Category: 702-82-9

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-82-9, name is 3-Aminoadamantan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 702-82-9

To a solution of 9 (2.0 g, 4.6 mmol) in DMF (20 mL) at room temperature, 3-amino-l- adamantanol (0.76 g, 4.5 mmol) and K2CO3 (1.2 g, 8.7 mmol) were added. The resulting mixture was stirred at 90 0C overnight then was cooled to room temperature and was diluted with ethyl acetate and water. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography, eluting with 1:1 hexanes:ethyl acetate, 3:7 hexanes:ethyl acetate, ethyl acetate and 9: 1 ethyl acetate: methanol to give 10 (1.8 g, 74% yield) as an off-white solid

With the rapid development of chemical substances, we look forward to future research findings about 702-82-9.

Reference:
Patent; ENCYSIVE PHARMACEUTICALS INC.; WO2009/53895; (2009); A2;,
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Related Products of 702-82-9, Adding some certain compound to certain chemical reactions, such as: 702-82-9, name is 3-Aminoadamantan-1-ol,molecular formula is C10H17NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-82-9.

27.6 g (0.30 mol, 1.5 eq) of glyoxylic acid monohydrate,3-amino-1-adamantanol 33.5 g (0.20 mol, 1.0 eq),38.8 g (0.30 mol, 1.5 eq) of diisopropylethylamine and 250 g of tetrahydrofuran were placed in the reaction flask.51.1 g (0.50 mol, 2.5 eq) of acetic anhydride was added dropwise.Heat and reflux for 2 hours.The remaining amount of controlled raw materials in HPLC is less than 1%.Add 50g of water and stir for 30 minutes.Layered,The aqueous layer was extracted once with 50 g of dichloromethane.The organic layer was concentrated under reduced pressure to give a white solid.Compound II 42.8g,The yield is 96.1%.Purity 96.6%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-82-9, 3-Aminoadamantan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dalian Zhengbang Information Advisory Co., Ltd.; Gao Feng; Xie Nan; (7 pag.)CN108503571; (2018); A;,
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Electric Literature of 702-82-9, Adding some certain compound to certain chemical reactions, such as: 702-82-9, name is 3-Aminoadamantan-1-ol,molecular formula is C10H17NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-82-9.

1) A mixed solution of 3-amino-1-adamantanol and 1-chloroacetyl-2-cyanopyrrolidine in a solvent was mixed with a suspension of a base and a catalyst and then preheated by a preheater;2) The preheated mixture enters the tubular reactor, the residence time of the material in the tubular reactor is 60min, and then the reaction liquid withdrawn from the tubular reactor is collected and filtered, washed and purified to obtain the product.The process parameters are as follows:The preheater temperature is 70 C, the tube reactor temperature is 70 C, and the flow rate of the material in the line is 0.5 m / s.The molar ratio of 3-amino-1-adamantanol to 1-chloroacetyl-2-cyanopyrrolidine was 2: 1,3-amino-1-adamantanol was 0.13 g / ml, 1-chloro The concentration of acetyl-2-cyanopyrrolidine was 0.068 g / ml, the molar ratio of potassium carbonate to 1-chloroacetyl-2-cyanopyrrolidine was 1: 1, the amount of potassium iodide was the same as that of 1-chloroacetyl The molar ratio of 2-cyanopyrrolidine was 0.5: 1, and the reaction solvent was 2-butanone.Under this operating condition, the yield of the Viglitin reaction was 85% and the amount of the disubstituted compound was 4.5%.

According to the analysis of related databases, 702-82-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Pharmaceutical Group Tsingtao Guofeng Pharmaceutical Co., Ltd.; Liu Zhenyu; Lu Weishen; Zu Jinxiang; Lv Yiqiang; Zhou Zhenyu; (7 pag.)CN104311467; (2017); B;,
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Electric Literature of 702-82-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 702-82-9, name is 3-Aminoadamantan-1-ol. A new synthetic method of this compound is introduced below.

Compound (S)-1-(2-chloroacetyl) pyrrolidine-2-carbonitrile (12.1 g, 70.3mmol) is added to dichloromethane (200mL), stir for 10 minutes, hydroxyl adamantanamine (12.7 g, 66.8mmol) is slowly added to the above solution, the resulting solution is stirred at room temperature for 10 minutes, Potassium carbonate (19. 3g, 140mmol) is added to the reaction solution, the reaction is stirred for 4 hours.The reaction solution has been filtered, the filter cake is washed with dichloromethane (50mL), combined filtrates. Rotate the solvent to get dryness, the residual oil is added to ethyl acetate to dissolve. The resulting ethyl acetate solution is washed with water (50mL X 2), dry over anhydrous sodium sulfate for 2 hours. The desiccant has been removed; and dried then obtained the crude compound 6 (21.2g).Vildagliptin crude (21. 2g) is added into the reactor which is containing 100mL 2-butanone. The mixture is heated to reflux (95 C) and stirred for 30 minutes. The mixture is filtered into a preheated (75 C) reactor; the filter cake is washed with using hot 2-butanone (100mL). The filtrate is heated to reflux for 30 minutes, slowly cool down at room temperature. Let stand overnight. The system is cooled with an ice water bath for 1 hour. The resulting suspension is filtered, the filter cake is washed twice with 2-butanone.The filter cake has been dried, and obtained target product Vildagliptin 12. 4g(white crystal), 61.3%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-82-9, its application will become more common.

Reference:
Patent; Shenzhen Hanyu Pharmaceutical Co., Ltd.; Liu Feimeng; Fang Yihua; Liu Jian; Ma Yaping; Yuan Jiancheng; (10 pag.)CN105884669; (2016); A;,
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Reference of 702-82-9 ,Some common heterocyclic compound, 702-82-9, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 5- (4-fluorophenyl) -7-trifluoromethylpyrazolo [1,5-a] pyrimidine-3-carboxylic acid (18, 3.08 mmol) obtained in the step 4) -dimethylaminopropyl) -3-ethylcarbodiimide (1.182 g, 6.18 mmol), 4-dimethylaminopyridine (0.3858, 3.08 mmol), 1-hydroxybenzotriazole (0.4158, 3.08 mmol ), 3-hydroxyamantanamine (4.62 mmol) and mixing to give a mixture I; sealing the vessel in which said mixture I is located, evacuating, passing nitrogen;After repeating the above steps three times, tetrahydrofuran and dimethylformamide were added to the mixture I under a nitrogen atmosphere to obtain a mixture; the tetrahydrofuran and TN, N-dimethylformamide were both dried and anhydrous ; Heating the mixture to a temperature of 40 C and heating for 6 hours, extracting, washing with water, combining and showing signs of drying to the mixture K; the extraction is carried out using a mixture of ethyl acetate Ester extraction, and the extraction process was repeated three times; the water washing process was repeated twice; and the drying was carried out using anhydrous sodium sulfate. The mixture K is subjected to distillation under reduced pressure to precipitate a solid; and the precipitated solid is filtered and washed to obtain a product. The washing was carried out using a mixed solution of ethyl acetate and n-hexane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-82-9, 3-Aminoadamantan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chongqing Medical College; SHI, LEI; NIU, YA HUI; (10 pag.)CN105884783; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 702-82-9 ,Some common heterocyclic compound, 702-82-9, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 5- (4-fluorophenyl) -7-trifluoromethylpyrazolo [1,5-a] pyrimidine-3-carboxylic acid (18, 3.08 mmol) obtained in the step 4) -dimethylaminopropyl) -3-ethylcarbodiimide (1.182 g, 6.18 mmol), 4-dimethylaminopyridine (0.3858, 3.08 mmol), 1-hydroxybenzotriazole (0.4158, 3.08 mmol ), 3-hydroxyamantanamine (4.62 mmol) and mixing to give a mixture I; sealing the vessel in which said mixture I is located, evacuating, passing nitrogen;After repeating the above steps three times, tetrahydrofuran and dimethylformamide were added to the mixture I under a nitrogen atmosphere to obtain a mixture; the tetrahydrofuran and TN, N-dimethylformamide were both dried and anhydrous ; Heating the mixture to a temperature of 40 C and heating for 6 hours, extracting, washing with water, combining and showing signs of drying to the mixture K; the extraction is carried out using a mixture of ethyl acetate Ester extraction, and the extraction process was repeated three times; the water washing process was repeated twice; and the drying was carried out using anhydrous sodium sulfate. The mixture K is subjected to distillation under reduced pressure to precipitate a solid; and the precipitated solid is filtered and washed to obtain a product. The washing was carried out using a mixed solution of ethyl acetate and n-hexane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-82-9, 3-Aminoadamantan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chongqing Medical College; SHI, LEI; NIU, YA HUI; (10 pag.)CN105884783; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 702-82-9, Adding some certain compound to certain chemical reactions, such as: 702-82-9, name is 3-Aminoadamantan-1-ol,molecular formula is C10H17NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-82-9.

Example 5: (3-Hydroxy-adamantan-l-ylamino)-acetonitrile (0107) In a 500 mL RBF 3-amino-adamantan-l -ol (30 g, leq.) was dissolved in ethyl acetate (300 mL, 10V). To this solution potassium carbonate (54.5 g, 2.2 eq.) and potassium iodide (3 g, 0.1 eq) was added under stirring. After 10 min. chloroacetonitrile (16.2 g, 1.2 eq.) was added and the mixture was heated at 75C under stirring for 5-6 h. Completion of reaction was confirmed by TLC. After complete conversion the reaction mixture was cooled to 20-25C. The reaction mass was filtered and washed the wet cake with ethyl acetate (30 mL, IV). The concentration of EtOAc layer gave 36 g (yield: 97%) of the title compound; 1H NMR Assay: 97.9%; NMR (CDC13, 400 MHz) delta: 1.49-1.78 (m, 12H, 6 CH2), 2.30 (s, 2H, 2x CH), 3.57 (s, 2H, l x CH2)

According to the analysis of related databases, 702-82-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HIKAL LIMITED; MOHILE, Swapnil Surendra; TAPKIR, Sandeep Rameshrao; PATIL, Manoj Vinayak; GANGOPADHYAY, Ashok Kumar; NIGHTINGALE, Peter David; WO2015/128718; (2015); A1;,
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Synthetic Route of 702-82-9 , The common heterocyclic compound, 702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 2(41 mg, 0.25 mmol) was dissolved in THF (15 ml). To the solution Et3N(69 mul, 0.50 mmol), indazole-3-carboxylic acid (27 mg, 0.16 mmol) and TBTU (79mg, 0.25 mmol) were added. The reaction mixture was left to stir overnight atroom temperature. Concentrated and purified on silica using a mobile phasesystem of EtOAc/n-heptane (4:1) to give compound 3 (41.5 mg, yield 81%).

The synthetic route of 702-82-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wallgren, Jakob; Vikingsson, Svante; Johansson, Anders; Josefsson, Martin; Green, Henrik; Dahlen, Johan; Wu, Xiongyu; Konradsson, Peter; Tetrahedron Letters; vol. 58; 15; (2017); p. 1456 – 1458;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 702-82-9 ,Some common heterocyclic compound, 702-82-9, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a suspension of 3a (206 mg, 0.748 mmol) in DMF (10 mL) was added DIPEA (0.392 mL, 2.245 mmol) and the solution was stirred at rt for 30 min. HBTU (568 mg, 1.497 mmol) was added portion wise, followed by the addition of 1-aminoadamantane (0.136 g, 0.898 mmol). The mixture was stirred at rt for 4 h and diluted with EtOAc (60 mL), washed with water (3 x 10 mL), HCl (0.5 M, 10 mL), water (10 mL) and brine (15 mL). Solvents were removed under reduced pressure and the residue was purified with flash chromatography using hexane:EtOAc (10:1 to 2:1) to give RS-005 (263 mg, 0.644 mmol, 86% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-82-9, its application will become more common.

Reference:
Article; Slavik, Roger; Herde, Adrienne Mueller; Bieri, Daniel; Weber, Markus; Schibli, Roger; Kraemer, Stefanie D.; Ametamey, Simon M.; Mu, Linjing; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 554 – 564;,
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Related Products of 702-82-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, molecular weight is 167.2481, as common compound, the synthetic route is as follows.

In a clean round bottom flask, (100gm) of 1-amino-3-adamantol in l000ml of acetonitrile were charged. 239.8gm of potassium carbonate was charged to the above flask. The reaction mass was heated to 82-85C. The compound of formula III (4x25gm), was charged after 60-90 mm intervals. After completion of reaction, the reaction mass was cooled to 65-70C. The reaction mass was filtered and the solid was washed with 500m1 acetonitrile and suck dried. Theacetonitrile was distilled out from filtrate under vacuum at 50-55C. Ethyl acetate was charged to the residue and the slurry stirred at 50-55C for 30-45 minutes. The slurry was cooled to 20-30C and stirred for 60-90 minutes. The solid was filtered and washed with ethyl acetate and suck dried, The wet cake was suspended in IPA and heated to 80-85C to get a clear solution. The clear solution was charcoalised and filtered through hyflo. The filtrate was distilled oUt undervacuum to get final volume to 5Volume. The reaction mass was cooled to -5 to 5C and stirred for 60-90 minutes. The solid was filtered and washed with IPA and suck dried. The solid was dried under vacuum at 50-55C. 105 to 120gm of solid was obtained (yield 59-68%, HPLC purity >98%)

The chemical industry reduces the impact on the environment during synthesis 702-82-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED; BHIRUD, Shekhar Bhaskar; BHUSHAN, Kumar Hari; THANEDAR, Amit Anant; RAUT, Changdev Namdev; CHAND, Prem; WO2014/102815; (2014); A1;,
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