, reducing demineralization, and promoting remineralization. Few data are available about the effect of these bioactive compounds on oral microbiota. This in vitro study evaluated the influence of two com.-available substituted n-HAp-based toothpastes α : Zn-carbonate substituted n-HAp; β: F, Mg, Sr-carbonate substituted (n-HAp) on early colonization (EC, 12 h) and biofilm formation (BF, 24 h) by oral microbiota. Controls were brushed with distilled water. Artificial oral microcosm and Streptococcus mutans biofilms were developed using human enamel and a resin-based composite (RBC) as adherence surfaces. Two test setups, a shaking multiwell plate and a modified drip-flow reactor (MDFR), were used to simulate clin. conditions during the night (low salivary flow and clearance) and daytime, resp. Energy-dispersive X-ray spectrometry (EDS) was used to evaluate specimens’ surfaces after toothpaste treatment. Fluoride release from β toothpaste was evaluated. Viable adherent biomass was quantified by MTT assay, and biofilms’ morphol. was highlighted using confocal microscopy. EDS showed the presence of remnants from the tested toothpastes on both adherence surfaces. β toothpaste showed significantly lower EC and BF compared to control using the artificial oral microcosm model, while α toothpaste showed lower EC and BF compared to control, but higher EC and BF compared to β toothpaste. The effect shown by β toothpaste was, to a minimal extent, due to fluoride release. Interestingly, this result was seen on both adherence surfaces, meaning that the tested toothpastes significantly influenced EC and BF even on RBC surfaces. Furthermore, the effect of toothpaste treatments was higher after 12 h than 24 h, suggesting that toothbrushing twice a day is more effective than brushing once. The efficacy of these treatments in reducing microbial colonization of RBC surfaces may represent a promising possibility in the prevention of secondary caries.

Journal of Functional Biomaterials published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leal-Duaso, A. published the artcileSynthesis of 3-alkoxypropan-1,2-diols from glycidol: experimental and theoretical studies for the optimization of the synthesis of glycerol derived solvents, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Green Chemistry (2017), 19(17), 4176-4185, database is CAplus.

A straightforward and green synthetic methodol. was derived for the synthesis of glycerol monoethers ROCH₂CH(OH)CH₂OH [R = Me, Et, i-Pr, etc.] from glycidol and alcs. Several homogeneous and heterogeneous basic catalysts were tested, the best results being obtained with readily available and inexpensive alk. metal hydroxides. In the best case, good yield of the desired monoether was obtained under smooth reaction conditions always with total conversion of glycidol. The selectivity of the reactions mainly depended on the alc. used, due to the concurrence of undesired side reactions. A mechanistic study carried out through computational DFT calculations, in which solvent effects were taken into account, also complemented the experiments and allowed to identify the main reaction paths taking place under reaction conditions, giving insights into the main causes affecting the reaction selectivity and also into how it could be improved.

Green Chemistry published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Warshaw, Erin M. published the artcilePatch Testing to Ethylhexylglycerin: The North American Contact Dermatitis Group Experience, 2013-2018, COA of Formula: C11H24O3, the publication is Dermatitis (2022), 33(1), 36-41, database is CAplus and MEDLINE.

Ethylhexylglycerin (EHG) is a recently recognized contact allergen. The aims of the study were to characterize individuals with pos. patch test reactions to EHG and to analyze reaction strength, clin. relevance, and allergen sources. This study was a retrospective anal. of the patients patch tested to EHG (5petrolatum) by the North American Contact Dermatitis Group (2013-2018). Of 15,560 patients tested to EHG, 39 (0.25) had pos. (final interpretation of “allergic”) reactions. Most were female (71.8) and/or older than 40 years (76.9). There were no statistically significant differences between age, sex, or atopic history when compared with EHG-neg. patients. The most common anat. sites of dermatitis were the face (28.2) and scattered generalized distribution (25.6). Most EHG-pos. reactions were + (35.9) or ++ (33.3). Current clin. relevance was high (79.5); none, however, were related to occupation. Personal care products were the most common source of exposure to EHG (59.0). Ethylhexylglycerin is a rare contact allergen; the pos. frequency of 0.25is similar to other low allergenic preservatives including parabens, benzyl alc., and phenoxyethanol. The patch test concentration of 5.0seems to be nonirritating. Although relatively uncommon, EHG reactions were usually clin. relevant (79.5), often because of moisturizers/lotions/creams.

Dermatitis published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C17H20ClN3, COA of Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts