Category: 6850-39-1

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6850-39-1, name is 3-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.17, as common compound, the synthetic route is as follows.Product Details of 6850-39-1

C. tert-butyl(3-Hydroxycyclohexyl)carbamate To a solution of 3-aminocyclohexanol (3.0 g, 26.0 mol) in THF (30 mL) was added di-tert-butyl dicarbonate (6.74 g, 31.2 mmol). The resulting mixture was stirred at 50 C. for 16 h. Then the reaction mixture was concentrated in vacuum and purified by silica gel column chromatography (30% ethyl acetate in petroleum ether) to afford the desired compound (4.40 g, 20.46 mmol, 78% yield). MS (ESI) m/z 216.1 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6850-39-1, 3-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Papa, Patrick; Cathers, Brian Edwin; CALABRESE, Andrew Antony; WHITEFIELD, Brandon Wade; BENNETT, Brydon; CASHION, Daniel; MORTENSEN, Deborah; HUANG, Dehua; TORRES, Eduardo; PARNES, Jason; SAPIENZA, John; HANSEN, Joshua; LEFTHERIS, Katerina; CORREA, Matthew; DELGADO, Maria Mercedes; RAHEJA, Neil; BAHMANYAR, Sami; HEGDE, Sayee; NORRIS, Stephen; PLANTEVIN-KRENITSKY, Veronique; US2015/175557; (2015); A1;,
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Application of 6850-39-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6850-39-1, name is 3-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

2- (t-butoxycarbonyl) amino) pyrazolo [1,5-a] pyrimidine-3-carboxylic acid (200mg, 0.72mmol)And 3-aminocyclohexanol (83 mg, 0.72 mmol)Dissolved in dichloromethane (8 mL)And 2- (7-azobenzotriazole) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate (334 mg, 0.88 mmol)And triethylamine (0.2 mL, 1.44 mmol).After the mixture was stirred at room temperature overnight,Quenched with water (30 mL)And extracted with ethyl acetate (100 mL x 3). The combined organic phases were washed with saturated brine (100 mL x 3), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether (v / v) = 1 / 2) to give the title compound as a light yellow solid (200 mg, 74.0%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6850-39-1, 3-Aminocyclohexanol.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; (88 pag.)CN104650092; (2017); B;,
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Reference of 6850-39-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6850-39-1, name is 3-Aminocyclohexanol. A new synthetic method of this compound is introduced below.

Treat a mixture of 3-hydroxycyclohexyl amine (10 g, 86.96 mmol), potassium carbonate (18 g, 130 mmol), ethyl acetate (150 mL) and water (70 mL) with benzyl chloroformate (22.17 g, 130 mmol). Stir the reaction at room temperature for 12 hours. Separate the organic layer, dry the organic over sodium sulfate, filter and concentrate. Add diethyl ether to the residuer. Filter the resulting white precipitate and air dry to afford 19.1 g of the title compound (88%). MS (m/z): 250 (M+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6850-39-1, 3-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Aicher, Thomas Daniel; Anzeveno, Peter Biagio; Li, Renhua; Krasutsky, Alexei Pavlovych; Mabry, Thomas Edward; Saeed, Ashraf; Snyder, Nancy June; Stephenson, Gregory Alan; Tian, Hongqi; Wallace, Owen Brendan; Winneroski, JR., Leonard Larry; Xu, Yanping; US2009/111800; (2009); A1;,
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Related Products of 6850-39-1 ,Some common heterocyclic compound, 6850-39-1, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of I [3 4.ch1oro.8methoxy- I H,2H,3 Wcyc1openta[ciquinolin7yl }oxy)propyl}pyrroiidine (Intermediate Wi) (250 mg, 0.69 mmoi, 100 eq.), i,4-dioxane (5 ml.), and t-l3uONa (331 mg, 3.45 mmol, 500 eq.) in a microwave reaction vial was purged with N2 for 5 mm. To the solution was added propan2amine (285 mg, 483 mol, 7.00 eq.), and 3rd Generation BrettPhos pre catalyst (64 mg, 007 rnmoi, 0.10 eq.). After being purged with N2 for additional 2 miii, the resultingsolution was sealed and subjected to microwave reactor (120 C, 1.5 h). The reaction mixture was allowed to cool to rt and quenched with H20 After removal of the volatiles under reduced pressure, the residue was redissoIved in DMSO, filtered and subjected to reverse preparative HPLC Prep C18, 5 mM XBndge column, 19x 150 mm, waters gradient elution of i025% MeCN in water over a 10 mm period, where both solvents contain 0.1% trifluoroacetic acid (TF A)) to provide the titlecompound as brown oil (70 ing, 15%). LCMS (ES) [[M+1]f m/z384.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6850-39-1, its application will become more common.

Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; YU, Ming; LI, Zhe; (206 pag.)WO2018/119208; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6850-39-1, 3-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6850-39-1, blongs to alcohols-buliding-blocks compound. Recommanded Product: 6850-39-1

To a stirred solution of 3-aminocyclohexanol (40.0 g, 0.348 mol) in DCM (350 ml) were added imidazole (71.0 g, 1.042 mol) and TBDMS-C1 (78.0 g, 0.520 mol) at 0 C. The mixture was allowed to stir at RT for 24 h. The reaction was quenched by H20, extracted with DCM, washed with brine solution, dried, filtered and concentrated to give title compound. Yield 78.1 g (crude); [M+H]+ = 230.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6850-39-1, 3-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; ORION CORPORATION; WOHLFAHRT, Gerd; RUMMAKKO, Petteri; KARJALAINEN, Arja; PASSINIEMI, Mikko; PIETIKAeINEN, Pekka; HAIKARAINEN, Anssi; VAeISAeNEN, Emilia; TIAINEN, Eija; WO2014/202827; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6850-39-1, 3-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Aminocyclohexanol, blongs to alcohols-buliding-blocks compound. name: 3-Aminocyclohexanol

To a solution of 4-chloropyrrolo[l,2-b]pyridazine-3-carbonitrile (15g) (0.15 g, 0.84 mmol) in DMF (2.5 mL) was added at room temperature 3-aminocyclohexanol (5In) (194 mgs, 1.68 mmol), DIPEA (0.87 mL, 5 mmol) and stirred at room temperature overnight. The reaction was quenched with water (10 mL) and extracted with ethyl acetate (10 mL). The aqueous layer was separated and extracted with ethyl acetate (2 x 10 mL). The organic layers were combined washed with water (2 x 10 ml), brine (10 mL), dried, filtered and concentrated in vacuum. The residue obtained was purified by flash column chromatography (silica gel 12g, eluting with 0- 100% ethyl acetate in hexanes) to furnish 4-(3-hydroxycyclohexylamino)pyrrolo[l,2- b]pyridazine-3-carbonitrile (51o) (0.105 g, 46 %) as a white solid: 1H NMR (300 MHz, DMSO) delta 7.90 (s, IH), 7.78 (d, J= 8.5 Hz, IH), 7.69 (dd, J= 2.6, 1.6 Hz, IH), 7.12 (dd, J= 4.4, 1.6 Hz, IH), 6.68 (dd, J= 4.4, 2.7 Hz, IH), 4.88 (d, J= 4.3 Hz, IH), 4.25 (m, IH), 3.54 (m, IH), 2.17 (m, IH), 1.92 (m,lH), 1.76 (d, J= 13.3 Hz, 2H), 1.54 – 1.24 (m, 3H), 1.16 (dd, J= 14.6, 10.6 Hz, IH). MS (ES+) 536.3 (2M+Na), MS (ES-) 291.0 (M+Cl).

The synthetic route of 6850-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda S.; KOTIAN, Pravin L.; KUMAR, V. Satish; WU, Minwan; LIN, Tsu-Hsing; WO2011/14817; (2011); A1;,
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Related Products of 6850-39-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6850-39-1, name is 3-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.17, as common compound, the synthetic route is as follows.

To a solution of 5-chloro-3-(5-fluoro-4-(methylsulfonyl)pyrimidin-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine, 1a, (1.09 g, 2.34 mmol) and 3-aminocyclohexanol (0.32 g, 2.82 mmol) in THE was added DIEA (0.60 g, 4.69 mmol). The reaction mixture was heated at 130 C. in microwave for 10 min. The solvent was removed under reduced pressure and the resulting residue was purified by silica gel chromatography to afford 550 mg of the desired product, 27a.

The chemical industry reduces the impact on the environment during synthesis 6850-39-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARIFSON, PAUL S; CLARK, MICHAEL P; BANDARAGE, UPUL K; BETHIEL, RANDY S; COURT, JOHN J; DENG, HONGBO; DAVIES, IOANA; DUFFY, JOHN P; FARMER, LUC J; GAO, HUAI; GU, WENXIN; JACOBS, DYLAN H; KENNEDY, JOSEPH M; LEDEBOER, MARK W; LEDFORD, BRIAN; MALTAIS, FRANCOIS; PEROLA, EMANUELE; WANG, TIAN-SHENG; WANNAMAKER, M WOODS; BYRN, RANDAL; CHOU, II; LIN, CHAO; JIANG, MIN; JONES, STEVEN; GERMANN, URSULA A; SALITURO, FRANCESCO G; KWONG, ANN DAK-YEE; (541 pag.)JP2015/38146; (2015); A;,
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