Category: 702-98-7

Synthetic Route of 702-98-7 ,Some common heterocyclic compound, 702-98-7, molecular formula is C11H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 77 4-(2-Methyl-2-adamantyloxy)-nitrobenzene To 13.8 g. (0.0830 mole) of 2-methyl-2-adamantanol stirred in a mixture of 80 ml. of benzene and 40 ml. of DMF was added in portions 4.18 g. (0.087 mole of NaH) of 50% NaH in oil. Heating was commenced and when vigorous gas evolution was evident, the heat was lowered. When the reaction subsided, the mixture was refluxed for 20 minutes. To this mixture, cooled almost to room temperature, was added 11.7 g. (0.0830 mole) of p-fluoronitrobenzene, and the mixture was refluxed for 6 hours. The mixture was allowed to cool. Water and CH2 Cl2 were added. The CH2 Cl2 layer was washed with two 250 ml. portions of water, which were extracted with 100 ml. of CH2 Cl2. The combined CH2 Cl2 solutions were dried over anhydrous MgSO4 and concentrated The crude product was chromatographed on 700 g. of silica gel, eluding with 1:1 Skellysolve B:CH2 Cl2, to give 17.0 g. of product. Anal. Calcd for C17 H21 NO3: C, 71.06; H, 7.37; N, 4.87; O, 16.70. Found: C, 71.19; H, 7.48; N, 5.12.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-98-7, its application will become more common.

Reference:
Patent; The Upjohn Company; US4036977; (1977); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 702-98-7 ,Some common heterocyclic compound, 702-98-7, molecular formula is C11H18O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 77 4-(2-Methyl-2-adamantyloxy)-nitrobenzene To 13.8 g. (0.0830 mole) of 2-methyl-2-adamantanol stirred in a mixture of 80 ml. of benzene and 40 ml. of DMF was added in portions 4.18 g. (0.087 mole of NaH) of 50% NaH in oil. Heating was commenced and when vigorous gas evolution was evident, the heat was lowered. When the reaction subsided, the mixture was refluxed for 20 minutes. To this mixture, cooled almost to room temperature, was added 11.7 g. (0.0830 mole) of p-fluoronitrobenzene, and the mixture was refluxed for 6 hours. The mixture was allowed to cool. Water and CH2 Cl2 were added. The CH2 Cl2 layer was washed with two 250 ml. portions of water, which were extracted with 100 ml. of CH2 Cl2. The combined CH2 Cl2 solutions were dried over anhydrous MgSO4 and concentrated The crude product was chromatographed on 700 g. of silica gel, eluding with 1:1 Skellysolve B:CH2 Cl2, to give 17.0 g. of product. Anal. Calcd for C17 H21 NO3: C, 71.06; H, 7.37; N, 4.87; O, 16.70. Found: C, 71.19; H, 7.48; N, 5.12.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-98-7, its application will become more common.

Reference:
Patent; The Upjohn Company; US4036977; (1977); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 702-98-7, 2-Methyladamantan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C11H18O, blongs to alcohols-buliding-blocks compound. Formula: C11H18O

A reactor made of glass was charged with 110 g of toluene, 50 g of n-undecane, 80 g of 2-methyladamantanol, 4.1 g of methacrylic acid and 0.92 g of p-toluenesulfonic monohydrate. The resulting mixture was heated until the reflux of toluene occurred, followed by reflux for 2 hours while distilling off water, whereby 2-methyleneadamantane was prepared it was then cooled to 0 C. A methacrylate forming reaction was carried out by adding 103.6 g of methacrylic acid and 13.7 g of boron trifluoride ethyl ether to it and stirring the resulting mixture for 2 hours. The reaction mixture was washed with 1275.5 g of a 10% aqueous sodium carbonate solution, followed by washing three times with 160 g of deionized water. Toluene was then distilled off at 70 C. under reduced pressure, whereby 148.8 g of crude 2-methyladamantan-2-yl methacrylate was obtained. The resulting product contained 59.9 wt. % of 2-methyladamantan-2-yl methacrylate and 7.6 wt. % of 2-methyleneadamantane.

The synthetic route of 702-98-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Mitsubishi Chemical Corporation; US2008/51597; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 702-98-7, Adding some certain compound to certain chemical reactions, such as: 702-98-7, name is 2-Methyladamantan-2-ol,molecular formula is C11H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-98-7.

To a stirred mixture of 2-methyl-2-adamantanol 14 (200 mg, 1.21 mmol), triethylamine(243 mg, 2.41 mmol) and acetic anhydride (246 mg, 2.41 mmol), 4-dimethylaminopyridine (DMAP) (18 mg, 0.12 mmol) was added as the acetylation catalyst. The mixture was stirred at room temperature for 72 h (TLC minitoring,hexane/ether 3:1). Petroleum ether was added and the mixture was washed withHCl 5%, saturated NaHCO3, brine and dried (Na2SO4). After solvent evaporation the residue was chromatographed on silica gel column using hexane-ether 4:1 as eluent to afford 150 mg (60 %) of pure acetyl derivative 20 (a second fraction including 2-methylene adamantane was obtained).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-98-7, 2-Methyladamantan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kolocouris, Antonios; Koch, Andreas; Kleinpeter, Erich; Stylianakis, Ioannis; Tetrahedron; vol. 71; 16; (2015); p. 2463 – 2481;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 702-98-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 702-98-7, name is 2-Methyladamantan-2-ol. A new synthetic method of this compound is introduced below.

Comparative Example 1 Preparation of 2-methyl-2-adamantyl methacrylate from 2-methyl-2-adamantanol in the presence of triethyl amine 150 g (0.9 mole) of 2-methyl-2-adamantanol, 900 ml of tetrahydrofuran (THF) and 132 ml of methacrylic chloride were charged in a three neck flask, and stirred. The contents of the flask were cooled on an ice bath, and maintained at a temperature of not more than 10 C. 226 g of triethyl amine was slowly dropwise added to the resulting reaction mixture. After the mixture was reacted overnight at an ordinary temperature, iced water was portionwise added to the mixture. The reaction was further continued at -20 C. for 2 hours, and then at room temperature for one hour. An organic layer was separated from the mixture, washed with a saturated aqueous solution of sodium hydrogencarbonate and then with a saturated brine, and dried on anhydrous magnesium sulfate. The resulting product was concentrated to obtain 180 g of a raw product. Following concentration, the raw product was purified on a column of silica gel to obtain 161.4 g of a pure product (yield: 76.5%). An analysis of the thus obtained product indicated that the product was the target compound, i.e., 2-methyl-2-adamantyl methacrylate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-98-7, 2-Methyladamantan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Fujitsu Limited; US6248920; (2001); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 702-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a 50 mL two-neck flask was placed 1.611 g (10 millimol) of 2-methyl-2-adamantanol and to dissolve the same, was added 10 mL of dry tetrahydrofuran. When the content in the flask was cooled with a cooling medium to minus 65C, the uniform solution turned to slurry. To the resultant slurry was added dropwise 6.25 mL (10.0 millimol, 1.6 M) of solution of n-butyllithium in hexane over a period of approximately 1 to 2 minutes with a result that the slurry turned to yellow transparent solution. Subsequently, the resultant solution was subjected to natural temperature raising to room temperature to proceed with reaction for 3 hours, and reaction liquid thus obtained was used as such for the next synthesis.

According to the analysis of related databases, 702-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDEMITSU PETROCHEMICAL CO., LTD.; EP1398309; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 702-98-7, 2-Methyladamantan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Methyladamantan-2-ol, blongs to alcohols-buliding-blocks compound. Safety of 2-Methyladamantan-2-ol

A reactor made of glass and equipped with a stirrer was charged with 9 L of toluene, 950 g of 2-methyladamantanol, 50 g of methacrylic acid and 5.3 g of cresol sulfonic acid. The resulting mixture was heated until the reflux of toluene occurred, followed by reflux for 2 hours while distilling off water, whereby 2-methyleneadamantane was prepared. After it was cooled to 50 C. and 8 L of toluene was distilled off from it under reduced pressure, the residue was cooled to 0 C. A methacrylate forming reaction was then caused by adding 1280 g of methacrylic acid and 83 g of boron trifluoride ethyl ether and stirring the resulting mixture for one hour. After the reaction mixture was washed with 6 L of a 10% aqueous sodium carbonate solution and 5 L of deionized water, toluene was distilled off at 70 C. under reduced pressure, whereby 1126 g of crude 2-methyladamantan-2-yl methacrylate was obtained. The resulting product contained 91.3 wt. % of 2-methyladamantan-2-yl methacrylate and 7.9 wt. % of 2-methyleneadamantane. The crude 2-methyladamantan-2-yl(meth)acrylate (100 g) thus obtained and 50 g of n-undecane (boiling point under atmospheric pressure: 194.5 C., coagulation point: -25.6 C., solubility of methyleneadamantane in 100 g of n-undecane at 0 C.: 101 g) were distilled at 60 C. and 1 mmHg by using a vacuum still and 61 g was distilled off in 60 minutes. The fraction thus distilled off contained 86% of 2-methyleneadamantane together with undecane. The distillation temperature was raised to 85 C. and 3.5 g was distilled off further in 10 minutes to adjust the amount of 2-methyleneadamantane remaining in the still to less than 1 wt. %. The residue in the still was then distilled at 125 C. and 1 mmHg, whereby 81.2 g of 2-methyladamantan-2-yl(meth)acrylate having a purity of 99.5 wt. % was obtained. The resulting product had a 2-methyleneadamantane content of 0.1 wt. %.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-98-7, 2-Methyladamantan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mitsubishi Chemical Corporation; US2008/51597; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 702-98-7, 2-Methyladamantan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C11H18O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C11H18O

COMPARATIVE EXAMPLE 1 Synthesis of 2-methyl-2-adamantyl alpha-trifluoromethylacrylate [MAFAC] from 2-methyl-2-adamantanol and alpha-trifluoromethylacryloyl Chloride A 500 ml flask was flushed with nitrogen to displace the air with nitrogen, and was charged with 83.1 g (0.50 mol) of 2-methyl-2-adamantanol, 101.2 g (1.0 mol) of triethylamine and 200 g of tetrahydrofuran. Then 118.9 g (0.75 mol) of alpha-trifluoromethylacryloyl chloride was dropwise added to the content in the flask over a period of about 1 hour, while the content was maintained at a reaction temperature of about 0 C. Then the content was stirred for 10 hours at room temperature. After completion of the reaction, the reaction mixture was washed with water and then with an aqueous saturated sodium chloride solution. The thus-obtained organic phase was subjected to column chromatography, and further, analyzed by NMR and mass spectrometry. Thus, 101.2 g (yield: 70.3%) of the object 2-methyl-2-adamantyl alpha-trifluoromethylacrylate was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-98-7, 2-Methyladamantan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; TOSOH CORPORATION; US2003/139613; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.702-98-7, name is 2-Methyladamantan-2-ol, molecular formula is C11H18O, molecular weight is 166.26, as common compound, the synthetic route is as follows.Recommanded Product: 702-98-7

A reactor made of glass was charged with 160 g of n-undecane, 80 g of 2-methyladamantanol, 4.1 g of methacrylic acid and 0.92 g of p-toluenesulfonic monohydrate. The resulting mixture was maintained for 1 hour while distilling off water under atmospheric pressure. Water was removed further by reflux at 120 C. for 1 hour under reduced pressure at 150 mmHg, whereby 2-methyladamantane was prepared. It was cooled to 0 C. A methacrylate forming reaction was then carried out by adding 103.6 g of methacrylic acid and 13.7 g of boron trifluoride ethyl ether to it while stirring the resulting mixture for 2 hours. After the reaction mixture was washed with 1275.5 g of a 10% aqueous sodium carbonate solution, followed by washing three times with 160 g of deionized water. In such a manner, 260 g of a n-undecane solution of 2-methyladamantan-2-yl methacrylate was obtained. The resulting solution contained 29.6 wt. % of 2-methyladamantan-2-yl methacrylate and 5.2 wt. % of 2-methyleneadamantane. The present invention was described specifically by using specific modes. It is however apparent for those skilled in the art that the present invention can be changed or modified without departing from the gist and scope of the present invention.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-98-7, 2-Methyladamantan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mitsubishi Chemical Corporation; US2008/51597; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 702-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

REFERENCE EXAMPLE 1 Synthesis of 2-methyleneadamantane One liter flask equipped with a Dean-Stark condenser was charged with 166.3 g (1.0 mol) of 2-methyl-2-adamantanol (supplied by Sigma-Aldrich Co.), 2.0 g (20 mmol) of sulfuric acid and 500 g of toluene. The content was heated to the solvent reflux temperature. While toluene and water produced through the reaction were collected as an azeotrope by the Dean-Stark condenser, the reaction mixture was refluxed for 2 hours. After completion of the reaction, the catalyst was removed by washing the reaction mixture with water and the obtained organic phase was concentrated to dryness to give 152.5 g of white solid 2-methyleneadamantane (purity: 99.0%, yield: 98.0%).

According to the analysis of related databases, 702-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOSOH CORPORATION; US2003/139613; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts