Category: 702-98-7

Synthetic Route of 702-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

b. Synthesis of 2-methyl-2-adamantyl acrylate 2-methyl-2-adamantanol (33 g, 0.2 mol) and triethylamine (0.22 mol) were dissolved in 300 ml of THF and then acryloyl chloride (19 g, 0.21 mol) was added slowly thereto using a dropping funnel. Then, the reaction was stirred at room temperature for about 12 hours. After completion of the reaction, excess THF was removed using a rotary evaporator and then the resultant product was poured into water. Then, the resultant product was neutralized with dilute sulfuric acid and extracted using diethyl ether and was then dried over magnesium sulfate. The diethyl ether removed crude product was vacuum-distilled to yield the desired product (yield: 80%). 1H-NMR (CDCl3; ppm): 6.3 (doublet), 6.1 (1H, dd), 5.7 (1H, d), 2.3 (2H, s), 1.5-2.1 (m) FT-IR (NaCl; cm-1): 2911, 2861, 1718, 1635, 1618, 1401, 1201

According to the analysis of related databases, 702-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chem Search Corp.; US6222061; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

702-98-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

An autoclave was charged with 2,3-dibromo-1,1,1-trifluoropropane (0.2559 g, 1.0 mmol), 2-methyl-2-adamantanol (0.249 g, 1.5 mmol), triethylamine (0.202 g, 2.0 mmol), lithium carbonate(0.0369 g, 0.5 mmol), dichlorobis (triphenylphosphine) palladium(II) (0.0070 g, 0.01 mmol), and tetrahydrofuran (2.0 mL), which were then stirred at 100C for 15 hours after introducing carbon monoxide (1.0 MPaG). After the end of the reaction, the autoclave was cooled, ventilated, and added with benzotrifluoride as an internal standard substance, followed by stirring and leaving still for a while to let a salt precipitate. Quantification using a 19F-NMR integration value revealed that 2-trifluoromethyl acrylic acid 2-methyl-2-adamantyl ester was obtained with a yield of 91.1% on the basis of 2,3-dibromo-1,1,1-trifluoropropane.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 702-98-7, 2-Methyladamantan-2-ol.

Reference:
Patent; Tosoh F-Tech, Inc.; SAGAMI CHEMICAL RESEARCH CENTER; EP1637514; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

702-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 702-98-7, name is 2-Methyladamantan-2-ol, molecular formula is C11H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4.67 g (28 mmol) of 2-methyl-2-adamantanol, 2.77 g (35 mmol) of pyridine and 30 mL of drytetrahydrofuran were added to a 100 mL three-necked flask equipped with a drying tube containing calcium chloride and adropping funnel And the mixture was stirred with a magnetic stirrer under ice cooling. A dropping funnel was charged with asolution of 4.42 g (39 mmol) of chloroacetyl chloride in 10 mL of dry tetrahydrofuran. This chloroacetyl chloride solution wasadded dropwise over 15 minutes under ice cooling, then the reaction solution was heated to 20 C. and stirred for 22 hours. Inthe GC analysis at this point, 2-chloroacetoxy-2-methyladamantane was 64.2 area%. This solution was poured into a beakercontaining 300 mL of ion exchanged water, the resulting mixture was extracted three times with 100 mL of diethyl ether, and 20g of anhydrous sodium sulfate was added to the combined organic phases and dried. The chromaticity of the organic phase atthis point was APHA over 1000 degrees and it was orange colored. The desiccant was removed by filtration and thenconcentrated under reduced pressure to obtain 7.99 g of crude 2-chloroacetoxy-2-methyladamantane as a brown oil. Theresidue was purified by silica gel column chromatography (silica gel: Wakosil (registered trademark) C-200 (Wako PureChemical Industries, 64 g, elution solvent: hexane / diethyl ether = 10: 1)) to obtain 5.03 g of 2-chloroacetoxy-2-methyladamantane (74% yield) as an ultrathin pale yellow solid. Further, the chromaticity of the liquid state obtained by heating and melting the obtained solid was APHA of about 300 C, and was colored in a pale yellow color.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-98-7, 2-Methyladamantan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NIPPON LIGHT METAL COMPANY LIMITED; TSUTSUI, HIDEYUKI; KATO, TOMOKI; TOYAMA, TAKASHI; (10 pag.)JP2018/127408; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts